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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Radiation toxicity to the heart:physiopathology and clinical data显示文摘 | Girand P Cosset JM | | 0，，37： | 1 |
| 3 | Radiation toxicity to the heart:physiopathology and clinical data显示文摘 | Giraud P Cosset JM | 2004 | Bull Cancer2004，91，3： | 1 |
| 4 | Overexpression of alveolar macmphage gelatinase B (MMP-9) in patients with idiopathic pulmonary fibrosis: effects of steroid and immunosuppressive treatment 显示文摘 | Lemjabbar H Cosset P Lechapt-Zalcman E etal | 1999 | Am J Respir Cell Mol Biol1999，20，5： | 1 |
| 5 | Suspension Packaging cell lines for the simplified generation of T-cell receptor encoding retrovirus vector partieles显示文摘 | Reuss S Biese P Cosset F L | 2007 | Gene Ther2007，14，7： | 1 |
| 6 | Peroxisome prolif- erator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells 显示文摘 | Cosset P Charbonnier AS Delefive P | 2001 | Eur J Immunol2001，31，10： | 1 |
| 7 | Radiation toxicity to the heart: physiopathol- ogy and clinical data 显示文摘 | Giraud P Cosset JM | 2004 | Bull Cancer2004，913，： | 1 |
| 8 | Radiation toxicitytothe heart:physiopathology and dinical data显示文摘 | Giraud P Cosset JM | 2004 | Bull Cancer2004，91，3： | 1 |
| 9 | Overgrowth and trisomy 15q26 1-qter including the IGF-I receptor gene: report of two families and review of the literature 显示文摘 | Faivre L Cosset P Cormier DV | 2002 | Eur J Hum Genet2002，10，11： | 1 |
| 10 | 显示文摘 | Gressier B Lebegue S Cosset P | 1994 | Fundam Clin Pharmacol1994，8，6： | 1 |
| 11 | Production of chemokines and proinflaramatory and antiinflammaory cytokines by human alveolar macrophages activated by IgE receptors显示文摘 | Cosset P Tillie-Leblond I Oudin S | 1999 | J Allergy Clin Immunol1999，103，21： | 1 |
| 12 | Radiation toxicity to the heart:physiopathology and clinical data显示文摘 | GIRAUD P COSSET J M | 2004 | Bull Cancer2004，91，： | 1 |
| 13 | Chromosome abnormalities in sperm from infertile men with normal somatic karyotypes: teratozoospermia显示文摘 | Machev N Cosset P Viville S | 2005 | Cytogenet Genome Res2005，111，34： | 1 |
| 14 | Radiation toxicity to the heart:physiopathology and clinical data显示文摘 | Girard P Cosset JM | 2004 | Bull Cancer2004，91，： | 1 |
| 15 | EGFR and EphA2are host factors for hepatitis C virus entry and possible targets for antiviral therapy显示文摘 | Lupberger J Zeisel M B Xiao F Thumann C Fofana I Zona L Davis C Mee C J Turek M Gorke S Royer C Fischer B Zahid M N Lavillette D Fresquet J Cosset F L Rothenberg S M Pietschmann T Patel A H Pessaux P Doffol M Raffelsbe-rger W Poch O McKeating J A Brino L Baumert T F | 2011 | Nat Med2011，17，5： | 1 |
| 16 | Cell and cytokine profiles in nasal secretions from patientswith nasal polyposis:effects of topical steroids and surgical treatment显示文摘 | Bolard F Cosset P Lamblin C | 2001 | Allergy2001，56，4： | 1 |
| 17 | Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C 显示文摘 | Pestka JM Zeisel MB Blfser E Schiirmann P Bartosch B Cosset FL Patel All Meisel H Baumert J Viazov S Rispeter K Blum HE Roggendorf M Baumert TF | 2007 | Proc Natl Acad Sci USA2007，104，14： | 1 |
| 18 | Cytokines and cytokine network in silicosis and coal workers' pneumoconiosis 显示文摘 | VANHEE D COSSET P BOITELLE A | 1995 | Eur Respir J1995，8，5： | 1 |
| 19 | Increased expression of ELAM-1ICAM-1, and VCAM-1 on bronchial biopsies from allergic asthmatic patients显示文摘 | Cosset P Tillie-leblond I Janin A | 1994 | Ann NY Acad Sci1994，725，： | 1 |
| 20 | A universal transgene silencing method based on RNA interference显示文摘 | Mangeot P E Cosset F L Colas P | 2004 | Nucleic Acids Res2004，32，12： | 1 |
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