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| 1 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 2 | The alpha-gluc-osidase inhibitor 1-deoxynojirimycin blocks human immunodefi-ciency virus envelope glycoprotein-mediated membrane fusion at theCXCR4 binding step显示文摘 | Papandréou MJ Barbouche R Guieu R | 2002 | Mol Pharmacol2002，61，1： | 1 |
| 3 | Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients显示文摘 | Ben-All M Barbouche MR Bousnina S Chabbou A Dellagi K | 2004 | Clin Diagn Lab hnmunol2004，11，3： | 1 |
| 4 | Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in T unisian patients显示文摘 | Ben All M Barbouche MR Bousnina S | | 0，，： | 1 |
| 5 | The α - glueosidase in- hibitor 1 - deoxynojirimycin blocks human immunodeficiency virus en- velope glycopl, otein - mediated membrane fusion at the CXCR4 binding step 显示文摘 | Papandreou MJ Barbouche R Guieu R | 2002 | Mol Pharmaco12002，61，1： | 1 |
| 6 | Contribution of redox status to hepatitis C virus E 2 envelope protein function and antigenicity显示文摘 | Emmanuet Fenouilfet Dimitri LaviHete SiIvia Loureiro George Krashias Guillemette Maurin Fran?ois-Lo?c Cosset lan M Jones Eym Barbouche | 2008 | The Journal of biological chemist ry2008，283，26： | 1 |
| 7 | Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tubercutosis in Tunisian patients显示文摘 | Ben-Ali M Barbouche MR Bousnina S Chabbou A Dellagi K | 2004 | Clin Diagn Lab Immunol2004，11，3： | 1 |
| 8 | Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients显示文摘 | Ben-Ali M Barbouche MR Bousnina S | 2004 | Clin Diagn Lab Immunol2004，11，： | 1 |
| 9 | Urinary tract infections following renal transplantation: a single-center experience显示文摘 | Barbouch S CherifM Ounissi M | 2012 | Saudi J Kidney Dis Transpl2012，23，6： | 1 |
| 10 | Toll-like receptor 2 Ar9677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients 显示文摘 | Ben-Ali M Barbouche MR Bousnina S | 2004 | Clin Diagn Lab Immunol2004，11，3： | 1 |
| 11 | The a-glucosidase inhibitor 1-deoxynojirimycin blocks human immunodeficiency virus envelope glycoprotein-mediated membrane fusion at the CXCR4 binding step 显示文摘 | Papandreou M J Barbouche R Guieu R | 2002 | Mol Pharmaco12002，61，1： | 1 |
| 12 | Clinical and genetic heterogeneity of inherited autosomal recessive susceptibility to disseminated Mycobacterium boris Bacille Calmette-Guerin infection 显示文摘 | Elloumi-Zghal H Barbouche MR Chemli J Bejaoui M Harbl A Snoussi N | 2002 | J Infect Dis2002，185，10： | 1 |
| 13 | A novel simple and rapid PCR-based site-directed mutagenesis method显示文摘 | Imen Rabhi Naouel Guedel Imen Chouk Khaled Zerria M. Ridha Barbouche Koussay Dellagi Dahmani M. Fathallah | 2004 | Molecular Biotechnology2004，，1： | 1 |
| 14 | Brown tumors in patients with chronic renal failure and secondary hyper parathyroidism: report of 12 cases显示文摘 | Fatma LB Barbouch S Fethi BH | 2010 | Saudi J Kidney Dis Transpl2010，21，4： | 1 |
| 15 | Glycosaminoglycans and protein disulfide isomerase-mediated reduction of HIV Env显示文摘 | Barbouche R Lortat-Jacob H Jones IM | 2005 | Mol Pharmacol2005，67，4： | 1 |
| 16 | The catalytic activity of protein disulfide isomerase is involved in human immunodeficiency virus envelope-mediated membrane fusion after CD4 cell binding显示文摘 | Fenouillet E Barbouche R Courageot J | 2001 | J Infect Dis2001，183，5： | 1 |
| 17 | Effect of product temperature during primary drying on the long-term stability of lyophilized proteins 显示文摘 | Passot S Fonseca F Barbouche N et d | 2007 | Pharm Dev Technol2007，12，6： | 1 |
| 18 | Successful treatment ofFusarium solani ecthyma gangrenosum in a patient affected by leukocyte adhesion deficiency type 1 with granulocytes transfusions显示文摘 | Mellouli F Ksouri H Barbouche R | 2010 | BMC Dermatol2010，10，1： | 1 |
| 19 | Toll-like receptor 2 Arg677Trp polymorphism is associated with susceptibility to tuberculosis in Tunisian patients显示文摘 | Ben-Ali M Barbouche MR Bousnina S | 2004 | Clin Diagn Lab Immunol2004，11，3： | 1 |
| 20 | Brown tumors in patients with chronic renal failure and secondary hyperparathyroidism:report of 12 cases显示文摘 | Fatma LB Barbouch S Fethi BH | 2010 | Saudi J Kidney Dis Transpl2010，21，4： | 1 |
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