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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Cadmium neurotoxicity显示文摘 | Marisela Méndez-Armenta Camilo Ríos | 2006 | Environmental Toxicology and Pharmacology2006，，3： | 3 |
| 3 | Preparation and characterization of (3-aminopropyl)triethoxysilane-coated magnetite nanoparticles显示文摘 | M Yamaura R.L Camilo L.C Sampaio M.A Macêdo M Nakamura H.E Toma | 2004 | Journal of Magnetism and Magnetic Materials2004，，2： | 1 |
| 4 | Individualized nutrition intervention is of major benefit to colorectal cancer patients:long-term follow-up of a randomized controlled trial of nutritional therapy 显示文摘 | Ravasco P Monteiro-Grillo l Camilo M | 2012 | Am J ClinNutr2012，96，6： | 1 |
| 5 | Preparation and characterization of (3-aminopropyl) triethoxysilane-coated magnetite nanoparticles显示文摘 | Yamaura M Camilo R L | 2004 | J Magn Magn Mater2004，279，： | 1 |
| 6 | Individualized nutrition intervention is of major benefit to colorectal cancer patients:long-term follow-up of a randomized controlled trial of nutritional therapy显示文摘 | RAVASCO P MONTEIRO GRILLO I CAMILO M | 2012 | Am J Clin Nutr2012，96，6： | 1 |
| 7 | Tube feeding in mechanically ventilated critically ill patients:a prospective clinical audit显示文摘 | Ravasco P Camilo M E | 2003 | Nutr Clin Pract2003，18，5： | 1 |
| 8 | Temperature correction and strut loads in Central Artery excavations 显示文摘 | Hashash Youssef M A Marulanda Camilo Kershaw Kyle A | 2003 | Journal of Geotechnical and Geoenvironmental Engineering2003，129，6： | 1 |
| 9 | Prparation and characterization of (3-aminopropyl) triethoxysilane-coated magnetite nanoparticles 显示文摘 | YAMAURA M CAMILO R L SAMPAIO L C | 2004 | J Magn Magn Mater2004，279，23： | 1 |
| 10 | Podophyllotoxin显示文摘 | Camilo C Rita M M Franck E D | 2005 | Phyto-chemistry2005，4，： | 1 |
| 11 | Non- surgical endodontic management using MTA for per- forative defect of internal root resorption: report of a long term follow-up显示文摘 | Brito-Jfinior M Quintino AF Camilo CC | 2010 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2010，110，6： | 1 |
| 12 | Dynamics of Pseudomonas aeruginosa genome evolution显示文摘 | Kalai M Giri N Camilo V | 2008 | PNAS2008，105，： | 1 |
| 13 | Water level fluctuations derived from ENVISAT Radar Altimeter (RA-2) and in-situ measurements in a subtropical waterbody: Lake Izabal (Guatemala) 显示文摘 | Camilo E M Jesus G-E Jose J | 2008 | Remote Sensing of Environment2008，112，： | 1 |
| 14 | Cadmium neurotoxicity显示文摘 | Marisela M'endez-Armenta Camilo R'ios | 2007 | Environmental Toxicology and Pharmacology2007，23，： | 1 |
| 15 | Novel Cellular Genes Essential for Transfomuation of Endothelial Cells by Kapesi's SarcomaAssociated Herpesvims显示文摘 | CAMILO R REBECCA R SHANE M A | 2005 | Cancer Res2005，65，12： | 1 |
| 16 | Thermal acclimation of leaf respiration of tropical trees and lianas : response to experimen- tal canopy wanning, and consequences for tropical forest carbon balance 显示文摘 | Slot M Camilo R Stefan G | 2014 | Global Change Biology2014，20，9： | 1 |
| 17 | Traditional Uses, Chemical Constituents, and Biological Activities of Bixa orellana L.: A Review显示文摘 | Daniela de Araújo Vilar Marina Suênia de Araujo Vilar Túlio Flávio Accioly de Lima e Moura Fernanda Nervo Raffin Márcia Rosa de Oliveira Camilo Flamarion de Oliveira Franco Petr?nio Filgueiras de Athayde-Filho Margareth de Fátima Formiga Melo Diniz José M | 2014 | The Scientific World Journal2014，，： | 1 |
| 18 | Optimal Coordinated Operation of Distributed Static Series Compensators for Wide-area Network Congestion Relief显示文摘Relieving network congestions is a critical goal for the safe and flexible operation of modern power systems, especially in the presence of intermittent renewables or distributed generation. This paper deals with the real-time coordinated operation of distributed static series compensators(DSSCs) to remove network congestions by suitable modifications of the branch reactance. Several objective functions are considered and discussed to minimize the number of the devices involved in the control actions, the total losses or the total reactive power exchanged, leading to a non-convex mixed-integer non-linear programming problem. Then, a heuristic methodology combining the solution of a regular NLP with k-means clustering algorithm is proposed to get rid of the binary variables, in an attempt to reduce the computational cost. The proposed coordinated operation strategy of the DSSCs is tested on several benchmark systems, providing feasible and sufficiently optimal solutions in a reasonable time frame for practical systems. | Camilo Andres Ordonez M Antonio Gomez-Exposito Guillermo EVinasco M Jose Maria Maza-Ortega | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，5： | 1 |
| 19 | Pharmacological characterization of AMP 579,a novel adenosine A1/A2 receptor agonist and cardioprotective显示文摘 | Linda M Camilo JR | 1998 | Drug Dev Res1998，45，： | 1 |
| 20 | conplement protein C1q inhibits antibody-dependent enhancement of flavivirus infection in aa IgG subclass-specific manner显示文摘 | Erin M Camilo AS Syd J | | 0，，06： | 1 |
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