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| 1 | 极高强度他汀治疗对冠状动脉粥样硬化消退的影响——ASTEROID试验显示文摘背景:以前的血管内超声(intravascular ultrasound,IVUS)试验证实,他汀治疗可减缓或阻止动脉粥样硬化的进展,但是迄今尚无应用动脉粥样斑块体积百分比(percent atheroma volume,PAV)证实粥样硬化消退的确切证据。PAV是最严格的评价病变进展和消退的IVUS测量指标。
目标:评价极高强度他汀治疗是否能逆转IVUS确定的冠状动脉粥样硬化。
设计和地点:于美国、加拿大、欧洲和澳大利亚53个社区和3级保健中心进行前瞻性开标盲法终点试验(A Study to Evaluate the Effect of Rosuvastatin on Intravascular Ultrasound-Derived Coronary Atheroma Burden,ASTEROID)。应用马达驱动回撤IVUS评价基线和治疗24个月时冠状动脉粥样斑块负荷。每对基线和随访IVUS测量结果均进行盲法分析。
病例:从2002年11月到2003年10月,507例患者有基线IVUS检查结果,并接受至少1个剂量的研究药物。在24个月后,349例患者具有可用于评估的系列IVUS检查结果。
干预:所有患者均接受瑞舒伐他汀40ms/d强化治疗。
主要观测指标:预先设定了两个一级疗效指标:PAV变化和基线最严重病变10min节段动脉粥样斑块体积变化。二级疗效指标为整个动脉标准化总斑块体积的变化。结果:平均(SD)LDL—C水平由基线时的130.4(34.3)ms/dL降至60.8(20.0)ms/扎,平均下降了53.2%(P〈0.001)。平均(SD)HDL-C水平从基线时的43.1(11.1)ms/dL升至49.0(12.6)ms/dL,平均增加了14.7%(P〈0.001)。整个血管PAV平均(SD)变化为-0.98%(3.15%),中位数为-0.79%(97.5%CI,-1.21%~-0.53%)(与基线比较,P〈0.001)。最严重病变10min节段斑块体积平均(SD)变化为-6.1(10.1)mm^3,中位数为-5.6mm^3(97.5%CI,-6.8~-4.0mm^3)(与基线比较,P〈0.001)。总斑块体积变化中位数降低了6.8%,平均减少了-14.7(25.7)mm^3,中位数为-12.5mm^3(95%CI,-15.1~-10.5mm^3)(与基线比较,P〈0.001)。不良事件少见,与其他他汀试验相似。
结论:应用瑞舒伐他汀40ms/d进行极高强度他汀治疗可使LDL-C平均水平达到60.8ms/dL,使HDL—C增加14.7%。这导致所有3个预先设定的IVUS斑块负荷指标均显示动脉粥样硬化消退。因此,将LDL-C降至低于目前指南规定的水平,同时显著提高HDL-C,可以使冠心病患者动脉粥样硬化斑块消退。这些变化对临床预后的影响尚需进一步研究确定。 | Steven E. Nissen Stephen J. Nicholls Ilks Sipahi Peter Libby Joel S. Raichlen Christie M. Ballantyne Jean Davignon Raimund Erbel Jean Charles Fruchart Jean-Claude Tardif Paul Schoenhagen Tim Crowe Valerie Cain Kathy Wolski Marlene Coormastic E. Murat Tuzcu 仝其广(译) 王淑敏(译) 胡大一(校) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 341 |
| 2 | 二倍体型及三倍体型卫氏并殖吸虫的DNA重复顺序的比较研究显示文摘从东北地区获得两类型卫氏并殖吸虫,提取其基因组DNA。用5种限制性内切酶消化,琼脂糖凝胶电泳后,观察两类型成虫基因组DNA的酶切片段。又用Southern印渍技术对两类型7种酶消化物的结果做了比较。显示两类型Bam HI、Hind Ⅲ及Eco RI的酶切结果基本相同,但Pst Ⅰ、DdeⅠ、HaeⅢ及HpaⅡ的结果却显示两类型的DNA重复顺序有明显差别。此结果在单个虫体DNA的杂交技术检测中也得到证实。 | 王恩荣 郑韧坚 Cain GD | 1991 | 中国寄生虫学与寄生虫病杂志1991，9，1： | 11 |
| 3 | 两型卫氏并殖吸虫蛋白质及其抗原性的比较研究显示文摘应用SDS-聚丙烯酰胺凝胶电泳(SDS-PAGE)和电泳转移酶标免疫印斑技术(Western-blot)对卫氏并殖吸虫二倍体型和三倍体型成虫的蛋白质及其抗原性进行了比较研究。SDS-PAGE结果表明,两型虫株的结构蛋白质均具有基本相同的分子量。Westernblot的分析结果显示,两型虫株的主要抗原22.5KD蛋白质区带均能分别与狗、犬鼠和兔抗两型虫株血清反应;两型虫株的27/28/兆9KD蛋白质区带分别与狗抗两型虫株血清发生反应。本研究结果表明,卫氏并殖吸虫的二倍体型和三倍体型虫株的蛋白质及其抗原性之间存在着高度的同源性。 | 郑韧坚 王恩荣 George Cain | 1991 | 中国人兽共患病杂志1991，7，3： | 6 |
| 4 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 5 | Esophageal obstruction due to enteral feed bezoar:A case report and literature review显示文摘This paper describes a rare complication of enteral feeding,esophageal obstruction due to feeding formula bezoar,and reviews the published cases. An attempt to re-insert the nasogastric tube in a chronically ventilated 80-year-old female fed via a nasogastric tube with Jevity failed. An esophagogastroduodenoscopy revealed an 18 cm-long concretion of the feeding formula,fi-lling most of the esophageal lumen,which was removed endo scopically. Forty-two cases of feeding formula esophageal bezoars have been reported in the literature. The formation of feeding formula bezoars is triggered by acidic gastroesophageal reflux. The acidic pH in the esophagus causes clotting of the casein in the formula. Predisposing factors for bezoar formation are:mechanical ventilation,supine position,neurological diseases,diabetes mellitus,hypothyroidism,obesity and history of partial gastrectomy. Diagnosis and removal of the bezoar is done endoscopically. Feeding in a semi-recumbent position,administration of prokinetic agents and proton pump inhibitors may prevent this complication. | Esther-Lee Marcus Ron Arnon Arkadiy Sheynkman Yehezkel G Caine Joseph Lysy | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，10： | 3 |
| 6 | 将中国自杀研究的重心从农村转向城市(英文)显示文摘The recent paper by Jiang and colleagues[1] regarding the characteristics of persons who made medically serious suicide attempts in rural Shandong Province from August 1998 to August 2000 reaffirmed observations reported by Phillips and his colleagues from the mid-1990s to the middle of the first decade of the 21st century.[2-5] Specifically, the characteristics of suicide decedents and of near-fatal suicide attempters were different from what has been encountered in the United States, European Union, Australia, and other economically developed countries.More were women, fewer had major diagnosed psychopathology, and many more had near-term stressful life events preceding relatively sudden, often unplanned (or low-planned) suicides. | Eric D. CAINE | 2013 | 上海精神医学2013，25，3： | 3 |
| 7 | Morphine Modulates NFκB Activation in Macrophages显示文摘 | Sabita Roy Kelly J. Cain Rebecca B. Chapin Richard G. Charboneau Roderick A. Barke | 1998 | Biochemical and Biophysical Research Communications1998，，2： | 2 |
| 8 | Nanoarchitectured LiMn_2O_4/Graphene/ZnO Composites as Electrodes for Lithium Ion Batteries显示文摘LiMn_2O_4 nanoparticles are facilely synthesized using a sol—gel processing method.Graphene is added to LiMn_2O_4 electrode aiming at increasing specific capacity and improving rate capability.In order to further improve cycling stability of LiMn_2O_4/graphene electrode,atomic layer deposition(ALD)is used to deposit ultrathin ZnO coating composed of six ZnO ALD layers and modify the surface of either LiMn_2O_4/graphene electrode or individual LiMn_2O_4 particles to form nanoarchitectured LiMn_2O_4/graphene/ZnO electrodes.Both ZnO-ALD-modified LiMn_2O_4/graphene electrodes demonstrate enhanced cycling performance at 1C retaining the final discharge capacity above 122 mA h g^(-1)after 100 electrochemical cycles,which is higher than115 mA h g^(-1)of pristine LiMn_2O_4/graphene electrode and 109 mA h g^(-1)of bare LiMn_2O_4 electrode.The improved electrochemical performance of nanoarchitectured LiMn_2O_4/graphene/ZnO electrodes can be attributed to the cooperative effects from high electronic conductivity of graphene sheets to facilitate electron transportation and effective protection of ZnO ALD coating to restrict Mn dissolution and electrolyte decomposition. | Saad Aziz Jianqing Zhao Carrington Cain Ying Wang | 2014 | Journal of Materials Science & Technology2014，30，5： | 2 |
| 9 | The Serotonin Transporter Polymorphism rs25531 Is Associated with Irritable Bowel Syndrome显示文摘 | Ruth Kohen Monica E. Jarrett Kevin C. Cain Sang-Eun Jun Grace P. Navaja Sarah Symonds Margaret M. Heitkemper | 2009 | Digestive Diseases and Sciences2009，，12： | 2 |
| 10 | Renal safety of intensive cholesterol-lowering treatment with rosuvastatin: A retrospective analysis of renal adverse events among 40,600 participants in the rosuvastatin clinical development program显示文摘 | Evan A. Stein Donald G. Vidt James Shepherd Valerie A. Cain Deborah Anzalone Michael D. Cressman | 2012 | Atherosclerosis2012，，2： | 2 |
| 11 | 如何使金融创新转化为盈利显示文摘即使在高度成熟的金融产品领域,也依然有无数方法进行创新以及在创新过程中创造价值。问题是很少有金融机构能够在创新的同时持续地将新点子转化为利润。创新不仅是产品、服务、程序、商业模型或其他方式的创新,而且是一个过程,因此与任何其他过程一样,需要严格管理和不断投入。 | James PAndrew Charmian Caines Thomas Klotz | 2006 | 新金融2006，，10： | 2 |
| 12 | Oral Sulfonylurea Hypoglycemic Agents Prevent Ischemic Preconditioning in Human Myocardium: Two Paradoxes Revisited显示文摘 | Joseph C. Jr Cleveland Daniel R. Meldrum Brian S. Cain Anirban Banerjee Alden H. Harken | 1997 | Circulation1997，，1： | 2 |
| 13 | Comparison of the efficacy and safety of rosuvastatin versus atorvastatin , simvastatin , and pravastatin across doses (STELLAR * * STELLAR = Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin. Trial)显示文摘 | Peter H Jones Michael H Davidson Evan A Stein Harold E Bays James M McKenney Elinor Miller Valerie A Cain James W Blasetto | 2003 | The American Journal of Cardiology2003，，2： | 2 |
| 14 | A spatially explicit test of foraging in a clonal plant显示文摘 | Evans Jonathan P Cain Michael L | 1995 | Ecology1995，76，4： | 1 |
| 15 | The cost of increased animal welfare standards in UK pig production systems 显示文摘 | GUY J H BORNETT H L I CAIN P J | 2003 | Farm Management2003，11，7： | 1 |
| 16 | Optimizing antibody panels for efficient and cost-effective flow cytometric diagnosis of acute leukemia显示文摘 | Haycocks NG Lawrence L Cain JW | 2011 | Cytometry B Clin Cytom2011，80，4： | 1 |
| 17 | The Rainfall Intensity-Duration Control of Shallow Landslides and Debris Flows显示文摘 | Caine N | 1980 | Geogr Ann Ser A1980，6，： | 1 |
| 18 | Relationship of texture profile analysis and Warner-Bratzler shear force with sensorycharacteristics of beef rib steaks显示文摘 | CAINE W R AALHUS J L BEST D R | 2003 | Meat Science2003，64，4： | 1 |
| 19 | Yeno-arterial CO2 difference during regional ischemic or hypoxie hypoxia 显示文摘 | Vallet B Teboul JL Cain S | 2000 | J Appl Physiol2000，89，4： | 1 |
| 20 | Linear network coding 显示文摘 | LIS Y R YEUNG R W CAIN | 2003 | IEEE Transactions on Information Theory2003，49，2： | 1 |
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