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| 1 | Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor显示文摘T 房间 receptor-CD3 建筑群(TCR ) 是能基于 CD3 细胞质的领域的各种各样的生物化学的变化开始抗原特定的有免疫力的回答的一台万用的发信号机器,但是内在的结构的基础留下逃犯。这里,我们开发了生物物理的途径学习 CD3 细胞质的领域的 conformational 动力学(CD3 CD ) 。在单个分子的水平,我们发现那 CD3 CD 能与三个功能的主题的不同坦诚有多重 conformational 状态,即, ITAM, BRS 和 PRS。因为,这些符合构造被产生 CD3 CD 有异构的类脂化合物绑定性质因此有异构的动力学。实时房间的成像实验证明不同抗原刺激能稳定 CD3 在不同符合构造的 CD 。类脂化合物依赖者 conformational 动力学因此为 TCR 的万用的发信号性质提供结构的基础。 | Xingdong Guo Chengsong Yan Hua Li Wenmao Huan Xiaoshan Shi Min Huang Yingfang Wang Weiling Pan Mingjun Cai Lunyi Li Wei Wu Yibing Bai Chi Zhang Zhijun Liu Xinyan Wang Xiaohui F Zhang Chun Tang Hongda Wang Wanli Liu Bo Ouyang Catherine C Wong Yi Cao Chenqi Xu | 2017 | Cell Research2017，27，4： | 5 |
| 2 | Visual characterization of targeted effect of holo-transferrin-tagged dihydroartemisinin on human breast cancer cells显示文摘Targeted drugs could significantly reduce cytotoxic effect and increase therapeutic activity. Dihydroartemisinin (DHA) has been shown to be effective in killing cancer cells. However, it exhibits non-targeted property. Holo-transferrin (TF) is a suitable drug-carrier to target cancer cells, because cancer cells need iron uptake by the TF-mediated mechanism to maintain their uncontrolled growth. Furthermore, TF receptors (TF-R) are highly expressed on cancer cell surfaces. In this paper, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the different killing effect of 4-(12-Dihydroartemisininoxy) Benzoic Acid Hydrozide-transferrin (DBAH-TF) on human breast cancer cells (MCF-7) cells and human normal breast (HNB) cells, and atomic force microscopy (AFM) was used to visually observe the targeted effect of DBAH-TF on MCF-7 cells. MTT results show that DBAH-TF is 172 times more potent than DHA in killing MCF-7 cells, while the cytotoxic effect of DBAH-TF on HNB cells is merely 1/33 to DHA. Also, the killing effect of DBAH-TF on MCF-7 cells is 286 times that on HNB cells, showing targeted effect. Moreover, there are distinct differences in ultrastructures of cellular surfaces after DBAH-TF and DHA treatment. Through AFM imaging, many characteristic holes were observed on the cancer cell surface after being effected by DBAH-TF, which differ from the holes with irregular shapes affected by DHA. These results visually show that the DBAH-TF targeted drug has more potent killing effect on MCF-7 cells compared with DHA. | XIE WeiLing YANG PeiHui ZENG Xin WANG Hui CAI HuaiHong CAI JiYe | 2010 | Chinese Science Bulletin2010，55，22： | 4 |
| 3 | Application of fluorescence in situ hybridization in the detection of bladder transitional-cell carcinoma: A multi-center clinical study based on Chinese population显示文摘Objective:To evaluate the diagnostic value of fluorescence in situ hybridization(FISH)in bladder cancer.Methods:We enrolled healthy volunteers and patients who were clinically suspected to have bladder cancer and conducted FISH tests and cytology examinations from August 2007 to December 2008.Receiver operating characteristic(ROC)curve analysis was performed and the area under curve(AUC)values were calculated for both the FISH and urine cytology tests.Results:A cohort of 988 healthy volunteers was enrolled to establish a reference range for the normal population.A total of 4807 patients with hematuria were prospectively,randomly enrolled for the simultaneous analysis of urine cytology,FISH testing,and a final diagnosis as determined by the pathologic findings of a biopsy or a surgically-excised specimen.Overall,the sensitivity of FISH in detecting transitional-cell carcinoma was 82.7%,while that of cytology was 33.4%(p<0.001).The sensitivity values of FISH for non-muscle invasive and muscle invasive bladder transitional-cell carcinoma were 81.7%and 89.6%,respectively(p=0.004).The sensitivity values of FISH for low and high grade bladder cancer were 82.6%and 90.1%,respectively(p=0.002).Conclusion:FISH is significantly more sensitive than voided urine cytology for detecting bladder cancer in patients evaluated for gross hematuria at all cancer grades and stages.Higher sensitivity using FISH was obtained in high grade and muscle invasive tumors. | Liqun Zhou Kaiwei Yang Xuesong Li Yi Ding Dawei Mu Hanzhong Li Yong Yan Jinyi Li Dongwen Wang Wei Li Yulong Cong Jiangping Gao Kewei Ma Yajun Xiao Sheng Zhang Hongyi Jiang Weilie Hu Qiang Wei Xunbo Jin Zhichen Guan Qingyong Liu Danfeng Xu Xin Gao Yongguang Jiang Weimin Gan Guang Sun Qing Wang Yanhui Liu Jianquan Hou Liping Xie Xishuang Song Fengshuo Jin Jiafu Feng Ming Cai Zhaozhao Liang Jie Zhang Dingwei Ye Lin Qi Lulin Ma Jianzhong Shou Yuping Dai Jianyong Shao Ye Tian Shizhe Hong Tao Xu Chuize Kong Zefeng Kang Yuexin Liu Xun Qu Benkang Shi Shaobin Zheng Yi Lin Shujie Xia Dong Wei Jianbo Wu Weiling Fu Zhiping Wang Jianbo Liang | 2019 | Asian Journal of Urology2019，6，1： | 2 |
| 4 | Fast and robust fuzzy c-means clustering algorithms incorporating local information for image segmentation 显示文摘 | Cai Weiling Chen Songcan Zhang Daoqiang | 2007 | Pattern Recognition2007，40，3： | 1 |
| 5 | Fast androbust fuzzy C-means clustering algorithms incorporatinglocal information for image segmentation 显示文摘 | Cai Weiling Chen Songcan Zhang Daoqiang | 2007 | PatternRecognition2007，40，3： | 1 |
| 6 | Fast and RobustFuzzy C-means Clustering Algorithms Incorporating LocalInformation for Image Segmentation显示文摘 | Cai Weiling Chen Songcan Zhang Daoqiang | 2007 | Pattern Recognition2007，40，3： | 1 |
| 7 | Fast and robust fuzzy C-means clustering algorithms incorporating local information for image segmenta- tion显示文摘 | CAI Weiling CHEN Songcan ZHANG Daoqiang | 2007 | Pattern Recognition2007，，3： | 1 |
| 8 | Influence of soil density on gas permeability and water retention in soils amended with in-house produced biochar显示文摘Biochar has been used as an environment-friendly enhancer to improve the hydraulic properties(e.g.suction and water retention)of soil.However,variations in densities alter the properties of the soil ebiochar mix.Such density variations are observed in agriculture(loosely compacted)and engineering(densely compacted)applications.The influence of biochar amendment on gas permeability of soil has been barely investigated,especially for soil with different densities.The major objective of this study is to investigate the water retention capacity,and gas permeability of biochar-amended soil(BAS)with different biochar contents under varying degree of compaction(DOC)conditions.In-house produced novel biochar was mixed with the soil at different amendment rates(i.e.biochar contents of 0%,5%and 10%).All BAS samples were compacted at three DOCs(65%,80%and 95%)in polyvinyl chloride(PVC)tubes.Each soil column was subjected to dryingewetting cycles,during which soil suction,water content,and gas permeability were measured.A simplified theoretical framework for estimating the void ratio of BAS was proposed.The experimental results reveal that the addition of biochar significantly decreased gas permeability kg as compared with that of bare soil(BS).However,the addition of 5%biochar is found to be optimum in decreasing kg with an increase of DOC(i.e.k_(g,65%)>k_(g,80%)>k_(g,95%))at a relatively low suction range(<200 kPa)because both biochar and compaction treatment reduce the connected pores. | Ankit Garg He Huang Weiling Cai Narala Gangadhara Reddy Peinan Chen Yifan Han Viroon Kamchoom Shubham Gaurav Hong-Hu Zhu | 2021 | Journal of Rock Mechanics and Geotechnical Engineering2021，13，3： | 1 |
| 9 | Fast and Robust Fuzzy C-Means Clustering Algorithms Incorporating Local Information for Image Segmentation 显示文摘 | CAI Weiling CHEN Songcan ZHANG Daoqiang | 2007 | Pattern Recognition2007，40，3： | 1 |
| 10 | Fast and robust fuzzy c-means clustering algorithms incorporating local information for image segmentation显示文摘 | Weiling Cai Songcan Chen Daoqiang Zhang | 2007 | Patrern Recognition2007，，40： | 1 |
| 11 | Fast androbust fuzzy c-means clustering algorithms incorporatinglocal information for image segmentation显示文摘 | Cai Weiling Chen Songcan Zhang Daoqiang | 2007 | Pattern Recognition2007，40，3： | 1 |
| 12 | Fast and robust fuzzy C-means clustering algorithms incorporating local information for image segmentation显示文摘 | Cai Weiling Chen Songcan Zhang Daoqiang | 2007 | Pattern Recognition2007，40，3： | 1 |
| 13 | Fast and Robust Fuzzy C-Means Clustering Algorithms Incorporating Local Information for Image Segmentation显示文摘 | Cai Weiling Chen Songcan Zhang Daoqiang | 2007 | Pattern Recognition2007，40，3： | 1 |
| 14 | Factor analysis of Xishan mining excavating velocity显示文摘 | WANG Yubao SHAN Renliang CAI Weiling | 2011 | Coal Technology2011，36，6： | 1 |
| 15 | Fast and robust fuzzy c-means clustering algorithms incorporating local information for image segmentation显示文摘 | Cai Weiling Song Chen Zhang Daoqiang | 2007 | Pattern Recognition2007，40，3： | 1 |
| 16 | Fast and Robust fuzzy c-means clustering algorithms incorpora- ting local information for image segmentation显示文摘 | Cai Weiling Chen Songcan Zhang Daoqiang | 2007 | Pat- tern Recognition2007，40，3： | 1 |
| 17 | Effective work for gaussian mixture model image segmentation frame- incorporating local information显示文摘 | Cai Weiling Ding Jundi | 2008 | Transactions of Nanjing University of Aeronautics and Astronautics2008，25，4： | 1 |
| 18 | Fast and robust fuzzy c-means clustering algorithms incorporating local information for image segmentation显示文摘 | Cai Weiling Chen Songcan Zhang Daoqiang | 2007 | The Journal of the Pattem Recognition Society2007，40，3： | 1 |
| 19 | Fast and Robust Fuzzy C-Means Clustering Algorithms Incorporating Local Information for Image Segmentation显示文摘 | Weiling Cai Songcan Chen Daoqiang Zhang | 2007 | Pattern Recognition2007，10，3： | 1 |
| 20 | Fast and robust fuzzy c -means clustering algorithms incorporating local information for image segmentation显示文摘 | Weiling Cai Songcan Chen Daoqiang Zhang | 2006 | Pattern Recognition2006，，3： | 1 |
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