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| 1 | Finite Element Simulation on Thermal Fatigue of a Turbine Blade with Thermal Barrier Coatings显示文摘In this paper,a finite element model was developed for a turbine blade with thermal barrier coatings to investigate its failure behavior under cyclic thermal loading.Based on temperature and stress fields obtained from finite element simulations,dangerous regions in ceramic coating were determined in terms of the maximum principal stress criterion.The results show that damage preferentially occurs in the chamfer and rabbet of a turbine blade with thermal barrier coatings and its thermal fatigue life decreases with the increase of thermal stress induced by high service temperature. | L.Yang Q.X.Liu Y.C.Zhou W.G.Mao C.Lu | 2014 | Journal of Materials Science & Technology2014，30，4： | 15 |
| 2 | Numerical Simulation of Temperature Distribution and ThermalStress Field in a Turbine Blade with Multilayer-Structure TBCs by a Fluid–Solid Coupling Method显示文摘To study the temperature distribution and thermal-stress?eld in different service stages,a twodimensional model of a turbine blade with thermal barrier coatings is developed,in which the conjugate heat transfer analysis and the decoupled thermal-stress calculation method are adopted.Based on the simulation results,it is found that a non-uniform distribution of temperature appears in different positions of the blade surface,which has directly impacted on stress?eld.The maximum temperature with a value of 1030°C occurs at the leading edge.During the steady stage,the maximum stress of thermally grown oxide(TGO)appears in the middle of the suction side,reaching 3.75 GPa.At the end stage of cooling,the maximum compressive stress of TGO with a value of -3.5 GPa occurs at the leading edge.Thus,it can be predicted that during the steady stage the dangerous regions may locate at the suction side,while the leading edge may be more prone to failure on cooling. | W.Z.Tang L.Yang W.Zhu Y.C.Zhou J.W.Guo C.LU | 2016 | Journal of Materials Science & Technology2016，32，5： | 15 |
| 3 | Methionine adenosyltransferases in liver health and diseases显示文摘Methionine adenosyltransferases(MATs)are essential for cell survival because they catalyze the biosynthesis of the biological methyl donor S-adenosylmethionine(SAMe)from methionine and adenosine triphosphate(ATP).Mammalian cells express two genes,MAT1A and MAT2A,which encode two MAT catalytic subunits,α1 andα2,respectively.Theα1 subunit organizes into dimers(MATIII)or tetramers(MATI).Theα2 subunit is found in the MATII isoform.A third gene MAT2B,encodes a regulatory subunit b,that regulates the activity of MATII by lowering the inhibition constant(Ki)for SAMe and the Michaelis constant(Km)for methionine.MAT1A expressed mainly in hepatocytes maintains the differentiated state of these cells whereas MAT2A and MAT2B are expressed in non-parenchymal cells of the liver(hepatic stellate cells[HSCs]and Kupffer cells)and extrahepatic tissues.A switch from the liverspecific MAT1A to MAT2A has been observed during conditions of active liver growth and dedifferentiation.Liver injury,fibrosis,and cancer are associated with MAT1A silencing and MAT2A/MAT2B induction.Even though both MAT1A and MAT2A are involved in SAMe biosynthesis,they exhibit distinct molecular interactions in liver cells.This review provides an update on MAT genes and their roles in liver pathologies. | Komal Ramani Shelly C.Lu | 2017 | Liver Research2017，1，2： | 5 |
| 4 | Dysregulation of glutathione synthesis in liver disease显示文摘Glutathione(GSH),a tripeptide that is present in all mammalian tissues,is especially highly concentrated in the liver.GSH synthesis occurs via two adenosine triphosphate(ATP)-requiring enzymatic steps:the first is rate-limiting,catalyzed by glutamate-cysteine ligase,generates g-glutamylcysteine from gluta-mate and cysteine;the second is catalyzed by GSH synthetase,generates GSH from g-glutamylcysteine and glycine.GSH defends against oxidative stress,participates in detoxification of xenobiotics,de-termines the redox status of the cell,and regulates vital processes such as growth and apoptosis.Hepatic GSH plays a central role in the interorgan GSH homeostasis because sinusoidal efflux of hepatic GSH determines plasma GSH level.In liver diseases GSH homeostasis is perturbed by multiple mechanisms.Hepatic GSH biosynthesis is impaired in cholestatic liver injury,endotoxemia,and fibrotic injury largely because the expression of the GSH synthetic enzymes falls.Lower hepatic GSH level further exacerbates and perpetuates ongoing liver injury.However,in hepatocellular carcinoma GSH synthetic enzymes are upregulated and this may play a role in chemoresistance.This review focuses on the current under-standing of hepatic GSH synthesis in health and disease. | Shelly C.Lu | 2020 | Liver Research2020，4，2： | 2 |
| 5 | A comparison of the effectiveness of dexmedetomidine versus propofol target‐controlled infusion for sedation during fibreoptic nasotracheal intubation显示文摘 | C.‐J.Tsai K.‐S.Chu T.‐I.Chen D. V.Lu H.‐M.Wang I.‐C.Lu | 2010 | Anaesthesia2010，，3： | 1 |
| 6 | Extent of prophylactic postoperative radiotherapy after radical surgery of thoracic esophageal squamous cell carcinoma显示文摘 | J.‐C.Lu H.Tao Y.‐Q.Zhang W.‐W.Zha P.‐D.Qian F.Li K.‐X.Xu | 2008 | Diseases of the Esophagus2008，，6： | 1 |
| 7 | Comparison of clinical outcome of single‐incision laparoscopic surgery using a simplified access system with conventional laparoscopic surgery for malignant colorectal disease显示文摘 | C.‐C.Lu S.‐E.Lin K.‐C.Chung K.‐M.Rau | 2012 | Colorectal Disease2012，，4： | 1 |
| 8 | 查看详情显示文摘 | C.D.Reddy C.Lu S.Rajendran | | 0，，： | 1 |
| 9 | Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta‐analysis显示文摘 | W.Wu O.Shen Y.Qin J.Lu X.Niu Z.Zhou C.Lu Y.Xia S.Wang X.Wang | 2012 | International Journal of Andrology2012，，1： | 1 |
| 10 | Interconnected network state estimation using randomly delayed measurements显示文摘 | C.Su C.Lu | | 0，，： | 1 |
| 11 | Application of nonlocal beam models for carbon nanotubes显示文摘 | P.Lu H.Lee C.Lu | | 0，，16： | 1 |
| 12 | A comparison of the effectiveness of dexmedetomidine versus propofol target‐controlled infusion for sedation during fibreoptic nasotracheal intubation显示文摘 | C.‐J.Tsai K.‐S.Chu T.‐I.Chen D. V.Lu H.‐M.Wang I.‐C.Lu | 2010 | Anaesthesia2010，，3： | 1 |
| 13 | Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay显示文摘The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars merge.In the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW 170817.We used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino candidates.The detected electron-antineutrino candidates were consistent with the expected background rates for all the three time windows.Assuming monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w indows.Under the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows. | F.P.An A.B.Balantekin H.R.Band M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.H.Gong H.Gong W.Q.Gu J.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans M.He K.M.Heeger Y.K.Heng A.Higuera Y.K.Hor Y.B.Hsiung B.Z.Hu J.R.Hu T.Hu Z.J.Hu H.X.Huang X.T.Huang Y.B.Huang P.Huber D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji R.A.Johnson D.Jones L.Kang S.H.Kettell S.Kohn M.Kramer T.J.Langford J.Lee J.H.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li J.J.Li Q.J.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li Y.F.Li Z.B.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link L.Littenberg B.R.Littlejohn J.C.Liu J.L.Liu C.Lu H.Q.Lu J.S.Lu K.B.Luk X.B.Ma X.Y.Ma Y.Q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald R.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova J.P.Ochoa-Ricoux A.OIshevskiy H.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi X.Qian N.Raper J.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner J.L.Sun T.Tmej K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang J.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei L.H.Wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.Xia Z.Q.Xie Z.Z.Xing J.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh B.L.Young H.Z.Yu Z.Y.Yu B.B.Yue S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang J.W.Zhang Q.M.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao L.Zhou H.L.Zhuang J.H.Zou | 2021 | Chinese Physics C2021，45，5： | 1 |
| 14 | Reconflgurable MEMS OADM Systems显示文摘This paper proposes a serial reconfigurable OADM consisting of optical circulator and 2×2 MEMS optical switch and tunable FBG. Based on MEMS technology, the OADM is demonstrated to increase the flexibility, decrease the cost and improve the reliability. | A.Q. Liu J.Li Q. X. Zhang W. D. Zhong C.Lu | 2003 | 光学学报2003，23，S1： | 0 |
| 15 | SHORT COMMUNICATION Realistic Assessment of Health Hazards of Chemicals显示文摘INTRODUCTION The general public is exposed to a variety of chemicals, including food additives,contaminants, and pesticides. To protect the public from any health hazards associ ated with these chemicals, toxicities are assessed by national regulatory agencies andat an international level by the World Health Organization (WHO) in conjunctionwith the Food and Agriculture Organization of the United Nations (FAO). A briefdescription of the work in this field conducted jointly by WHO and FAO has | FRANK C.LU | 1989 | Biomedical and Environmental Sciences1989，2，1： | 0 |
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