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| 1 | 老年人睾丸组织退化的基因表达谱研究显示文摘目的 :研究老年人睾丸组织基因表达谱变化 ,为研究老年人睾丸功能衰退机制奠定基础。方法 :知情同意下获取正常青年人和老年人睾丸组织标本各 3例 ,采用QIAGENRNA提取试剂盒提取总RNA ,分别等量混合后制备探针。利用ClonTech公司生产的包含 80 0 0个已知基因的人类cDNA基因芯片 [AtlasPlasticHuman 8KMi croarray (Cat.# 790 5 1) ]筛选差异表达基因。按基因功能分类方法对老年睾丸组织中差异表达的基因进行归类分析。用RT -PCR、T -A克隆测序等方法选择目的基因 ,验证基因芯片结果。结果 :筛选到差异表达基因 117个(1.4 6 % ) ,83个基因在老年睾丸组织中表达下调 ,34个基因表达上调。在表达下调的基因中 ,代谢相关基因 16个(19.3% ) ,与基因和蛋白表达相关的基因 18个 (2 1.7% ) ,信号通路相关基因 16个 (19.3% ) ,细胞分化相关基因19个 (2 2 .9% ) ,细胞结构和运动相关基因 6个 (7.2 % ) ,细胞或内环境稳态相关基因 4个 (4 .8% ) ,未知功能基因 4个 (4 .8% )。在表达上调的基因中 ,代谢相关基因 3个 (8.8% ) ,与基因和蛋白表达相关的基因 10个 (2 9.4 % ) ,信号通路相关基因 2个 (5 .9% ) ,细胞分化相关基因 11个 (32 .4 % ) ,细胞结构和运动相关基因 8个 (2 3.5 % )。RT -PCR及T | 辛钟成 刘武江 田龙 袁亦铭 辛华 付杰 林桂亭 Ching S.LIN Tom F.LUE | 2003 | 北京大学学报(医学版)2003，35，4： | 19 |
| 2 | Active Immunization to Prevent De Novo Hepatitis B Virus Infection in Pediatric Live Donor Liver Recipients显示文摘 | C.‐C.Lin C.‐L.Chen A.Concejero C.‐C.Wang S.‐H.Wang Y.‐W.Liu C.‐H.Yang C.‐C.Yong T.‐S.Lin B.Jawan Y.‐F.Cheng H.‐L.Eng | 2006 | American Journal of Transplantation2006，，1： | 4 |
| 3 | Vascular Stents in the Management of Portal Venous Complications in Living Donor Liver Transplantation显示文摘 | Y.‐F.Cheng H.‐Y.Ou L. L.‐C.Tsang C.‐Y.Yu T.‐L.Huang T.‐Y.Chen A.Concejero C.‐C.Wang S.‐H.Wang T.‐S.Lin Y.‐W.Liu C.‐H.Yang C.‐C.Yong K.‐W.Chiu B.Jawan H.‐L.Eng C.‐L.Chen | 2010 | American Journal of Transplantation2010，，5： | 2 |
| 4 | Low-density parity-check codes based on finite geometries:A rediscovery and new results显示文摘 | Y.Kou S.Lin M.Fossorier | | 0，，07： | 1 |
| 5 | Near-shannonlimit quasi-cyclic low-density parity-check codes显示文摘 | L.Chen J.Xu I.Djurdjevic S.Lin | | 0，，07： | 1 |
| 6 | Cost‐effectiveness of screening for hepatocellular carcinoma in patients with cirrhosis due to chronic hepatitis C显示文摘 | O. S.Lin E. B.Keeffe G. D.Sanders D. K.Owens | 2004 | Alimentary Pharmacology & Therapeutics2004，，11： | 1 |
| 7 | Graph embedding and extensions: a general framework for dimensionality reduction显示文摘 | S.Yan D.Xu B.Zhang H.Zhang Q.Yang S.Lin | | 0，，01： | 1 |
| 8 | A Phase III Study of Belatacept‐based Immunosuppression Regimens versus Cyclosporine in Renal Transplant Recipients (BENEFIT Study)显示文摘 | F.Vincenti B.Charpentier Y.Vanrenterghem L.Rostaing B.Bresnahan P.Darji P.Massari G. AMondragon‐Ramirez M.Agarwal G.Di Russo C.‐S.Lin P.Garg C. P.Larsen | 2010 | American Journal of Transplantation2010，，3： | 1 |
| 9 | 查看详情显示文摘 | L.Cai J.W.Guo S.Lin | | 0，，： | 1 |
| 10 | An effective heuristic algorithm for the travelling-salesman Problem显示文摘 | S.Lin B.Kernighan | | 0，，2： | 1 |
| 11 | The application of social cognitive theory to web-based learning through NetPorts显示文摘 | Wang S S.Lin | | 0，，04： | 1 |
| 12 | Cost‐effectiveness of screening for hepatocellular carcinoma in patients with cirrhosis due to chronic hepatitis C显示文摘 | O. S.Lin E. B.Keeffe G. D.Sanders D. K.Owens | 2004 | Alimentary Pharmacology & Therapeutics2004，，11： | 1 |
| 13 | Low-density parity-check codes based on finite geometries:A rediscovery and new results显示文摘 | Y.Kou S.Lin M.P.C.Fossorier | | 0，，07： | 1 |
| 14 | Design of LDPC codes:A survey and new results显示文摘 | G.Lira S.Song Y.Ryan W.Lan L.Zhang and S.Lin | | 0，，03： | 1 |
| 15 | Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay显示文摘The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars merge.In the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW 170817.We used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino candidates.The detected electron-antineutrino candidates were consistent with the expected background rates for all the three time windows.Assuming monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w indows.Under the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows. | F.P.An A.B.Balantekin H.R.Band M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.H.Gong H.Gong W.Q.Gu J.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans M.He K.M.Heeger Y.K.Heng A.Higuera Y.K.Hor Y.B.Hsiung B.Z.Hu J.R.Hu T.Hu Z.J.Hu H.X.Huang X.T.Huang Y.B.Huang P.Huber D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji R.A.Johnson D.Jones L.Kang S.H.Kettell S.Kohn M.Kramer T.J.Langford J.Lee J.H.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li J.J.Li Q.J.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li Y.F.Li Z.B.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link L.Littenberg B.R.Littlejohn J.C.Liu J.L.Liu C.Lu H.Q.Lu J.S.Lu K.B.Luk X.B.Ma X.Y.Ma Y.Q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald R.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova J.P.Ochoa-Ricoux A.OIshevskiy H.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi X.Qian N.Raper J.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner J.L.Sun T.Tmej K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang J.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei L.H.Wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.Xia Z.Q.Xie Z.Z.Xing J.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh B.L.Young H.Z.Yu Z.Y.Yu B.B.Yue S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang J.W.Zhang Q.M.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao L.Zhou H.L.Zhuang J.H.Zou | 2021 | Chinese Physics C2021，45，5： | 1 |
| 16 | Extrusion Process Parameters, Sensory Characteristics, and Structural Properties of a High Moisture Soy Protein Meat Analog显示文摘 | S.Lin H.E.Huff F.Hsieh | 2006 | Journal of Food Science2006，，3： | 1 |
| 17 | Development and in-vitro evaluation of an optimized carvedilol transdermal therapeutic system using experimental design approach显示文摘The effect of formulation variables on in-vitro release and permeation properties of carvedilol from transdermal patch was studied by varying one factor at a time as preliminary study.Based on these results,design of experiments technique was applied followed by regression analysis and response surface methodology to optimize formulation variables.Central Composite IV model design was used with four formulation variables:drug loading,matrix thickness,adhesive layer thickness,and propylene glycol concentration.Nineteen formulations were prepared according to the design;and the effect of formulation variables was studied on in-vitro release and permeation profiles of these formulations.In all cases,the permeation profiles paralleled in-vitro release profiles.The drug released at 7 h and 24 h was used as release response parameters while permeation flux obtained was employed as permeation response parameter.All four formulation variables were found to be significant for release properties and three of these exhibited significant effect on permeation profile of carvedilol across artificial membrane.Constrained optimization,using 47.9%of cumulative carvedilol released at 7 h and 99.8%at 24 h as well as 25.7 mg/cm2/h of permeation flux,was applied to obtain desired release and permeation profiles.Experimentally,carvedilol was observed to release from the optimized formulation with 51.4%drug release at 7 h and 98.5%at 24 h with an observed flux value of 27.4 mg/cm2/h across artificial membrane,which showed an excellent agreement with the predicted values.The results of this investigation show that the quadratic mathematical model developed could be used to further predict formulations with desirable release and permeation properties. | Namrata Vora S.Lin P.L.Madan | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，1： | 0 |
| 18 | A decision aid for the port placement problem in robot-assisted hysterectomy显示文摘Objective:In robot-assisted minimally invasive surgery,proper port positioning ensures that surgical tools have adequate access to the surgical site and avoids mid-surgery collisions of robotic arms.To date,several guidelines have been proposed for more accurate port placement.However,challenges remain due to variations in patient morphology,anatomy,and,in particular,organ displacement due to insuf-flation in certain laparoscopic procedures.The objective of this study was to design and develop a de-cision aid for optimal port placement in robot-assisted hysterectomy that accounts for patient variability and organ displacement due to insufflation.Methods:Three components were constructed:a robot model,a patient-specific model,and an opti-mization algorithm.The three components were integrated,and the system was verified using four different patients who underwent robotic hysterectomy.Once verified,two expert surgeons were asked to evaluate the decision aid for face and construct validity.A usability test was conducted using a torso phantom with target organs located in three different locations.Two expert surgeons performed a simulated hysterectomy task with and without the decision aid to evaluate performance and satisfaction.Results:The optimization algorithm was sensitive to individual differences in anatomy in the four pa-tients.Expert surgeons successfully established face and construct validity.Usability test results showed a 28%-40% reduction in time to task completion with the optimized ports compared to expert-determined port locations without using the decision aid.Conclusions:The decision aid,based on an individualized patient-specific model,robot model,and optimization algorithm,was shown to be effective at addressing the challenges of displaced organs due to insufflation in robot-assisted hysterectomy.The face and construct validity of the decision aid was established by expert surgeons,while efficiency gains in task performance were demonstrated experimentally. | Mohammad R.Maddah Jean-Marc Classe Isabelle Jaffre Keith A.Watson Katherine S.Lin Damien Chablat Cedric Dumas Caroline G.L.Cao | 2023 | Laparoscopic, Endoscopic and Robotic Surgery2023，6，2： | 0 |
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