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| 1 | Improved measurement of electron antineutrino disappearance at Daya Bay显示文摘We report an improved measurement of the neutrino mixing angle θ_(13) from the Daya Bay Reactor Neutrino Experiment. We exclude a zero value for sin^2 θ_(13) with a significance of 7.7 standard deviations. Electron antineutrinos from six reactors of 2.9 GW_(th) were detected in six antineutrino detectors deployed in two near (flux-weighted baselines of 470 m and 576 m) and one far (1648 m) underground experimental halls. Using 139 days of data, 28909 (205308) electron antineutrino candidates were detected at the far hall (near halls). The ratio of the observed to the expected number of antineutrinos assuming no oscillations at the far hall is 0.944±0.007(stat.)±0.003(syst.). An analysis of the relative rates in six detectors finds sin^2 θ_(13) =0.089±0.010(stat.)±0.005(syst.) in a three-neutrino framework. | 安丰鹏 安琪 白景芝 A.B.Balantekin H.R.Band W.Beriguete M.Bishai S.Blyth R.L.Brown 曹国富 曹俊 R.Carr W.T.Chan 常劲帆 Y.Chang C.Chasman 陈和生 H.Y.Chen 陈申见 陈少敏 陈潇聪 陈晓辉 陈晓苏 陈羽 陈义学 J.J.Cherwinka 朱明中 J.P.Cummings 邓子艳 丁雅韵 M.V.Diwan E.Draeger 杜小峰 D.Dwyer W.R.Edwards S.R.Ely 方绍东 付金煜 付在伟 葛良全 R.L.Gi11 M.Gonchar 龚光华 宫辉 Y.A.Gornushkin 顾文强 关梦云 郭新恒 R.W.Hackenburg R.L.Hahn S.Hans 郝慧峰 何苗 贺青 K.M.Heeger 衡月昆 P.Hinrichs Y.K.Hor Y.B.Hsiung B.z.Hu 胡涛 黄翰雄 H.z.Huang 黄性涛 P.Huber V.Issakov z.Isvan D.E.Jaffe S.Jetter 季筱璐 季向盼 姜海静 焦健斌 R.A.Johnson 康丽 S.H.Kettell M.Kramer 关健强 郭文伟 郭人能 C.Y.Lai 赖万昌 W.H.Lai K.Lau L.Lebanowski J.Lee 雷瑞霆 R.Leitner 梁干庄 梁嘉怡 C.A.Lewis 李飞 李高嵩 李秋菊 李卫东 李小波 李小男 李学潜 李仪 李志斌 梁昊 林政儒 C.L.Lin S.K.Lin 林延畅 凌家杰 J.M.Link L.Littenberg B.R.Littlejohn D.W.Liu 刘金昌 刘江来 刘颖彪 陆昌国 路浩奇 陆永康 K.B.Luk 马秋梅 马续波 马骁妍 马宇蒨 K.T.McDonald M.C.McFarlane R.D.McKeown Y.Meng D.Mohapatra Y.Nakajima J.Napolitano D.Naumov I.Nemchenok 倪浩然 W.K.Ngai 聂阳波 宁哲 J.P.Ochoa-Ricoux A.Olshevski S.Patton V.Pec J.C.Peng L.E.Piilonen L.Pinsky 潘振声 齐法制 祁鸣 钱鑫 N.Raper 任杰 R.Rosero B.Roskovec 阮锡超 邵贝贝 师恺 H.Steiner 孙功星 孙吉良 N.Tagg 谭耀豪 H.K.Tanaka 唐晓 H.Themann Y.Torun S.Trentalange O.Tsai K.V.Tsang R.H.M.Tsang C.E.Tull Y.C.Tung B.Viren V.Vorobe1 C.H.Wang 王灵淑 王玲玉 王龙泽 王萌 王乃彦 王瑞光 W.Wang 王玺 王贻芳 王喆 王铮 王志民 D.M.Webber 魏瀚宇 魏亚东 温良剑 K.Whisnant C.G.White L.Whitehead Y.Williamson T.Wise H.L.H.Wong E.T.Worcester F.F.Wu 吴群 习建博 夏冬梅 邢志忠 徐建一 徐晶 徐吉磊 徐晔 薛涛 杨长根 杨雷 叶梅 M.Yeh Y.S.Yeh B.L.Young 于泽源 占亮 C.Zhang 章飞虹 张家文 张清民 张书华 张一纯 张银鸿 张一心 张志坚 张子平 张智勇 赵洁 赵庆旺 赵豫斌 郑磊 钟玮丽 周莉 周祖英 庄红林 邹佳恒 | 2013 | Chinese Physics C2013，37，1： | 38 |
| 2 | Obesity and diabetes accelerate hepatocarcinogenesis via hepatocyte proliferation independent of NF-κB or Akt/mTORC1显示文摘Background:There are strong links between obesity,diabetes and hepatocellular carcinoma(HCC),but molecular mechanisms remain unclear.Aim:We tested the proposed involvement of NF-κB,IL-6/STAT3 and Akt/mTORC1 before onset(at 3 months)and at onset(6 months)of accelerated hepatocarcinogenesis in DEN-injected obese and diabetic foz/foz compared to lean wildtype(Wt)mice,and also studied the hepatocyte proliferative response to DNA damage between the obese and lean lines.Methods:Male foz/foz and Wt littermates fed normal chow were DEN-injected(10mg/kg i.p.)at age 12-15 days.To test the effect of mTOR inhibitor on growth of dysplastic hepatocytes,a separate cohort of DEN-injected foz/foz mice was administered rapamycin(4 mg/kg body weight/day).Results:foz/foz mice developed obesity,hyperinsulinemia,diabetes,adipokine dysregulation and fatty liver,without increased serum or liver TNF-αor serum IL-6.All DEN-injected foz/foz mice developed HCC by 6 mths vs.0/10 lean Wt.At 3 mths,there were more dysplastic hepatocytes in DEN-injected foz/foz than Wt,with increased liver injury(serum ALT),hepatocyte apoptosis(M30-positive cells)and proliferation(cyclin D1,cyclin E,PCNA),but neither NF-κB nor STAT3 activation.foz/foz livers exhibited upregulation of DNA damage sensors ATM and ATR,with inadequate cell cycle checkpoint controls(CHK1,CHK2,p53,p21).Akt and mTORC1 were highly activated in livers from foz/foz vs.Wt mice.Despite such activation,rapamycin failed to reduce growth of dysplastic hepatocytes.Conclusions:Accelerated DEN-induced HCC in obese/diabetic mice is linked to enhanced growth of dysplastic hepatocytes that cannot be attributed to NF-κB or IL-6/STAT3 activation,nor to sustained mTORC1 activation.The critical mechanism for obesity-enhanced hepatocarcinogenesis lies in the disconnection between hepatocellular injury with DNA damage,and an unrestrained proliferative response.Relevance for patients:This study supports the epidemiological data linking obesity,diabetes and fatty liver disease with increased risk for developing HCC.The findings also suggest that mTORC1 inhibition may not be beneficial in the prevention of obesity-related hepatocarcinogenesis. | Evi Arfianti Claire Z Larter Seungsoo Lee Vanessa Barn Geoffrey Haigh Matthew M.Yeh George NIoannou Narci C.Teoh Geoffrey C.Farrell | 2016 | Journal of Clinical & Translational Research2016，2，1： | 1 |
| 3 | Effects of an educational program with interactive videodisc systems in improving critical thinking dispositions for RN-BSN students in Taiwan显示文摘 | M.Yeh H.Chen | | 0，，： | 1 |
| 4 | WONCA研究论文摘要汇编——儿童癌症幸存者累积剩余死亡率模型的评价显示文摘背景虽然儿童癌症幸存率显著增加,但幸存者要面对威胁生命远期作用增高的风险,包括继发癌。目的就幸存者预期寿命,评价与疾病和治疗相关死亡风险的累积作用。设计用状态转移模型模拟儿童癌症幸存者寿命临床过程。设施儿童癌症幸存者研究。对象患儿童癌5年幸存者。测量针对儿童癌幸存者寿命,评价诊断为原发癌死亡风险;继发癌和心脏、肺、外部和其他并发症剩余死亡风险和固有死亡(一般人群年龄-特异死亡)的概率。结果 10岁时被诊断为癌症、5年、15岁幸存者定群研究,平均寿命几率迟发死亡率为0.10;治疗-相关继发癌和死于心脏、肺和外部原因为0.15;死于其他剩余风险为0.05。15岁者预期寿命为50.6岁,与一般人群比较,要少10.4岁(17.1%)。因诊断不同预期寿命减少程度也不同,范围从肾肿瘤幸存者的4.0岁(6.0%)到脑及骨肿瘤幸存者的17.8岁更易存在迟发死亡风险,剩余死亡风险持久。有限性所评价有基础数据幸存者接受的是20~40年前的治疗方法,接受新疗法病人可有较好的结果。结论儿童癌幸存者成人期要面对较大死亡风险,剩余风险可使预期寿命减少28%。有必要做好目前幸存者的健康状况监测;对癌新发病例、治疗迟发毒力应仔细评估。 | Jennifer M.Yeh Larissa Nekhlyudov Sue J.Goldie 周淑新 | 2010 | 中国全科医学2010，13，29： | 1 |
| 5 | Cost‐effectiveness of treatment and endoscopic surveillance of precancerous lesions to prevent gastric cancer显示文摘 | Jennifer M.Yeh ChinHur Karen M.Kuntz MajidEzzati Sue J.Goldie | 2010 | Cancer2010，，12： | 1 |
| 6 | Search for electron-antineutrinos associated with gravitational-wave events GW150914,GW151012,GW151226,GW170104,GW170608,GW170814,and GW170817 at Daya Bay显示文摘The establishment of a possible connection between neutrino emission and gravitational-wave(GW)bursts is important to our understanding of the physical processes that occur when black holes or neutron stars merge.In the Daya Bay experiment,using the data collected from December 2011 to August 2017,a search was per-formed for electron-antineutrino signals that coincided with detected GW events,including GW150914,GW151012,GW151226,GW170104,GW170608,GW 170814,and GW 170817.We used three time windows of±10,±500,and±1000 s relative to the occurrence of the GW events and a neutrino energy range of 1.8 to 100 MeV to search for correlated neutrino candidates.The detected electron-antineutrino candidates were consistent with the expected background rates for all the three time windows.Assuming monochromatic spectra,we found upper limits(90%confidence level)of the electron-antineutrino fluence of(1.13-2.44)×10^(11)cm^(-2)at 5 MeV to 8.0×10^(7)cm^(-2)at 100 MeV for the three time w indows.Under the assumption of a Fermi-Dirac spectrum,the upper limits were found to be(5.4-7.0)×10^(9)cm^(2)for the three time windows. | F.P.An A.B.Balantekin H.R.Band M.Bishai S.Blyth G.F.Cao J.Cao J.F.Chang Y.Chang H.S.Chen S.M.Chen Y.Chen Y.X.Chen J.Cheng Z.K.Cheng J.J.Cherwinka M.C.Chu J.P.Cummings O.Dalager F.S.Deng Y.Y.Ding M.V.Diwan T.Dohnal J.Dove M.Dvorak D.A.Dwyer J.P.Gallo M.Gonchar G.H.Gong H.Gong W.Q.Gu J.Y.Guo L.Guo X.H.Guo Y.H.Guo Z.Guo R.W.Hackenburg S.Hans M.He K.M.Heeger Y.K.Heng A.Higuera Y.K.Hor Y.B.Hsiung B.Z.Hu J.R.Hu T.Hu Z.J.Hu H.X.Huang X.T.Huang Y.B.Huang P.Huber D.E.Jaffe K.L.Jen X.L.Ji X.P.Ji R.A.Johnson D.Jones L.Kang S.H.Kettell S.Kohn M.Kramer T.J.Langford J.Lee J.H.C.Lee R.T.Lei R.Leitner J.K.C.Leung F.Li J.J.Li Q.J.Li S.Li S.C.Li W.D.Li X.N.Li X.Q.Li Y.F.Li Z.B.Li H.Liang C.J.Lin G.L.Lin S.Lin J.J.Ling J.M.Link L.Littenberg B.R.Littlejohn J.C.Liu J.L.Liu C.Lu H.Q.Lu J.S.Lu K.B.Luk X.B.Ma X.Y.Ma Y.Q.Ma C.Marshall D.A.Martinez Caicedo K.T.MeDonald R.D.McKeown Y.Meng J.Napolitano D.Naumov E.Naumova J.P.Ochoa-Ricoux A.OIshevskiy H.-R.Pan J.Park S.Patton J.C.Peng C.S.J.Pun F.Z.Qi M.Qi X.Qian N.Raper J.Ren C.Morales Reveco R.Rosero B.Roskovec X.C.Ruan H.Steiner J.L.Sun T.Tmej K.Treskov W.-H.Tse C.E.Tull B.Viren V.Vorobel C.H.Wang J.Wang M.Wang N.Y.Wang R.G.Wang W.Wang W.Wang X.Wang Y.Wang Y.F.Wang Z.Wang Z.Wang Z.M.Wang H.Y.Wei L.H.Wei L.J.Wen K.Whisnant C.G.White H.L.H.Wong E.Worcester D.R.Wu F.L.Wu Q.Wu W.J.Wu D.M.Xia Z.Q.Xie Z.Z.Xing J.L.Xu T.Xu T.Xue C.G.Yang L.Yang Y.Z.Yang H.F.Yao M.Ye M.Yeh B.L.Young H.Z.Yu Z.Y.Yu B.B.Yue S.Zeng Y.Zeng L.Zhan C.Zhang F.Y.Zhang H.H.Zhang J.W.Zhang Q.M.Zhang X.T.Zhang Y.M.Zhang Y.X.Zhang Y.Y.Zhang Z.J.Zhang Z.P.Zhang Z.Y.Zhang J.Zhao L.Zhou H.L.Zhuang J.H.Zou | 2021 | Chinese Physics C2021，45，5： | 1 |
| 7 | Factors predictive of survival for esophageal carcinoma treated with preoperative radiotherapy with or without chemotherapy followed by surgery显示文摘 | Alexander M.Yeh William M.Mendenhall Christopher G.Morris Robert A.Zlotecki Rodwige J.Desnoyers Stephen B.Vogel | 2003 | J Surg Oncol2003，，1： | 1 |
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