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| 1 | Patterns of local recurrence in rectal cancer after a multidisciplinary approach显示文摘Improvements in surgery and the application of combined approaches to fight rectal cancer have succeeded in reducing the local recurrence (LR) rate and when there is LR it tends to appear later and less often in isolation. Moreover, a subtle change in the distribution of LRs with respect to the pelvis has been observed. In general terms, prior to total mesorectal excision the most common LRs were central types (perianastomotic and anterior) while lateral and posterior forms (presa-cral) have become more common since the growth in the use of combined treatments. No differences have been reported in the current pattern of LRs as a function of the type of approach used, that is, neo-adjuvant therapies (short-term or long-course radiotherapy, orchemoradiotherapy versus extended lymphadenectomy, though there is a trend towards posterior or presacral LR in patients in the Western world and lateral LR in Asia. Nevertheless, both may arise from the same mechanism. Moreover, as well as the mode of treatment, the type of LR is related to the height of the initial tumor. Nowadays most LRs are related to the advanced nature of the disease. Involvement of the circumferential radial margin and spillage of residual tumor cells from lymphatic leakage in the pelvic side wall are two plausible mechanisms for the genesis of LR. The patterns of pelvic recurrence itself (pelvic subsites) also have important implications for prognosis and are related to the potential success of salvage curative approach. The re-operability for cure and prognosis are generally better for anastomotic and anterior types than for presacral and lateral recurrences. Overall survival after LR diagnosis is lower with radio or chemoradiotherapy plus optimal surgery approaches, compared to optimal surgery alone. | Jose M Enríquez-Navascués Nerea Borda Aintzane Liz-erazu Carlos Placer Jose L Elosegui Juan P Ciria Adelaida Lacasta Luis Bujanda | 2011 | World Journal of Gastroenterology2011，17，13： | 14 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | Role of magnetic resonance cholangiopancreatography in patients with suspected choledocholithiasis显示文摘 | Calvo MM Bujanda L Calderon A | 2002 | Mayo Clin Proc2002，77，5： | 1 |
| 4 | Aspirin inthe prevention of colorectal cancer显示文摘 | Zubiaurre L Bujanda Fernández de Pierola L | | 0，，05： | 1 |
| 5 | Colonoscopy versus fecal immuneoch-emical testing in colorectal cancer screening 显示文摘 | Quinlero E Castells A Bujanda L | 2012 | N Engl J Med2012，366，： | 1 |
| 6 | Ten-day sequential treatment for Helicobacter pylori eradication in clinical practice显示文摘 | Sanchez-Delgado J Calvet X Bujanda L | 2008 | Am J Gastroenterol2008，103，9： | 1 |
| 7 | Krukenberg tumor secondary to gastric carcinoma in a women in her eighth month of pregnancy显示文摘 | Cosme A Ojeda E Bujanda L | 2001 | Gastroenterol Hepatol2001，24，1： | 1 |
| 8 | Malignant eolorectal polyps 显示文摘 | Bujanda L Cosme A Gil I | 2010 | WorldJ Gastroenterol2010，，25： | 1 |
| 9 | Novelmethylated biomarkers and a robust assay to detect circulatingtumor DNA in metastatic breast cancer显示文摘 | FACKLER M J BUJANDA Z L UMBRICHT C | 2014 | Cancer Res2014，74，8： | 1 |
| 10 | The effects of alcohol consumption upon the gastro-intestinal tract显示文摘 | Bujanda L | 2000 | Am J Gastroenterol2000，95，12： | 1 |
| 11 | Ten-day sequential treatment for Helicobacter pylori eradication in clinical practice显示文摘 | SANCHEZ-DELGADO J CALVET X BUJANDA L | 2008 | Am J Gastroenteral2008，103，9： | 1 |
| 12 | Comparison between magnetic resonance cholangiopancreatography and ERCP for evaluation of the pancreatic duct显示文摘 | Mari M Calvo Luis Bujanda Angel Calderón I?aki Heras José L Cabriada Antonio Bernal Victor Orive Elena Astigarraga | 2002 | The American Journal of Gastroenterology2002，，2： | 1 |
| 13 | Malignant colorectal polyps 显示文摘 | Bujanda L Cosme A Gil I | 2010 | World J Gastroenterol2010，16，25： | 1 |
| 14 | Aspirin in the prevention of eoloreetal eaneer显示文摘 | Zubiaurre L Bujanda Femandez de Pierola L | 2011 | Gastroenterol Hepatol2011，34，5： | 1 |
| 15 | Relevance of GSTM1, GSTF1, and GSTP1 gene polymor- phisms to gastric cancer susceptibility and phenotype 显示文摘 | GARCIA- GONZALEZ M A QUINTERO E BUJANDA L | 2012 | Muta- genesis2012，27，6： | 1 |
| 16 | Role of magnetic resonance cholangiopancreatography in patients with suspected choledocholithiasis显示文摘 | Calvo MM Bujanda L Calderon A | 2002 | Mayo Clin Proc2002，77，5： | 1 |
| 17 | Ten-day se- quential treatment for Helicobacter pylori eradication in clini- cal practice显示文摘 | Snchez-Delgado J Calvet X Bujanda L | 2008 | Am J Gastroenterol2008，103，9： | 1 |
| 18 | The effects of alcohol consumption upon the gastrointestinal tract显示文摘 | Bujanda L | 2000 | Am J Gastroenterol2000，95，12： | 1 |
| 19 | Resveratrol inhibits nonalcoholic fatty liver disease in rats显示文摘 | Bujanda L Elizabeth H Mikel L | | 0，，： | 1 |
| 20 | MRCP in the diagnosis of iatrogenic bile duct injury显示文摘 | Bujanda L Calvo MM Cabriada JL | 2003 | NMR Biomed2003，16，8： | 1 |
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