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| 1 | Biliary cast syndrome:literature review and a single centre experience in liver transplant recipients显示文摘BACKGROUND:Biliary cast syndrome(BCS)is an unusual complication of orthotopic liver transplantation (OLTx),and its management is difficult.Limited success using endoscopic retrograde cholangiopancreatography (ERCP)or open exploration to clear casts has been reported, but failure usually results in re-transplantation.We aimed to review our experience with BCS and highlight a novel combined percutaneous and endoscopic approach for duct clearance.A brief review of the literature is given. METHODS:We retrospectively reviewed our experience of managing BCS using case notes review.Details were also gathered from radiology,where interventional procedures were carried out. RESULTS:We had a total of three cases of BCS reported between 2002 and 2005.Multiple attempts were made to remove these casts.All three were treated in a variety of ways.Management is discussed along with highlighting a novel combined percutaneous and endoscopic approach for duct clearance. CONCLUSIONS:BCS is a potential complication of OLTx. Surgical and endoscopic methods of removing casts are used.However,in circumstances where these methods are technically difficult,a percutaneous endoscopic approach with serial dilatation of the cutaneous port and surgical removal of casts can be done. | Narasimhaiah Srinivasaiah Mettu Srinivas Reddy Schlok Balupuri David Talbot Bryon Jaques Derek Manas | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，3： | 8 |
| 2 | The peach genome显示文摘 | Pere Arús Ignazio Verde Bryon Sosinski Tatyana Zhebentyayeva Albert Abbott | 2012 | Tree Genetics & Genomes2012，，3： | 3 |
| 3 | Hepatic progenitor cell activation in liver repair显示文摘The liver possesses an extraordinary ability to regenerate after injury.Hepatocyte-driven liver regeneration is the default pathway in response to mild-to-moderate acute liver damage.When replication of mature hepatocytes is blocked,facultative hepatic progenitor cells(HPCs),also referred to as oval cells(OCs)in rodents,are activated.HPC/OCs have the ability to proliferate clonogenically and differentiate into several lineages including hepatocytes and bile ductal epithelia.This is a conserved liver injury response that has been studied in many species ranging from mammals(rat,mouse,and human)to fish.In addition,improper HPC/OC activation is closely associated with fibrotic responses,characterized by myofibroblast activation and extracellular matrix production,in many chronic liver diseases.Matrix remodeling and metalloprotease activities play an important role in the regulation of HPC/OC proliferation and fibrosis progression.Thus,understanding molecular mechanisms underlying HPC/OC activation has therapeutic implications for rational design of anti-fibrotic therapies. | Adam Bria Jorgensen Marda Junmei Zhou Xiaowei Sun Qi Cao Bryon E.Petersen Liya Pi | 2017 | Liver Research2017，1，2： | 3 |
| 4 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 5 | Lipopolysaccharide triggers nuclear import of Lpcat1 to regulate inducible gene expression in lung epithelia显示文摘AIM:To report that Lpcat1 plays an important role in regulating lipopolysaccharide (LPS) inducible gene tran-scription. METHODS:Gene expression in Murine Lung Epithelial MLE-12 cells with LPS treatment or Haemophilus influenza and Escherichia coli infection was analyzed by employing quantitative Reverse Transcription Polymerase Chain Reaction techniques. Nucleofection was used to deliver Lenti-viral system to express or knock down Lpcat1 in MLE cells. Subcellular protein fractionation and Western blotting were utilized to study Lpcat1 nuclear relocation. RESULTS:Lpcat1 translocates into the nucleus from thecytoplasm in murine lung epithelia (MLE) after LPS treatment. Haemophilus influenza and Escherichia coli , two LPS-containing pathogens that cause pneumonia, triggered Lpcat1 nuclear translocation from the cytoplasm. The LPS inducible gene expression profile was determined by quantitative reverse transcription polymerase chain reaction after silencing Lpcat1 or overexpression of the enzyme in MLE cells. We detected that 17 out of a total 38 screened genes were upregulated, 14 genes were suppressed, and 7 genes remained unchanged in LPS treated cells in comparison to controls. Knockdown of Lpcat1 by shRNA dramatically changed the spectrum of the LPS inducible gene transcription, as 18 genes out of 38 genes were upregulated, of which 20 genes were suppressed or unchanged. Notably, in Lpcat1 overex-pressed cells, 25 genes out of 38 genes were reduced in the setting of LPS treatment.CONCLUSION:These observations suggest that Lpcat1 relocates into the nucleus in response to bacterial infection to differentially regulate gene transcriptional repression. | Bryon Ellis Leah Kaercher Courtney Snavely | 2012 | World Journal of Biological Chemistry2012，3，7： | 2 |
| 6 | Bone Marrow–Derived Hepatic Oval Cells Differentiate Into Hepatocytes in 2-Acetylaminofluorene/Partial Hepatectomy–Induced Liver Regeneration显示文摘 | Seh–Hoon Oh Rafal P. Witek Si–Hyun Bae Donghang Zheng Youngmi Jung Anna C. Piscaglia Bryon E. Petersen | 2007 | Gastroenterology2007，，： | 1 |
| 7 | White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1:A diffusion tensor imaging study显示文摘 | Jeffrey RW Bryon AM Erin E | | 0，，02： | 1 |
| 8 | The peach genome显示文摘 | Pere Arus Ignazio Verde Bryon Sosinski | 2012 | Tree Genetics & Genomes2012，8，3： | 1 |
| 9 | Annexin-V promotes anti-tumor immunity and inhibits neuroblastoma growth in vivo显示文摘 | Xiaocai Yan Kara Doffek Chaobo Yin Michael Krein Michael Phillips Sonia L. Sugg Bryon Johnson Joel Shilyansky | 2012 | Cancer Immunology, Immunotherapy2012，，11： | 1 |
| 10 | Ogunnaike nonlinear model predictive control of a simulated multivariable polymerization reactor using second-order Votterra models显示文摘 | Bryon R Maner Francis J Doyle lII Babatunde A | 1996 | Automati- ca1996，32，9： | 1 |
| 11 | White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1:A diffusion tensor imaging study显示文摘 | Jeffrey RW Bryon AM Erin E | 2011 | Neuromuscul Disord2011，21，2： | 1 |
| 12 | SSeCKS immunolabeling in rat primary sensory neurons 显示文摘 | Sandra MS Bryon DG Patrick AC | 2002 | Brain Res2002，926，12： | 1 |
| 13 | Andson, The physics of sailing 显示文摘 | Bryon D | 2008 | Physicstoday2008，61，2： | 1 |
| 14 | Proceduresand equipment for staining large numbers of plantroot samples for endomycorrhizal assay 显示文摘 | Komanik P P Bryon W C Schultz R C | 1980 | CanadianJournal of Microbiology1980，26，4： | 1 |
| 15 | Procedures and equipment for staining large numbers of plant root samples for endomycorrhizal assay显示文摘 | Komanik P P Bryon W C Schultz R C | 1980 | Canadian Journal of Microbiology1980，26，4： | 1 |
| 16 | Procedures and equipment for staining large numbers of plant root samples for endomycorrhizal assay显示文摘 | Kormanik P P Bryon W C Schultz R C | 1980 | Canadian Journal of Microbiology1980，26，4： | 1 |
| 17 | Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: A diffusion tensor imaging (DTI) study显示文摘 | Jeffrey R. Wozniak Linda Krach Erin Ward Bryon A. Mueller Ryan Muetzel Sarah Schnoebelen Andrew Kiragu Kelvin O. Lim | 2007 | Archives of Clinical Neuropsychology2007，，5： | 1 |
| 18 | Practical value of the histopathological diagnosis of malignant lymphomas显示文摘 | Bryon PA | 1993 | Rev Prat1993，43，13： | 1 |
| 19 | Nonlinear model predictive control of a simulated multivariable polymerization reactor using second-order voherra models 显示文摘 | BRYON R M FRANCIS J D BABATUNDE A | 1996 | Automatica1996，32，9： | 1 |
| 20 | Procedures and equipment for staining large numbers of plant root samples for endomycorrhizal assay显示文摘 | Komanik P P Bryon W C Schultz R C | 1980 | Canadian Journal of Microbiology1980，26，4： | 1 |
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