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	题名	作者	年代	出处	被引量
1	Molecular phenotypes of human parvovirus B19 in patients with myocarditis显示文摘AIM:To investigate molecular phenotypes of myocardial B19V-infection to determine the role of B19V in myocarditis and dilated cardiomyopathy(DCM).METHODS:Endomyocardial biopsies(EMBs) from 498 B19V-positive patients with myocarditis and DCMwere analyzed using molecular methods and functional experiments.EMBs were obtained from the University Hospitals of Greifswald and Tuebingen and additionally from 36 German cardiology centers.Control tissues were obtained at autopsy from 34 victims of accidents,crime or suicide.Identification of mononuclear cell infiltrates in EMBs was performed using immunohistological staining.Anti-B19V-IgM and anti-B19V-IgG were analyzed by enzyme-linked immunosorbent assay(ELISA).B19V viral loads were determined using in-house quantitative real-time polymerase chain reaction(PCR).For B19V-genotyping a new B19V-genotype-specific restriction fragment length polymorphism(RFLP)-PCR was established.B19V-genotyping was verified by direct DNAsequencing and sequences were aligned using BLAST and BioEdit software.B19V P6-promoter and HHV6-U94-transactivator constructs were generated for cell culture experiments.Transfection experiments were conducted using human endothelial cells 1.Luciferase reporter assays were performed to determine B19Vreplication activity.Statistical analysis and graphical representation were calculated using SPSS and Prism5 software.RESULTS:The prevalence of B19V was significantly more likely to be associated with inflammatory cardiomyopathy(iCMP) compared to uninflamed DCM(59.6% vs 35.3%)(P < 0.0001).The detection of B19V-mRNA replication intermediates proved that replication of B19V was present.RFLP-PCR assays showed that B19V-genotype 1(57.4%) and B19V-genotype 2(36.7%) were the most prevalent viral genotypes.B19V-genotype 2 was observed more frequently in EMBs with iCMP(65.0%) compared to DCM(35%)(P = 0.049).Although there was no significant difference in gender-specific B19V-loads,women were more frequently infected with B19V-genotype 2(44.6%) than men(36.0%)(P = 0.0448).Coinfection with B19V and other cardiotropic viruses was found in 19.2% of tissuesamples and was associated with higher B19V viral load compared to B19V-monoinfected tissue(P = 0.0012).The most frequent coinfecting virus was human herpes virus 6(HHV6,16.5%).B19V-coinfection with HHV6 showed higher B19V-loads compared to B19V-monoinfected EMBs(P = 0.0033),suggesting that HHV6 had transactivated B19V.In vitro experiments confirmed a 2.4-fold increased B19V P6-promoter activity by the HHV6 U94-transactivator.CONCLUSION:The finding of significantly increased B19V loads in patients with histologically proven cardiac inflammation suggests a crucial role of B19V-genotypes and reactivation of B19V-infection by HHV6-coinfection in B19V-associated iCMP.Our findings suggest that B19V-infection of the human heart can be a causative event for the development of an endothelial cell-mediated inflammatory disease and that this is related to both viral load and genotype.	C-Thomas Bock Anja Düchting Friederike Utta Eva Brunner Bui Tien Sy Karin Klingel Florian Lang Meinrad Gawaz Stephan B Felix Reinhard Kandolf	2014	World Journal of Cardiology2014，6，4：	3
2	Pulmonary embolism caused by acrylic cement:A rare complication of percutaneous vertebroplasty显示文摘	Padovani B Kasmel O brunner P	1999	Am J Nenroradid1999，20，3：	1
3	Special Techniques in Internal Fixation显示文摘	Brunner C Weber B	1982	Berlin: Springer-Verlag1982，，：	1
4	Highly enantio- selective syntheses of heterocycles via intramolecular Ir-catalyzed allylic amination and etherification显示文摘	Welter C Dahnz A Brunner B	2005	Organic Letters2005，7，7：	1
5	Pulmonary erllbolism caused by acrylic cement:a rare corn plication percutaneous venebmplasty 显示文摘	PADOVANI B KASMEI O BRUNNER P	1999	Am J Nenroradid1999，20，3：	1
6	pulmonary embolism caused by acrylic cement:a rare complication of percutaneous vertebroplasty显示文摘	Padovani B Kasriel O Brunner P	1999	Am J Neuroradiol1999，20，3：	1
7	Phosphate oxygen isotopes:insights into sedimentary phosphorus cycling from the Benguela upwelling system显示文摘	Goldhammer T K M Brunner B Bernasconi S M	2011	Geochimica et Cosmochimica Acta2011，75，13：	1
8	Allelic series of four powdery mildew resistance genes at the Pm3 locus in hexaploid bread wheat显示文摘	Srichumpa P Brunner S Keller B	2005	Plant Physiology2005，139，：	1
9	Pulmonary embolism caused by acrylic cement a rare complication of percutaneous vertebroplasty显示文摘	Kasriel O Brunner P	1999	Am J Neuroradiol1999，20，：	1
10	Blood levels of angiogenin and vascular endothelial growth factor are elevated in myelodysplastic syndrome and in actue myeloid leukemia 显示文摘	Brunner B Gunsilius E Schumacher P	2002	Journal of Heamatotherapy & Stem Cell Research2002，11，：	1
11	Classification systems for tibial plateau fractures; does computed tomography scanning improve their reliability? 显示文摘	Brunner A Horisberger M Ulmar B	2010	Injury2010，41，2：	1
12	Favourable dermal penetration of diclofenac after administration to the skin using a novel spray gel formulation显示文摘	Brunner M Dehghanyar P Seigfried B	2005	Br J Clin Pharmacol2005，60，5：	1
13	DLR's robotics technologies for On-orbit servicing 显示文摘	Hirzinger G Landzettel K Brunner B	2004	Advanced Robotics(SO169-1864)2004，18，2：	1
14	Classification systems for tibial plateau fractures; does computed tomo graphy scanning improve their reliability? 显示文摘	Brunner A Horisberger M Ulmar B	2010	Injury2010，41，17：	1
15	Inhibition of mitochondrial fusion byα-synuclein is rescued by PINK1,Parkin and DJ-1显示文摘	Kamp F Exner N Lutz AK Wender N Hegermann J Brunner B	2010	EMBO J2010，29，20：	1
16	Porphyrin platinum conjugates-new aims显示文摘	Arndt M R Treittinger B	2004	Inorganica Chimica Acta2004，357，：	1
17	Dose-response relation of liquid aerosol inhaled insulin in type 1 diabetic patients 显示文摘	Brunner GA Balent B Ellmerre M	2001	Diabetologia2001，44，3：	1
18	Innate immunity in plants and animals:striking similarities and obvious differences 显示文摘	Nurnberger T Brunner F Kemmerling B	2004	Immunol Rev2004，198，：	1
19	Using color in machine vision systems for wood processing 显示文摘	Brunner C C Shaw G B Butler D A	1990	Wood Fiber Sci1990，22，5：	1
20	Impact of collateral cir- culation on early outcome and risk of hemorrhagic complications after systemic thrombolysis显示文摘	Brunner F Tomandl B Hanken K	2012	Int J Stroke2012，23，：	1

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