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| 1 | An air-stable and waterproof lithium metal anode enabled by wax composite packaging显示文摘The reviving use of lithium metal anode(LMA)is one of the most promising ways to upgrade the energy density of lithium ion batteries.In the roadmap towards the real use,besides the formation of the dendrite,various adverse reactions due to the high activity of LMA when exposed to air or the electrolyte limit its practical applications.Learning from the packaging technology in electronic industry,we propose a wax-based coating compositing with the ion conducting poly(ethylene oxide)by a simple dip-coating technology and the prepared LMA is featured with an air-stable and waterproof surface.The LMA thus remains stable for 24 h in ambient air even with the relative humidity of 70% while retaining about85% its electrochemical capacity.More importantly,the LMA is accessible to water and when dipping in water,no obvious adverse reactions or capacity decay is observed.With the composite coating,a steady cycling performance for 500 h in symmetrical cells and a low capacity decay rate of 0.075% per cycle after 300 cycles in lithium-sulfur batteries assembled with the packaged anode have been achieved.This work demonstrates a very simple and effective LMA package technology which is easily scalable and is very promising for speeding up the industrialization of lithium-sulfur batteries and shows potentials for the large-scale production of air-sensitive electrode materials not limited to LMAs. | Yunbo Zhang Wei Lv Zhijia Huang Guangmin Zhou Yaqian Deng Jun Zhang Chen Zhang Boyu Hao Qi Qi Yan-Bing He Feiyu Kang Quan-Hong Yang | 2019 | Science Bulletin2019，64，13： | 7 |
| 2 | Olfactory and gustatory dysfunctions of COVID-19 patients in China:A multicenter study显示文摘Introduction:With the spread of the epidemic worldwide,an increasing number of doctors abroad have observed the following atypical symptoms of coronavirus disease 2019(COVID-19):olfactory or taste disorders.Therefore,clarifying the incidence and clinical characteristics of olfactory and taste disorders in Chinese COVID-19 patients is of great significance and urgency.Materials and Methods:A retrospective study was conducted,which included 229 severe acute respiratory syndrome coronavirus 2 confirmed patients,through face-to-face interviews and telephone follow-up.Following the completion of questionnaires,the patients participating in the study,were categorized according to the degree of olfactory and taste disorders experienced,and the proportion of each clinical type of patient with olfactory and taste disorders and the time when symptoms appeared were recorded.Results:Among the 229 patients,31(13.54%)had olfactory dysfunction,and 44(19.21%)had gustatory dysfunction.For the patients with olfactory dysfunction,6(19.35%)developed severe disease and became critically ill.Olfactory dysfunction appeared before the other symptoms in 21.43%of cases.The proportion of females with olfactory and gustatory dysfunction was higher than that of males(P<0.001).Conclusions:The incidence of olfactory and gustatory dysfunction was much lower than that reported abroad;the prognosis of patients with olfactory dysfunction is relatively favorable;olfactory and gustatory dysfunction can be used as a sign for early screening;females are more prone to olfactory and gustatory dysfunction. | Jianhui Li Yi Sun Enqiang Qin Hu Yuan Mingbo Liu Wenqi Yi Zhu Chen Chengcheng Huang Fengjie Zhou Ruiyao Chen Leibo Zhang Ning Yu Qiong Liu Xuejun Zhou Jingjing He Boyu Li Fusheng Wang Changliang Yang Shiming Yang | 2022 | World Journal of Otorhinolaryngology-Head and Neck Surgery2022，8，4： | 2 |
| 3 | Graphene Oxide Assemblies for Sustainable Clean-Water Harvesting and Green-Electricity Generation显示文摘CONSPECTUS:The urgent problems of water scarcity and the energy crisis have given rise to the development of a range of sustainable technologies with the great advancement of nanotechnologies and advent of attractive nanomaterials.Graphene oxides(GO),a derivative of graphene with an atom-thin thickness and abundant oxygen-containing functional groups(such as−OH,−COOH),are water-soluble and can be assembled into a variety of structures(such as fiber,membrane,and foam)with great potential in environmental and energy-related fields.As a typical precursor of graphene,GO can be easily reduced to graphene by chemical or thermal treatments to demonstrate excellent photothermal properties as well as tunable thermal conduction,which is highly desirable for efficient solar-driven water evaporation.The intrinsic large specific area of GO nanosheets can provide enough sites for ions adsorption and its porous assemblies facilitate the transport of water.In addition,the abundant functional groups allow the spontaneous adsorption of water molecules from the ambient environment and give birth to movable ions(usually protons)under the solvation effect.Once a chemical gradient is formed on the component,a remarkable electricity is generated from the directional transport of protons.Thanks to the excellent chemical properties of GO nanosheets,a wide range of assemblies with 1D aligned fibers,2D layered membranes and 3D porous foam can be easily fabricated by wet-spinning,solution-filtration,and freezingdrying methods.The various GO assemblies are able to exhibit abundant functions with remarkable weaving capability for GO fibers,superior flexibility for GO membranes,and exceptional adsorption capacity for GO foams.In light of all the advantages,GO and its assemblies are remarkably promising in the fields of sustainable development to meet the pressing challenges of water and energy crisis.In this Account,we will discuss the progress of clean-water production and green-electricity generation technologies based on GO assemblies.The fundamental working mechanism,optimization strategies,and promising applications are explored with an emphasis on the materials development.We also discuss the functions of GO assemblies in the water and electricity generation process and present their limitations and possible solutions.Current challenges and promising directions for the development of clean-water production and green-electricity generation are also demonstrated for their realistic implementations.We anticipate that this Account would promote more efforts toward fundamental research on graphene functionalization and encourage a broad exploration on the application of graphene assemblies in clean-water production and electric power generation systems. | Yaxin Huang Chengzhi Wang Changxiang Shao Boyu Wang Nan Chen Haibo Jin Huhu Cheng Liangti Qu | 2021 | Accounts of Materials Research2021，2，2： | 2 |
| 4 | Differential expression of voltage-gated K+ channel genes in left ventricular remodeled myocardium after experimental myocardial infarction显示文摘 | Boyu Huang Praveer Jain | 1996 | Circ Res1996，79，4： | 1 |
| 5 | Plasmodium vivax in the Elimination Phase—China,2013–2020显示文摘Summary What is already known about this topic?Plasmodium vivax(P.vivax)was the most widely distributed and major human malaria parasite in China,considered the last parasite to be eliminated.What is added by this report?The last domestic P.vivax case was reported in 2016,while hundreds of imported cases were reported annually from 2013–2020,predominantly from Southeast Asia.What are the implications for public health practice?In the post-elimination phase,adaptive and practical strategies focusing on imported P.vivax cases should be updated and adopted to prevent malaria resurgence. | Li Zhang Boyu Yi Zhigui Xia Fang Huang | 2022 | China CDC weekly2022，4，28： | 1 |
| 6 | Effective diffusivity of oxygen in the ash layer of Huadian oil shale semicoke显示文摘Diffusion of oxygen in the ash layer usually dominated the combustion of oil shale semicoke particles due to the high ash content.Thus,effective diffusivity of oxygen in the ash layer was a crucial parameter worthy of careful investigation.In this paper,the effective diffusivity of oxygen in the ash layer of Huadian oil shale semicoke was measured directly using an improved Wicke-Kallenbach diffusion apparatus.The experimental results showed that higher temperature would lead to a higher effective diffusivity and a thicker ash layer had the negative effect.Especially,the effective diffusivity along the direction perpendicular to bedding planes was much lower than that along the direction parallel to bedding planes.In addition,an effective diffusivity model was developed,which could be used to describe the mass transfer of oxygen in the ash layer of oil shale semicoke. | Yiqun HUANG Yiran LI Man ZHANG Boyu DENG Hao KONG Junfeng WANG Junfu LYU Hairui YANG Lingmei WANG | 2021 | Frontiers in Energy2021，15，2： | 0 |
| 7 | A state-of-the-art review on transition between the fast fluidization and pneumatic transport of Geldart group B particles显示文摘The fluidization state in the circulating fluidized bed(CFB)boiler is crucial to its stable and safe operation.However,up to now,the research field has not reached unanimity on whether the fluidization regime that the upper furnace of the boiler operates in is the fast fluidization or pneumatic transport.To this end,this paper reviewed relevant research on the transition between the fast fluidization and pneumatic transport of Geldart group B particles,including the flow characteristics of the fast fluidization,the transition condition between the fast fluidization and pneumatic transport,the determination methods of the transport velocity utr and saturation carrying capacity G_(s)* and the influencing factors on these two parameters.Previous research findings can provide certain guidelines for the design and optimization of the CFB boiler,and result in plenty of prediction correlations for utr and G_(s)*.Nonetheless,owing to insufficient data available on Geldart group B particles,especially the ones obtained under high temperature or pressure conditions and in large-scale CFB apparatuses,the existing correlations are not well suited for the prediction of u_(tr) and G_(s)* of Geldart group B particles.Thus,further efforts are urgently demanded on the fast fluidization transition of Geldart group B particles. | Boyu Deng Yi Zhang Man Zhang Yi Ding Tuo Zhou Xinhua Yang Zhong Huang Hairui Yang Guangxi Yue | 2023 | Particuology2023，，2： | 0 |
| 8 | Cut-dip-budding delivery system enables genetic modifications in plants without tissue culture显示文摘Of the more than 370000 species of higher plants in nature,fewer than 0.1%can be geneticallymodified due to limitations of the current gene delivery systems.Even for those that can be genetically modified,the modification involves a tedious and costly tissue culture process.Here,we describe an extremely simple cut-dip-budding(CDB)delivery system,which uses Agrobacterium rhizogene to inoculate explants,generating transformed roots that produce transformed buds due to root suckering.We have successfully used CDB to achieve the heritable transformation of plant species inmultiple plant families,including two herbaceous plants(Taraxacum kok-saghyz and Coronilla varia),a tuberous root plant(sweet potato),and three woody plant species(Ailanthus altissima,Aralia elata,and Clerodendrum chinense).These plants have previously been difficult or impossible to transform,but the CDB method enabled efficient transformation or gene editing in them using a very simple explant dipping protocol,under non-sterile conditions and without the need for tissue culture.Our work suggests that large numbers of plants could be amenable to genetic modifications using the CDB method. | Xuesong Cao Hongtao Xie Minglei Song Jinghua Lu Ping Ma Boyu Huang Mugui Wang Yifu Tian Fan Chen Jun Peng Zhaobo Lang Guofu Li Jian-Kang Zhu | 2023 | The Innovation2023，4，1： | 0 |
| 9 | A real-world study of immune checkpoint inhibitors in advanced triple-negative breast cancer显示文摘Background:Triple-negative breast cancer(TNBC)is the most aggressive type of breast cancer.Immune checkpoint inhibitors(ICIs)have been widely used to treat various tumors and have changed the landscape of tumor management,but the data from real-world studies of ICIs for TNBC treatment remain limited.The aim of this study was to evaluate the efficacy of ICIs in the treatment of patients with advanced TNBC in a real-world setting and to explore possible correlates.Methods:The clinical data of advanced TNBC patients who received ICI treatment in the Chinese People's Liberation Army(PLA)General Hospital were collected.Treatment responses,outcomes and adverse events(AEs)were assessed.Results:Eighty-one patients were included in the study.The confirmed objective response rate(ORR)was 32.1%,and the disease control rate(DCR)was 64.2%.The median progression-free survival(PFS)was 4.2 months,and the median overall survival(OS)was 11.0 months.PFS and OS were longer in patients who achieved clinical benefit from ICIs and shorter in patients who received later-line ICIs and higher levels of inflammation;specifically,patients with higher TILs had longer PFS.Overall AEs were tolerable.Conclusions:ICIs are effective in the treatment of advanced TNBC,and the adverse reactions are tolerable.A panel of biomarkers including LDH,ALP,and bNLR were identified to predict the efficacies of ICIs in TNBC treatment. | Zheng Zhang Yadi Zhang Chuanling Liu Jiakang Shao Yimeng Chen Yimin Zhu Li Zhang Boyu Qin Ziqing Kong Xixi Wang Yutong Wang Deqin Huang Liqun Liu Yuxin Zhou Ran Tao Zengjie Yang Mei Liu Weihong Zhao | 2023 | Cancer Innovation2023，2，3： | 0 |
| 10 | Effects of Dropsonde Data in Field Campaigns on Forecasts of Tropical Cyclones over the Western North Pacific in 2020 and the Role of CNOP Sensitivity显示文摘Valuable dropsonde data were obtained from multiple field campaigns targeting tropical cyclones,namely Higos,Nangka,Saudel,and Atsani,over the western North Pacific by the Hong Kong Observatory and Taiwan Central Weather Bureau in 2020.The conditional nonlinear optimal perturbation(CNOP)method has been utilized in real-time to identify the sensitive regions for targeting observations adhering to the procedure of real-time field campaigns for the first time.The observing system experiments were conducted to evaluate the effect of dropsonde data and CNOP sensitivity on TC forecasts in terms of track and intensity,using the Weather Research and Forecasting model.It is shown that the impact of assimilating all dropsonde data on both track and intensity forecasts is case-dependent.However,assimilation using only the dropsonde data inside the sensitive regions displays unanimously positive effects on both the track and intensity forecast,either of which obtains comparable benefits to or greatly reduces deterioration of the skill when assimilating all dropsonde data.Therefore,these results encourage us to further carry out targeting observations for the forecast of tropical cyclones according to CNOP sensitivity. | Xiaohao QIN Wansuo DUAN Pak-Wai CHAN Boyu CHEN Kang-Ning HUANG | 2023 | Advances in Atmospheric Sciences2023，40，5： | 0 |
| 11 | Novel reusable sulfate-type zirconium alginate ion-exchanger for fluoride removal显示文摘It is still a challenge to eliminate efficiently fluoride ion from groundwater,especially to design and synthesis an adsorbent possessing high adsorption capacity,recyclability and wide pH application conditions.Herein we present millimeter-sized sulfate-type zirconium alginate hydrogel beads with 3D network structure(AHB@Zr-SO^(2−)_(4))that exhibited a maximum adsorption capacity of 101.3 mg/g with wide pH applicability(pH 3−9).This material have~2.5 times higher adsorption capacity than that of pure zirconium alginate hydrogel beads(AHB@Zr)and it was ascribed to ion exchange between SO^(2−)_(4)and F−on the surface of AHB@Zr-SO^(2−)_(4),which was verified via ion chromatography measurement coupled with X-ray photoelectron spectroscopy(XPS)and Fourier Transform Infrared Spectrometer(FTIR Spectrometer)analysis.Density functional theory(DFT)calculations indicated that the ion exchange process between SO^(2−)_(4)and F−in AHB@Zr-SO^(2−)_(4)was energetically favorable than OH^(−)and F^(−)in AHB@Zr.In addition,310 bed volumes(BV)of effluent was realized via column adsorption of groundwater containing fluoride on AHB@Zr-SO^(2−)_(4)and indicated that it is a promising candidate for mitigating the problem of fluoride-containing groundwater. | Tao Yua Yiliang Chen Yizhong Zhang Xin Tan Tao Xie Boyu Shao Xiang Huang | 2021 | Chinese Chemical Letters2021，32，11： | 0 |
| 12 | How to prevent malicious use of intelligent unmanned swarms?显示文摘With advancements in swarm intelligence,artificial intelligence,and wireless mobile network technology,unmanned swarms such as unmanned aerial vehicles,ground vehicles,ships,and other unmanned systems are becoming increasingly autonomous and intelligent.Benefiting from these technologies,intelligent unmanned swarms are able to efficiently perform complex tasks through collaboration in various fields.However,malicious use of intelligent unmanned swarms raises concerns about the potential for significant damage to national infrastructures such as airports and power facilities.Defending against malicious activities is essential but challenging due to the swarms’abilities to perceive,understand complex environments. | Qi Wang Tingting Li Yongjun Xu Fei Wang Boyu Diao Lei Zheng Jincai Huang | 2023 | The Innovation2023，4，2： | 0 |
| 13 | Jigsaw-Sketch:a fast and accurate algorithm for finding top-k elephant flows in high-speed networks显示文摘Finding top-k elephant flows in high-speed networks is one of the most fundamental network measurement tasks.It is more challenging than per-flow size estimation since the IDs and sizes of top-k flows must be tracked simultaneously.Most existing studies only record the IDs of a small number of elephant flows to fit their estimators in the extremely limited high-speed on-chip memory.However,these solutions need too many memory accesses when a packet arrives to track the elephant flows with high accuracy,which limits their practicability.Therefore,this paper proposes Jigsaw-Sketch,a new algorithm to find the top-k elephant flows with much fewer memory accesses while achieving high memory efficiency and accuracy.In this design,we propose a novel two-stage jigsaw storage scheme,which can capture the candidate top-k flows from massive network steams efficiently,and further find the top-k elephant flows with high memory efficiency and only a few memory accesses for each packet.Extensive experimental results based on real network traces show that Jigsaw-Sketch improves the packet processing throughput by at least 86%,while achieving smaller memory footprints and higher accuracy compared to the SOTA. | Boyu ZHANG He HUANG Yu-E SUN Yang DU Dan WANG | 2024 | Science China(Information Sciences)2024，67，4： | 0 |
| 14 | E674Q(Shanghai APP mutant),a novel amyloid precursor protein mutation,in familial late-onset Alzheimer's disease显示文摘Identified as the pathogenic genes of Alzheimer's disease(AD),APP,PSEN1,and PSEN2 mainly lead to early-onset AD,whose course is more aggressive,and atypical symptoms are more common than sporadic AD.Here,a novel missense mutation,APP E674Q(also named“Shanghai APP”),was detected in a Chinese index patient with typical late-onset AD(LOAD)who developed memory decline in his mid-70s.The results from neuroimaging were consistent with AD,where widespread amyloidβdeposition was demonstrated in 18 F-florbetapir Positron Emission Tomography(PET).APP E674Q is close to theβ-secretase cleavage site and the well-studied Swedish APP mutation(KM670/671NL),which was predicted to be pathogenic in silico.Molecular dynamics simulation indicated that the E674Q mutation resulted in a rearrangement of the interaction mode between APP and BACE1 and that the E674Q mutation was more prone to cleavage by BACE1.The in vitro results suggested that the E674Q mutation was pathogenic by facilitating the BACE1-mediated processing of APP and the production of Aβ.Furthermore,we applied an adeno-associated virus(AAV)-mediated transfer of the human E674Q mutant APP gene to the hippocampi of two-month-old C57Bl/6 J mice.AAV-E674Q-injected mice exhibited impaired learning behavior and increased pathological burden in the brain,implying that the E674Q mutation had a pathogenicity that bore a comparison with the classical Swedish mutation.Collectively,we report a strong amyloidogenic effect of the E674Q substitution in AD.To our knowledge,E674Q is the only pathogenic mutation within the amyloid processing sequence causing LOAD. | Yongfang Zhang Xinyi Xie Boyu Chen Lina Pan Jianping Li Wanbing Wang Jintao Wang Ran Tang Qiang Huang Xiaofen Chen Rujing Ren Zhentao Zhang Wei Fu Gang Wang | 2024 | Genes & Diseases2024，11，2： | 0 |
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