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1食道的有鳞的房间癌 - 先锋损害和早诊断显示文摘 Squamous cell carcinoma of the esophagus (SCCE) carries a poor prognosis due to late diagnosis.Early detection is highly desirable,since surgical and endoscopic resection offers the only possible cure for esophageal cancer.Population screening should be undertaken in high risk areas,and in low or moderate risk areas for people with risk factors (alcoholics,smokers,mate drinkers,history of head and neck cancer,achalasia and lye stricture of the esophagus).Esophageal balloon cytology is an easy and inexpensive sampling technique,but the current methods are insufficient for primary screening due to sampling errors.Conventional endoscopy with biopsy remains the standard procedure for the identification of pre-malignant and early malignant changes in esophageal mucosa and endoscopic detection.It may be enhanced by several techniques such as dye and optic chromoendoscopy,magnifying endoscopy,and optical-based spectroscopic and imaging modalities.Since more than 80% of SCCE deaths occur in developing countries,where expensive techniques such as narrow band imaging (NBI) and autofluorescence imaging are unavailable,the most cost-effective tool for targeting biopsies may be Lugol dye chromoendoscopy,since it is easy,accurate,inexpensive and available worldwide.In ideal conditions,or in developed countries,is it reasonable to think that optimal detection will require a combination of techniques,such as the combination of Lugol’s chromoendoscopy and NBI to identify esophageal areas that require further characterization by a high resolution technique.The efficacy and cost-effectiveness will determine whether these modalities will become part of standard endoscopy practice.Antonio Barros Lopes Renato Borges Fagundes 2012World Journal of Gastrointestinal Endoscopy2012,4,1:20
2Reducing preoperative fasting time: A trend based on evidence显示文摘Preoperative fasting is mandatory before anesthesia to reduce the risk of aspiration.However,the prescribed 6-8 h of fasting is usually prolonged to 12-16 h for various reasons.Prolonged fasting triggers a metabolic response that precipitates gluconeogenesis and increases the organic response to trauma.Various randomized trials and meta-analyses have consistently shown that is safe to reduce the preoperative fasting time with a carbohydrate-rich drink up to 2 h before surgery.Benefits related to this shorter preoperative fasting include the reduction of postoperative gastrointestinal discomfort and insulin resistance.New formulas containing amino acids such as glutamine and other peptides are being studied and are promising candidates to be used to reduce preoperative fasting time.JoséEduardo de Aguilar-Nascimento Diana Borges Dock-Nascimento 2010World Journal of Gastrointestinal Surgery2010,2,3:17
3Antioxidant properties of glutamine and its role in VEGF-Akt pathways in portal hypertension gastropathy显示文摘AIM: To investigate the effects of glutamine on oxidative/nitrosative stress and the vascular endothelial growth factor (VEGF)-Akt-endothelial nitric oxide synthase (eNOS) signaling pathway in an experimental model of portal hypertension induced by partial portal vein ligation (PPVL). METHODS: Portal hypertension was induced by PPVL. The PPVL model consists of a partial obstruction of the portal vein, performed using a 20 G blunt needle as a guide, which is gently removed after the procedure. PPVL model was performed for 14 d beginning treatment with glutamine on the seventh day. On the fifteenth day, the mesenteric vein pressure was checked and the stomach was removed to test immunoreactivity and oxidative stress markers. We evaluated the expression and the immunoreactivity of proteins involved in the VEGF-Akt-eNOS pathway by Western blotting and immunohistochemical analysis. Oxidative stress was measured by quantification of the cytosolic concentration of thiobarbituric acid reactive substances (TBARS) as well as the levels of total glutathione (GSH), superoxide dismutase (SOD) activity, nitric oxide (NO) production and nitrotyrosine immunoreactivity. RESULTS: All data are presented as the mean ± SE. The production of TBARS and NO was significantly increased in PPVL animals. A reduction of SOD activity was detected in PPVL + G group. In the immunohistochemical analyses of nitrotyrosine, Akt and eNOS, the PPVL group exhibited significant increases, whereas decreases were observed in the PPVL + G group, but no difference in VEGF was detected between these groups. Western blotting analysis detected increased expression of phosphatidylinositol-3-kinase (PI3K), P-Akt and eNOS in the PPVL group compared with the PPVL + G group, which was not observed for the expression of VEGF when comparing these groups. Glutamine administration markedly alleviated oxidative/nitrosative stress, normalized SOD activity, increased levels of total GSH and blocked NO overproduction as well as the formation of peroxynitrite. CONCLUSION: Glutamine treatment demonstrated to reduce oxidative damage but does not reduce angiogenesis induced by PH in gastric tissue, demonstrating a beneficial role for the PI3K-Akt-eNOS pathway.Camila Marques Francielli Licks Ingrid Zattoni Beatriz Borges Luiz Eduardo Rizzo de Souza Claudio Augusto Marroni Norma Possa Marroni 2013World Journal of Gastroenterology2013,19,28:9
4Contemporary Themes in Language Teacher Education显示文摘1 Introduction In this talk I provide a contemporary overview of the field of language teacher education (LTE).Following brief comments on the global and varied scope of LTE and its relatively recent history as a field of inquiry,I examine in turn a number of central themes highlighted in current LTE literature.They are:(1) Teacher cognition; (2) The knowledge base for LTE;(3) Knowledge about language;(4) Reflective practice;(5)Simon Borg 2010中国外语2010,7,4:6
5The chemosensory appendage proteome of Amblyomma americanum (Acari: Ixodidae) reveals putative odorant-binding and other chemoreception-related proteins显示文摘Proteomic 分析在孤独的星的 2 个化学感应的附器上被做滴答响, Amblyomma americanum。蛋白质在在先 tarsi,包含嗅觉的 Hallers 机关,并且在触官,包括味觉的 sensilla,与在第三 tarsi 的蛋白质相比。另外,男性和女性滴答响被比较。蛋白质被顺序类似,并且由 3-dimensional 相同建模识别到已知的蛋白质。Proteomic 数据也与从 tick Rhipicephalus microplus 的器官特定的 transcriptomes 相比。在先 tarsi 快车没在第三 tarsi 或触官发现的 lipocalin。在先, tarsi 和触官富有地表示 2 蛋白质,它类似于昆虫有气味的东西绑定蛋白质(OBP ) 。与昆虫 OBP 相比, tick 象 OBP 一样序列缺乏半胱氨酸在 C 减 OBP 不在,并且 1 滴答响象 OBP 一样顺序有类似于 C 加 OBP 的另外的半胱氨酸。类似于抗菌素蛋白质 microplusin 的四蛋白质被发现:2 只表示了在在先 tarsi 并且 1 只在触官表示了。这些蛋白质缺乏 microplusin 铜绑定地点,而是他们被建模有一个重要的内部洞,潜在地一个 ligand 有约束力的地点。类似于 7 被发现差别的灰尘螨变应原 Der p7 和 Der f 的蛋白质在先在女性表示了 tarsi。只表示在的蛋白质在先, tarsi 有类似到否决权,它被知道涉及 ionotropic glutamate 受体聚类。这些结果组成象 OBP 一样蛋白质序列的第一份报告在滴答响并且点到几条研究大街在上滴答响化学感应的接收。Robert Renthal Leena Manghnani Sandra Bernal Yanyan Qu Wendell P. Griffith Kim Lohmeyer Felix O. Guerrero Ligia M.F. Borges Adalberto Perez de Leon 2017Insect Science2017,24,5:4
6DNA damage-induced cell death: lessons from the central nervous system显示文摘脱氧核糖核酸损坏不能,但是总是,导致房间死亡。当连接脱氧核糖核酸的几条小径损坏信号到线粒体依赖者,独立死亡机械被阐明了时,这些小径的连接由多重其它服从于规定不好的因素理解。我们建议了二个概念的模型解释推迟并且对脱氧核糖核酸的可变房间死亡反应损坏:综合监视对自治小径。在这评论,我们讨论这二个模型怎么可以解释在死亡反应被辐射剂量,房间周期地位和 neuronal 开发调整的地方,离子辐射(红外) 在发展中的中枢神经系统导致的房间死亡的体内规定。Helena Lobo Borges Rafael Linden Jean YJ Wang 2008Cell Research2008,18,1:4
7AngiotensinⅡor epinephrine hemodynamic and metabolic responses in the liver of L-NAME induced hypertension and spontaneous hypertensive rats显示文摘AIM To study hepatic vasoconstriction and glucose release induced by angiotensin(Ang)Ⅱ or Epi in rats with pharmacological hypertension and spontaneously hypertensive rat(SHR).METHODS Isolated liver perfusion was performed following portal vein and vena cava cannulation; AngⅡ or epinephrine(Epi) was injected in bolus and portal pressure monitored; glucose release was measured in perfusate aliquots. RESULTS The portal hypertensive response(PHR) and the glucose release induced by AngⅡ of L-NAME were similar to normal rats(WIS). On the other hand, the PHR inducedby Epi in L-NAME was higher whereas the glucose release was lower compared to WIS. Despite the similar glycogen content, glucose release induced by AngⅡ was lower in SHR compared to Wistar-Kyoto rats although both PHR and glucose release induced by Epi in were similar. CONCLUSION AngⅡ and Epi responses are altered in different ways in these hypertension models. Our results suggest that inhibition of NO production seems to be involved in the hepatic effects induced by Epi but not by AngⅡ; the diminished glucose release induced by AngⅡ in SHR is not related to glycogen content.Debora Conte Kimura Marcia Regina Nagaoka Durval Rosa Borges Maria Kouyoumdjian 2017World Journal of Hepatology2017,9,17:4
8No evidence of HPV DNA in esophageal squamous cell carcinoma in a population of Southern Brazil显示文摘AIM:To investigate the association between human papillomavirus(HPV)and esophageal squamous cell carcinoma(ESCC)in southern Brazil.METHODS:We studied 189 esophageal samples from125 patients from three different groups:(1)102 biopsies from 51 patients with ESCC,with one sample from the tumor and another from normal esophageal mucosa distant from the tumor;(2)50 esophageal biopsies from 37 patients with a previous diagnosis of head and neck squamous cell carcinoma(HNSCC);and(3)37 biopsies from esophageal mucosa with normal appearance from 37 dyspeptic patients,not exposed to smoking or alcohol consumption.Nested-polymerase chain reaction(PCR)with the MY09/11 and GP5/6 L1primers was used to detect HPV L1 in samples fixed in formalin and stored in paraffin blocks.All PCR reactions were performed with a positive control(cervicovaginal samples),with a negative control(Human Genomic DNA)and with a blank reaction containing all reagents except DNA.We took extreme care to prevent DNA contamination in sample collection,processing,and testing.RESULTS:The histological biopsies confirmed the diagnosis of ESCC in 52 samples(51 from ESCC group and 1 from the HNSCC group)and classified as well differentiated(12/52,23.1%),moderately differentiated(27/52,51.9%)or poorly differentiated(7/52,13.5%).One hundred twenty-eight esophageal biopsies were considered normal(51 from the ESCC group,42 from the HNSCC group and 35 from dyspeptic patients).Nine had esophagitis(7 from the HNSCC and 2 from dyspeptic patients).Of a total of 189 samples,only 6 samples had insufficient material for PCR analysis:1 from mucosa distant from the tumor in a patient with ESCC,3from patients with HNSCC and 2 from patients without cancer.In 183 samples(96.8%)GAPDH,G3PDH and/orβ-globin were amplified,thus indicating the adequacy of the DNA in those samples.HPV DNA was negative in all the 183 samples tested:52 with ESCC,9 with esophagitis and 122 with normal esophageal mucosa.CONCLUSION:There was no evidence of HPV infection in different ESCC from southern Brazil.Luís Carlos Moreira Antunes Joo Carlos Prolla Antonio de Barros Lopes Marta Pires da Rocha Renato Borges Fagundes 2013World Journal of Gastroenterology2013,19,39:4
9Perspectives on new biomarkers in gastric cancer: Diagnostic and prognostic applications显示文摘Gastric cancer is considered one of the most deadly tumors worldwide. Even with the decline in its incidence, the mortality rate of this disease has remained high, mainly due to its late diagnosis and to the lack of precise prognostic markers. The main purpose of this review is to present genetic, epigenetic and proteomic molecular markers that may be used in a diagnostic and prognostic manner and to discuss the pros and cons of each type of marker for improving clinical practice. In this sense, we observed that the use of genetic markers, especially mutations and polymorphisms, should be carefully considered, as they are strongly affected by ethnicity. Proteomic-based markers show promise, but the higher costs of the associated techniques con-tinue to make this approach expensive for routine use. Alternatively, epigenetic markers appear to be very promising, as they can be detected in bodily fluids as well as tissues. However, such markers must be used carefully because epigenetic changes may occur due to environmental factors and aging. Despite the advances in technology and its access, to date, there are few defined biomarkers of prognostic and diagnostic use for gastric tumors. Therefore, the use of a panel of several approaches(genetic, epigenetic and proteomic) should be considered the best alternative for clinical practice.Danilo do Rosário Pinheiro Wallax Augusto Silva Ferreira Mariceli Baia Leo Barros Mariana Diniz Araújo Symara Rodrigues-Antunes Bárbara do Nascimento Borges 2014World Journal of Gastroenterology2014,20,33:4
10Method development for the determination of cadmium in fertilizer samples using high-resolution continuum source graphite furnace atomic absorption spectrometry and slurry sampling显示文摘Aline R. Borges Emilene M. Becker Céline Lequeux Maria Goreti R. Vale Sergio L.C. Ferreira Bernhard Welz 2011Spectrochimica Acta Part B: Atomic Spectroscopy2011,,7:3
11Determination of heavy metals in activated charcoals and carbon black for Lyocell fiber production using direct solid sampling high-resolution continuum source graphite furnace atomic absorption and inductively coupled plasma optical emission spectrometry显示文摘Fábio G. Lepri Daniel L.G. Borges Rennan G.O. Araujo Bernhard Welz Frank Wendler Marcus Krieg Helmut Becker-Ross 2010Talanta2010,,3:3
12中国大学英语教师对科研的理解与态度探究(英文)显示文摘本文通过半结构访谈方式对中国大学英语教师对待科研的理解和态度及从事科研对教师职业发展的影响进行了探索性研究。研究发现大学英语教师对待科研的理解存在着多种矛盾,包括以发表为目的还是以提高教学质量为目的之间的矛盾,做理论研究还是做教学实践研究的矛盾,采用质的研究范式还是量的研究范式的矛盾,出于个人动机做研究还是迫于外力做研究的矛盾。通过对访谈话语的深入分析,我们发现教师对待科研的这些矛盾是受其在职业发展过程中所听到的多元声音以及各种经历的影响。通过分析大学英语教师对待研究的理解与态度,探索了如何有效地使教师对科研投入促进中国大学英语教师职业发展。刘熠 Simon Borg 2014Chinese Journal of Applied Linguistics2014,37,3:3
13巴西南部第三中心早产儿视网膜病变(英文)显示文摘目的:评估2002-10/2006-10在巴西de Clinicasde Porto Alegre医院出生的所有早产儿的早产儿视网膜病变(ROP)的发生率,其治疗和预后的比率。方法:对323例出生体质量低于或等于1500g或者出生时孕龄等于或者少于32wk的早产儿进行前瞻性队列研究。所有的新生儿都在出生后6wk内进行开睑器开睑,瞳孔散大,间接检眼镜及28D透镜眼底检查,根据疾病的分类进行复查。结果由均数表示,发病率为于95%的可信区间,主要的临床结果为任何分期的ROP发生。结果:新生儿82例发生了ROP,发生率为25.7%。患者中只有17例((5.3%)发生了阈病变,他们的病变都累及后部第II区,需要激光治疗。除了3例经治疗的患儿需要两次激光治疗外,没有一个经过治疗的患儿有I区病变或者严重的后部病变。重复治疗组的1例患儿因发展成为4期ROP而需要行赤道部硅胶带巩膜环扎术。结论:ROP的发生率和阈病变同国际其它的研究结果类似。本研究显示了孕期28wk以内或出生后体重1000g的新生儿高生存率(70.1%)、高视网膜病变发病率和激光治疗的高度必要性。这组患儿需要眼科专家和新生儿专家为发现ROP进行仔细筛查和随访。本组患儿中没有确诊1例有I区后部病变,此点是本研究值得引起注意之处。Joao Borges Fortes Filho Cristiano Koch Barros Gabriela Unchalo Eckert Leticia Procianoy Renato S. Procianoy 2007国际眼科杂志2007,7,1:3
14Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia显示文摘Mitsuro Kanda Hanno Matthaei Jian Wu Seung–Mo Hong Jun Yu Michael Borges Ralph H. Hruban Anirban Maitra Kenneth Kinzler Bert Vogelstein Michael Goggins 2012Gastroenterology2012,,4:3
15Cirrhosis in children and adolescents: An overview显示文摘Several conditions, especially chronic liver diseases, can lead to cirrhosis in children and adolescents. Most cases in clinical practice are caused by similar etiologies. In infants, cirrhosis is most often caused by biliary atresia and genetic-metabolic diseases, while in older children, it tends to result from autoimmune hepatitis,Wilson's disease, alpha-1-antitrypsin deficiency and primary sclerosing cholangitis. The symptoms of cirrhosis in children and adolescents are similar to those of adults. However, in pediatric patients, the first sign of cirrhosis is often poor weight gain. The complications of pediatric cirrhosis are similar to those observed in adult patients, and include gastrointestinal bleeding caused by gastroesophageal varices, ascites and spontaneous bacterial peritonitis. In pediatric patients, special attention should be paid to the nutritional alterations caused by cirrhosis, since children and adolescents have higher nutritional requirements for growth and development. Children and adolescents with chronic cholestasis are at risk for several nutritional deficiencies. Malnutrition can have severe consequences for both pre- and post-liver transplant patients. The treatment of cirrhosis-induced portal hypertension in children and adolescents is mostly based on methods developed for adults. The present article will review the diagnostic and differential diagnostic aspects of end-stage liver disease in children, as well as the major treatment options for this condition.Raquel Borges Pinto Ana Claudia Reis Schneider Themis Reverbel da Silveira 2015World Journal of Hepatology2015,7,3:3
16Systematic review of noninvasive treatments to arrest dentin non-cavitated caries lesions显示文摘AIM: To systematically review the literature on the efficacy of noninvasive methods of arresting the progression of non-cavitated occlusal carious lesions in dentin.METHODS: The Medline/Pub Med,LILACS,Sci ELO and Scopus databases were searched to identify relevant publications through to November 2013.Only clinical trials evaluating the ability of noninvasive methods to arrest the progression of occlusal non-cavitated carious lesions in dentin were included.Screening,data extraction and quality assessment were conducted independently and in duplicate.RESULTS: Of 167 citations identified,nine full text articles were screened and five were included in the analysis.All papers reported on occlusal fissure sealing using a self-curing glass ionomer(n = 1) or resin-based(n = 4) sealant.Only the use of resin-based sealant to obliterate occlusal fissures arrested the progression of non-cavitated occlusal carious lesions in dentin.CONCLUSION: Occlusal fissure sealing with a resin-based sealant may arrest the progression of non-cavitated occlusal dentinal caries.Further clinical trials with longer follow-up times should be performed to increase scientific evidence.Isauremi Vieira de Assun??o Giovanna de Fátima Alves da Costa Boniek Castillo Dutra Borges 2014World Journal of Clinical Cases2014,2,5:3
17抗氧化剂L-乙酰半胱氨酸对大鼠脉冲噪声的保护作用显示文摘目的 研究抗氧化剂L 乙酰半胱氨酸是否能够保护脉冲噪声引起的耳聋。方法 第 1组动物 :8只大鼠暴露在16 0dBSPL 5 0次脉冲噪声。第 2组动物 :10只大鼠同样暴露 16 0dBSPL 5 0次脉冲噪声 ,但在噪声暴露前 1h ,噪声暴露后立刻 ,噪声暴露后 3h ,给予L 乙酰半胱氨酸腹腔内注射 (35 0mg·kg-1,IP)。第 3组动物 :5只给予腹腔注射L 乙酰半胱氨酸 3次 ,注射方法与第 2组相同 ,不暴露脉冲噪声。全部动物通过脑干诱发电位检测听力阈值在噪声前 ,噪声后立刻 ,噪声后 1d ,1,2 ,4wk。结果 第 1组 :比较噪声前和噪声后 ,全部频率有明显听力损失。第 2组 :大鼠暴露同样剂量噪声 ,立刻和 1天后检测ABR阈值与暴露前相比听力损失明显 ,1wk后在 4到 2 0kHz都有听力损失 ,但在 31 5和 4 0kHz已不明显。在 2和 4wk之后 ,各频率听力损失不明显。第 3组 :立刻 ,1d后 ,4wk后测量脑干诱发电位各频率无听力损失。结论 抗氧化剂L 乙酰半胱氨酸能够保护脉冲噪声引起的听力损害。邱建新 童步升 吴开乐 Gran Laurell Erik Borg 段茂利 2004中国药理学通报2004,20,7:3
18Symposia Report Immunoglobulin G for the Treatment of Chronic Pain:Report of an Expert Workshop显示文摘背景:慢性疼痛的治疗效果仍不理想。尽管现在治疗慢性疼痛的药物种类较多,但许多患者对疗效仍不满意或诉药物的副作用太大。越来越多的证据表明,免疫系统参与了伤害性和神经病理性慢性疼痛的病理过程。设计:在英国利物浦的专题会议上,专家们出示了免疫系统参与慢性疼痛的证据。近来的研究表明,静脉(IVIg)或皮下(SCIg)注射免疫调节药物——多价免疫球蛋白(Ig G)可缓解外周神经病理性疼痛和其他疼痛性疾病。专题会议讨论了IVIg和SCIg治疗的适应证、效价比及其副作用。结果:Ig G可缓解某些伤害性和神经病理性慢性疼痛,如糖尿病、干燥综合征、纤维肌痛症、复杂性区域疼痛综合征、小儿麻痹后遗症和继发于病理性自身抗体的疼痛。结论:Ig G对某些慢性疼痛具有一定的治疗前景。Ig G是一种相对安全的治疗方法,副作用少而轻,但价格较贵。今后有必要对Ig G治疗顽固性疼痛进行随机对照研究和预测性临床试验。Stefano Tamburin Kristian Borg Xavier J. Caro Stefano Jann Alexander J. Clark Francesca Magrinelli Gen Sobue Lars Werhagen Giampietro Zanette Haruki Koike Peter J. Spath Angela Vincent Andreas Goebel 2014中国疼痛医学杂志2014,20,11:3
19典型沥青路面应变响应的现场实测研究显示文摘为了揭示沥青路面在车辆荷载作用下的力学响应变化规律,为耐久性路面设计提供参考,采用光纤光栅传感技术,对柔性基层(S1)、组合式基层(S2)及半刚性基层(S3)3种典型沥青路面结构开展了动静载作用下的应变现场测试试验,分析了路面应变沿水平和深度方向的应变场变化规律。结果表明,中上面层及下基层底为沥青路面最不利层位;此外,面层和基层的最不利荷载点位分别为轮载中心和轮隙中心;随着基层模量的增加,面层最不利层位逐渐由下面层上移至中上面层;揭示了结构层应变与车速之间的幂函数关系;相对于其他路面结构,半刚性基层沥青路面结构应变值最小,其可作为耐久性路面的优选结构类型。潘勤学 郑策策 吕松涛 钱国平 张军辉 文丕华 MILKOS Borges Cabrera 周怀德 2021Journal of Central South University2021,28,2:3
20不同乙酸浓度的液体发酵饲料对猪生长性能的影响显示文摘已经证实饲喂液体发酵饲料(FLF)有益于猪的胃肠道健康。然而,饲喂FLF的乳猪及育成猪的生长性能变异较大,且与饲喂非FLF或干饲料相比,饲喂FLF通常会降低猪的采食量。FLF中的微生物代谢产物(乙酸)的累积,可能伴随着饲料p H的降低,最终通过破坏适口性来降低饲料的采食量。但是,这个假设目前为止还未作深入的研究,本次试验意在探查FLF中的乙酸浓度对断奶仔猪采食量的影响。试验使用3种含有不同乙酸浓度的FLF日粮(30mM、60mM及120mM)。试验分为3组,每组20只仔猪,4周龄断奶且单独饲养,断奶后采用试验日粮饲喂6周,每周检测仔猪的采食量和体重变化。试验结果显示,高乙酸浓度的FLF略微降低饲料的pH,在不影响体增重的情况下,降低仔猪的饲料采食量。看似矛盾的结果可能由于饲喂液体饲料很难准确测定仔猪干物质采食量所导致的。总之,通常FLF中的乙酸浓度并不会显著影响仔猪的生长性能。张瑞霜 Nuria Canibe Anni yan Pedersen Bent Borg Jensen 2015饲料与畜牧(新饲料)2015,0,11:2
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