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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Effects of overburden characteristics on dynamic failure in underground coal mining显示文摘Dynamic failures, or ‘‘bumps', remain an imperative safety concern in underground coal mining, despite significant advancements in engineering controls. The presence of spatially discrete, stiff roof units are one feature that has been linked to these events. However, an empirical stratigraphic review indicates that no significant difference exists in the relative commonality of discrete units between bumping and non-bumping deposits. Instead an apparent relationship exists between reportable bumping and the overall stiffness of the host rock. However, this initial study is too simplistic to be conclusive; to weight the relative impact of changes in a single variable, such as the thickness or location of sandstone members, it must be examined in isolation—i.e., in a setting where all other variables are held constant.Numerical modelling provides this setting, and the effects of variability in a stiff discrete member in a hypothetical longwall mining scenario are investigated within the context of three stratigraphic ‘‘types',Compliant, Intermediate and Stiff. A modelling experiment examines changes in rupture potential in stiff roof units for each stratigraphic type as discrete unit thickness and location are manipulated through a range of values. Results suggest that the stiff-to-compliant ratio of the host rock has an impact on the relative stress-inducing effects of discrete stiff members. In other words, it is necessary to consider both the thickness and the distance to the seam, within the context of the host rock, to accurately anticipate areas of elevated rupture-induced hazard; acknowledging the presence of a discrete unit within the overburden in general terms is an insufficient indicator of risk. This finding helps to refine our understanding of the role of individual stiff, strong roof members in bumping phenomena, and suggests that a holistic view of overburden lithology and site-specific numerical modelling may be necessary to improve miner safety. | Lawson Heather E. Tesarik Douglas Larson Mark K Abraham Habte | 2017 | International Journal of Mining Science and Technology2017，27，1： | 7 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Using 1 Hz GPS Data to Measure Deformations Caused by the Denali Fault Earthquake显示文摘 | Larson K Bodin P and Gomberg J | 2003 | Science2003，300，： | 1 |
| 5 | Effect of acute and chronic arecoline treatment on cerebralmetabolism and blood flow in the conscious rat显示文摘 | MAIESE K HOLLOWAY H H LARSON D M | 1994 | Brain Res1994，641，1： | 1 |
| 6 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 7 | Absence of association of genetic linkage between the angiotensin converting-enzyme gene and left ventricular mass显示文摘 | Lindpaintner K Lee M Larson MG | 1996 | N Engl J Med1996，334，： | 1 |
| 8 | The effect of removing the true dental follicle on premolar eruption in the dog 显示文摘 | LARSON E K CAHILL D R GORSKI J P | 1994 | Arch Oral Biol1994，39，4： | 1 |
| 9 | A phase Ⅱ multicenter study of lenalidomide in relapsed or refractory classical Hodgkin lymphoma显示文摘 | Fehniger TA Larson S Trinkaus K | 2009 | Blood2009，114，： | 1 |
| 10 | Rapid com- munication: restriction fragment length polymorphisms at the porcine transporter associated with antigen processing 1 (TAP1) locus显示文摘 | Vaske D A Ruohonen M K Larson R ~ | 1994 | JAnim Sci1994，72，1： | 1 |
| 11 | The rising tide of dementia worldwide显示文摘 | Larson E Langa K | | 0，，9637： | 1 |
| 12 | Binding and insertion of alpha-helical anti-microbial peptides in POPC bilay- ers studied by molecular dynamics simulations 显示文摘 | Kandasamy S K Larson R G | 2004 | Chemistry and physics of lipids2004，132，1： | 1 |
| 13 | Minimally invasive plating of high-energy metaphyseal distal tibia fractuxe8显示文摘 | Collinge C Kuper M Larson K | 2007 | J Orthop Trauma2007，21，6： | 1 |
| 14 | A meta-analysis of strawberry yield response to replant soil fumigation with combination of methyl bromide-chloropicrin and from alternative systems显示文摘 | SHAW D V LARSON K D | 1999 | Hortscience1999，34，5： | 1 |
| 15 | Association of blood pressure with fibrinolytic potential in the Framingham offspring population显示文摘 | Poli K A Tofler G H Larson M G | 2000 | Circulation2000，25，： | 1 |
| 16 | Global plate velocities from Global Positioning System 显示文摘 | Larson M K Freymueller J | 1997 | Journal of Geophysical Research1997，102，5： | 1 |
| 17 | Locating discretionary service facility(Ⅱ):minimizing inconvenience显示文摘 | Berman O Bertismas K Larson R C | 1995 | Operations Research1995，43，4： | 1 |
| 18 | Different patterns of cerebral injury in dementia with or without diabetes显示文摘 | Sonnen JA Larson EB Brickell K | 2009 | Arch Neurol2009，66，3： | 1 |
| 19 | Two-photon luminescence imaging of cancer ceils using molecularly targeted gold nanorods显示文摘 | Durr N J Larson T Smith D K | 2007 | Nano Lett2007，7，4： | 1 |
| 20 | Collocation versus differential inclusion in direct optimization 显示文摘 | Conway B A Larson K M | 1998 | Journal of Guidance Control and Dynamics1998，21，5： | 1 |
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