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| 1 | Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development显示文摘Insulin-like growth factor-I(IGF-I)regulates cell growth,survival,and differentiation by acting on the IGF-I receptor,(IGF-IR)-a tyrosine kinase receptor,which elicits diverse intracellular signaling responses.All skeletal cells express IGF-I and IGF-IR.Recent studies using tissue/cell-specific gene knockout mouse models and cell culture techniques have clearly demonstrated that locally produced IGF-I is more critical than the systemic IGF-I in supporting embryonic and postnatal skeletal development and bone remodeling.Local IGF-I/IGF-IR signaling promotes the growth,survival and differentiation of chondrocytes and osteoblasts,directly and indirectly,by altering other autocrine/paracrine signaling pathways in cartilage and bone,and by enhancing interactions among these skeletal cells through hormonal and physical means.Moreover,local IGF-I/IGF-IR signaling is critical for the anabolic bone actions of growth hormone and parathyroid hormone.Herein,we review evidence supporting the actions of local IGF-I/IGF-IR in the above aspects of skeletal development and remodeling. | Yongmei Wang Daniel D. Bikle Wenhan Chang | 2013 | Bone Research2013，1，3： | 2 |
| 2 | Effects of simulated weightlessness on bone mineral metabolism 显示文摘 | GLOBUS R K BIKLE D D Morey-Hohon E | 1984 | Endocrinology1984，114，： | 1 |
| 3 | Skeletal unloading causes resistance of osteoprogenitor cells to parathyroid hormone and to insulin-like growth factor-I显示文摘 | Kostenuik PJ Harris J Halloran BP Turner RT Morey-Holton ER Bikle DD | | 0，，： | 1 |
| 4 | Repetition suppression of faces is modulated by emotion显示文摘 | ISHAI A PESSOA L BIKLE P C | 2004 | Proceedins of National Academy of Sciences of United States of America2004，101，26： | 1 |
| 5 | The response of bone to unloading显示文摘 | Bikle DD Halloran BP | | 0，，04： | 1 |
| 6 | Biochemical marlceng in the bsessmcnl of bone disease显示文摘 | Bikle DD | 1997 | Am J Med1997，103，： | 1 |
| 7 | The vitamin D response element of the involucrin gene mediates its regulation by 1,25 -dihydroxyvitamin D3显示文摘 | Bikle DD Ng D Oda Y | 2002 | J Invest Dermatol2002，119，5： | 1 |
| 8 | Development and progres- sion of alopecia in the vitamin D receptor null mouse显示文摘 | Bikle DD Elalieh H Chang S | 2006 | J Cell Physiol2006，207，2： | 1 |
| 9 | Nonclassic actions of vitmin D显示文摘 | Bikle D | 2009 | J Clin Endocrinol Metab2009，94，1： | 1 |
| 10 | Insulin like growth factor-I:a critical mediator of the skeletal response to parathyroid hormone显示文摘 | Bikle DD Wang Y | | 0，，： | 1 |
| 11 | Nonclassic Actions of Vitamin D显示文摘 | Daniel Bikle | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，1： | 1 |
| 12 | Nonclassic actions of vitmin D显示文摘 | Bikle D | 2009 | J Clin Endocrinol Metab2009，94，1： | 1 |
| 13 | Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice显示文摘 | TEICHERT A ELALIEH H BIKLE D | 2010 | J Cell Physiol2010，225，2： | 1 |
| 14 | Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice显示文摘 | Teichert A Elalieh H Bikle D | 2010 | J Cell Physiol2010，225，2： | 1 |
| 15 | The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gammal activation and human keratinocyte differentiation显示文摘 | XIE Z BIKLE DD | 2007 | Biol Chem2007，282，12： | 1 |
| 16 | 1α,25(OH) 2 -Dihydroxyvitamin D 3 /VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway显示文摘 | Yan J. Jiang Arnaud E. Teichert Frankie Fong Yuko Oda Daniel D. Bikle | 2013 | Journal of Steroid Biochemistry and Molecular Biology2013，，： | 1 |
| 17 | Nonclassic actions of vitamin D 显示文摘 | Bikle D | 2009 | J Clin Endocrinol Metab2009，94，1： | 1 |
| 18 | Role of IGF-I sig- naling in muscle bone interactions显示文摘 | Bikle DD Tahimic C Chang W | 2015 | Bone2015，，80： | 1 |
| 19 | Evidence for separate control mechanisms at the message, protein, and enzyme activation levels for transglutaminase during calcium-induced differentiation of normal and transformed human keratinocytes显示文摘 | Gibson D F Ratnam A V Bikle D D | 1996 | J Invest Dermatol1996，106，1： | 1 |
| 20 | The nonskeletal effects of vitamin D:an Endocrine Society scientific statement显示文摘 | Rosen CJ Adams JS Bikle DD Black DM Demay MB Manson JE Murad MH Kovacs CS | | 0，，03： | 1 |
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