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| 1 | Hematopoietic stem cell-derived exosomes promote hematopoietic differentiation of mouse embryonic stem cells in vitro via inhibiting the miR126/Notch1 pathway显示文摘导出房间的 exosomes (前) 能经由他们带了的 microRNAs (米尔) 调制目标房间区别。以前的研究证明了 miR126 高度在造血的干细胞(HSC ) 被表示并且经由 modulating 在造血作用起一个作用参予祖先房间命运决定的槽口小径。在这研究,我们调查了导出 HSC 的前(HSC 前) 是否能影响老鼠的区别胚胎的干细胞(转换字符) 进 HSC。我们准备了 HSC 前 反对 ,HSC 前 sc 和 HSC 前 从控制 HSC 和 HSC transfected 与的 miR126 爬控制或 miR126 分别地模仿。HSC 前被 ultracentrifugation 孤立并且分析了使用追踪分析的 nanoparticle。我们孵化了在一个 10-d 区别正式就职时期上与老鼠转换字符收集了前,在哪个 HSC 前和槽口小径使活跃之物期间(Jagged1, 100 ng/mL ) 被加到文化每 3 d。在在转换字符的 10-d 区别时期, miR126 的表示层次, SSEA1, CD117, Sca1, Notch1 和 Hes1 被估计以后。产生 HSC 被流动 cytometry 对 HSC 标记(CD117, CD34 和 Sca1 ) 用抗体验证。我们的结果揭示了那:(1 ) 有 miR126 的 transfection 在 HSC 前 miR126 。(2 )HSC 前合作文化支持了老鼠转换字符区别进 HSC,最突出的效果在 HSC 前 miR126 合作文化。(3 ) HSC 区别被减少的 SSEA1 表示验证并且增加了 CD117 和 Sca1 表示。(4 )HSC 前引起的所有效果被 Notch1 和 Hes1 表示的重要减小伴随,这样 Notch1/Hes1 小径的抑制,而由 Jagged1 的槽口的激活废除了 HSC 前 miR126 。在结论, HSC 前由禁止 miR126/Notch1 小径在 vitro 支持老鼠转换字符的造血的区别。 | Feng-ling LIAO Lin TAN Hua LIU Jin-ju WANG Xiao-tang MA Bin ZHAO Yanfang CHEN Ji BIHL Yi YANG Ri-ling CHEN | 2018 | Acta Pharmacologica Sinica2018，39，4： | 7 |
| 2 | Health-related quality of life outcomes after cholecystectomy显示文摘Gallbladder diseases are very common in developed countries. Complicated gallstone disease represents the most frequent of biliary disorders for which surgery is regularly advocated. As regards, cholecystectomy represents a common abdominal surgical intervention; it can be performed as either an elective intervention or emergency surgery, in the case of gangrene, perforation, peritonitis or sepsis. Nowadays, the laparoscopic approach is preferred over open laparotomy. Globally, numerous cholecystectomies are performed daily; however, little evidence exists regarding assessment of post-surgical quality of life (QOL) following these interventions. To assess post-cholecystectomy QOL, in fact, documentation of high quality care has been subject to extended discussions, and the use of patientreported outcome satisfaction for quality improvement has been advocated for several years. However, there has been little research published regarding QOL out-comes following cholecystectomy; in addition, much of the current literature lacks systematic data on patientcentered outcomes. Then, although several tools have been used to measure QOL after cholecystectomy, diffi culty remains in selecting meaningful parameters in order to obtain reproducible data to reflect postoperative QOL. The aim of this study was to review the impact of surgery for gallbladder diseases on QOL. This review includes Medline searches of current literature on QOL following cholecystectomy. Most studies demonstrated that symptomatic patients profi ted more from surgery than patients receiving an elective intervention. Thus, the gain in QOL depends on the general conditions before surgery, and patients without symptoms profi t less or may even have a reduction in QOL. | Amedeo Carraro Dania El Mazloum Florian Bihl | 2011 | World Journal of Gastroenterology2011，17，45： | 5 |
| 3 | Liver transplantation from hepatitis B surface antigen positive donors: A safe way to expand the donor pool显示文摘 | Elisabetta Loggi Lorenzo Micco Giorgio Ercolani Alessandro Cucchetti Florian K. Bihl Gian Luca Grazi Stefano Gitto Andrea Bontadini Mauro Bernardi Paolo Grossi Alessandro Nanni Costa Antonio Daniele Pinna Christian Brander Pietro Andreone | 2011 | Journal of Hepatology2011，，3： | 2 |
| 4 | Adaptive response in hepatitis B virus infection显示文摘 | E. Loggi N. Gamal F. Bihl M. Bernardi P. Andreone | 2014 | J Viral Hepat2014，，5： | 1 |
| 5 | Proliferation of human non- small-cell lung cancer cell lines : role of interleukin-6 显示文摘 | BIHL M TAMM M NAUCK M | 1998 | Am J Respir Cell Mol Biol1998，19，4： | 1 |
| 6 | Clinicopathological and protein characterization of BRAF - and K - RAS - mutated colorectal cancer and implications for prognosis 显示文摘 | Zlobec I Bihl M P Schwarb H | 2010 | International Journal of Cancer2010，127，2： | 1 |
| 7 | Opposite effect of corticosteroids and long-acting beta(2)-agonists on serum-and TGF-beta (1)-induced extracellular matrix deposition by primary human lung fibroblasts显示文摘 | Goulet S Bihl MP Gambazzi F | | 0，，： | 1 |
| 8 | Anticoagulant therapy for nodular regenerative hyperplasia in a HIV-infected patient显示文摘 | Bihl F Janssens F Boehlen F | 2010 | BMC Gastroenterology2010，10，： | 1 |
| 9 | Calcifying fibrous tumor of the stomach:clinicopathologic and molecular study of seven cases with literature review and reappraisal of histogenesis显示文摘 | Agaimy A Bihl MP Tornillo L | | 0，，2： | 1 |
| 10 | Clinicopathological and protein chamcterization of BRAF - and - K - ras - mutated colorectal cancer and implications for prognesis 显示文摘 | Zlobec I Bihl MP Schwarb H | 2010 | Int J Cancer2010，127，2： | 1 |
| 11 | Clinicopathologicalandpro- tein characterization of BRAF-and K-RAS-mutated colorectalca- ncer and implications for prognosis 显示文摘 | ZlobecI Bihl MP Sehwarb H | 2010 | Int J Cancer2010，127，： | 1 |
| 12 | Calcifying fibroustumor of the stomach : clinicopathologic and molecular study ofseven cases with literature review and reappraisal ofhistogenesis 显示文摘 | Agaimy A Bihl M P Tomillo L | 2010 | Am J Surg Pathol2010，34，2： | 1 |
| 13 | Human bronchial epithelium controls TH2 responses by TH1-InducedNitric Oxide-mediated STAT5 dephosphorylation : Implications for the pathogenesis of asthma显示文摘 | Eriksson U Egermann U Bihl MP | 2005 | Immunology2005，175，： | 1 |
| 14 | Anti-HBs re- seroeonversion after liver transplantation in a patient with past HBV infection receiving a HBsAg positive graft 显示文摘 | Loggi E Bihl F Chisholm JV | 2009 | J Hepatol2009，50，3： | 1 |
| 15 | Recurrent renal stone disease-advances in pathogenesis and clinical management显示文摘 | Bihl G Meyers A | 2001 | Lancet2001，358，9282： | 1 |
| 16 | Characterization of CDKN2A (p16) methylation and impact in colorectal cancer: systematic analy- sis using pyrosequencing显示文摘 | Bihl MP Foerster A Lugli A | 2012 | J Transl Med2012，10，1： | 1 |
| 17 | Clinicopathological and protein characterization of BRAF-and K-RAS-mutated colorectal cancer and implications for prognosis显示文摘 | Zlobec I Bihl MP Schwarb H | 2010 | Int J Cancer2010，127，： | 1 |
| 18 | Whole body positron emission tomography in the treatment of Hodgkin disease显示文摘 | Hueltenschmidt B Sautter -Bihl ML Lang O | 2001 | Cancer2001，91，2： | 1 |
| 19 | Toll-Like Receptor 4 Expression Is Required to Control Chronic Mycobacterium tuberculosis In- fection in Mice显示文摘 | Abel B Thieblemont N Quesniaux VJ Brown N Mpagi J Miyake K Bihl F Ryffel B | 2002 | J Immunol2002，169，6： | 1 |
| 20 | Clinicopathological and protein characterization of BRAF and K-HAS-mutated colorectal cancer and implications for prognosis显示文摘 | ZLOBEC I BIHL M P SCHWARB H | 2010 | Int J Cancer2010，127，2： | 1 |
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