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| 1 | The Chinese Society of Clinical Oncology(CSCO):Clinical guidelines for the diagnosis and treatment of gastric cancer,2021显示文摘There exist differences in the epidemiological characteristics,clinicopathological features,tumor biological characteristics,treatment patterns,and drug selections between gastric cancer patients from the Eastern and Western countries.The Chinese Society of Clinical Oncology(CSCO)has organized a panel of senior experts specializing in all sub-specialties of gastric cancer to compile a clinical guideline for the diagnosis and treatment of gastric cancer since 2016 and renews it annually.Taking into account regional differences,giving full consideration to the accessibility of diagnosis and treatment resources,these experts have conducted expert consensus judgment on relevant evidence and made various grades of recommendations for the clinical diagnosis and treatment of gastric cancer to reflect the value of cancer treatment and meeting health economic indexes in China.The 2021 CSCO Clinical Practice Guidelines for Gastric Cancer covers the diagnosis,treatment,follow-up,and screening of gastric cancer.Based on the 2020 version of the CSCO Chinese Gastric Cancer guidelines,this updated guideline integrates the results ofmajor clinical studies from China and overseas for the past year,focused on the inclusion of research data from the Chinese population for more personalized and clinically relevant recommendations.For the comprehensive treatment of non-metastatic gastric cancer,attentions were paid to neoadjuvant treatment.The value of perioperative chemotherapy is gradually becoming clearer and its recommendation level has been updated.For the comprehensive treatment of metastatic gastric cancer,recommendations for immunotherapy were included,and immune checkpoint inhibitors fromthird-line to the first-line of treatment for different patient groups with detailed notes are provided. | Feng-Hua Wang Xiao-Tian Zhang Yuan-Fang Li Lei Tang Xiu-Juan Qu Jie-Er Ying Jun Zhang Ling-Yu Sun Rong-Bo Lin Hong Qiu Chang Wang Miao-Zhen Qiu Mu-Yan Cai QiWu Hao Liu Wen-Long Guan Ai-Ping Zhou Yu-Jing Zhang Tian-Shu Liu Feng Bi Xiang-Lin Yuan Sheng-Xiang Rao Yan Xin Wei-Qi Sheng Hui-Mian Xu Guo-Xin Li Jia-Fu Ji Zhi-Wei Zhou Han Liang Yan-Qiao Zhang Jing Jin Lin Shen Jin Li Rui-Hua Xu | 2021 | Cancer Communications2021，41，8： | 97 |
| 2 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 3 | Biodegradation of phenol by free and immobilized Acinetobacter sp.strain PD12显示文摘有高 biodegradation 活动和酚的 hightolerance 的一个新降级酚的细菌,种类 PD12 ,在 China.This 从天津 JizhuangziWastewater 处理设备的激活的污泥被孤立种类能够在集中在 9 h 和使产生代射变化的酚以内在在99.6%中等的 liquidminimal 移开 500 mg phenol/L 直到 1100 mg/L.DNAsequencing 和识别的 16S rRNA 基因的相应分析是 Acinetobactersp.Polyvinyl 白酒( PVA )的 PD12 用作一个胶化矩阵到 | WANG Ying TIAN Ye HAN Bin ZHAO Hua-bing BI Jian-nan CAI Bao-li | 2007 | Journal of Environmental Sciences2007，19，2： | 24 |
| 4 | Schisandrol B protects against acetaminophen- induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway显示文摘目的: 原子因素 erythroid 2-related 因素(NRF2 ) 2 通过抗氧化剂反应元素行动() 处理调整许多除去和为 cytoprotective 负责的抗氧化剂基因的表示。我们以前报导从五味子 sphenanthera 孤立的 Schisandrol B (SolB ) 对导致的 acetaminophen (APAP ) 生产了保护的效果肝损害。在这研究,我们调查了表明小径的 NRF2/ARE 是否涉及这 hepato 保护的 effect.Methods : 男 C57BL/6 老鼠与 SolB 被对待(200 mg· kg −1·d−1, ig ) 为在 APAP 的注射前的 3 d (400 mg/kg, ip ) 。浆液和肝织物样品被收集 6 h 以后。mRNA 和蛋白质表示分别地用 qRT-PCR 和西方的污点试金被测量。 NRF2 的激活用酶记者基因 assay.Results 在 HepG2 房间被检验:显著地减轻的 SolB 预告的处理肝的损害(肝的湾穴的大补缀的坏死和 hyperemia ),浆液著名计算机生产厂商的增加,中高音层次和肝的 MDA 满足,并且肝和 mitochondrial 谷胱甘肽的减少在 对待APAP 的老鼠铺平。而且, SolB 预告的处理显著地增加了 NRF2 的原子累积并且增加了 NRF2 下游的蛋白质的肝的表示,包括在对待 APAP 的鼠标的 GCLC, GSR, NQO1, GST, MRP2, MRP3 和 MRP4。而且,有 SolB 的处理(2.5-20 μ mol/L ) dose-dependently 在 HepG2 cells.Conclusion 增加了 NRF2 记者基因的活动: SolB 对导致 APAP 的 hepatotoxicity 展出显著保护的效果,部分,经由 NRF2/ARE 的激活, NRF2 的小径和规定指向基因,它导致 detoxification 和增加抗氧化剂能力。 | Yi-ming JIANG Ying WANG Hua-sen TAN Tao YU Xiao-mei FAN Pan CHEN Hang ZENG Min HUANG Hui-chang BI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 24 |
| 5 | Microstructure,mechanical and corrosion properties of Mg-2Dy-xZn(x=0,0.1,0.5 and 1 at.%)alloys显示文摘Microstructure,mechanical and corrosion properties of as-cast Mg-2Dy-xZn(x=0,0.1,0.5,and 1)(at.%)alloys were investigated.The microstructures of the as-cast Mg-2Dy and Mg-2Dy-0.1Zn alloys mainly consisted ofα-Mg phase and Mg_(24)Dy_(5)eutectic phase.With 0.5 at.%Zn addition,Mg_(12)ZnDy phase with 18R-type long period stacking ordered(LPSO)structure and Mg_(2)Dy phase precipitated at the grain boundaries.When the content of Zn is 1 at.%,only the Mg_(3)Zn_(3)Dy_(2)phase formed in theα-Mg matrix.The electrochemical measurements and immersion testing results indicated that the Mg-2Dy-0.1Zn alloy exhibited the best corrosion resistance.It revealed that the morphology,scale,amount and distribution of the second phase have a great effect on the corrosion resistance of alloy.Additionally,the tensile testing results showed that the Mg-2Dy-0.5Zn alloy exhibited the higher tensile strength and good elongation,especially at 200℃.The improvement of mechanical properties was mainly due to the strengthening of LPSO phase and grain refinement of α-Mg. | Guangli Bi Yuandong Li Shijun Zang Jianbin Zhang Ying Ma Yuan Hao | 2014 | Journal of Magnesium and Alloys2014，2，1： | 13 |
| 6 | Acupoint Catgut Embedding Alleviates Insomnia in Different Chinese Medicine Syndrome Types: A Randomized Controlled Trial显示文摘Objective: To investigate the effects and safety of catgut embedding on alleviating insomnia. Methods: Totally 510 patients with insomnia were divided into 5 Chinese medicine(CM) syndrome types: Xin(Heart) and Pi(Spleen) deficiency, yin deficiency with excess fire, Xin and gut qi deficiency, Wei(Stomach) disorder, and qi and blood deficiency, respectively. These 5 types of patients were randomly assigned to a catgut embedding group, an acupuncture group or a medication group(30 cases in Xin and Pi deficiency type, Wei disorder type, Xin and gut qi deficiency type, respectively;40 cases in yin deficiency with excess fire type and qi and blood deficiency type, respectively). In the catgut embedding group, patients were treated by implanting catgut into acupoints once every 10 days for a total of 30 days. In the acupuncture group, patients were treated with acupuncture once per day over 30 days(excluding weekends);and patients in the medication group took 1 mg Eurodin Tablet orally every night for 30 days. Pittsburgh Sleep Quality Index(PSQI) was evaluated before treatment, on 30 and 60 days after the first treatment, respectively. The International Unified Sleep Efficiency Value(IUSEV) was measured at 30 and 60 days. The safety was evaluated after treatment and adverse events were analyzed. Results: The objective PSQI scores including subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disturbance, daytime dysfunction, and total scores at 30 days were significantly improved compared with pre-treatment in the catgut embedding and acupuncture groups(P<0.01 or P<0.05). At 30 days, the PSQI scores in catgut embedding group were superior to the medication group in the patients with each type of insomnia, with the exception of sleep duration(P<0.01 or P<0.05). At 60 days, significant differences were found between the catgut embedding group and the medication group(P<0.01 for all indices). The IUSEV scores in the catgut embedding group were significantly higher than the acupuncture group at 60 days, and the scores in acupuncture group were higher than the medication group at 30 days(P<0.05 for all types). No severe adverse events were found in this study. Conclusions: Acupoint catgut embedding and acupuncture were more effective than medication in alleviating insomnia syndrome in different Chinese medicine syndrome type. However, the sustained effects of acupoint catgut embedding were superior to acupuncture. | XU Fu XUAN Li-hua ZHOU Hai-jiang CHEN Fei-yu ZHENG Zhao-jian BI Ying WU Xiang | 2019 | Chinese Journal of Integrative Medicine2019，25，7： | 9 |
| 7 | Disturbance of hippocampal H2S generation contributes to CUMS-induced depression-like behavior: involvement in endoplasmic reticulum stress of hippocampus显示文摘长期的无法预言的温和压力淫液模型是消沉的一个广泛地使用的试验性的模型。在马头鱼尾的怪兽的外长的导致压力的 neuronal 房间死亡仔细与消沉的致病被联系。过多、延长的 endoplasmic 蜂窝胃嗯压力扳机房间死亡。氢硫化物 H 2 S,第三内长的发信号 gasotransmitter,作为 neuromodulator 和 neuroprotectant 在大脑功能起一个重要作用。我们假设了内长的 H 2 S 产生并且嗯在马头鱼尾的怪兽的应力可能涉及导致淫液的像消沉的行为。因此,集中于是否达到高潮的现在的学习扰乱内长的 H 2 S 和起来调整嗯在马头鱼尾的怪兽的应力并且是否外长的 H 2 S 阻止导致淫液的象压抑一样行为。结果证明对待淫液的老鼠展出像消沉的行为并且海马趾嗯包括调整葡萄糖的蛋白质的起来调整的层次的压力回答 78, CCAAT/enhancer 有约束力的蛋白质相应蛋白质,和劈开的 caspase-12 表示,当时 H 2 在马头鱼尾的怪兽的 S 在对待淫液的老鼠被压制。而且,外长的 H 2 S 阻止导致淫液的像消沉的行为。这些数据显示导致淫液的像消沉的行为与内长的 H 2 S 产生并且嗯在马头鱼尾的怪兽的应力并且建议了那内长的 H 2 S 并且嗯应力是消沉的新奇处理目标。 | Huiying Tan Wei Zou Jiamei Jiang Ying Tian Zhifang Xiao Lili Bi Haiying Zeng Xiaoqing Tang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 8 |
| 8 | Signal transducer and activator of transcription 3 promotes the Warburg effect possibly by inducing pyruvate kinase M2 phosphorylation in liver precancerous lesions显示文摘BACKGROUND Study shows that signal transducer and activator of transcription 3(STAT3) can increase the Warburg effect by stimulating hexokinase 2 in breast cancer and upregulate lactate dehydrogenase A and pyruvate dehydrogenase kinase 1 in myeloma. STAT3 and pyruvate kinase M2(PKM2) can also be activated and enhance the Warburg effect in hepatocellular carcinoma. Precancerous lesions are critical to human and rodent hepatocarcinogenesis. However, the underlying molecular mechanism for the development of liver precancerous lesions remains unknown. We hypothesized that STAT3 promotes the Warburg effect possibly by upregulating p-PKM2 in liver precancerous lesions in rats.AIM To investigate the mechanism of the Warburg effect in liver precancerous lesions in rats.METHODS A model of liver precancerous lesions was established by a modified Solt-Farber method. The liver pathological changes were observed by HE staining and immunohistochemistry. The transformation of WB-F344 cells induced with Nmethyl-N'-nitro-N-nitrosoguanidine and hydrogen peroxide was evaluated by the soft agar assay and aneuploidy. The levels of glucose and lactate in the tissue and culture medium were detected with a spectrophotometer. The protein levels of glutathione S-transferase-π, proliferating cell nuclear antigen(PCNA), STAT3,and PKM2 were examined by Western blot and immunofluorescence.RESULTS We found that the Warburg effect was increased in liver precancerous lesions in rats. PKM2 and p-STAT3 were upregulated in activated oval cells in liverprecancerous lesions in rats. The Warburg effect, p-PKM2, and p-STAT3 expression were also increased in transformed WB-F344 cells. STAT3 activation promoted the clonal formation rate, aneuploidy, alpha-fetoprotein expression,PCNA expression, G1/S phase transition, the Warburg effect, PKM2 phosphorylation, and nuclear translocation in transformed WB-F344 cells.Moreover, the Warburg effect was inhibited by stattic, a specific inhibitor of STAT3, and further reduced in transformed WB-F344 cells after the intervention for PKM2.CONCLUSION The Warburg effect is initiated in liver precancerous lesions in rats. STAT3 activation promotes the Warburg effect by enhancing the phosphorylation of PKM2 in transformed WB-F344 cells. | Yang-Hui Bi Wen-Qi Han Ruo-Fei Li Yun-Jiao Wang Zun-Shu Du Xue-Jiang Wang Ying Jiang | 2019 | World Journal of Gastroenterology2019，25，16： | 8 |
| 9 | Role of interleukin-8 in the progression of estrogen receptor-negative breast cancer显示文摘背景雌激素受体(嗯) 是乳癌的很重要的 biomarker。嗯删除一致地与肿瘤前进,复发,转移和差的预后被联系了,但是生物机制仍然是不清楚的。嗯 interieukin-8 (IL-8 ) 的否定乳癌快车高水平。嗯表示罐头 downregulate IL-8 promotor 活动。作为多功能的 cytokine, IL-8 在肿瘤开始和开发举办许多重要生物活动。旨在在嗯否定的乳癌前进调查 IL-8 的角色,我们把 RNA 干扰技术用于明确地击倒在房间线 MDA-MB-231.Methods 介入 pRNA-IL-8 和控制是的嗯否定的乳癌的 IL-8 表示 transfected 进嗯(-) MDA-MB-231。增长,房间 apotosis,和侵略能力在 transfected, untransfected 和否定 transfected 房间被记录。这些房间被注入裸体鼠标估计 tumorigenicity,增长,转移和 microvessel 密度(MVD ) 在 vitro 的 .Results, IL-8 的减少的表示与被联系减少了房间侵略(P0.001 ) ,但是没在房间增长(P0.05 ) 上有效果。在 vivo, neutrophils 渗入显著地与 untransfected 相比并且否定地在 pRNA-IL-8 transfected 房间被禁止 transfected 房间(P=0.001, P0.001 ) 。更少的转移在 transfected 房间被发现与相比否定地 transfected 房间(0% 对 80% , P=0.048 ) 。不过,我们与控制相比在 transfected 房间观察了更少的 MVD 在里面裸体老鼠(P0.001 ).Conclusions IL-8 禁止嗯否定的乳癌房间生长并且在 vivo 支持它的转移,它可以被相关, neutrophils 渗入由 IL-8 导致了。 | YAO Chen LIN Ying YE Cai-sheng BI Jiong ZHU Yi-fan WANG Shen-ming | 2007 | Chinese Medical Journal2007，，20： | 8 |
| 10 | Expert consensus on maintenance treatment for metastatic colorectal cancer in China显示文摘The impact of maintenance therapy on progression-free survival and overall survival as well as quality of life of Chinese patients with metastatic colorectal cancer has long been under discussion.Recently,some phase III clinical trials have revealed that maintenance therapy can significantly prolong the progression-free survival while maintain an acceptable safety profile.Based on this evidence and common treatment practice in China,we now generated one Expert Consensus on Maintenance Treatment for Metastatic Colorectal Cancer in China to further specify the necessity of maintenance therapy,suitable candidates for such treatment,and appropriate regimens. | Rui-Hua Xu Lin Shen Jin Li Jian-Ming Xu Feng Bi Yi Ba Li Bai Yong-Qian Shu Tian-Shu Liu Yu-Hong Li Chun-Mei Bai Xiang-Lin Yuan Jun Zhang Gong Chen Ai-Ping Zhou Ying Yuan Xi-Jing Wang Xiao-Ping Qian Yan-Hong Deng | 2016 | Chinese Journal of Cancer2016，35，1： | 8 |
| 11 | The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer显示文摘Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous cells1 that play crucial negative regulatory roles in immune-associated diseases,including infections,2 cancer,3 transplantation4,and autoimmunity.5 We and others have shown that mTOR signaling and its downstream metabolic pathways regulate MDSC recruitment and function in inflammation and autoimmunity. | Anna Jia Yuexin Wang Yufei Wang Yan Li Qiuli Yang Yejin Cao Ying He Lin Dong Yingjie Dong Yueru Hou Ruoning Wang Yujing Bi Guangwei Liu | 2021 | Cellular & Molecular Immunology2021，18，4： | 7 |
| 12 | Interaction between retanning agents and wet white tanned by a novel bimetal complex tanning agent显示文摘A promising and practical chrome-free tanning system has been developed based on a novel Al–Zr bimetal complex tanning agent.However,to achieve satisfactory resultant leather,the retanning process that is compatible with this emerging tannage needs to be investigated systematically.This paper aims to explore the interaction between the bimetal complex tanned wet white and retanning agents.The isoelectric point(pI)of wet white was 7.2,which was nearly the same as wet blue.The electropositivity of wet white was even higher than that of wet blue during post-tanning processes,resulting in higher uptake rate of retanning agents.The distribution of various retanning agents in wet white was analyzed by pI measurement of layered leather and fluorescent tracing technique.The retanning agents were unevenly distributed throughout the cross-section,which might be an important restriction factor in obtaining satisfactory organoleptic properties of the crust leather.This fact is mainly due to the strong electrostatic interaction between anionic retanning agents and wet white.Applying a high dosage of multiple retanning agents in a proper sequence of addition benefited the full penetration of retanning agents in leather matrix and thus improved the organoleptic properties of crust leather.This work provides guidance for optimizing retanning process of the wet white leather. | Wanli Huang Ying Song Yue Yu Ya-nan Wang Bi Shi | 2020 | Journal of Leather Science and Engineering2020，2，1： | 7 |
| 13 | Dry sliding wear behavior of an extruded Mg-Dy-Zn alloy with long period stacking ordered phase显示文摘The dry sliding wear behavior of extruded Mg-2Dy-0.5Zn alloy(at.%)was investigated using a pin-on-disk configuration.The friction coefficient and wear rate were measured within a load range 20-760 N at a sliding velocity of 0.785 m/s.Microstructure and wear surface of alloy were examined using scanning electron microscopy.The mechanical properties of alloy were tested at room and elevated temperatures.Five wear mechanisms,namely abrasion,oxidation,delamination,thermal softening and melting dominated the whole wear behavior with increasing applied load.The extruded Mg-2Dy-0.5Zn alloy exhibited the better wear resistance as compared with as-cast Mg_(97)Zn_(1)Y_(2) alloy under the given conditions through contact surface temperature analysis.The improved wear resistance was mainly related to fine grain size,good thermal stability of long period stacking order(LPSO)phase and excellent higher-temperature mechanical properties. | Guangli Bi Yuandong Li Xiaofeng Huang Tijun Chen Ying Ma Yuan Hao | 2015 | Journal of Magnesium and Alloys2015，3，1： | 6 |
| 14 | Optimization of Vehicle Side Curtain Airbag Module Based on Computer Aided Engineering显示文摘Compared with other kinds of airbags,curtain airbag(CAB) has more complex structures and larger coverage area. The product development process depends on many module tests,sled tests and full size vehicle tests. Computer aided engineering(CAE) technology can replace tests to a great extent,also save test costs and product development time. This paper introduces the way of setting up simulation models and application of static deployment tests and free motion headform(FMH) tests to verify simulation models. In the CAB simulation,uniform pressure airbag models and computational fluid dynamics(CFD) models are all used. The uniform pressure airbag models are not able to simulate the pressure difference among different parts inside the cushion during inflating process. CFD-based CAB models are used to help the curtain airbag optimization design. Based on effective CAE simulation,the optimization analyses related to diffuser tube parameters,inflator mass flow rate and cushion folding patterns are discussed and performed in different cases. The optimization result shows that the proposed techniques are helpful to the parametric optimization design of side curtain airbag module in curtain airbag development process. | ZHANG Junyuan LI Dongjun BI Ying YANG Donglin QIU Feng | 2009 | Chinese Journal of Mechanical Engineering2009，22，4： | 6 |
| 15 | Clinicopathological features and surgical outcomes of four rare subtypes of primary liver carcinoma显示文摘Objective:This study aimed to analyze clinicopathological and prognostic features of four rare pathological subtypes of primary liver malignancies to make better understanding of their clinical features.Methods:The clinicopathological data of 114 patients who were diagnosed with histologically proven four subtypes:clear cell carcinoma(CCC),giant cell carcinoma(GCC),sarcomatoid carcinoma(SC),and combined hepatocellular-cholangiocarcinoma(CHC)between October 1998 and August 2015 were reviewed.Their survival data were compared with those of 908 patients with histologically proven common hepatocellular carcinoma(HCC)(early-and advanced-stage HCC)during the same period.Results:The outcome of the CCC group was better than that of the other three subgroups,and was similar to that of the early-stage HCC group.Also,the smallest tumor size and the highest incidence of pseudocapsule formation were observed in the CCC group.The SC group had the worst outcome among these four subgroups;the prognosis was much poorer than that of any other subgroups,even poorer than that of the advanced-stage common HCC group.No statistical difference was observed between the GCC,CHC and advanced-stage HCC groups on survival analysis.The incidences of tumor vascular emboli,TNM staging and non-radical resection were three risk factors of the prognosis.Conclusions:CCC is a low-degree malignancy and relatively favorably prognostic subtype of HCC.However,GCC,SC,and CHC are three rare high-degree malignancy subtypes of HCC with poor prognosis. | Zhiyu Li Xiaolong Wu Xinyu Bi Yefan Zhang Zhen Huang Haizhen Lu Hong Zhao Jianjun Zhao Jianguo Zhou Muxing Li Jianming Ying Jianqiang Cai | 2018 | Chinese Journal of Cancer Research2018，30，3： | 6 |
| 16 | Combination of ranibizumab with photodynamic therapy vs ranibizumab monotherapy in the treatment of age-related macular degeneration: a systematic review and meta-analysis of randomized controlled trials显示文摘AIM:To compare the efficacy and safety of combination of ranibizumab with photodynamic therapy(PDT)vs ranibizumab monotherapy in the treatment of age-related macular degeneration(AMD).METHODS:The Cochrane Central Register of Controlled Trials(CENTRAL)in the Cochrane Library,Pubmed,and Embase were searched.There were no language or data restrictions in the search for trials.Only randomized controlled trials(RCTs)were included.Methodological quality of the literatures was evaluated according to the Jadad Score.RevMan 5.2.6 software was used to do the meta-analysis.RESULTS:Seven studies were included in our systematic review,among which four of them were included in quantitative analysis.The result shows that the ranibizumab monotherapy group had a better mean best corrected visual acuity(BCVA)change vs baseline at month 12 compared with that of the combination treatment group,and the statistical difference was significant(WMD,-2.61;95%CI,-5.08 to-0.13;P=0.04).However,after the removal of one study,the difference between the two groups showed no significant difference(WMD,-2.29;95%CI,-4.81 to 0.23;P=0.07).Meanwhile,no significant central retinal thickness(CRT)reduction was found in the combination treatment group and the ranibizumab monotherapy group at 12 months follow-up.Nevertheless,the combination group tended to have a greater reduction in CRT(WMD,-4.13μm;95%CI,-25.88to 17.63,P=0.71).The proportion of patients gaining more than 3 lines at month 12 in the ranibizumab group was higher than in the combination group and there was a significant difference(RR,0.72;95%CI,0.54 to 0.95;P=0.02).Whereas there was no significant difference for the proportion of patients gaining more than 0 line at month12 between the two groups(RR,0.93;95%CI,0.76 to1.15;P=0.52).The general tendency shows a reduction in ranibizumab retreatment number in the combination treatment group compared with the ranibizumab monotherapy group.As major adverse events,the differences in the number of eye pain,endophthalmitis,hypertension and arterial thromboembolic events were not significant between the two groups,and the incidence of serious adverse events in the two groups was very low.CONCLUSION:For the maintenance of vision,the comparison of the combination of ranibizumab with PDT vs ranibizumab monotherapy shows no apparent difference.Compared with the combination of ranibizumab and PDT,patients treated with ranibizumab monothearpy may gain more visual acuity(VA)improvement.The combination treatment group had a tendency to reduce the number of ranibizumab retreatment.Both the two treatment strategies were well tolerated. | Jun-Kang Si Kai Tang Hong-Sheng Bi Da-Dong Guo Jun-Guo Guo Yu-Xiang Du Yan Cui Xue-Mei Pan Ying Wen Xing-Rong Wang | 2014 | International Journal of Ophthalmology(English edition)2014，7，3： | 5 |
| 17 | Gust load alleviation wind tunnel tests of a large-aspect-ratio flexible wing with piezoelectric control显示文摘An active control technique utilizing piezoelectric actuators to alleviate gust-response loads of a large-aspect-ratio flexible wing is investigated. Piezoelectric materials have been extensively used for active vibration control of engineering structures. In this paper, piezoelectric materials further attempt to suppress the vibration of the aeroelastic wing caused by gust. The motion equation of the flexible wing with piezoelectric patches is obtained by Hamilton's principle with the modal approach, and then numerical gust responses are analyzed, based on which a gust load alleviation(GLA) control system is proposed. The gust load alleviation system employs classic propor tional-integral-derivative(PID) controllers which treat piezoelectric patches as control actuators and acceleration as the feedback signal. By a numerical method, the control mechanism that piezoelectric actuators can be used to alleviate gust-response loads is also analyzed qualitatively. Furthermore, through low-speed wind tunnel tests, the effectiveness of the gust load alleviation active control technology is validated. The test results agree well with the numerical results. Test results show that at a certain frequency range, the control scheme can effectively alleviate the z and x wingtip accelerations and the root bending moment of the wing to a certain extent. The control system gives satisfying gust load alleviation efficacy with the reduction rate being generally over 20%. | Bi Ying Xie Changchuan An Chao Yang Chao | 2017 | Chinese Journal of Aeronautics2017，30，1： | 5 |
| 18 | Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis显示文摘Immunomodulatory signaling imposes tight regulations on metabolic programs within immune cells and consequentially determines immune response outcomes.Although the glucocorticoid receptor(GR)has been recently implicated in regulating the function of myeloid-derived suppressor cells(MDSCs),whether the dysregulation of GR in MDSCs is involved in immune-mediated hepatic diseases and how GR regulates the function of MDSCs in such a context remains unknown.Here,we revealed the dysregulation of GR expression in MDSCs during innate immunological hepatic injury(IMH)and found that GR regulates the function of MDSCs through modulating HIF1α-dependent glycolysis.Pharmacological modulation of GR by its agonist(dexamethasone,Dex)protects IMH mice against inflammatory injury.Mechanistically,GR signaling suppresses HIF1αand HIF1α-dependent glycolysis in MDSCs and thus promotes the immune suppressive activity of MDSCs.Our studies reveal a role of GR-HIF1αin regulating the metabolism and function of MDSCs and further implicate MDSC GR signaling as a potential therapeutic target in hepatic diseases that are driven by innate immune cell-mediated systemic inflammation. | Yun Lu Huanrong Liu Yujing Bi Hui Yang Yan Li Jian Wang Zhengguo Zhang Yu Wang Chunxiao Li Anna Jia Linian Han Ying Hu Yong Zhao Ruoning Wang Guangwei Liu | 2018 | Cellular & Molecular Immunology2018，15，6： | 4 |
| 19 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 20 | TanshinoneⅡA improves distribution and anti-tumor efficacy of pegylated liposomal doxorubicin via normalizing the structure and function of tumor vasculature in hepa1-6 hepatoma mice model显示文摘OBJECTIVE: To investigate whether the Tandistribution and anti-tumor Ⅱef A could improve the ficacy of Pegylated Liposomal Doxorubicin(PLD) via normalizing the structure and function of vasculature in Hepa1-6 hepatoma mice model.METHODS: Hepa1-6 hepatoma-bearing mice were treated with TanⅡA for 14 d. Distribution and anti-tumor efficacy of PLD, and the structure and function of the tumor vasculature were evaluated using various techniques.RESULTS: TanⅡ A significantly reduced the micro-vessel density(MVD). After Tan vascular walls were betteⅡr s A treatment,the tumor tructured, as the increased coverage of the pericytes and the promoted contact of the basement membrane and endothelial cell. Functional tests showed that tumor hypoxia was improved and the exudation amount of Evans blue in the parenchyma of the tumor decreased. In addition, mice treated with TanA had greater PLD penetration distance intratumoⅡrally. Furthermore, combined therapy of Tanibited tumor growth.ⅡA and PLD significantly inhCONCLUSION: This study suggests that Tanasculature andⅡ h A helps normalizing the tumor vas therapeutic potential in increasing the distribution of chemotherapy drug in the tumor. | Zhang Ying Tie MingHui Bi Feng Wang Ke | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 4 |
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