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| 1 | Secondary organic carbon quantification and source apportionment of PM_(10) in Kaifeng, China显示文摘During 2005, the filter samples of ambient PM10 from five sites and the source samples of particulate matter were collected in Kaifeng, Henan Province of China. Nineteen elements, water-soluble ions, total carbon (TC) and organic carbon (OC) contained in samples were analyzed. Seven contributive source types were identified and their contributions to ambient PM10 were estimated by chemical mass balance (CMB) receptor model. Weak associations between the concentrations of organic carbon and element carbon (EC) were observed during the sampling periods, indicating that there was secondary organic aerosol pollution in the urban atmosphere. An indirect method of 'OC/EC minimum ratio' was applied to estimate the concentration of secondary organic carbon (SOC). The results showed that SOC contributed 26.2%, 32.4% and 18.0% of TC in spring, summer-fall and winter, respectively, and the annual average SOC concentration was 7.07 μg/m3, accounting for 5.73% of the total mass in ambient PM10. The carbon species concentrations in ambient PM10 were recalculated by subtracting SOC concentrations from measured concentrations of TC and OC to increase the compatibility of source and receptor measurements for CMB model. | WU Lin FENG Yinchang WU Jianhui ZHU Tan BI Xiaohui HAN Bo YANG Weihong YANG Zhiqiang | 2009 | Journal of Environmental Sciences2009，21，10： | 26 |
| 2 | Source apportionment of ambient PM_(10) in urban areas of Wuxi,China显示文摘A total of 168 PM_(10)samples were collected during the year of 2005 at eight sites in the city of Wuxi in China.Fifteen chemical elements,three water-soluble ions,total carbon and organic carbon were analyzed.Six source categories were identified and their contributions to ambient PM_(10)in Wuxi were estimated using a nested chemical mass balance method that reduces the effects of colinearity on the chemical mass balance model.In addition,the concentrations of secondary aerosols,such as secondary organic carbon,sulfate and nitrate,were quantified.The spatially averaged PM_(10)was high in the spring and winter(123μg·m^(-3)and low in the summer-fall(90μg·m^(-3)).According to the result of source apportionment,resuspended dust was the largest contributor to ambient PM_(10),accounting for more than 50%of the PM_(10)mass.Coal combustion(14.6%)and vehicle exhaust(9.4%)were also significant source categories of ambient PM_(10).Construction and cement dust,sulfates,secondary organic carbon,and nitrates made contributions ranging between 4.1%and 4.9%.Other source categories such as steel manufacturing dust and soil dust made low contributions to ambient PM_(10). | Bo HAN Xiaohui BI Yonghua XUE Jianhui WU Tan ZHU Baogui ZHANG Jianqing DING Yuanxin DU | 2011 | Frontiers of Environmental Science & Engineering2011，5，4： | 5 |
| 3 | Multivariate predictive model for asymptomatic spontaneous bacterial peritonitis in patients with liver cirrhosis显示文摘BACKGROUNDSpontaneous bacterial peritonitis (SBP) is a detrimental infection of the asciticfluid in liver cirrhosis patients, with high mortality and morbidity. Earlydiagnosis and timely antibiotic administration have successfully decreased themortality rate to 20%-25%. However, many patients cannot be diagnosed in theearly stages due to the absence of classical SBP symptoms. Early diagnosis ofasymptomatic SBP remains a great challenge in the clinic.AIMTo establish a multivariate predictive model for early diagnosis of asymptomaticSBP using positive microbial cultures from liver cirrhosis patients with ascites.METHODSA total of 98 asymptomatic SBP patients and 98 ascites liver cirrhosis patients withnegative microbial cultures were included in the case and control groups,respectively. Multiple linear stepwise regression analysis was performed toidentify potential indicators for asymptomatic SBP diagnosis. The diagnosticperformance of the model was estimated using the receiver operatingcharacteristic curve.RESULTSPatients in the case group were more likely to have advanced disease stages,cirrhosis related-complications, worsened hematology and ascites, and higher mortality. Based on multivariate analysis, the predictive model was as follows: y (P) = 0.018 + 0.312 × MELD (model of end-stage liver disease) + 0.263 × PMN(ascites polymorphonuclear) + 0.184 × N (blood neutrophil percentage) + 0.233 ×HCC (hepatocellular carcinoma) + 0.189 × renal dysfunction. The area under thecurve value of the established model was 0.872, revealing its high diagnosticpotential. The diagnostic sensitivity was 73.5% (72/98), the specificity was 86.7%(85/98), and the diagnostic efficacy was 80.1%.CONCLUSIONOur predictive model is based on the MELD score, polymorphonuclear cells,blood N, hepatocellular carcinoma, and renal dysfunction. This model mayimprove the early diagnosis of asymptomatic SBP. | Bo Tu Yue-Ning Zhang Jing-Feng Bi Zhe Xu Peng Zhao Lei Shi Xin Zhang Guang Yang En-Qiang Qin | 2020 | World Journal of Gastroenterology2020，26，29： | 5 |
| 4 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 5 | Total ionizing dose effects and annealing behaviors of HfO2-based MOS capacitor显示文摘With the continuously scaling down of semiconductor technology,the traditional SiO_2as gate dielectric is approaching the physical and electrical limits.Some problems,such as the increasing leakage current and reliability issues,seriously affect the transistor performance[1].HfO_2 has been considered to be one of the reasonable alternative solutions due to a suitable dielectric constant(about 25),the relatively large band gap(5.68 e V) | Yannan XU Jinshun BI Gaobo XU Kai XI Bo LI Ming LIU | 2017 | Science China(Information Sciences)2017，60，12： | 4 |
| 6 | Characteristics of soil organic carbon and total nitrogen under various grassland types along a transect in a mountain-basin system in Xinjiang, China显示文摘Soil organic carbon(SOC) and soil total nitrogen(STN) in arid regions are important components of global C and the N cycles, and their response to climate change will have important implications for both ecosystem processes and global climate feedbacks. Grassland ecosystems of Funyun County in the southern foot of the Altay Mountains are characterized by complex topography, suggesting large variability in the spatial distribution of SOC and STN. However, there has been little investigation of SOC and STN on grasslands in arid regions with a mountain-basin structure. Therefore, we investigated the characteristics of SOC and STN in different grassland types in a mountain-basin system at the southern foot of the Altai Mountains, north of the Junggar Basin in China, and explored their potential influencing factors and relationships with meteorological factors and soil properties. We found that the concentrations and storages of SOC and STN varied significantly with grassland type, and showed a decreasing trend along a decreasing elevation gradient in alpine meadow, mountain meadow, temperate typical steppe, temperate steppe desert, and temperate steppe desert. In addition, the SOC and STN concentrations decreased with depth, except in the temperate desert steppe. According to Pearson's correlation values and redundancy analysis, the mean annual precipitation, soil moisture content and soil available N concentration were significantly positively correlated with the SOC and STN concentrations. In contrast, the mean annual temperature, p H, and soil bulk density were significantly and negatively correlated with the SOC and STN concentrations. The mean annual precipitation and mean annual temperature were the primary factors related to the SOC and STN concentrations. The distributions of the SOC and STN concentrations were highly regulated by the elevation-induced differences in meteorological factors. Mean annual precipitation and mean annual temperature together explained 97.85% and 98.38% of the overall variations in the SOC and STN concentrations, respectively, at soil depth of 0–40 cm, with precipitation making the greatest contribution. Our results provide a basis for estimating and predicting SOC and STN concentrations in grasslands in arid regions with a mountain-basin structure. | BI Xu LI Bo NAN Bo FAN Yao FU Qi ZHANG Xinshi | 2018 | Journal of Arid Land2018，10，4： | 4 |
| 7 | LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells显示文摘LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and metabolism.Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs,and few have addressed LIN28's role within the nucleus.Here,we show that LIN28 displays dynamic temporal and spatial expression during murine embryo development.Maternal LIN28 expression drops upon exit from the 2-cell stage,and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blas-tocyst stage development,to become dominantly expressed in the cytosol after implantation.In cultured pluripotent stem cells(PSCs),loss of LIN28 led to nucleolar stress and activation of a 2-cell/4-cell-like transcriptional program characterized by the expression of endogenous retrovirus genes.Mechanistically,LIN28 binds to small nucleolar RNAs and rRNA to maintain nucleolar integrity,and its loss leads to nucleolar phase separation defects,ribosomal stress and activation of P53 which in turn binds to and activates 2C transcription factor Dux.LIN28 also resides in a complex containing the nucleolar factor Nucleolin(NCL)and the transcrip-tional repressor TRIM28,and LIN28 loss leads to reduced occupancy of the NCL/TRIM28 complex on the Dux and rDNA loci,and thus de-repressed Dux and reduced rRNA expression.Lin28 knockout cells with nucleolar stress are more likely to assume a slowly cycling,translationally inert and anabolically inactive state,which is a part of previously unappreciated 2C-like transcriptional program.These findings elucidate novel roles for nucleolar LIN28 in PSCs,and a new mechanism linking 2C program and nucleolar functions in PSCs and early embryo development. | Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang Anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei Wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao Wu Jianlong Wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang | 2022 | Protein & Cell2022，13，7： | 4 |
| 8 | Flotillin-2 is an acrosome-related protein involved in mouse spermiogenesis显示文摘Spermatogenesis is a complex process of terminal differentiation by which mature sperms are generated,and it can be divided into three phases:mitosis,meiosis and spermiogenesis.In a previous study,we established a series of proteomic profiles for spermatogenesis to understand the regulation of male fertility and infertility.Here,we further investigated the localization and the role of flotillin-2 in spermiogenesis.Flotillin-2 expression was investigated in the testis of male CD1 mice at various developmental stages of spermatogenesis by using Western blotting,immunohistochemistry and immunofluorescence.Flotillin-2 was knocked down in vivo in three-week-old male mice using intratesticular injection of small inhibitory RNA(siRNA),and sperm abnormalities were assessed three weeks later.Flotillin-2 was expressed at high levels in male germ cells during spermatogenesis.Flotillin-2 immunoreactivity was observed in pachytene spermatocytes as a strong dot-shaped signal and in round spermatids as a sickle-shaped distribution ahead of the acrosome.Immunofluorescence confirmed flotillin-2 was localized in front of the acrosome in round spermatids,indicating that flotillin-2 was localized to the Golgi apparatus.Knockdown of flotillin-2 in vivo led to a significant increase in head sperm abnormalities isolated from the cauda epididymis,compared with control siRNA-injected testes.This study indicates that flotillin-2 is a novel Golgi-related protein involved in sperm acrosome biogenesis. | Yibo Wu Xin Chen Shuai Wang Min Jiang Bo Zheng Quan Zhou Ye Bi Zuomin Zhou Xiaoyan Huang Jiahao Sha | 2012 | The Journal of Biomedical Research2012，26，4： | 3 |
| 9 | Long-Time Behaviour of the Solutions for the Multidimensional Kolmogorov-Spieqel-Sivashinsky Equation | Bo Ling GUO Bi Xiang WANG Institute of Applied Physics and Computational Mathematics, P. O. Box 8009. Beijing 100088. P. R. China | 2002 | Acta Mathematica Sinica,English Series2002，18，3： | 3 |
| 10 | Industrial production of unconventional gas in coal-measure of Well HJD1 in Jixi Basin,Eastern Heilongjiang Province,China显示文摘1.Objective The coalbed methane(CBM)exploration in the Jixi Basin began with the gas control in the coal mine(Fig.1).The object is mostly the main minable coal seams shallower than 1000 m.The coalbed methane and unconventional gas in coal-measure deeper than 1000 m are rarely concerned(Bi CQ et al.,2018).The coal measure“three gas”referred to as coalbed methane,coal-measure shale gas,and tight sandstone gas is the main part of the unconventional gas in coal-measure.Since 2015,China Geological Survey(CGS)has carried out a systematic geological survey and evaluation of unconventional gas in coal measure of the Chengzihe Formation of Lower Cretaceous in this area.The favorable areas and target areas have been optimized.This study is to obtain the coal-measure reservoir parameters and gas-bearing parameters of mid-deep layers of the Chengzihe Formation(1000-1500 m),to ascertain the development of gas-bearing layers.It is also to search for new methods and technologies,such as the production layer optimization methods,the reservoir reconstruction process,and the joint production of coal measure“three-gas”of the thin interbedded coal-measure composite reservoir,to obtain high industrial production,and to evaluate the technical recoverability of unconventional gas in coal-measure. | Cai-qin Bi Jia-qiang Zhang Zhi-fang Hu Shi Xie Yang Zhou Bo Pang Yan-sheng Shan Huan-peng Chi Yue Tang Yuan Yuan | 2022 | China Geology2022，5，3： | 3 |
| 11 | Detailed resume of RNA m^(6)A demethylases显示文摘N6-Methyladenosine(m^(6)A) is the most abundant internal modification in eukaryotic mRNA,playing critical role in various bioprocesses. Like other epigenetic modifications, m^(6)A modification can be catalyzed by the methyltransferase complex and erased dynamically to maintain cells homeostasis. Up to now, only two m^(6)A demethylases have been reported, fat mass and obesity-associated protein(FTO)and alkylation protein AlkB homolog 5(ALKBH5), involving in a wide range of mRNA biological progress, including mRNA shearing, export, metabolism and stability. Furthermore, they participate in many significantly biological signaling pathway, and contribute to the progress and development of cancer along with other diseases. In this review, we focus on the studies about structure, inhibitors development and biological function of FTO and ALKBH5. | Dandan Shen Bo Wang Ya Gao Lijuan Zhao Yaping Bi Jinge Zhang Ning Wang Huiqin Kang Jingru Pang Ying Liu Luping Pang Zhe-Sheng Chen Yi-Chao Zheng Hong-Min Liu | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 3 |
| 12 | Synthesis of poly[methyl(3,3,3-trifluoropropyl)siloxane]-b-poly(ethylene oxide) block copolymers显示文摘一系列新 amphiphilic poly [甲基(3,3,3-trifluoropropyl ) siloxane ]-b-poly(ethylene 氧化物)(PMTFPS-b-PEO ) 把钓饵轻轻放进水里有到吸水的片断的恐水病的片断的不同比率的锁共聚物被联合结束功能的 PMTFPS 和 PEO 人聚合物的反应准备。共聚物被显示由象胶化浸透层析(GPC ) 和 1 H-nudear 磁性的回声(1 H-NMR ) 。 | Xiao-li ZHAN Bi CHEN Qing-hua ZHANG Ling-min YI Bo JIANG Feng-qiu CHEN | 2008 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2008，9，9： | 3 |
| 13 | Progress and prospects of horizontal well fracturing technology for shale oil and gas reservoirs显示文摘By systematically summarizing horizontal well fracturing technology abroad for shale oil and gas reservoirs since the “13th Five-Year Plan”, this article elaborates new horizontal well fracturing features in 3D development of stacked shale reservoirs, small well spacing and dense well pattern, horizontal well re-fracturing, fracturing parameters optimization and cost control. In light of requirements on horizontal well fracturing technology in China, we have summarized the technological progress in simulation of multi-fracture propagation, horizontal well frac-design, electric-drive fracturing equipment, soluble tools and low-cost downhole materials and factory-like operation. On this basis, combined with the demand analysis of horizontal well fracturing technology in the “14th Five-Year Plan” for unconventional shale oil and gas, we suggest strengthening the research and development in the following 7 aspects:(1) geology-engineering integration;(2) basic theory and design optimization of fracturing for shale oil and gas reservoirs;(3) development of high-power electric-drive fracturing equipment;(4) fracturing tool and supporting equipment for long horizontal section;(5) horizontal well flexible-sidetracking drilling technology for tapping remaining oil;(6) post-frac workover technology for long horizontal well;(7) intelligent fracturing technology. | LEI Qun XU Yun CAI Bo GUAN Baoshan WANG Xin BI Guoqiang LI Hui LI Shuai DING Bin FU Haifeng TONG Zheng LI Tao ZHANG Haoyu | 2022 | Petroleum Exploration and Development2022，49，1： | 3 |
| 14 | High starter phosphorus fertilization facilitates soil phosphorus turnover by promoting microbial functional interaction in an arable soil显示文摘Microbial phosphorus(P)turnover is critical in C utilization efficiency in agroecosystems.It is therefore necessary to understand the P mobilization processes occurring during P fertilization in order to ensure both crop yield and environmental quality.Here,we established a controlled pot experiment containing soil amended with three different levels of starter P fertilizer and collected soil samples after 30,60,and 90 days of incubation.Quantitative microbial element cycling(QMEC)smart chip technology and 16S rRNA gene sequencing were used to investigate functional gene structures involved in carbon,nitrogen and P cycling and the bacterial community composition of the collected samples.Although P fertilization did not significantly affect the structure of the soil microbial community,some rare microbiota were changed in particular phosphorus-solubilizing bacteria were enriched at the high P fertilization level,suggesting that the rare taxa make an important contribution to P turnover.P fertilization also altered the functional gene structure,and high P concentrations enhanced the functional gene diversity and abundance.Partial redundancy analysis further revealed that changes in rare taxa and functional genes of soil microorganisms drive the alteration of soil P pools.These findings extend our understanding of the microbial mechanisms of P turnover. | Hongzhe Li Qingfang Bi Kai Yang Simon bo Lasson Bangxiao Zheng Li Cui Yongguan Zhu Kai Ding | 2020 | Journal of Environmental Sciences2020，32，8： | 3 |
| 15 | Inflammatory stress induces lipid accumulation in multi-organs of db/db mice显示文摘Dyslipidemia 和长期的发炎在糖尿病的前进起关键作用。这研究试图在糖尿病在多器官在类脂化合物累积上调查煽动性的应力的效果。Eight-week-old 男 db/db 老鼠随机与轮流出现的白天被分到煽动的组有提取的水的每日的注射的 10% 酷蛋白或控制组的下的注射。煽动性的 cytokines 的类脂化合物侧面和血浆层次用临床的生物化学的试金和连接酶的 immunosorbent 试金被决定。在目标机关的类脂化合物累积上的发炎的效果被 hematoxylineosin 染色,染色的油红 O,染色的 Filipin,和量的细胞内部的胆固醇试金评估。低密度的脂蛋白受体(LDLr ) 的蛋白质表情,甾醇规章的元素绑定 protein-2 (SREBP-2 ) ,和在纸巾的 SREBP-cleavage-activating 蛋白质(SCAP ) 被 immunohistochemical 染色并且西方的弄污估计。结果证明煽动性的 cytokines 的浆液层次显著地在注射酷蛋白的老鼠被提高,建议一个煽动的糖尿病的模型被建立。而且,在主动脉,肝,肾,和肠的煽动性的 cytokines 的蛋白质表达式显著地与控制相比在煽动的组被增加。而在煽动的鼠标的类脂化合物一半的浆液层次不与控制相比是不同的,煽动性的应力显著地在主动脉,肝,肾,和肠增加了类脂化合物累积,它在煽动的鼠标的这些机关与 LDLr, SREBP-2,和 SCAP 的增加的蛋白质表达式与一致。在结论,发炎从发行量在 db/db 老鼠的多器官导致类脂化合物累积到外部纸巾,潜在地,由于类脂化合物,再分配由 LDLr 反馈的混乱调停了规定。 | Kun Ling Ma Yang Zhang Jing Liu Yu Wu Ze Bo Hu Liang Liu Bi Cheng Liu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，10： | 3 |
| 16 | Syntheses and Liquid Crystal Properties of New Rare Earth Sandwich Type Heteropoly Compounds显示文摘 | BI Li hua \{**\}, LIU Jing hua *** , WANG En bo **** , HUANG Ru dan YU Yong zhang and WU Ping song (Department of Chemistry, Northeast Normal University, Changchun 130024, P.R. China) (Received March 29, 1999) | 1999 | Chemical Research in Chinese Universities1999，15，4： | 2 |
| 17 | Total ionizing dose effects on graphene-based charge-trapping memory显示文摘This study investigates the total ionizing dose effects in graphene-based charge-trapping memory(GCTM) capacitors by using60 Co γ-irradiation. Electrical properties including C-V hysteresis window,gate leakage current, and flat band voltage shifts are evaluated with ionizing dose levels up to 1 Mrad(Si).The C-V hysteresis memory window is hardly affected by the irradiation. The gate leakage current increases with the increase of ionizing dose due to the multiple-trap assisted tunneling mechanism. Significant electrical degrade of the devices in programmed and erased states has been observed with the increase of the dose levels. Mechanisms behind the degradation are attributed to the photo-emission in the graphene nanodisc charge-trapping sets, radiation-induced holes trapping in the peripheral oxides, and the recombination of the stored electrons with the radiation-induced holes. | Kai XI Jinshun BI Sandip MAJUMDAR Bo LI Jing LIU Yannan XU Ming LIU | 2019 | Science China(Information Sciences)2019，62，12： | 2 |
| 18 | Nano-polycrystalline diamond formation under ultra-high pressure显示文摘 | Chao Xu Duanwei He Haikuo Wang Junwei Guan Chunmei Liu Fang Peng Wendan Wang Zili Kou Kai He Xiaozhi Yan Yan Bi Lei Liu Fengjiao Li Bo Hui | 2013 | International Journal of Refractory Metals and Hard Materials2013，，： | 2 |
| 19 | Electrochemical study on adsorption behavior of surfactants at β-2CaO·SiO2/NaAlO2 interface显示文摘-2CaO? 木慃 ?? 匠佩 ? 慎汁 ? ? 迥蒚???? 隌觥蒚郥? 蒙 ? ?? 蒚铧钰賥? 髧 ????? 泔?? | Hai-yan YU Bo WANG Xiao-lin PAN Ting-ting DING Shi-wen BI | 2013 | Transactions of Nonferrous Metals Society of China2013，23，8： | 2 |
| 20 | KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling显示文摘IL-6 plays important and pleiotropic roles in infection and inflammatory diseases,and its production needs to be tightly regulated.However,the epigenetic mechanism underlying Il6 gene transcription remains to be fully elucidated.Here,we report that lysine-specific demethylase 2b(KDM2B),which demethylates H3K4me3 and H3K36me2,is required in macrophages and dendritic cells for the induction of IL-6 but not TNF-α,IL-1,and IFN-β.Compared to wild-type mice,KDM2B-deficient mice were more resistant to endotoxin shock and colitis,with a less severe inflammatory pathogenesis phenotype and decreased IL-6 production in sera.KDM2B selectively bound the Il6 promoter but did not alter histone demethylation;instead,KDM2B interacted with Brahma-related gene 1(Brg1),the core ATPase subunit of SWI/SNF chromatin remodeling complexes,to facilitate chromatin accessibility of the Il6 promoter.Furthermore,KDM2B directly recruited RNA Polymerase II to further initiate and promote Il6 transcription.Thus,our finding identifies a novel nonclassical function of KDM2B in gene-specific transcription initiation and enhancement of Il6 independent of its demethylase activity and adds new insight into the specific epigenetic modification mechanism of inflammatory immune responses. | Qingqing Zhou Yunkai Zhang Bo Wang Wenhui Zhou Yong Bi Wanwan Huai Xi Chen Yihan Chen Zhongmin Liu Xingguang Liu Zhenzhen Zhan | 2020 | Cellular & Molecular Immunology2020，17，8： | 2 |
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