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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Transmission Dynamics of an Outbreak of the COVID-19 Delta Variant B.1.617.2——Guangdong Province,China,May-June 2021显示文摘On May 21,2021,a local case of coronavirus disease 2019(COVID-19)was confirmed in a 75-year-old woman(experienced onset of symptoms on May 18)in Liwan District,Guangzhou City,Guangdong Province,China.The number of infections has increased in the following 10 days and led to 5 generations of transmission. | Meng Zhang Jianpeng Xiao Aiping Deng Yingtao Zhang Yali Zhuang Ting Hu Jiansen Li Hongwei Tu Bosheng Li Yan Zhou Jun Yuan Lei Luo Zimian Liang Youzhi Huang Guoqiang Ye Mingwei Cai Gongli Li Bo Yang Bin Xu Ximing Huang Yazun Cui Dongsheng Ren Yanping Zhang Min Kang Yan Li | 2021 | China CDC weekly2021，3，27： | 51 |
| 3 | Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF) is a chronic progressive fibrotic interstitial pneumonia with unknown causes. The incidence rate increases year by year and the prognosis is poor without cure.Recently, phosphatidylinositol 3-kinase(PI3 K)/protein kinase B(PKB/AKT) signaling pathway can be considered as a master regulator for IPF. The contribution of the PI3 K/AKT in fibrotic processes is increasingly prominent, with PI3 K/AKT inhibitors currently under clinical evaluation in IPF. Therefore,PI3 K/AKT represents a critical signaling node during fibrogenesis with potential implications for the development of novel anti-fibrotic strategies. This review epitomizes the progress that is being made in understanding the complex interpretation of the cause of IPF, and demonstrates that PI3 K/AKT can directly participate to the greatest extent in the formation of IPF or cooperate with other pathways to promote the development of fibrosis. We further summarize promising PI3 K/AKT inhibitors with IPF treatment benefits, including inhibitors in clinical trials and pre-clinical studies and natural products, and discuss how these inhibitors mitigate fibrotic progression to explore possible potential agents, which will help to develop effective treatment strategies for IPF in the near future. | Jincheng Wang Kaili Hu Xuanyan Cai Bo Yang Qiaojun He Jiajia Wang Qinjie Weng | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 31 |
| 4 | Expansion and differentiation of human hepatocyte-derived liver progenitor-like cells and their use for the study of hepatotropic pathogens显示文摘The study of pathophysiological mecha nisms in huma n liver disease has bee n constrained by the in ability to expa nd primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. We and others have previously shown that mouse mature hepatocytes can be con verted to liver progenitor-like cells in vitro with defined chemical factors. Here we describe a protocol achieving efficient conversion of human primary hepatocytes into liver progenitor-like cells (HepLPCs) through delivery of developmentally relevant cues, including NAD +-dependent deacetylase SIRT1 signaling. These HepLPCs could be expanded sign ifica ntly duri ng in vitro passage. The expa nded cells can readily be con verted back into metabolically functional hepatocytes in vitro and upon tran splantati on in vivo. Under three-dime nsional culture conditions, differentiated cells gen erated from HepLPCs regai ned the ability to support infect io n or reactivatio n of hepatitis B virus (HBV). Our work dem on strates the utility of the con versi on betwee n hepatocyte and liver proge nitor-like cells for studying HBV biology and an tiviral therapies. These fin dings will facilitate the study of liver diseases and regenerative medicine. | Gong-Bo Fu Wei-Jian Huang Min Zeng Xu Zhou Hong-Ping Wu Chang-Cheng Liu Han Wu Jun Weng Hong-Dan Zhang Yong-Chao Cai Charles Ashton Min Ding Dan Tang Bao-Hua Zhang Yi Gao Wei-Feng Yu Bo Zhai Zhi-Ying He Hong-Yang Wang He-Xin Yan | 2019 | Cell Research2019，29，1： | 18 |
| 5 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 6 | Influence of FasL gene expression on hepatic metastasis of colorectal carcinoma显示文摘BACKGROUND: FasL expression was reported to be asso- ciated with hepatic metastasis of colorectal cancer. The aim of this study was to study FasL gene expression in colorectal carcinoma and its influences on biological behavior and he- patic metastasis of colorectal carcinoma. METHODS: FasL gene expressions were examined with re- verse transcriptase-polymerase chain reaction (RT-PCR) in the primary focus of colorectal carcinoma, adjacent can- cerous mucosae, and metastasized liver focus from colorec- tal cancer. HR-8348 cells of human rectal cancer cell line were transfected with FasL cDNA. Cell growth suppression rate and response to 5-FU and carboplatin were observed and analyzed with the MTT method. RESULTS: FasL gene expression was detected in the prima- ry focus of colorectal cancer ( n = 58), adjacent cancerous mucosae ( n = 58), and metastasized hepatic tumor tissues (n =28). The positive rate of FasL expression was 24% (14/ 58), 8% (5/58), and 100% (58/58) in the primary focus, adjacent cancerous mucosae and metastasized hepatic tumor tissues respectively. FasL expression rate in the me- tastasized hepatic tumor tissues was higher than that in the primary focus (χ2 = 43.49, P<0. 01) and adjacent cance- rous mucosae (χ2=57.66, P<0.01). In a group of patients with hepatic metastasis, the FasL expression rate in primary focus was higher than that in patients without hepatic me- tastasis (χ2=3.96, P <0.05). In vitro study positive expres- sion of FasL was shown in transfected HR-8348 cells. When 5-FU or carboplatin was added, there was a significant difference in growth suppression rate between FasL positive and controlled cancer cells (t=9.02, t = 11.93, P<0.01). Under the same concentration of chemotherapeutic agents, the survival rate of FasL positive HR-8348 cells was higher than that of controlled cells. CONCLUSIONS: FasL positive cancer cells are powerfullyresistant to chemotherapeutic agents. The expression of the FasL gene in colorectal cancer cells is related to immune evasion to escape from being killed by immune cells, show- ing stronger drug-resistance, and it facilitates hepatic me- tastasis. | Shi-Yong Li, Bo Yu, Ping An, Jia-Chen Wei, Fu-Yi Zuo and Hui-Yun Cai Beijing, China Department of General Surgery, Beijing Military Commend General Hospital, Beijing 100700, China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 14 |
| 7 | Clinical efficacy and safety of selective trans-cystic intra-operative cholangiography in primary suture following three-port laparoscopic common bile duct exploration显示文摘 | SUN Dong-lin ZHANG Feng CHEN Xue-min JIANG Hong-yuan YANG Chun SUN Ya-ping YANG Bo YANG Yue CAI Hui-hua WANG Cao-ye WU Xin-quan | 2012 | Chinese Medical Journal2012，，19： | 14 |
| 8 | Outcomes of preoperative chemoradiotherapy followed by surgery in patients with unresectable locally advanced sigmoid colon cancer显示文摘Background: Complete resection of locally advanced sigmoid colon cancer(LASCC) is sometimes difficult. Patients with LASCC have a dismal prognosis and poor quality of life, which has encouraged the evaluation of alternative multimodality treatments. This prospective study aimed to assess the feasibility and efficacy of neoadjuvant chemora?diotherapy(neo CRT) followed by surgery as treatment of selected patients with unresectable LASCC.Methods: We studied the patients with unresectable LASCC who received neo CRT followed by surgery between October 2010 and December 2012. The neoadjuvant regimen consisted of external?beam radiotherapy to 50 Gy and capecitabine?based chemotherapy every 3 weeks. Surgery was scheduled 6–8 weeks after radiotherapy.Results: Twenty?one patients were included in this study. The median follow?up was 42 months(range, 17–57 months). All patients completed neo CRT and surgery. Resection with microscopically negative margins(R0 resection) was achieved in 20 patients(95.2%). Pathologic complete response was observed in 8 patients(38.1%). Multivisceral resection was necessary in only 7 patients(33.3%). Two patients(9.5%) experienced grade 2 postopera?tive complications. No patients died within 30 days after surgery. For 18 patients with pathologic M0(yp M0) disease, the cumulative probability of 3?year local recurrence?free survival, disease?free survival and overall survival was 100.0%, 88.9% and 100.0%, respectively. For all 21 patients, the cumulative probability of 3?year overall survival was 95.2% and bladder function was well preserved.Conclusion: For patients with unresectable LASCC, preoperative chemoradiotherapy and surgery can be performed safely and may result in an increased survival rate. | Bo Qiu Pei-Rong Ding Ling Cai Wei-Wei Xiao Zhi-Fan Zeng Gong Chen Zhen-Hai Lu Li-Ren Li Xiao-Jun Wu Rene-Olivier Mirimanoff Zhi-Zhong Pan Rui-Hua Xu Yuan-Hong Gao | 2016 | Chinese Journal of Cancer2016，35，10： | 14 |
| 9 | Effect of Tempering Temperature on Microstructure and Properties of E690 Offshore Plate Steel显示文摘A new kind of Mn-Mo-Nb-Cu-B bainite steel which satisfied mechanical demands of E690 offshore plate steel was designed. The effect of two processes--thermomechanical control process (TMCP)+tempering (T) and thermomechanical control process (TMCP)+reheating and quenching (RQ)+tempering (T)--on microstructure and mechanical properties were studied by means of scan electron microscope (SEM), transmission electron microscope (TEM) and electron back scatter diffraction (EBSD). The results showed that optimal mechanical properties were available when tempering at 550 ℃ for both processes. The microstructure of the TMCP+T treated sample tempering in the range of 450 to 550 ℃ for 1 h did not change dramatically yet the lath in the TMCP+RQ+T treated sample merged together and transformed into polygonal ferrite. At the same time, the sub-structure of grain bainite transformed from lath to cell-shape to refine grains with tempering temperature mounting. Lots of sub-grain boundaries were located within bainite and adjacent bainite grain boundaries were high angle. | ZHANG Jie, CAI Qing-wu, WU Hui-bin, ZHANG Kun, WU Bo (Research Institute of Metallurgy Engineering, University of Science and Technology Beijing, Beijing 100083, China) | 2012 | Journal of Iron and Steel Research(International)2012，19，3： | 13 |
| 10 | Tree-ring-based May-July mean temperature history for Lüliang Mountains,China,since 1836显示文摘As a consequence of recent global warming and its social impact, regional climate change is attracting an increasing amount of attention from scientists. A May-July temperature proxy extending back to 1836 was developed from tree-ring width of Chinese pine (Pinus tabulaeformis Carr.) found in the middle Lüliang Mountains, northern China. Correlations with climatic data from six nearby meteorological stations range from -0.58 to -0.65, indicating a strong response of tree-ring index to May-July mean temperatures, which were subsequently reconstructed. The reconstruction captures 45% (F=38.474, P<0.001) of the regional variance in the instrumental data over the calibration period 1955-2003. Reconstructed warm and cold periods were verified by additional temperature reconstructions based on tree-ring data from northern China. In addition, the reconstruction was significantly corre-lated with May-July mean temperatures from 13 other meteorological stations in northern China, suggesting that our reconstruction is also representative of north-central China. The warming trend during the second half of the 20th century is seen in the reconstruction, but only the 1994-2002 mean temperature seems unprecedented over the whole reconstructed period. | CAI QiuFang LIU Yu BAO Guang LEI Ying SUN Bo | 2010 | Chinese Science Bulletin2010，55，26： | 12 |
| 11 | Insights into the molecular mechanisms of Polygonum muitiflorum Thunb-induced liver injury: a computational systems toxicology approach显示文摘导致植物的肝损害(HILI ) 的越来越多的案例被报导了,提出新临床的挑战。在这研究,作为一个例子拿蓼 multiflorum Thunb (PmT ) ,我们建议了一条计算系统毒物学途径探索 HILI 的分子的机制。首先, PmT 的化学部件象与自然产品有关的文学一样从 3 个主要 TCM 数据库被提取。然后,已知的目标通过数据集成被收集,并且潜在的复合目标的相互作用(CTI ) 用我们的 substructure-drug-target 被预言基于网络的推理(SDTNBI ) 方法。在由估计 HILI 的症状为 hepatotoxicity 相关的基因屏蔽以后,一个复合目标的相互作用网络被构造。得分功能,也就是 Ascore,被开发在肝估计化学药品的毒性。我们进行了网络分析用分析工具决定 biphasic 效果的可能的机制,包括宾果游戏,小径丰富,机关分发分析和和 CYP450 酶的相互作用的预言。在 PmT 的化学部件之中,有好肠的吸收的 54 个部件被用于分析,并且 2939 CTI 被获得。在在 BioGPS 数据库分析 mRNA 表达式数据以后,与肝疾病有关的 1599 CTI 和 125 个目标被识别。在 15 加重的顶,七与 Ascore 价值 >(emodin,橡黄素, apigenin, resveratrol,法国的酸, kaempferol 和 luteolin ) 3000 显然与 hepatotoxicity 被联系。从小径丰富分析的结果建议在 apoptosis 和新陈代谢之间的多重相互作用可以位于导致 PmT 的肝损害下面。许多在特定的混合物小径被验证了,例如谷胱甘肽新陈代谢,细胞色素 P450 新陈代谢,和 p53 小径,在其它之中。肝炎症状,九胆汁酸的不安和黄或黄褐色的尿也有相应小径,认为我们的方法正当。在结论,这个计算系统毒物学方法揭示可能的有毒的部件并且能对理解 HILI 的机制很有用。这样,方法可能也便于新奇肝毒素的植物的鉴定。 | Yin-yin WANG Jie LI Zeng-rui WU Bo ZHANG Hong-bin YANG Qin WANG Ying-chun CAI Gui-xia LIU Wei-hua LI Yun TANG | 2017 | Acta Pharmacologica Sinica2017，38，5： | 12 |
| 12 | Influence of lactic acid on the two-phase anaerobic digestion of kitchen wastes显示文摘在 methanogenesis 上评估乳的酸的影响,厨房浪费的 anaerobicdigestion 第一在一个二阶段的厌氧的消化过程被进行,用乳的酸和葡萄糖喂的二 digesters 的 andperformance 是随后乳的酸是水解作用使发酸阶段 inthe 的主要发酵产品的 compared.The resultsshowed 为厨房 wastes.The 的二阶段的厌氧的消化过程乳的酸 concentrationconstituted 约50%化学的氧 | ZHANG Bo CAI Wei-min HE Pin-jing | 2007 | Journal of Environmental Sciences2007，19，2： | 11 |
| 13 | Double-balloon enteroscopy for mesenchymal tumors of small bowel:Nine years' experience显示文摘AIM:To assess the value of double-balloon enteroscopy(DBE) for the diagnosis of gastrointestinal mesenchymal tumors(GIMTs) in the small bowel and clarify their clinical and endoscopic characteristics.METHODS:A retrospective review in a total of 783 patients who underwent a DBE procedure from January 2003 to December 2011 was conducted.Data from patients with pathologically confirmed GIMTs were analyzed at a single tertiary center with nine years' experience.The primary outcomes assessed included characteristics of patients with GIMTs,indications for DBE,overall diagnostic yield of GIMTs,endoscopic morphology,positive biopsy,comparison of diagnosis with capsule endoscopy,and subsequent interventional management.RESULTS:GIMTs were identified and analyzed in 77 patients.The mean age was 47.74 ± 14.14 years(range:20-77 years),with 63.6% being males.The majority of individuals presented with gastrointestinal bleeding,accounting for 81.8%,followed by abdominal pain,accounting for 10.4%.Small bowel pathologies were found in 71 patients,the detection rate was 92.2%.The diagnostic yield of DBE for GIMTs was 88.3%.DBE was superior to capsule endoscopy in the diagnosis of GIMTs(P = 0.006;McNemar's χ2 test).Gastrointestinal stromal tumor was the most frequent and leiomyoma was the second frequent GIMT.Single and focal lesions were typical of GIMTs,and masses with smooth or unsmooth surface were the most common in the small bowel.GIMTs were removed from all the patients surgically except one patient treated with endoscopic resection.CONCLUSION:DBE is a safe and valuable procedure for patients with suspected GIMTs,and it provides an accurate position for subsequent surgical intervention. | Qiong He Yang Bai Fa-Chao Zhi Wei Gong Hong-Xiang Gu Zhi-Min Xu Jian-Qun Cai De-Shou Pan Bo Jiang | 2013 | World Journal of Gastroenterology2013，19，11： | 11 |
| 14 | Improved Brassica rapa reference genome by single-molecule sequencing and chromosome conformation capture technologies显示文摘Brassica rapa comprises several important cultivated vegetables and oil crops.Current reference genome assemblies of Brassica rapa are quite fragmented and not highly contiguous,thereby limiting extensive genetic and genomic analyses.Here,we report an improved assembly of the B.rapa genome(v3.0)using single-molecule sequencing,optical mapping,and chromosome conformation capture technologies(Hi-C).Relative to the previous reference genomes,our assembly features a contig N50 size of 1.45 Mb,representing a~30-fold improvement.We also identified a new event that occurred in the B.rapa genome~1.2 million years ago,when a long terminal repeat retrotransposon(LTR-RT)expanded.Further analysis refined the relationship of genome blocks and accurately located the centromeres in the B.rapa genome.The B.rapa genome v3.0 will serve as an important community resource for future genetic and genomic studies in B.rapa.This resource will facilitate breeding efforts in B.rapa,as well as comparative genomic analysis with other Brassica species. | Lei Zhang Xu Cai Jian Wu Min Liu Stefan Grob Feng Cheng Jianli Liang Chengcheng Cai Zhiyuan Liu Bo Liu Fan Wang Song Li Fuyan Liu Xuming Li Lin Cheng Wencai Yang Mai-he Li Ueli Grossniklaus Hongkun Zheng Xiaowu Wang | 2018 | Horticulture Research2018，5，1： | 10 |
| 15 | 2019冠状病毒病(COVID-19)概览显示文摘2019年12月中国湖北省武汉市爆发由严重急性呼吸综合征冠状病毒2(severeacuterespiratory syndrome coronavirus 2,SARS-CoV-2)感染引起的新型冠状病毒肺炎。2020年2月11日,世界卫生组织(World Health Organization,WHO)将该疾病正式命名为COVID-19(coronavirus disease2019)。COVID-19临床表现多样,典型表现为发热、干咳和乏力,常出现肺部受累。SARS-Co V-2传染性较强,人群普遍易感。野生动物宿主和患者为SARS-Co V-2主要传染源,呼吸道飞沫传播和接触传播为主要传播途径。自发现该病流行以来,中国政府和科学界迅速明确了此次疫情病原体,并及时向全世界公开病毒基因序列,同时采取一系列措施控制疫情。全球科研工作者从新型冠状病毒肺炎的病原生物学和发病机制、流行病学、临床特征、诊断治疗和药物疫苗研发等各方面入手,开展了一系列研究工作。本文通过综述最新研究成果、专家共识,以及中国抗疫经验,以期加强对该新发传染病的认识,为防控治疗提供参考。 | Yu SHI Gang WANG Xiao-peng CAI Jing-wen DENG Lin ZHENG Hai-hong ZHU Min ZHENG Bo YANG Zhi CHEN | 2020 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2020，21，5： | 10 |
| 16 | Preoperative albumin levels predict prolonged postoperative ileus in gastrointestinal surgery显示文摘BACKGROUND Prolonged postoperative ileus(PPOI) is a prolonged state of 'pathological'gastrointestinal(GI) tract dysmotility. There are relatively few studies examining the influence of preoperative nutritional status on the development of PPOI in patients who underwent GI surgery. The association between preoperative albumin and PPOI has not been fully studied. We hypothesized that preoperative albumin may be an independent indicator of PPOI.AIM To analyze the role of preoperative albumin in predicting PPOI and to establish a nomogram for clinical risk evaluation.METHODS Patients were drawn from a prospective hospital registry database of GI surgery.A total of 311 patients diagnosed with gastric or colorectal cancer between June 2016 and March 2017 were included. Potential predictors of PPOI were analyzed by univariate and multivariable logistic regression analyses, and a nomogram for quantifying the presence of PPOI was developed and internally validated.RESULTS The overall PPOI rate was 21.54%. Advanced tumor stage and postoperative opioid analgesic administration were associated with PPOI. Preoperative albumin was an independent predictor of PPOI, and an optimal cutoff value of 39.15 was statistically calculated. After adjusting multiple variables, per unit or per SD increase in albumin resulted in a significant decrease in the incidence of PPOI of 8%(OR = 0.92, 95%CI: 0.85-1.00, P = 0.046) or 27%(OR = 0.73, 95%CI:0.54-0.99, P = 0.046), respectively. Patients with a high level of preoperative albumin(≥ 39.15) tended to experience PPOI compared to those with low levels(< 39.15)(OR = 0.43, 95%CI: 0.24-0.78, P = 0.006). A nomogram for predicting PPOI was developed [area under the curve(AUC) = 0.741] and internally validated by bootstrap resampling(AUC = 0.725, 95%CI: 0.663-0.799).CONCLUSION Preoperative albumin is an independent predictive factor of PPOI in patients who underwent GI surgery. The nomogram provided a model to screen for early indications in the clinical setting. | Wen-Quan Liang Ke-Cheng Zhang Hua Li Jian-Xin Cui Hong-Qing Xi Ji-Yang Li Ai-Zhen Cai Yu-Hua Liu Wang Zhang Lan Zhang Bo Wei Lin Chen | 2020 | World Journal of Gastroenterology2020，26，11： | 10 |
| 17 | Distribution feature of terrestrial heat flow densities in the Bohai Basin,East China显示文摘Temperature logging curves at 8 boreholes and well-testing temperature data at 142 boreholes are used to determine geotemperature gradients in the Bohai Basin. The thermal conductivities of 86 rock samples are measured at laboratory and the effects of porosity and temperature are corrected to obtain conductivities in situ. Terrestrial heat flow densities at 76 wells are determined based on these data. The distribution of the heat flow indicates that the terrestrial heat flow in the Bohai Basin is relatively high with an average value of 65.8 mW/m2. This characteristic is caused by the tectonic evolution of the basin. During Cenozoic, the litho-sphere stretched intermittently and the crust thinned so that heat conducted from the mantle increased and formed thermal abnormity at depth beneath the basin. | WANG Liangshu LIU Shaowen XIAO Weiyong LI Cheng LI Hua GUO Suiping LIU Bo LUO Yuhui CAI Dongsheng | 2002 | Chinese Science Bulletin2002，47，10： | 10 |
| 18 | Laparoscopic splenectomy by secondary pedicle division strategy: a highly cost-effective method显示文摘背景:Laparoscopic 脾切除术(LS ) 除了高费用与开的外科相比显示出许多优点。这研究被瞄准与高划算推荐第二等的小花梗部门策略为一个方法。方法:从 2003 年 1 月到 2005 年 6 月, 14 个连续病人经历了 laparoscopic 脾切除术。脾的小花梗被第二等的小花梗部门策略在另外的 6 个盒子中在 8 种情况中并且由 Endo-GIA 控制。回顾的研究被执行评估起作用的时间,失血,节食的时间,起作用的病态,手术后的停留,和起作用的费用。结果:LS 总共 14 个盒子的成功地被执行。在在起作用的时间,失血,节食的时间,起作用的病态和手术后的停留的二策略之间没有有效差量。第二等的小花梗部门策略的起作用的费用组织(RMB 8354.38 +/- 752.10 ) 比 Endo-GIA 组的显著地低(RMB 11053.33 +/- 602.27 )(P <
0.01 ) 。结论:由第二等的小花梗部门策略的 Laparoscopic 脾切除术是有在开发国家的通俗化的价值的一个安全、有效、节俭的过程。 | CAI Xiu-jun SHEN Bo YU Hong LIANG Xiao ZHU Lin-hua WANG Yi-fan DAI Yi YANG Jin | 2008 | Chinese Medical Journal2008，，2： | 9 |
| 19 | SIZ1-Mediated SUMOylation of TPR1 Suppresses Plant Immunity in Arabidopsis显示文摘Plant immune responses are tightly regulated to ensure their appropriate deployment. Overexpression of TOPLESS-RELATED 1 (TPR1), a SUPPRESSOR OF npr1-1, CONSTITUTIVE 1 (SNC1)-interacting protein, results in autoimmunity that reduces plant growth and development. However, how TPR1 activity is regulated remains unknown. Loss of function of SIZ1, a (SUMO) E3 ligase, induces an autoimmune response, partially due to elevated SNC1 levels. Here we show that SNC1 expression is upregulated in Arabidopsis thaliana siz1-2 due to positive-feedback regulation by salicylic acid. SIZ1 physically interacts with TPR1 and facilitates its SUMO modification. The K282 and K721 residues in TPR1 serve as critical SUMO attachment sites. Simultaneous introduction of K282R and K721R substitutions in TPR1 blocked its SUMOylation, enhaneed its transcriptional co-repressor activity, and increased its association with HISTONE DEACETYLASE 19 (HDA19), suggesting that SUMOylation of TPR1 represses its transcriptional co-repressor activity and inhibits its interaction with HDA19. In agreement with this finding, the simultaneous introduction of K282R and K721R substitutions enhanced TPR1 mediated immunity, and the tpr1 mutation partially suppressed autoimmunity in siz1-2. These results demonstrate that SIZ1-mediated SUMOylation of TPR1 represses plant immunity, which at least partly contributes to the suppression of autoimmunity under nonpathogenic conditions to ensure proper plant development. | De Niu Xiao-Li Lin Xiangxiong Kong Gao-Ping Qu Bin Cai Jiyoung Lee Jing Bo Jin | 2019 | Molecular Plant2019，12，2： | 9 |
| 20 | Ultrasonographic features of medullary thyroid carcinoma and their diagnostic values显示文摘背景髓的甲状腺癌(MTC ) 是一个稀罕恶性肿瘤并且通常困难与超声诊断。学习的目的是总结 MTC 的 sonographic 特征并且评估他们我们分析了的诊断 values.Methods 关于榴状的尺寸, echogenecity,内部内容,形状,高度 / 宽度,边阶,外部光圈,石灰化和颜色的 35 MTC 和 50 个良性的小瘤的 sonographic 特征流动模式。比率也长在在 MTC 之间的 sonographic 特征处于颈的淋巴 nodes.The 差别被估计到短轴, echogenecity,内部内容和石灰化,良性的小瘤与迟一起被分析平方测试。每个 sonographic 特征的诊断效率是主要 sonographic MTC 展示的 determined.Results 是 hypoechogenicity (包括的显著 hypoechogenicity )(n=34,97%),内部稳固的内容( n=29 ,83%),比高宽( n=34 ,97%),明确的边阶( n=24 ,69%), microcalcifications 或 macrocalcifications ( n=23 ,66%)。, echogenicity,内部内容,形状,外部光圈和石灰化在这二个组之间是显著地不同的高 / 宽,边阶,和 pednodular 和 intranodular vascularisation 不是显著地不同的。在所有单个 sonographic 特征之中,不规则的形状与 51% 的敏感和 92% 的特性有最高诊断的效率。显著 hypoechogenicity, microcalcifications,和不规则的形状的联合产出 77% 的敏感和典型 sonographic MTC 展示的 86%.Conclusions 的特性是 hypoechogenicity,主要稳固,不规则地与微石灰化的 intranodular 或宏石灰化塑造了。多重 sonographic 特征的联合有用,然而并非权威,为 MTC 的诊断。 | CAI Sheng LIU He LI Wen-bo OUYANG Yun-shu ZHANG Bo LI Peng WANG Xue-lian ZHANG Xiao-yan LI Jian-chu JIANG Yu-xin | 2010 | Chinese Medical Journal2010，，21： | 9 |
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