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| 1 | Studies of Novel Water-Soluble Colored Polyesters Containing Azo Moiety 显示文摘 | Manish P Patel Bhavin J Modi Ranjan G Patel | 1998 | Journal Applied Polymer Science1998，69，12： | 1 |
| 2 | A rapid and sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method for the estimation of rivastigmine in human plasma显示文摘 | Jignesh Bhatt Gunta Subbaiah Sandeep Kambli Bhavin Shah Samita Nigam Mehul Patel Ashish Saxena Ashok Baliga Hetal Parekh Gunvat Yadav | 2007 | Journal of Chromatography B2007，，： | 1 |
| 3 | Determination of asenapine in presence of its inactive metabolites in human plasma by LC-MS/MS显示文摘A highly selective and sensitive liquid chromatography-tandem mass spectrometry(LC-MS/MS) assay has been described for the determination of asenapine(ASE) in presence of its inactive metabolites N-desmethyl asenapine(DMA) and asenapine-N-glucuronide(ASG). ASE, and ASE 13C-d3, used as internal standard(IS), were extracted from 300 mL human plasma by a simple and precise liquid-liquid extraction procedure using methyl tert-butyl ether. Baseline separation of ASE from its inactive metabolites was achieved on Chromolith Performance RP_(8e)(100 mm×4.6 mm) column using acetonitrile-5.0 mM ammonium acetate-10% formic acid(90:10:0.1, v/v/v) within 4.5 min. Quantitation of ASE was done on a triple quadrupole mass spectrometer equipped with electrospray ionization in the positive mode. The protonated precursor to product ion transitions monitored for ASE and ASE 13C-d3 were m/z 286.1→166.0 and m/z 290.0→166.1, respectively. The limit of detection(LOD) and limit of quantitation(LOQ) of the method were 0.0025 ng/mL and 0.050 ng/mL respectively in a linear concentration range of 0.050–20.0 ng/mL for ASE. The intra-batch and inter-batch precision(% CV) and mean relative recovery across quality control levels were ≤5.8% and 87.3%, respectively. Matrix effect, evaluated as IS-normalized matrix factor, ranged from 1.03 to 1.05. The stability of ASE under different storage conditions was ascertained in presence of the metabolites. The developed method is much simpler, matrix free, rapid and economical compared to the existing methods. The method was successfully used for a bioequivalence study of asenapine in healthy Indian subjects for the first time. | Nirav R Patel Mallika Sanyal Naveen Sharma Dinesh S.Patel Pranav S.Shrivastav Bhavin N.Patel | 2018 | Journal of Pharmaceutical Analysis2018，8，5： | 1 |
| 4 | A Prospective Randomized, Controlled Study Comparing Low Pressure Versus High Pressure Pneumoperitoneum During Laparoscopic Cholecystectomy显示文摘 | Vismit Pradyumna Joshipura Sanjiv P. Haribhakti Nitin R. Patel Rahul P. Naik Harshad N. Soni Bhavin Patel Mahendra S. Bhavsar Mahendra B. Narwaria Rashmi Thakker | 2009 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2009，，3： | 1 |
| 5 | Sex and racial disparities in non-alcoholic fatty liver disease-related cardiovascular events: National inpatient sample analysis (2019)显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)increases cardiovascular disease(CVD)risk irrespective of other risk factors.However,large-scale cardiovascular sex and race differences are poorly understood.AIM To investigate the relationship between NAFLD and major cardiovascular and cerebrovascular events(MACCE)in subgroups using a nationally representative United States inpatient sample.METHODS We examined National Inpatient Sample(2019)to identify adult hospitalizations with NAFLD by age,sex,and race using ICD-10-CM codes.Clinical and demographic characteristics,comorbidities,and MACCE-related mortality,acute myocardial infarction(AMI),cardiac arrest,and stroke were compared in NAFLD cohorts by sex and race.Multivariable regression analyses were adjusted for sociodemographic characteristics,hospitalization features,and comorbidities.RESULTS We examined 409130 hospitalizations[median 55(IQR 43-66)years]with NFALD.NAFLD was more common in females(1.2%),Hispanics(2%),and Native Americans(1.9%)than whites.Females often reported non-elective admissions,Medicare enrolment,the median age of 55(IQR 42-67),and poor income.Females had higher obesity and uncomplicated diabetes but lower hypertension,hyperlipidemia,and complicated diabetes than males.Hispanics had a median age of 48(IQR 37-60),were Medicaid enrollees,and had non-elective admissions.Hispanics had greater diabetes and obesity rates than whites but lower hypertension and hyperlipidemia.MACCE,all-cause mortality,AMI,cardiac arrest,and stroke were all greater in elderly individuals(P<0.001).MACCE,AMI,and cardiac arrest were more common in men(P<0.001).Native Americans(aOR 1.64)and Asian Pacific Islanders(aOR 1.18)had higher all-cause death risks than whites.CONCLUSION Increasing age and male sex link NAFLD with adverse MACCE outcomes;Native Americans and Asian Pacific Islanders face higher mortality,highlighting a need for tailored interventions and care. | Rupak Desai Ali Tariq Alvi Advait Vasavada Yashwitha Sai Pulakurthi Bhavin Patel Adil Sarvar Mohammed Shreyans Doshi Ikechukwu Ogbu | 2024 | World Journal of Cardiology2024，16，3： | 0 |
| 6 | 泊沙康唑肠溶片在健康受试者的生物等效性研究显示文摘目的研究健康受试者中泊沙康唑肠溶片的药代动力学,评估国产受试制剂与原研参比制剂的生物等效性.方法用单中心、随机、开放、单剂量、两周期、两序列、双交叉、空腹或餐后给药试验设计,空腹组和餐后组分别入组44例和34例健康受试者口服泊沙康唑肠溶片受试制剂或参比制剂100 mg.用LC-MS/MS法测定血浆中泊沙康唑的浓度,用WinNonlin■8.0版计算药代动力学参数,SAS■9.4版对主要药代动力学参数进行了生物等效性分析评价.结果空腹试验受试制剂和参比制剂的泊沙康唑C_(max)分别为(174.28±71.34)和(169.41±63.43)ng·mL^(-1),AUC_(0-t)分别为(5972.47±2118.29)和(5685.16±2054.80)h·ng·mL^(-1),AUC_(0-∞)分别为(6222.48±2304.83)和(5912.98±2165.39)h·ng·mL^(-1).餐后试验受试制剂和参比制剂的泊沙康唑C_(max)分别为(439.08±100.88)和(440.52±110.73)ng·mL^(-1),AUC_(0-t)分别为(1.32×10^(4)±2928.30)和(1.32×10^(4)±2982.31)h·ng·mL^(-1)、AUC_(0-∞)分别为(1.37×10^(4)±3137.21)和(1.36×10^(4)±3191.62)h·ng·mL^(-1).空腹组和餐后组受试制剂/参比制剂的泊沙康唑主要药代动力学参数经对数转换后几何均值比(90%CI)均落在80.00%~125.00%.在试验过程中,空腹试验组和餐后试验组不良事件反应发生率分别为2.2%和0,未发生严重不良事件.结论2种泊沙康唑肠溶片在餐后和空腹给药条件下在印度健康受试者体内生物等效、安全. | 张永恒 周铭 BHAVIN Patel 沈建人 李坤 | 2022 | 中国临床药理学杂志2022，38，7： | 0 |
| 7 | Binding energy effects in the decay properties of charmonia显示文摘The di-gamma and di-gluon decay widths of P-wave cc mesons are computed in nonrelativistic phenomenological quark-antiquark potential of the type V (r) =-4 3 α s r+ Ar ν with different choices of ν using spectroscopic parameters.The numerically obtained radial solutions are employed to obtain the di-gamma and di-gluon decay widths.The computed decay widths are consistent with other model predictions as well as with the known experimental values in the range of potential index 0.7 ≤ν≤ 1.1. | P.C.Vinodkumar Bhavin Patel | 2010 | Chinese Physics C2010，34，9： | 0 |
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