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| 1 | Design,synthesis,in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antibacterial,antifungal and anti-tubercular agents显示文摘A series of 5-substitued-3-(5-(4-(furan-2-yl)-6-methyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-thiadiazol-2- ylimino)indolin-2-one derivatives were synthesized,characterized and were screened for anti-bacterial,anti-fungal and antitubercular activity. | Tarunkumar Nanjibhai Akhaja Jignesh Priyakant Raval | 2012 | Chinese Chemical Letters2012，23，4： | 7 |
| 2 | Application of an LC–MS/MS method for the analysis of amlodipine,valsartan and hydrochlorothiazide in polypill for a bioequivalence study显示文摘A sensitive and selective method has been proposed for the simultaneous determination of amlodipine(AML),valsartan(VAL) and hydrochlorothiazide(HCTZ) in human plasma by liquid chromatography–tandem mass spectrometry(LC–MS/MS). The analytes and their deuterated analogs were quantitatively extracted from100 μL human plasma by solid phase extraction on Oasis HLB cartridges. The chromatographic separation of the analytes was achieved on a Chromolith RP18 e(100 mm × 4.6 mm) analytical column within 2.5 min. The resolution factor between AML and VAL, AML and HCTZ, and VAL and HCTZ was 2.9, 1.5 and 1.4, respectively,under isocratic conditions. The method was validated over a dynamic concentration range of 0.02–20.0 ng/m L for AML, 5.00–10,000 ng/m L for VAL and 0.20–200 ng/m L for HCTZ. Ion-suppression/enhancement effects were investigated by post-column infusion technique. The mean IS-normalized matrix factors for AML, VAL and HCTZ were 0.992, 0.994 and 0.998, respectively. The intra-batch and inter-batch precision(% CV) across quality control levels was ≤ 5.56% and the recovery was in the range of 93.4%–99.6% for all the analytes. The method was successfully applied to a bioequivalence study of 5 mg AML + 160 mg VAL + 12.5 mg HCTZ tablet formulation(test and reference) in 18 healthy Indian males under fasting. The mean log-transformed ratios of C max, AUC0–120 h and AUC0-inf and their 90% CIs were within 90.2%–102.1%. The assay reproducibility was demonstrated by reanalysis of 90 incurred samples. | Jaivik V.Shah Jignesh M.Parekh Priyanka A.Shah Priya V.Shah Mallika Sanyal Pranav S.Shrivastav | 2017 | Journal of Pharmaceutical Analysis2017，7，5： | 3 |
| 3 | Design,synthesis and in vitro evaluation of tetrahydropyrimidine-isatin hybrids as potential antitubercular and antimalarial agents显示文摘A series of 5-substituted-3-[{5-(6-methyl-2-oxo/thioxo-4-phenyl-1,2,3,4-tetrahydropyrimidin-5-yl)-1,3,4-oxadiazol-2-yl}-imino] -1,3-dihydro-2H-indol-2-one were synthesized,characterized and screened for their anti-tubercular and antimalarial activity. | Tarunkumar Naniibhai Akhaia Jignesh Privakant Raval | 2012 | Chinese Chemical Letters2012，23，7： | 2 |
| 4 | Mortality and morbidity in patients with atrial fibrillation and liver cirrhosis显示文摘BACKGROUND Atrial fibrillation(AF)is the most common cardiac arrhythmia encountered in clinical practice.However,the outcomes associated with AF in hospitalized patients with liver cirrhosis are unknown.AIM To determine the outcomes of hospitalized patients with liver cirrhosis and AF.METHODS In this study,we examined morbidity and mortality of patients with concomitant AF and liver cirrhosis from the National Inpatient Sample database,the largest publicly available inpatient healthcare database in the United States.RESULTS A total of 696937 patients with liver cirrhosis were included,45745 of whom had concomitant AF(6.6%).Liver cirrhosis patients with AF had higher rates of inhospital mortality(12.6%vs 10.3%,P<0.001),clinical stroke(1.6%vs 1.1%,P<0.001),and acute kidney injury(28.2%vs 25.1%,P<0.001),and less gastrointestinal bleeding(4.4%vs 5.1%,P<0.001)and blood transfusion(22.5%vs 23.8%,P<0.001)compared with those who did not have the arrhythmia.In addition,they had a longer length of stay(8±10 d vs 7±8 d,P<0.001)and higher hospitalization costs(20720±33210$vs 16272±24166$,P<0.001).CONCLUSION In subjects with liver cirrhosis,AF is associated with higher rates of inpatient mortality,stroke,and acute kidney injury compared to those who do not have the cardiac arrhythmia. | Yousef H Darrat Aiman Smer Claude-Samy Elayi Gustavo X Morales Fahad Alqahtani Mohamad Alkhouli John Catanzaro Jignesh Shah Mohsin Salih | 2020 | World Journal of Cardiology2020，12，7： | 2 |
| 5 | Cardiac Troponin I Is Associated With Impaired Hemodynamics, Progressive Left Ventricular Dysfunction, and Increased Mortality Rates in Advanced Heart Failure显示文摘 | Tamara B. Horwich Jignesh Patel W. Robb MacLellan Gregg C. Fonarow | 2003 | Circulation: Journal of the American Heart Association2003，，7： | 2 |
| 6 | Influence of system variables on the morphological and dynamic mechanical behavior of polydimethylsiloxane based segmented polyurethane and polyurea copolymers:a comparative perspective显示文摘 | Jignesh P S Aneja A Wilkes G L | 2004 | Polymer2004，45，20： | 1 |
| 7 | Rapid and sensitive liquid chromatography mass spectrometry method for determination of ropinirole in human plasma显示文摘 | Jignesh B Arvind J Raghavendra S | 2006 | Journal of Pharmaceutical and Biomedical Analysis2006，40，5： | 1 |
| 8 | Nodular regenerative hyperplasia of liver--a rare cause of portal hypertension in patients of rheumatoid arthritis显示文摘 | Agasti AK Jignesh P Vashisth C | | 0，，： | 1 |
| 9 | Solid state structure- property behavior of semicrystallinepoly(ether-block-amide) PEBAw ther- moplastic elastomers显示文摘 | Jignesh P Sheth Jiannong Xu Garth L Wilkes | 2003 | Polymer2003，44，： | 1 |
| 10 | Bleaching of mustard oil with some alternative bleaching agents and acid activated clay显示文摘 | Bijay Krishna De Jignesh Dahyabhai Patel Jignesh Bharatbhai Patel | | 0，，02： | 1 |
| 11 | Nodular regenerative hyperplasia of liver: a rare cause of portal hypertension in patients of rheumatoid arthritis 显示文摘 | Agasti AK Jignesh P Vashisth C | 2011 | J Assoc Physicians India2011，59，： | 1 |
| 12 | Dynamics of reactive distillation processes with potential liquid phase splitting based on equilibrium stage models 显示文摘 | Gabriel Radulescu Jignesh Gangadwa Nicolae Paraschiv | 2009 | Computers and Chemical Engineering2009，32，3： | 1 |
| 13 | Image registration using NSCT and invariant moment显示文摘 | Jignesh Sarvaiya Suprava Patnaik Hemant Goklani | 2010 | International Journal of Image Processing(S2419-1724)2010，4，2： | 1 |
| 14 | Influence of system variables on the mprphological and dynamic mechanical behavior of polydimethylsiloxane based segmented polyurethane and polyurea copolymers:a comparative perspective显示文摘 | Jignesh P S Aneja A Wilkes G L | 2004 | Polymer2004，45，20： | 1 |
| 15 | Esterification of acetic acid with butanol in the presence of ion-exchange resins as catalysts 显示文摘 | Jignesh G Surendra M Sanjay M | 2003 | Ind Eng Chem Res2003，42，： | 1 |
| 16 | Automatic image registration using mexican hat wavelet, invariant moment, and randon transform显示文摘 | Jignesh N S Suprava P | 2011 | International Journal of Advanced Computer Sciences and Application2011，，： | 1 |
| 17 | Monocyte/Macrophage Regulation of Vascular Calcification In Vitro显示文摘 | Yin Tintut Jignesh Patel Mary Territo Trishal Saini Farhad Parhami Linda L. Demer | 2002 | Circulation: Journal of the American Heart Association2002，，5： | 1 |
| 18 | Turn or necrosis factor - a promotes in vitro calcification of vascular cells via the cAMP path way 显示文摘 | Yin T Jignesh P Farhad P | 2000 | Circulation2000，102，21： | 1 |
| 19 | Tumor necrosis factor-α promotes in vitro calcification of vascular cells via the c AMP pathway显示文摘 | Yin T Jignesh P Farhad P | 2000 | Circulation2000，102，21： | 1 |
| 20 | Image registration using NSCT and invariant moment显示文摘 | JIGNESH S SUPRAVA P HEMANT G | 2010 | International Journal of Image Processing2010，4，2： | 1 |
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