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| 1 | 人参皂甙对CD_(34)^+造血干/祖细胞的增殖和分化作用显示文摘目的 :探索人参皂甙 (GS)对CD34 +造血干 /祖细胞的刺激增殖和诱导分化作用。方法 :采用免疫磁珠法 (MACS)分离纯化脐血CD34 +细胞 ,在造血细胞半固体和液体培养体系中加入不同浓度的GS ,检测对CD34 +造血干 /祖细胞增殖 ,形成祖细胞集落的提高率 ,并用流式细胞仪检测液体培养后细胞表面标记的变化。结果 :GS( 5~ 50 μg/ml)能提高BFU E、CFU E、CFU GM、CFU GEMM集落产率 ( % ) ,分别为87 6± 2 6、63 3± 2 8、58 0± 3 1和 96 3± 5 5(均P <0 0 1)。GS 2 5μg/ml是液体培养刺激CD34 +细胞体外增殖的最佳浓度。GS诱导细胞 14天后 ,细胞表面表达CD33+细胞随GS的浓度升高而增加 ,在GS 50 μg/ml时以CD15+细胞数最高 ,CD71+细胞和G A+细胞数仅在 2 5μg/ml时高于未加GS的对照组。结论 :GS不但能促进CD34 +造血干 /祖细胞的增殖 ,并且能诱导定向分化 ,具有类生长因子和协同生长因子的作用。 | 金锦梅 Tao Helen 高瑞兰 BH Chong | 2000 | 中国中西医结合杂志2000，20，9： | 43 |
| 2 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 3 | 内燃机振动声学特性的预测显示文摘本文提出了在设计的初始阶段预测柴油机结构传递特性和声辐射的方法.在确定发动机结构广义传递函数时,利用了发动机重量和外表面面积与基本参数之间的统计关系式.激励力谱由柴油机工作过程的数学模拟和谱分析得到,发动机结构噪声的声功率谱等于结构广义传递函数和激励力谱的迭加,预测精度对于设计初始阶段是可以接受的. | 刘佳才 鲁卡宁BH | 1993 | 内燃机学报1993，11，3： | 8 |
| 4 | 樟叶胡椒中新木脂素成分的研究显示文摘自胡椒科胡椒属植物樟叶胡椒(Piper polysyphorum C. DC)中分离到六个新木脂素(neolignans)类化合物,经光谱(UV,IR,MS,~1H-NMR,^(13)C-NMR,2D-NMR,CD)分析及衍生物制备,确定Ⅱ为新化合物,即threo-△~7-7-羟基-3,4,5,3′,5′-五甲氧基-8-O-4′-新木脂素,为一对对映体,命名为樟叶素(polysyphorin),Ⅰ,Ⅲ,Ⅳ为新的对映体,分別为(+)-virolongin,(+)-grandisin及(+)-lancifolin D.化合物Ⅴ为南藤素(wallichinine),Ⅵ为山蒟素D(hancinone D)。血小板活化因子(PAF)受体结合实验及PAF引起的血小板聚集实验证明化合物Ⅰ~Ⅴ具有明显的抑制活性。 | 马迎 韩桂秋 李长龄 诚静容 BH Arison SB Hwang | 1991 | 药学学报1991，26，5： | 7 |
| 5 | 动脉血压监测及其影响因素显示文摘动脉血压 (ABP)是一项重要的血流动力学指标 ,正确监测很重要。重点介绍ABP的生理及影响 ABP的生理及病理生理学因素 ,ABP的监测原则 ,ABP波形及其临床解释。 | McGhee BH Bridges MEJ 何平 马青华 | 2003 | 国外医学(护理学分册)2003，22，10： | 6 |
| 6 | “Anti-HBc alone” in human immunodefi ciency virus-positive and immuno-suppressed lymphoma patients显示文摘Hepatitis B virus (HBV) infection is endemic in various parts of the world. A proportion of patients have resolved prior exposure to HBV, as evidenced by the clearance of circulating hepatitis B surface antigen and the appearance of antibody to hepatitis B core antigen (anti-HBc), which could produce protective antibody to hepatitis B surface antigen (anti-HBs). With time, anti-HBs in some patients may become negative. Such patients are described as having occult HBV infection or 'anti-HBc alone'. In the context of immunodef icient patients, such as HIV patients or lymphoma patients undergoing immunosuppressive immunotherapy, the lack of protective anti-HBs may increase the risk of hepatitis B reactivation. Serum HBV DNA testing may be necessary in 'anti-HBc alone' patients, to detect patients at a high risk of developing HBV infection allowing appropriate prophylactic management. | Yu Xuan Koo Daniel SW Tan Iain BH Tan Richard Quek Miriam Tao Soon Thye Lim | 2009 | World Journal of Gastroenterology2009，15，30： | 5 |
| 7 | 住院患者药物不良反应的发生率:前瞻性研究的汇总 …显示文摘目的-对住院患者严重和致命药物不良反应(adversedrugreactions,ADR)的发生率进行评价。资料来源-检索1966-1996年4种电子资料库。研究的选择-在153项研究中,选择了39项来自美国各医院的前瞻性研究。资料的提取-对2位研究者各自提取物的采用随机-效果模式进行分析。为了取得患者ADRs的总发生率,我们将住院期间ADRs的发生率与ADRs所致住院的发生经合并计算。 | Laza.,J Pome.,BH | 1998 | 美国医学会杂志(中文版)1998，17，6： | 4 |
| 8 | 重组日本血吸虫副肌球蛋白的表达与纯化显示文摘用基因重组技术 ,将日本血吸虫副肌球蛋白 (rSj97)基因亚克隆至表达载体pQE30上。在IPTG诱导下 ,重组日本血吸虫副肌球蛋白在大肠杆菌中得以高效表达。通过快速蛋白质液相色谱仪 (FPLC) ,经TALON柱和离子交换柱两步分离纯化 ,获得大量高纯度的重组日本血吸虫副肌球蛋白 。 | 周金春 易新元 Kalinna BH Mc Manus DP | 2000 | 湖南医科大学学报2000，25，2： | 3 |
| 9 | Single vertical spin density gradient ultracentrifugation显示文摘 | Chung BH Segrest JP Ray MJ | 1986 | Methods Enzymol1986，128，： | 2 |
| 10 | Classification of subtype of acute ischemic显示文摘 | Adame H Bendixen BH Kapelle LT | 1993 | Stroke1993，24，1： | 2 |
| 11 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 12 | Pycnogenol inhibits tumor necrosis factoralpha-induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells 显示文摘 | Peng Q Wei Z Lau BH | 2000 | Cell Mol Life Sci2000，57，5： | 2 |
| 13 | Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy, as evidenced by reducing bone resorption and urinary calcium excretion显示文摘 | Arjmandi BH Khalil DA Smith BJ | 2003 | J CIin Endocrinol Metab2003，88，： | 2 |
| 14 | 英国液态排渣鲁奇炉(BGL)在联合循环发电系统中的应用显示文摘 | Thom.,BH 马瑞海 | 1989 | 国外煤气1989，，1： | 2 |
| 15 | Proposal for standardization of flow cytometric reticulocyte maturity index (RMI) measurements 显示文摘 | Davis BH DiCorato M Bigelow NC | 1993 | Cytometry1993，14，： | 2 |
| 16 | 查看详情显示文摘 | Kalinna BH | | 0，，： | 2 |
| 17 | Current approaches to diagnosis and treatment of invasive aspergillosis 显示文摘 | Segal BH Walsh TJ | 2006 | Am J Respir Crit Care Med2006，173，7： | 1 |
| 18 | The Strengths and Difficulties Self-Report Questionnaire as a screening instrument in Norwegian community samples显示文摘 | Ronning J A Handegaard BH Sourander A | 2004 | Eur Child Adolesc Psychiatry2004，13，2： | 1 |
| 19 | The effect on reliability of adding a separate written assessment component to an objective structured clinical examination显示文摘 | Verhoeven BH Hamers JG Scherpbier AJ | 2000 | Med Educ2000，34，7： | 1 |
| 20 | The use of electrical impedance spectroscopy in the detection of cervical intraepithelial neoplasia显示文摘 | Abdul S Brown BH Milnes P | 2006 | Int J Gynecol Cancer2006，16，： | 1 |
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