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| 1 | FADD and TRADD expression and apoptosis in primary hepatocellular carcinoma显示文摘AIM To investigate the clinical features ofFADD and TRADD expressions in primaryhepatocellular carcinoma(HCC)and todetermine their relationship with hepaticapoptosis.METHODS FADD and TRADD expressions weredetected by immunohistochemistry and hepaticapoptosis were determined by in situ end-labeling(ISEL).RESULTS Ten(25.6%)cases of HCC weredetected to express FADD protein.The positiverate in HCC is lower than that in non-cancerousadjacent liver tissues(62.5%)(P<0.05).Inthose of grade Ⅰ-Ⅱ,8(38.1%)cases wereFADD positive,while only 2/18(11.1%)casesof grade Ⅲ-Ⅳ had detectable FADD protein(P<0.05).No relationship was found betweenFADD expression and other clinical features,such as gender,age,tumor size,differentiationor metastasis.ISEL positive cells can be seen inall cases of HCC.The hepatic apoptosis wasassociated with FADD expression as moreapoptotic cells were detected in those caseswhich had moderately to strongly positiveFADD,as compared with negative or weakpositive FADD cases(P<0.05).No relationshipwas found between FADD expression and hepaticapoptosis in non-cancerous adjacent livertissues.Fifteen of 39(38.5%)cases of HCCwere found positive for TRADD protein,andsimilar positive rate(37.5%)in non-cancerousadjacent liver tissues(P>0.05).The expressionof TRADD is correlated with HCC differentiation, as only 22.2% of moderately to highlydifferentiated HCC showed positive TRADDprotein,while as high as 52.4% of poorlydifferentiated HCC had TRADD(P<0.05),Norelationship was found between TRADDexpression and gender,age,tumor size or gradeor metastasis,although 42.9% of HCC of gradeⅠ/Ⅱ showed positive TRADD which wasslightly higher than that of grade Ⅲ/Ⅳ(33.3%,P>0.05).Hepatic apoptosis was not related toTRADD expression in HCC or non-cancerousadjacent liver tissues.CONCLUSION Loss of FADD expression playsan important role in HCC carcinogenesis,andexpression of TRADD also contributes to HCCdevelopment.The cell apoptosis in HCC isassociated with FADD expression.However,theexpression of TRADD does not correlate wellwith hepatic apoptosis in HCC. | Sun BH Zhao XP Wang BJ Yang DL Hao LJ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Natural Selection and Adaptive Evolution of Leptin in the Ochotona Family Driven by the Cold Environmental Stress 显示文摘 | Wang ZL Zhao XQ Wang DP Qi DL Xu BH Ren YH Tian HF | 2008 | PLoS ONE2008，3，1： | 1 |
| 3 | Circu- lating endothelial progenitor cells in Chinese pa- tients with acute stroke 显示文摘 | Zhou WJ Zhu DL Yang GY | 2009 | Hypertens Res2009，32，： | 1 |
| 4 | Inhibition of autophagy promotes cell apoptosis induced by the proteasome inhibitor MG-132 in human esophageal squamous cell carcinoma EC9706 cells 显示文摘 | Liu DL Gao M Yang Y | 2015 | Oncol Lett2015，9，5： | 1 |
| 5 | Resveratrol inhibits right ventricular hypertrophy induced by monocrotaline in rats 显示文摘 | Yang DL Zhang HG Xu YL | 2010 | Clin Exp Pharmacol Physiol2010，37，2： | 1 |
| 6 | Design, synthesis, and evaluation of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-ribitylaminolumazines as inhibitors of riboflavin synthase and lumazine synthase 显示文摘 | CUSHMAN M YANG DL GERHARDT S | 2002 | J Org Chem2002，67，16： | 1 |
| 7 | Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade显示文摘 | Yang DL Yao J Mei CS | 2012 | Proc Natl Acad Sci USA2012，109，： | 1 |
| 8 | Texturization of monocrystalline silicon with tribasic sodium phosphate显示文摘 | Xi ZQ Yang DR Que DL | 2003 | Solar Energy Materials & Solar Cells2003，77，： | 1 |
| 9 | Freehand placement of depth electrodes using electromagnetic frameless stereotactic guidance 显示文摘 | Wray CD Kraemer DL Yang T | 2011 | J Neurosurg Pediatr2011，8，5： | 1 |
| 10 | L1cam promotes tumor progression and metastasis and is an iudependent unfavorable prognostic factor in gastric cancer显示文摘 | Chen DL Zeng ZL Yang J | 2013 | J Hematol Oncol2013，6，： | 1 |
| 11 | Breast lymphoma: ima- ging findings of 32tumors in 27 patients 显示文摘 | Yang WT Lane DL Le-Petross HT | 2007 | Radiology2007，，245： | 1 |
| 12 | Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells显示文摘 | YANG X PHILLIPS DL FERGUSON AT | | 0，，19： | 1 |
| 13 | The drug/metabolite transporter superfamily显示文摘 | Jack DL Yang NM Saier MH | 2001 | Eur J Biochem2001，268，13： | 1 |
| 14 | Studyon the solid circulationrate and gas bypassing in spouted fluid-bed witha draft tube显示文摘 | Yang WC Keairns DL | 1983 | Canadian Journal of ChemicalEngineering1983，61，： | 1 |
| 15 | Catabolic effects of contin-uous human PTH (1--38) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation显示文摘 | Ma YL Cain RL Halladay DL Yang X Zeng Q Miles RR Chandrasekhar S Martin TJ Onyia JE | | 0，，： | 1 |
| 16 | Effects of oestrogen deficiency on rat mandibular and tibial microarchitecture显示文摘 | Yang J Pham SM Crabbe DL | 2003 | Dentomaxillofac Radiol2003，32，4： | 1 |
| 17 | Ultrastructural lung pathology of experimental Chlamydia pneumoniae pneumonitis in mice显示文摘 | Yang ZP Cummings PK Patton DL | 1994 | J Infect Dis1994，170，： | 1 |
| 18 | D5 dopamine receptor regulation of NADPH oxidase and blood pressure in mice显示文摘 | Yang Z Yu P Asico DL | 2003 | J Am Soc Nephrol2003，14，： | 1 |
| 19 | Evaluation of autoSCAN-W/A and the Vitek GNI + AutoMicrobic system for identification for non-glucose-fermenting gram-negative bacilli显示文摘 | Sung LL Yang DL Hung CC | 2000 | J Clin Microbiol2000，38，： | 1 |
| 20 | Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells 显示文摘 | Yang B Gay DL MacLeod MK | 2008 | Nat hnmunol2008，9，12： | 1 |
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