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| 1 | Comprehensive metabolomics expands precision medicine for triple-negative breast cancer显示文摘Metabolic reprogramming is a hallmark of cancer.However,systematic characterizations of metabolites in triple-negative breast cancer(TNBC)are still lacking.Our study profiled the polar metabolome and lipidome in 330 TNBC samples and 149 paired normal breast tissues to construct a large metabolomic atlas of TNBC.Combining with previously established transcriptomic and genomic data of the same cohort,we conducted a comprehensive analysis linking TNBC metabolome to genomics.Our study classified TNBCs into three distinct metabolomic subgroups:C1,characterized by the enrichment of ceramides and fatty acids;C2,featured with the upregulation of metabolites related to oxidation reaction and glycosyl transfer;and C3,having the lowest level of metabolic dysregulation.Based on this newly developed metabolomic dataset,we refined previous TNBC transcriptomic subtypes and identified some crucial subtype-specific metabolites as potential therapeutic targets.The transcriptomic luminal androgen receptor(LAR)subtype overlapped with metabolomic C1 subtype.Experiments on patient-derived organoid and xenograft models indicate that targeting sphingosine-1-phosphate(S1P),an intermediate of the ceramide pathway,is a promising therapy for LAR tumors.Moreover,the transcriptomic basal-like immune-suppressed(BLIS)subtype contained two prognostic metabolomic subgroups(C2 and C3),which could be distinguished through machine-learning methods.We show that N-acetyl-aspartyl-glutamate is a crucial tumor-promoting metabolite and potential therapeutic target for high-risk BLIS tumors.Together,our study reveals the clinical significance of TNBC metabolomics,which can not only optimize the transcriptomic subtyping system,but also suggest novel therapeutic targets.This metabolomic dataset can serve as a useful public resource to promote precision treatment of TNBC. | Yi Xiao Ding Ma Yun-Song Yang Fan Yang Jia-Han Ding Yue Gong Lin Jiang Li-Ping Ge Song-Yang Wu Qiang Yu Qing Zhang François Bertucci Qiuzhuang Sun Xin Hu Da-Qiang Li Zhi-Ming Shao Yi-Zhou Jiang | 2022 | Cell Research2022，32，5： | 18 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 4 | Analytical methods for the determination of folic acid in a nolvmeric micellar carrier显示文摘 | V Andrisano M Bartolini C Bertucci | 2003 | Journal of Pharmaceutical and Biomedical analystica2003，32，： | 1 |
| 5 | Reversible and covalent binding of drugs to human serum albumin: method- ological approaches and physiological relevance显示文摘 | BERTUCCI C DOMENIC1 E | 2002 | Curr Med Chem2002，9，15： | 1 |
| 6 | ,The In/visible Woman:Mariangela Ardinghelli and the Circulation of Knowledge between Paris and Naples in the Eighteenth Century 显示文摘 | Bertucci P | 2013 | Isis2013，104，2： | 1 |
| 7 | Expression ofFGF and FGF receptor genes in human breast cancer显示文摘 | H Penault-Llorca F Bertucci F Adelaide J | 1995 | Int JCancer1995，61，2： | 1 |
| 8 | Reversible and covalent binding of drugs to human serum albumin: methodological approaches and physiological relevance显示文摘 | Bertucci C Domenici E | 2002 | Curr Med Chem2002，9，： | 1 |
| 9 | Phaselclinical and pharmaeolog- ical study of 06 -benzylguanine followed by carmustine in patients with advanced cancer显示文摘 | Schilsky RL Dolan ME Bertucci D | 2000 | Clin Caner Res2000，6，8： | 1 |
| 10 | Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms 显示文摘 | Breequeville M Rey J Bertucci F | 2012 | Genes Chromosomes Cancer2012，51，8： | 1 |
| 11 | A compre- hensive approach to the recognition, diagnosis, and severity-based treatment of focal hyperhidrosis: recommendations of the Canadian Hyperhidrosis Advisory Committee显示文摘 | SOLISH N BERTUCCI V DANSEREAU A | 2007 | Dermatol Surg2007，33，8： | 1 |
| 12 | Rapid Screening of Small Ligand Affinity to Human Serum Albumin by an Optical Biosensor显示文摘 | Bertucci C Cimitan S | 2003 | J Pharm Biomed Anal2003，32，： | 1 |
| 13 | Stereoselective Binding of 2,3-Substituted 3-Hydroxypropionic Acids on an Immobilised Human Serum Albumin Chiral Stationary Phase:Stereochemical Characterisation and Quantitative Structure-Retention Relationship Study显示文摘 | Andrisano V Bertucci C Cavrini V | 2000 | J Chromatogr A2000，876，1： | 1 |
| 14 | Posttranscriptional changes of serum albumin: Clinical and prognostic significance in hospitalized patients with cirrhosis显示文摘 | Marco Domenicali Maurizio Baldassarre Ferdinando A Giannone Marina Naldi Marianna Mastroroberto Maurizio Biselli Maristella Laggetta Daniela Patrono Carlo Bertucci Mauro Bernardi Paolo Caraceni | 2014 | Hepatology2014，，6： | 1 |
| 15 | Proteomics of breast cancer 显示文摘 | Bertucci F Birnbaum D Goncalves A | 2006 | Mol Cell Proteomics2006，5，10： | 1 |
| 16 | A comprehensive approachtothe recognition, diagnosis, and severity-based treatment of focal hyperhidrosis: recommendations of the Ca-nadian Hyperhidrosis Advisory Committee 显示文摘 | Solish N Bertucci V Dansereau A | 2007 | Dermatol Surg2007，33，8： | 1 |
| 17 | Clinical proteomics and breast cancer:strategies for diagnostic and therapeutic biomarker discovery显示文摘 | BERTUCCI F GONCALVES A | 2008 | Future Oncol2008，4，2： | 1 |
| 18 | Sounds modulate males' aggressiveness in a cichlid fish 显示文摘 | BERTUCCI F BEAUCHAUD M ATTIA J | 2010 | Ethology2010，116，12： | 1 |
| 19 | Heptad repeat 2 in herpes simplex virus 1 gH interacts with heptad repeat 1 and is critical for virus entry and fusion 显示文摘 | Gianni T Piccoli A Bertucci C | 2006 | Virol2006，80，5： | 1 |
| 20 | A gene signature in breast cancer显示文摘 | Bertucci F Cervera N Bimbaum D | 2007 | N Engl Med2007，356，18： | 1 |
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