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| 1 | Potential beneficial effects of butyrate in intestinal and extraintestinal diseases显示文摘The multiple beneficial effects on human health of the short-chain fatty acid butyrate,synthesized from nonabsorbed carbohydrate by colonic microbiota,are well documented.At the intestinal level,butyrate plays a regulatory role on the transepithelial fluid transport,ameliorates mucosal inflammation and oxidative status,reinforces the epithelial defense barrier,and modulates visceral sensitivity and intestinal motility.In addition,a growing number of studies have stressed the role of butyrate in the prevention and inhibition of colorectal cancer.At the extraintestinal level,butyrate exerts potentially useful effects on many conditions,including hemoglobinopathies,genetic metabolic diseases,hypercholesterolemia,insulin resistance,and ischemic stroke.The mechanisms of action of butyrate are different;many of these are related to its potent regulatory effects on gene expression.These data suggest a wide spectrum of positive effects exerted by butyrate,with a high potential for a therapeutic use in human medicine. | Roberto Berni Canani Margherita Di Costanzo Ludovica Leone Monica Pedata Rosaria Meli Antonio Calignano | 2011 | World Journal of Gastroenterology2011，17，12： | 52 |
| 2 | The role of estradiol in male reproductive function显示文摘传统地,睾丸激素和雌激素被认为分别地是男、女的性荷尔蒙。然而, estradiol,雌激素的占优势的表格,也在男性功能起一个关键作用。在人的 Estradiol 为 modulating 性欲,可勃起的功能,和精子发生是必要的。雌激素受体,以及 aromatase,把睾丸激素变换成雌激素的酶,充满大脑,阴茎,和睾丸,为性功能重要的机关。在大脑, estradiol 合成在与性唤起有关的区域被增加。在阴茎,另外,雌激素受体在神经与血管的捆附近与高集中在整个阴茎海绵体被发现。低睾丸激素和提高的雌激素独立于对方增加可勃起的机能障碍的发生。在睾丸,精子发生被雌激素在每水平调制,以 hypothalamus-pituitary-gonadal 轴开始,由 Leydig, Sertoli,和细菌房间列在后面,并且与 ductal 上皮, epididymis,和成熟精子完成。由 estradiol 的阴囊的房间的规定显示出两个一禁止并且 stimulatory 影响,显示剂量依赖者并且时间地的一曲复杂交响乐敏感调整。我们在这评论的目标是阐明到由看荷尔蒙的男性功能的 estradiol 的全面贡献在可勃起的功能,精子发生,和性欲上完成。 | Michael Schulster Aaron M Bernie Ranjith Ramasamy | 2016 | Asian Journal of Andrology2016，18，3： | 17 |
| 3 | 起垄措施对重度盐碱化草地土壤水盐和植被状况的影响显示文摘通过对起垄处理5年(2003-2007年)后的重度苏打盐碱化草地土壤水盐分布、物理特性及植被状况等相关指标的测定,探讨了起垄措施对重度苏打盐碱化草地的改良效果。结果表明:与自然状态下的土壤相比,起垄提高了0-30 cm内垄沟和垄台的表层土壤含水量,垄沟的土壤电导率(EC)及pH呈现出一定程度的降低,其中0-10cm内的土壤EC显著降低(P〈0.05),但是垄台土壤EC,pH升高,其土壤表面出现积盐现象,地表出现条带状碱斑;起垄后垄沟、垄台的土壤物理状况得到改善,其中垄沟0-10 cm的土壤容重显著降低而土壤孔隙度显著提高(P〈0.05);起垄还提高了地表植被生物量和植被盖度。因此,起垄措施的应用加快了重度盐碱化草地的改良进程。 | 关法春 苗彦军 Tianfang Bernie Fang 兰小中 梁正伟 | 2010 | 草地学报2010，18，6： | 10 |
| 4 | 施P肥和外生菌根菌接种对蓝桉林产量和养分积累的影响显示文摘主要研究施P肥和接种外生菌根菌对蓝桉生长、生物量和养分积累的影响。在云南楚雄的试验表明:接种外生菌根菌只能在幼林期促进树木生长,3a后这种促进作用不显著。施P肥能在幼林期促进蓝桉树高和胸径的生长,但4 5a后这种促进作用也变得不显著。由于施P肥提高了蓝桉的保存率,所以也显著地提高了蓝桉林的生物量。低P处理时,树木保存率低,较大的生长空间促进了树木的后期生长,可能会导致施P肥对后期单株蓝桉树高和胸径生长作用不显著。施P肥还增加了树木N、P和K的养分积累量,提高了上述养分的利用效率。施P肥同时还明显增加了林下植被和林下凋落物P的积累量,但不能明显增加N和K的养分积累量。树木叶片和土壤分析结果进一步说明施P肥对蓝桉幼林作用明显。试验表现出接种外生菌根菌只能在低P情况下促进树木生长,不能在高P情况下促进树木生长的基本趋势。 | 徐大平 Bernie Dell 弓明钦 Nick Malajczuk 王志和 | 2004 | 林业科学研究2004，17，1： | 10 |
| 5 | Characterization of Prealloyed Ti–6Al–4V Powders from EIGA and PREP Process and Mechanical Properties of HIPed Powder Compacts显示文摘Prealloyed Ti–6Al–4V powders were prepared by electrode induction melting gas atomization(EIGA) and plasma rotating electrode process(PREP) in this work. A comparative study of EIGA and PREP powders for hot isostatic pressing(HIPing) compaction was conducted. Characterization of important technological parameters such as particle size distribution, powder surface morphology and flowability was carried out. Microstructure and mechanical properties of Ti–6Al–4V powder compacts HIPed from EIGA and PREP powders were also investigated. The results showed that the EIGA powder has a finer average particle size and higher tap density, while the PREP powder has better flowability and less pores. Micropores can be observed in heat-treated EIGA powder compacts by X-ray tomography and the porosity was found to be about 0.02%. There are no micropores(C4 μm) to be detected in heat-treated PREP powder compacts.Transgranular fracture mode as well as micropores contributes to the scatter in fatigue property of heat-treated PREP powder compacts. The respective advantages and disadvantages of both EIGA and PREP powders for producing Ti-based complex parts through HIPing were also discussed. | Rui-Peng Guo Lei Xu Bernie Ya-Ping Zong Rui Yang | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，8： | 9 |
| 6 | Single Mutations in the Transmembrane Domains of Maize Plasma Membrane Aquaporins Affect the Activity of Monomers within a Heterotetramer显示文摘Aquaporins 是越过生物的膜便于水或小无电荷的溶质的散开的隧道。他们作为 homotetramers 集合,但是他们中的一些也形成 heterotetramers,特别在植物。在 Zea mays,属于血浆膜的 aquaporins 当在 Xenopus 卵母细胞表示了时,内在的蛋白质(果仁) 亚科被聚类进二个组, PIP1 和 PIP2,它展出不同水隧道活动。当 PIP1 和 PIP2 isoforms 被共同表示时,他们身体上交往调制他们的 subcellular 本地化和隧道活动。这里,我们由亲密关系层析纯化证明当在 Xenopus 卵母细胞共同表示时,玉米 PIP1; 2 并且 PIP2; 5 isoforms 作为人集合 -- 并且在 heterotetramers 以内的 heterodimers。我们由根据菠菜 SoPIP2 的比较建模造了如此的 heterotetramers 的 3D 结构;在通常认为地在在单体之间的接口交往的 transmembrane 域的 1 X 光检查结构和识别氨基酸残余。他们在水隧道活动, subcellular 本地化,蛋白质丰富,和物理相互作用的角色被 mutagenesis 调查。我们加亮也使 PIP2 失去活性的单个残余的替换; 5 或激活的 PIP1; 2 没有影响他们的相互作用。有趣地,在 transmembrane 领域的 Phe220Ala 变化 5 PIP1; 2 激活它的水隧道活动并且同时,使 PIP2 失去活性; 5 在 heterotetramer 以内。总的来说,这些数据在他们的水隧道活动贡献在果仁 isoforms 和 heterotetramerization 的角色之间的相互作用机制的更好的理解。 | Marie C. Berny Dimitri Gilis Marianne Rooman Francois Chaumont | 2016 | Molecular Plant2016，9，7： | 5 |
| 7 | Microsurgical epididymal sperm aspiration: indications, techniques and outcomes显示文摘Microsurgical epididymal 精子渴望(方山) 从被选择并且取样了使用一台操作显微镜提供的高力量的光放大的 epididymis 的最佳的区域指包含精子的液体的检索。检索精子随后被使用让 intracytoplasmic 精子注射(ICSI ) 导致授精和怀孕。方山被是为在有给它复杂并发症的优秀精子,优秀报导授精和怀孕率,和低风险的高收益的妨碍的精子缺乏的人的精子检索的标准答案技术的许多专家考虑。然而,方山必须在一个操作房间里被执行,要求 microsurgical 技巧并且为用 ICSI 的复制仅仅是有用的。此处我们在场为方山,过程的技术表演和被报导了的结果的候选人病人的评估的概述。 | Aaron M Bernie Ranjith Ramasamy Doron S Stember Peter J Stahl | 2013 | Asian Journal of Andrology2013，15，1： | 4 |
| 8 | Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms显示文摘 | Anna Iacono Giuseppina Mattace Raso Roberto Berni Canani Antonio Calignano Rosaria Meli | 2011 | The Journal of Nutritional Biochemistry2011，，8： | 4 |
| 9 | Growth hormone regulates intestinal ion transport through a modulation of the constitutive nitric oxide synthase-nitric oxide-cAMP pathway显示文摘瞄准:生长激素(GH ) 直接与刺激离子吸收并且减少营地的收缩筋导致的离子分泌物的 enterocyte 交往。后来氮的氧化物(没有) 为 GH 血液动力学的效果作为第二个送信人涉及 transepithelial 离子运输和行为的规定,我们测试了可以不在肠的离子运输上涉及 GH 的产生效果的假设。方法:反映 trans 上皮的离子运输的电的参数在房间单层在 Ussing 房间装了并且独自或在联合暴露了到 GH 和霍乱毒素(CT ) 的 Caco-2 被测量,当面或 NO 的缺席 synthase (NOS ) 禁止者, Nomega-nitro-L-arginine 甲基酉旨(L 名字) 。类似的实验被进行决定营地和亚硝酸根 / 硝酸盐集中。NOS 表示是由西方的污点分析的 assayed。结果:L 名字原因在肠的离子运输上由 GH 总计吸收性、反能分泌的效果的废除。另外, L 名字能在基础条件下面并且响应 CT 在细胞内部的营地集中上禁止 GH 效果。GH 导致了 Ca (2+) 亚硝酸根 / 硝酸盐生产的依赖增加,显示参与组成而非可诱导的 NOS 对碘氧基苯甲醚,它被西方的污点分析直接证实。结论:这些结果建议在基础条件下面或面对刺激营地的离子分泌物,肠的离子运输上的 GH 效果被 cNOS 的活动在细胞内部的水平调停。 | Roberto Berni Canani Pia Cirillo Giuseppe Mallardo Vittoria Buccigrossi Annalisa Passariello Serena Ruotolo Giulio De Marco Francesco Porcaro Alfredo Guarino | 2006 | World Journal of Gastroenterology2006，12，29： | 3 |
| 10 | 迈向学习型社会——运用ICT学习的全球挑战显示文摘知识时代的来临,在全世界提出了对学习型社会的新需求。'运用ICT进行学习'作为一种新的终身技能、新的学习理论、新的全球学习方式和新的学习工具格外引人瞩目。运用ICT来创造未来学习型社会存在着十大挑战。 | Bernie Trilling 陆伟玲 | 2005 | 中国电化教育2005，，1： | 3 |
| 11 | Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study显示文摘AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care system.METHODS This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults. | Cristina Stasi Caterina Silvestri Roberto Berni Maurizia Rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani | 2018 | World Journal of Hepatology2018，10，5： | 3 |
| 12 | The causes and management of oral malodor显示文摘 | Bernie KM | 2002 | Dent Today2002，21，2： | 2 |
| 13 | Initial experience with magnetic resonance imaging of atrial scar and co-registration with electroanatomic voltage mapping during atrial fibrillation: Success and limitations显示文摘 | David D. Spragg Irfan Khurram Stefan L. Zimmerman Hirad Yarmohammadi Bernie Barcelon Matthew Needleman David Edwards Joseph E. Marine Hugh Calkins Saman Nazarian | 2012 | Heart Rhythm2012，，12： | 2 |
| 14 | Diarrhea in neonatal intensive care unit显示文摘AIM:To investigate the frequency,etiology,and current management strategies for diarrhea in newborn.METHODS:Retrospective,nationwide study involving 5801 subjects observed in neonatal intensive care units during 3 years.The main anamnesis and demographic characteristics,etiology and characteristics of diarrhea,nutritional and therapeutic management,clinical outcomes were evaluated.RESULTS:Thirty-nine cases of diarrhea(36 acute,3 chronic) were identified.The occurrence rate of diarrhea was 6.72 per 1000 hospitalized newborn.Etiology was defined in 29 of 39 newborn(74.3%):food allergy(20.5%),gastrointestinal infections(17.9%),antibiotic-associated diarrhea(12.8%),congenital defects of ion transport(5.1%),withdrawal syndrome(5.1%),Hirschsprung's disease(2.5%),parenteral diarrhea(2.5%),cystic fibrosis(2.5%),and metabolic disorders(2.5%).Three patients died due to complications related to diarrhea(7.7%).In 19 of 39 patients(48.7%),rehydration was performed exclusively by the enteral route.CONCLUSION:Diarrhea in neonates is a challenging clinical condition due to the possible heterogeneous etiologies and severe outcomes.Specific guidelines are advocated in order to optimize management of diarrhea in this particular setting. | Annalisa Passariello Gianluca Terrin Maria Elisabetta Baldassarre Mario De Curtis Roberto Paludetto Roberto Berni Canani | 2010 | World Journal of Gastroenterology2010，16，21： | 2 |
| 15 | Thermal and narrowband multispectral remote sensing for vegetation monitoring from an un- manned aerial vehicle显示文摘 | Berni J Zarco-Tejada P J Suarez L | 2009 | IEEE Transactions on Geoscience and Re- mote Sensing2009，47，3： | 1 |
| 16 | Ce 3d XPS study of composite CexMn1-xO2-y wet oxidation catalysts显示文摘 | Larachi F Pierre J Adnot A Bernis A | | 0，，1： | 1 |
| 17 | Mapping radiation interception in row-structured or- chards using 3D simulation and high-resolution airborne imagery acquired from a UAV显示文摘 | Guillen-Climent M L Zarco-Tejada P J Berni J A J et al | 2012 | Precision Agricul- ture2012，13，4： | 1 |
| 18 | Diagnostic value of faecal calprotectin in paediatric gastroenterology clinical practice显示文摘 | R. Berni Canani L. Rapacciuolo M.T. Romano L. Tanturri de Horatio G. Terrin F. Manguso P. Cirillo F. Paparo R. Troncone | 2004 | Digestive and Liver Disease2004，，7： | 1 |
| 19 | Secular trend and intrapop2ulational variation in age at menopause in Spanish women显示文摘 | Varea C Bernis C Montero P | 2000 | J Biosoc Sci2000，32，： | 1 |
| 20 | Offshore wind energy in urope-a yeview of the state-of-the-art 显示文摘 | ANDREW R HENDERSON COLIN MOEGAN BERNIE SMITH | 2003 | Wind Energy2003，，6： | 1 |
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