|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis显示文摘AIM:To investigated the molecular cause of very early-onset ulcerative colitis(UC)in an 18-mo-old affected child.METHODS:We analysed the interleukin-10(IL10)receptor genes at the DNA and RNA level in the proband and his relatives.Beta catenin and tumor necrosis factor-α(TNFα)receptors were analysed in the proteins extracted from peripheral blood cells of the proband,his relatives and familial adenomatous polyposis(FAP)and PTEN hamartoma tumor syndrome(PHTS)patients.Samples were also collected from the proband’s inflamed colorectal mucosa and compared to healthy and tumour mucosa collected from a FAP patient and patients affected by sporadic colorectal cancer(CRC).Finally,we examined mesalazine and azathioprine effects on primary fibroblasts stabilised from UC and FAP patients.RESULTS:Our patient was a compound heterozygote for the IL10RB E47K polymorphism,inherited from his father,and for a novel point mutation within the IL10RA promoter(the-413G->T),inherited from his mother.Beta catenin and tumour necrosis factorαreceptors-Ⅰ(TNFRI)protein were both over-expressed in peripheral blood cells of the proband’s relatives more than the proband.However,TNFRII was over-expressed only in the proband.Finally,both TNFα-receptors were shown to be under-expressed in the inflamed colon mucosa and colorectal cancer tissue compared to healthy colon mucosa.Consistent with this observation,mesalazine and azathioprine induced,in primary fibroblasts,IL10RB and TNFRII over-expression and TNFRI and TNFαunder-expression.We suggest thatβ-catenin and TNFRI protein expression in peripheral blood cells could represent molecular markers of sub-clinical disease in apparently healthy relatives of patients with early-onset UC.CONCLUSION:A synergistic effect of several variant alleles of the IL10 receptor genes,inherited in a Mende-lian manner,is involved in UC onset in this young child. | Martina Galatola Erasmo Miele Caterina Strisciuglio Lorella Paparo Daniela Rega Paolo Delrio Francesca Duraturo Massimo Martinelli Giovanni Battista Rossi Annamaria Staiano Paola Izzo Marina De Rosa | 2013 | World Journal of Gastroenterology2013，19，46： | 7 |
| 2 | CT of the abdomen : degree and quality of enhancement obtained with two concentrations of the same iodinated contrast medium with fixed iodine delivery rate and total iodine load 显示文摘 | Paparo F Garello I Bacigalupo L | 2014 | Eur J Radio12014，83，11： | 1 |
| 3 | Diagnostic value of faecal calprotectin in paediatric gastroenterology clinical practice显示文摘 | R. Berni Canani L. Rapacciuolo M.T. Romano L. Tanturri de Horatio G. Terrin F. Manguso P. Cirillo F. Paparo R. Troncone | 2004 | Digestive and Liver Disease2004，，7： | 1 |
| 4 | Optical spin-to-orbital angular momentum conversion in inhomogeneous anisntropic media 显示文摘 | Marrucci L Manzo C Paparo D | 2006 | Physical Review Letters2006，96，16： | 1 |
| 5 | Optical spin-to-or- bital angular momentum conversion in inhomogeneous ani- sotropic media显示文摘 | MARRUCCI L MANZO C PAPARO D | 2006 | Physical Review Letters2006，96，16： | 1 |
| 6 | Seronegative spondy- loarthropathies: what radiologists should know 显示文摘 | Paparo F Revelli M Semprini A | 2014 | Radiol Med2014，119，3： | 1 |
| 7 | Multimodality imaging of chronic tophaceous out 显示文摘 | Paparo F Sconfienza LM Muda A | 2010 | Reumatismo2010，62，： | 1 |
| 8 | Optical spin-to-orbital angular momentum conversion in inhomogeneous anisotropic media显示文摘 | Marrucci L Manzo C Paparo D | 2006 | Physical Review Letters2006，96，16： | 1 |
| 9 | Optical spin- to-orbital angular momentum conversion in inhomogeneous anisotropic media显示文摘 | Marrucci L Manzo C Paparo D | 2006 | Physical review letters2006，，16： | 1 |
| 10 | Optical spin-to- orbital angular momentum conversion in inhomogeneous anisotropic media 显示文摘 | MARRUCCI L MANZO C PAPARO D | 2006 | Physical Review Letters2006，96，16： | 1 |
| 11 | Effect of etadication of Helicobacter pylori in patient fundic atrophic fastritis显示文摘 | Tucci A Biasco G Paparo GT | 1997 | New England Journal of Medcine1997，336，： | 1 |
| 12 | Interleukine 6 ( IL 6) may be a link between myasthenia gravis and myoepithelioma of the parotid gland显示文摘 | Saaaano P Paparo F Ramineri V | 2007 | Med Hypothesis2007，68，2： | 1 |
| 13 | Parotid glands tumours:overview of a 10-year experience with 282 patients,focusing on 231 benign epithelial neoplasms显示文摘 | Ungari C Paparo F Colangeli W | 2008 | Eur Rev Med Pharmacol Sci2008，12，5： | 1 |
| 14 | Primary non-Hodgkin’s T-Cell lymphoma of the esophagus显示文摘 | Luigi Bolondi MD Roberto Giorgio MD Vittorio Santi MD Giovanni F. Paparo MD Stefano Pileri MD Giulio Febo MD Gian Carlo Caletti MD Simonetta Poggi MD Roberto Corinaldesi MD Dr. Luigi Barbara MD | 1990 | Digestive Diseases and Sciences1990，，11： | 1 |
| 15 | CT of the abdomen: degree and quality of enhancement obtained with two concentrations of the same iodinated contrast medium with fixed iodine delivery rate and total iodine load显示文摘 | Paparo F Garello I Bacigalupo L | 2014 | Eur J Radiol2014，83，： | 1 |
| 16 | Interleukine-6 (IL-6) may be a link between myasthenia gravis and myoepithelioma of the parotid gland显示文摘 | Sassano P Paparo F Ramiefi V | 2007 | Med Hypotheses2007，68，2： | 1 |
| 17 | Giant cell arteritis:a systematic review of the qualitative and semiquantitative methods to assess vasculitis with 18Ffluorodeoxyglucose positron emission tomography显示文摘 | Puppo C Massollo M Paparo F | 2014 | Biomed Res Int2014，2014，57： | 1 |
| 18 | Experimental evidence for critical dynamics in microfacturing processes显示文摘 | Paparo G Vespignani A | 1994 | Phys Rev Lett1994，73，25： | 1 |
| 19 | Weekend therapy for the treatment of Helicobacter pylori infection显示文摘 | Tucci A Poli L Paparo G F | 1998 | Am J Gastroenterol1998，93，5： | 1 |
| 20 | Gastric acid secretion and gastric emptying of liquids in 99 male duodenal ulcer patients显示文摘 | Prof. Roberto Corinaldesi Vincenzo Stanghellini Giovanni Francesco Paparo Anna Paternicò Anna Giulia Rusticali Luigi Barbara | 1989 | Digestive Diseases and Sciences1989，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员