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您的检索式：作者名="Arda Demirkan"
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| 1 | Enteral glutamine pretreatment does not decrease plasma endotoxin level induced by ischemia-reperfusion injury in rats显示文摘AIM:To investigate whether oral glutamine pretreatment prevents impairment of intestinal mucosal integrity during ischemia-reperfusion (I/R) in rats. METHODS: The study was performed as two series with 40 rats in each. Each series of animals was divided into four groups. The first group was used as a control. Animals in the second group were only pretreated with oral glutamine, 1 g/kg for 4 d. The third group received a normal diet, and underwent intestinal I/R, while the fourth group was pretreated with oral glutamine in the same way, and underwent intestinal I/R. Intestinal mucosal permeability to 51Cr-labeled EDTA was measured in urine in the first series of animals. In the second series, histopathological changes in intestinal tissue and plasma endotoxin levels were evaluated. RESULTS: Intestinal I/R produced a significant increase in intestinal permeability, plasma endotoxin level and worsened histopathological alterations. After intestinal I/R, permeability was significantly lower in glutamine- treated rats compared to those which received a normal diet. However, no significant change was observed in plasma endotoxin levels or histopathological findings. CONCLUSION: Although glutamine pretreatment seems to be protective of intestinal integrity, upon I/R injury, such an effect was not observable in the histopathological changes or plasma endotoxin level. | Arda Demirkan Erkin Orazakunov Berna Sava■ M Ayhan Kuzu Mehmet Melli | 2008 | World Journal of Gastroenterology2008，14，3： | 2 |
| 2 | Endotoxin level in ischemia–reperfusion injury in rats: Effect of glutamine pretreatment on endotoxin levels and gut morphology显示文摘 | Arda Demirkan Berna Sava? Mehmet Melli | 2010 | Nutrition2010，，1： | 1 |
| 3 | Unroofing and Curettage for the Treatment of Acute and Chronic Pilonidal Disease显示文摘 | Ilknur Kepenekci Arda Demirkan Haydar Celasin Ibrahim Ethem Gecim | 2010 | World Journal of Surgery2010，，1： | 1 |
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