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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 3 | Sudden sensorineural hearing loss显示文摘 | Benjamin E Schreiber Charlotte Agrup Dorian O Haskard Linda M Luxon | 2010 | The Lancet2010，，9721： | 1 |
| 4 | Inflammatory Bowel Disease in African American Children Compared With Other Racial/Ethnic Groups in a Multicenter Registry显示文摘 | Jolanda M. White Siobhán O’Connor Harland S. Winter Melvin B. Heyman Barbara S. Kirschner George D. Ferry Stanley A. Cohen Robert N. Baldassano Terry Smith Traci Clemons Benjamin D. Gold | 2008 | Clinical Gastroenterology and Hepatology2008，，12： | 1 |
| 5 | Genetically modied cells in regenerative medicine and tissue engineering显示文摘 | Sheyn D Mizrahi O Benjamin S | 2010 | Adv Drug Deliver Rev2010，62，78： | 1 |
| 6 | The effect of dietary docosahexaenoic acid (DHA)on growth,survival and pigmentation of California halibut Paralichthys californicus larvae ( Ayres, 1810 ) 显示文摘 | Veronica V O Juan P L a Benjamin B S | 2010 | Aquaculture2010，302，： | 1 |
| 7 | Esophageal varices on computed tomography and subsequent variceal hemorrhage显示文摘 | Ma Somsouk Katherine To’o Mujtaba Ali Eric Vittinghoff Benjamin M. Yeh Judy Yee Alex Monto John M. Inadomi Rizwan Aslam | 2014 | Abdominal Imaging2014，，2： | 1 |
| 8 | Diagnosis and localization of insulinoma: the value of modern magnetic resonance imaging in conjunction with calcium stimuluation catheterisation显示文摘 | Maralun R Druce Vasantha M Muthuppalaniappan Benjamin O' Leary | 2010 | European Journal of Endocrinology2010，162，： | 1 |
| 9 | Laparoscopic colectomy for colonic polyps显示文摘 | Zomra O Benjamin B Reshef A | 2009 | Surg Enclose2009，23，3： | 1 |
| 10 | Root distri- bution following spatial separation of water and nitrogen supply in furrow irrigated corn 显示文摘 | Skinner R H Hanson J D Benjamin J O | 1998 | Plant and Soil1998，199，2： | 1 |
| 11 | Sa1899 Fecal Recovery of Ingested Cellular DNA: Implications for Noninvasive Detection of Upper Gastrointestinal Neoplasms显示文摘 | Benjamin B. Strauss Tracy C. Yab Helen M. O William R. Taylor Douglas W. Mahoney Julie A. Simonson John D. Christensen Suresh T. Chari David A. Ahlquist | 2014 | Gastroenterology2014，，5： | 1 |
| 12 | Metformin therapy in a transgenic mouse model of Huntington's disease 显示文摘 | THONG C M JESSICA L B BENJAMIN O | 2007 | Neurosci Lett2007，411，2： | 1 |
| 13 | The multi- functional NS1 protein of influenza A viruses显示文摘 | BENJAMIN G H RICHARD E R JUAN O | 2008 | The Journal of General Virology2008，89，10： | 1 |
| 14 | Thrust vectoring-theory, labora- tory, and flight tests 显示文摘 | BENJAMIN G O SHERBAUM V | 1993 | Journal of Propulsion and Power1993，9，1： | 1 |
| 15 | Passively mode-locked diode laser with optimized dispersion man- agement 显示文摘 | Jan C B Rouven O H P Benjamin D | 2015 | IEEE Journal of Selected Topics in Quan- tum Electronics2015，21，11： | 1 |
| 16 | Comparison of crystal and solution structures and 1H-NMR and ^13C-NMR chemical shifts for grandiflorenic acid, and monoginoic acid 显示文摘 | Raul G E Jutie B Benjamin O | 1997 | Can J Chem1997，75，： | 1 |
| 17 | Relation of frequency and severity of mitral regurgitation to survival among patients with left ventricular systolic dysfunction and heart failure显示文摘 | Benjamin H Trichon G.Michael Felker Linda K Shaw Christopher H Cabell Christopher M O’Connor | 2003 | The American Journal of Cardiology2003，，5： | 1 |
| 18 | Phenoloxidase from shrimp(Penaeus setiferus) : purification and some properties显示文摘 | Benjamin K S Maurice R M Steven O W | 1987 | Journal of Agricultural and Food Chemistry1987，，35： | 1 |
| 19 | Laparoscopic colectomy for co- Ionic polyps 显示文摘 | Zmora O Benjamin B Reshef A | 2009 | Surg Endosc2009，23，3： | 1 |
| 20 | CPR quality improvement during in-hospital cardiac arrest using a real-time audiovisual feedback system显示文摘 | Benjamin S. Abella Dana P. Edelson Salem Kim Elizabeth Retzer Helge Myklebust Anne M. Barry Nicholas O’Hearn Terry L. Vanden Hoek Lance B. Becker | 2006 | Resuscitation2006，，1： | 1 |
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