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| 1 | Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis显示文摘MicroRNAs (miRNA ) 指导在基因表示的一个重要角色在植物为到环境条件的发展进程和回答要求了的顺序特定的 posttranscriptional 基因 silencing 玩。然而,很少对 transcriptional 和 miRNA 表示的 posttranscriptional 规定被知道。Histone acetylation 在染色质改变起一个重要作用并且为基因激活被要求。由在 Arabidopsis 的异种分析 miRNAs 和相应主要 miRNAs 的子集的累积,我们显示出那 histone acetyltransferase GCN5 (一般控制非镇压的 protein5 )在 miRNA 上有一般压抑的效果生产,当它为一个子集的表示被要求时(例如压力可诱导) MIRNA 基因。在 miRNA 生产的 GCN5 的一般否定功能多半通过象 DICER LIKE1 (DCL1 ) 那样的 miRNA 机械基因的间接压抑被完成,有锯齿(SE ) ,偏下性的 LEAVES1 (HYL1 ) 和 ARGONAUTE1 (AGO1 ) 。染色质 immunoprecipitation 试金表明 GCN5 指向到 MIRNA 基因的一个子集并且为在这些 loci 的 histone H3 离氨酸 14 的 acetylation 被要求。而且,由 trichostatin 的 histone deacetylation 的抑制一个处理或在 histone deacetylase,基因异种损害了某些 miRNAs 的累积。这些数据一起建议 Arabidopsis GCN5 在 transcriptional 和 posttranscriptional 层次防碍 miRNA 小径, histone acetylation/deacetylation 是涉及 miRNA 的规定的 epigenetic 机制生产。 | Wanhui Kim Moussa Benhamed Caroline Servet David Latrasse Wei Zhang Marianne Delarue Dao-Xiu Zhou | 2009 | Cell Research2009，19，7： | 10 |
| 2 | The lncRNA APOLO interacts with the transcription factor WRKY42 to trigger root hair cell expansion in response to cold显示文摘Plant long noncoding RNAs(lncRNAs)have emerged as important regulators of chromatin dynamics,impacting on transcriptional programs leading to different developmental outputs.The lncRNA AUXIN-REGULATED PROMOTER LOOP(APOLO)directly recognizes multiple independent loci across the Arabidopsis genome and modulates their three-dimensional chromatin conformation,leading to transcriptional shifts.Here,we show that APOLO recognizes the locus encoding the root hair(RH)master regulator ROOT HAIR DEFECTIVE 6(RHD6)and controls RHD6 transcriptional activity,leading to cold-enhanced RH elongation through the consequent activation of the transcription factor gene RHD6-like RSL4.Furthermore,we demonstrate that APOLO interacts with the transcription factor WRKY42 and modulates its binding to the RHD6 promoter.WRKY42 is required for the activation of RHD6 by low temperatures and WRKY42 deregulation impairs cold-induced RH expansion.Collectively,our results indicate that a novel ribonucleoprotein complex with APOLO and WRKY42 forms a regulatory hub to activate RHD6 by shaping its epigenetic environment and integrate signals governing RH growth and development. | Michael Moison Javier Martinez Pacheco Leandro Lucero Camille Fonouni-Farde Johan Rodriguez-Melo Natanael Mansilla Aurelie Christ Jeremie Bazin Moussa Benhamed Fernando Ibanez Martin Crespi Jose M.Estevez Federico Ariel | 2021 | Molecular Plant2021，14，6： | 8 |
| 3 | 严重创伤病人心肌肌钙蛋白Ⅰ释放的发生率及其意义显示文摘 | Alain R.Edouard Marie-Louise Felten Jean-Louis Hebert Claudine Cosson Laurent Martin Dan Benhamou 钟敏(译) 曾因明(审) | 2005 | 国外医学(麻醉学与复苏分册)2005，26，1： | 6 |
| 4 | Applicability and variability of liver stiffness measurements according to probe position显示文摘AIM: To investigate the liver stiffness measurement (LSM) applicability and variability with reference to three probe positions according to the region of liver biopsy. METHODS: The applicability for LSM was defined as at least 10 valid measurements with a success rate greater than 60% and an interquartile range/median LSM < 30%. The LSM variability compared the inter-position concordance and the concordance with FibroTest. RESULTS: Four hundred and forty two consecutive patients were included. The applicability of the anterior position (81%) was significantly higher than that of the reference (69%) and lower positions (68%), (both P = 0.0001). There was a signif icant difference (0.5 kPa, 95% CI 0.13-0.89; P < 0.0001) between mean LSM estimated at the reference position (9.3 kPa) vs the anterior position (8.8 kPa). Discordance between positions was associated with thoracic fold (P = 0.008). The discordance rate between the reference position result and FibroTest was higher when the 7.1 kPa cutoff was used to define advanced fibrosis instead of 8.8 kPa (33.6% vs 23.5%, P = 0.03).CONCLUSION: The anterior position of the probe should be the fi rst choice for LSM using Fibroscan, as it has a higher applicability without higher variability compared to the usual liver biopsy position. | Patrick Ingiliz Kim Pav Chhay Mona Munteanu Pascal Lebray Yen Ngo Dominique Roulot Yves Benhamou Dominique Thabut Vlad Ratziu Thierry Poynard | 2009 | World Journal of Gastroenterology2009，15，27： | 5 |
| 5 | Hepatitis B virus genotypes and extrahepatic manifestations显示文摘 | Patrice Cacoub David Saadoun Marc Bourlière Hacene Khiri Agnes Martineau Yves Benhamou Marina Varastet Stanislas Pol Vincent Thibault Michel Rotily Philippe Halfon | 2005 | Journal of Hepatology2005，，5： | 5 |
| 6 | The Clinical Efficacy and Pharmacokinetics of Intraperitoneal Ropivacaine for Laparoscopic Cholecystectomy显示文摘 | Thierry Labaille Jean Xavier Mazoit Xavier Paqueron Dominique Franco Dan Benhamou | 2002 | Anesthesia & Analgesia2002，，1： | 2 |
| 7 | Small dimension PDE for discrete Asian options显示文摘 | Benhamou E Duguet A | 2003 | Journal of Economic Dynamics & Control2003，27，： | 2 |
| 8 | HIV感染者中富马酸替诺福韦酯抗HBV的功效显示文摘Tenofovir disoproxil fumarate(TDF)has shown in vitro activity against both HIV and hepatitis B virus(HBV).We retrospectively evaluated the efficacy of TDF(300 mg/d),administered as a part of anti-retroviral therapy,in a large cohort of HIV/HBVcoinfected patients.Sixty-five HIV/HBV-coinfected patients who received TDF for at least 6 months with serum HBV DNA levels above 2.3 log10 copies/mL at TDF initiation and who had stored serum samples before and during TDF therapy were included.Serum HBV DNA was measured on stored samples.The median follow-up period was 12(Q1-Q3:8-17)months.Serum hepatitis B e antigen(HBeAg)was positive in 54 patients(83.1%).Fifty-two patients(80.0%)were receiving lamivudine(LAM)(150 mg twice a day),and 68.8%had documented LAM resistance at baseline.Among HBeAg positive patients,the median reduction from baseline(8.17;Q1-Q3 = 7.30-8.30 log10copies/mL)of serum HBV DNA was 4.56 log10 copies/mL(Q1-Q3 = 3.33-5.55)(P <.0001).In HBeAg-negative patients,serum HBV DNA decline from baseline(4.83;Q1-Q3 = 2.69-6.40 log10 copies/mL)was 2.53 log10 copies/mL(Q1-Q3 = 0.39-4.10).At the end of the study,HBV DNA became undetectable in 29.6%and 81.6%of the HBeAg positive and HBeAg-negative patients,respectively.Serum HBeAg became negative in 4 patients,2 of whom acquired serum hepatitis B e antibody.In conclusion,this retrospective analysis demonstrates the efficacy of TDF against wild-type,presumed precore mutants and LAM-resistant HBV when used as a part of anti-retroviral therapy in HIV-coinfected patients. | Benhamou Y Fleury H. Trimoulet P. 陈云茹(译) 史敏(校) | 2006 | 世界核心医学期刊文摘(胃肠病学分册)2006，2，9： | 2 |
| 9 | Anti-hepatitis B virus efficacy of tenofovir disoproxil fumarate in HIV-infected patients显示文摘 | Benhamou Y Fleury H Trimoulet P | 2006 | Hepatology2006，43，3： | 1 |
| 10 | Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome显示文摘 | Regimbeau C Benhamou Y | 2001 | Aliment Pharmacol Ther2001，15，3： | 1 |
| 11 | Cytological effects of cellulases in the parasitism of Phytophthora parasitica by Pythium oligandrum显示文摘 | Picard K Tirilly Y Benhamou N | 2000 | Applied and Environmental Microbiology2000，66，10： | 1 |
| 12 | Postoperative analgesia after cesarean section:sublingual buprenorphine versus subcutaneous morphine显示文摘 | Abid A Benhamou D Labaille T | 1990 | Ann Fr Anesth Reanim1990，9，： | 1 |
| 13 | Effects of milsana and benzothiadiazole on the ultrastructure of powdery mildew haustoria on cucumber 显示文摘 | Wurms K Labbe C Benhamou N | 1999 | Phy-topathology1999，89，9： | 1 |
| 14 | Safety and efficacy of adefovir dipivoxil in patients infected with lamivudine-resistant hepatitis B and HIV-1显示文摘 | Benhamou Y Thibault V Vig P | 2006 | J Hepatol2006，44，1： | 1 |
| 15 | Simple recipe for blocking ion channels显示文摘 | Benham CD | 2005 | Nat Biotechnol2005，23，10： | 1 |
| 16 | The Long Tail: Myth or Reality?显示文摘 | BENGHOZI P J BENHAMOU F | 2010 | International Journal of Arts Management2010，12，3： | 1 |
| 17 | Successful rescue therapy with tenofovir in a patient with hepatic decompensation and adefovir resistant HBV mutant 显示文摘 | Ratziu V Thibanh V Benhamou Y | 2006 | Comp Hepatol2006，5，： | 1 |
| 18 | Large-scale open trials with etodolac in France:an assessmsnt of safety显示文摘 | | 1990 | Rheumatology International1990，10，1： | 1 |
| 19 | Vanilloid and TRP channels:a family of lipid-gated cation channels显示文摘 | DAVIS JB RANDALL AD | 2002 | Neuropharmacology2002，42，7： | 1 |
| 20 | Strontium ranelate reduces the risk of vertebral and nonvertebral fractures in women eighty years of age and older显示文摘 | Seeman E Vellas B Benhamou C | 2006 | J Bone Miner Res2006，21，7： | 1 |
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