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| 1 | Dental stem cell and dental tissue regeneration显示文摘The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important function in mastication, articulation, and aesthetics. These characteristics, to a certain extent, greatly complicate the research in tooth regeneration. Recently, new ideas for tooth and tissue regeneration have begun to appear with rapid developments in the theories and technologies in tissue engineering. Numerous types of stem cells have been isolated from dental tissue, such as dental pulp stem cells (DPSCs), stem cells isolated from human pulp of exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAPs), and dental follicle cells (DFCs). All these cells can regenerate the tissue of tooth. This review outlines the cell types and strategies of stem cell therapy applied in tooth regeneration, in order to provide theoretical basis for clinical treatments. | Qiming Zhai Zhiwei Dong Wei Wang Bei Li Yan Jin | 2019 | Frontiers of Medicine2019，13，2： | 23 |
| 2 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 3 | A Novel Phenylpropanoid-substituted Catechin Glycoside and a New Dihydrochalcone from Sarcandra glabra显示文摘A novel phenylpropanoid-substituted catechin glycoside glabraoside A 1 and a newdihydrochalcone 3′-(7″-allylphenyl)-2′,4′,4″-trihydroxy-6′-methoxydihydrochalcone 2 wereisolated from the herbs of Sarcandra glabra. Their structures were elucidated on the basis ofspectroscopic analyses and chiroptical methods. | Yuan LI Dong Ming ZHANG Shi Shah YU Jian Bei LI Yong Ming LUO | 2006 | Chinese Chemical Letters2006，17，2： | 11 |
| 4 | Metabolism pathways of arachidonic acids:mechanisms and potential therapeutic targets显示文摘The arachidonic acid(AA)pathway plays a key role in cardiovascular biology,carcinogenesis,and many inflammatory diseases,such as asthma,arthritis,etc.Esterified AA on the inner surface of the cell membrane is hydrolyzed to its free form by phospholipase A2 (PLA2),which is in turn further metabolized by cyclooxygenases(COXs)and lipoxygenases(LOXs)and cytochrome P450(CYP)enzymes to a spectrum of bioactive mediators that includes prostanoids,leukotrienes(LTs),epoxyeicosatrienoic acids(EETs),dihydroxyeicosatetraenoic acid(diHETEs),eicosatetraenoic acids(ETEs),and lipoxins(LXs).Many of the latter mediators are considered to be novel preventive and therapeutic targets for cardiovascular diseases(CVD),cancers,and inflammatory diseases.This review sets out to summarize the physiological and pathophysiological importance of the AA metabolizing pathways and outline the molecular mechanisms underlying the actions of AA related to its three main metabolic pathways in CVD and cancer.progression will provide valuable insight for developing new therapeutic drugs for CVD and anti-cancer agents such as inhibitors of EETs or 2J2.Thus,we herein present a synopsis of AA metabolism in human health,cardiovascular and cancer biology,and the signaling pathways involved in these processes.To explore the role of the AA metabolism and potential therapies,we also introduce the current newly clinical studies targeting AA metabolisms in the different disease conditions. | Bei Wang Lujin Wu Jing Chen Lingli Dong Chen Chen Zheng Wen Jiong Hu Ingrid Fleming Dao Wen Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 7 |
| 5 | Observation and modeling on irregular purple soil water infiltration process显示文摘The infiltration process is a critical link between surface water and groundwater. In this research, a specific device to observe infiltration processes in homogeneous and heterogeneous soils with triangular and inverted triangular profiles was designed, and the Green-Ampt model was employed for the process simulation. The results indicate that(1) the wetting front in coarse texture soils transports faster than in fine texture soils;(2) for the homogeneous case, the wetting front in triangularshaped soils transports faster than the inverted triangular type, but the triangular-shaped soils show a lower infiltration rate;(3) in the initial step, the wetting front in triangular-shaped soils shows higher transport speed, but depicts lower speed with increase in the time;(4) both the wetting front and infiltration rate show a significant exponential relation with the time. From these findings, an empirical model was developed which agrees well with the observed data and provides a useful method for this field of soil research. | CHENG Dong-bing DONG Lin-yao QIAN Feng SUN Bei | 2017 | Journal of Mountain Science2017，14，6： | 6 |
| 6 | Ionomycin ameliorates hypophosphatasia via rescuing alkaline phosphatase deficiency-mediated L-type Ca^(2+) channel internalization in mesenchymal stem cells显示文摘The loss-of-function mutations in the ALPL result in hypophosphatasia(HPP), an inborn metabolic disorder that causes skeletal mineralization defects. In adults, the main clinical features are early loss of primary or secondary teeth, osteoporosis, bone pain,chondrocalcinosis, and fractures. However, guidelines for the treatment of adults with HPP are not available. Here, we show that ALPL deficiency caused a reduction in intracellular Ca2+ influx, resulting in an osteoporotic phenotype due to downregulated osteogenic differentiation and upregulated adipogenic differentiation in both human and mouse bone marrow mesenchymal stem cells(BMSCs). Increasing the intracellular level of calcium in BMSCs by ionomycin treatment rescued the osteoporotic phenotype in alpl+/- mice and BMSC-specific(Prrx1-alpl-/-) conditional alpl knockout mice. Mechanistically, ALPL was found to be required for the maintenance of intracellular Ca2+ influx, which it achieves by regulating L-type Ca2+ channel trafficking via binding to the α2δsubunits to regulate the internalization of the L-type Ca2+ channel. Decreased Ca2+ flux inactivates the Akt/GSK3β/β-catenin signaling pathway, which regulates lineage differentiation of BMSCs. This study identifies a previously unknown role of the ectoenzyme ALPL in the maintenance of calcium channel trafficking to regulate stem cell lineage differentiation and bone homeostasis. Accelerating Ca2+ flux through L-type Ca2+ channels by ionomycin treatment may be a promising therapeutic approach for adult patients with HPP. | Bei Li Xiaoning He Zhiwei Dong Kun Xuan Wei Sun Li Gao Shiyu Liu Wenjia Liu Chenghu Hu Yimin Zhao Songtao Shi Yan Jin | 2020 | Bone Research2020，8，2： | 4 |
| 7 | Bioremediation of Hexavalent Chromium Pollution by Sporosarcina saromensis M52 Isolated from Offshore Sediments in Xiamen, China显示文摘Objective Cr(VI)removal from industrial effluents and sediments has attracted the attention of environmental researchers.In the present study,we aimed to isolate bacteria for Cr(VI)bioremediation from sediment samples and to optimize parameters of biodegradation.Methods Strains with the ability to tolerate Cr(VI)were obtained by serial dilution and spread plate methods and characterized by morphology,16S r DNA identification,and phylogenetic analysis.Cr(VI)was determined using the 1,5-diphenylcarbazide method,and the optimum p H and temperature for degradation were studied using a multiple-factor mixed experimental design.Statistical analysis methods were used to analyze the results.Results Fifty-five strains were obtained,and one strain(Sporosarcina saromensis M52;patent application number:201410819443.3)having the ability to tolerate 500 mg Cr(VI)/L was selected to optimize the degradation conditions.M52 was found be able to efficiently remove 50-200 mg Cr(VI)/L in24 h,achieving the highest removal efficiency at p H 7.0-8.5 and 35°C.Moreover,M52 could completely degrade 100 mg Cr(VI)/L at p H 8.0 and 35°C in 24 h.The mechanism involved in the reduction of Cr(VI)was considered to be bioreduction rather than absorption.Conclusion The strong degradation ability of S.saromensis M52 and its advantageous functional characteristics support the potential use of this organism for bioremediation of heavy metal pollution. | ZHAO Ran WANG Bi CAI Qing Tao LI Xiao Xia LIU Min HU Dong GUO Dong Bei WANG Juan FAN Chun | 2016 | Biomedical and Environmental Sciences2016，29，2： | 4 |
| 8 | 假肥大型肌营养不良症(DMD/BMD)遗传学诊断及剪接突变的致病性分析(英文)显示文摘目的:针对100例无亲缘关系的假肥大型肌营养不良症(DMD/BMD)患者,联合应用多种检测技术进行遗传学诊断,并且建立个体化产前诊断及胚胎植入前遗传学诊断方案,以最大限度地降低DMD/BMD患儿的出生。创新点:通过minigene剪接实验分析DMD:c.1149+1G>A和c.1150-2A>G突变是否导致剪接异常,并确定剪接方式。方法:收集100例无亲缘关系DMD/BMD患者的临床资料,应用多重连接依赖式探针扩增技术(MLPA)、第二代测序(NGS)、minigene剪接实验(HMSA)进行遗传学诊断,并通过单体型分析及性别鉴定进行胚胎植入前遗传学诊断。结论:联合应用多种检测技术可以尽早地对患者进行遗传学诊断,为临床遗传咨询和产前诊断及胚胎植入前遗传学诊断提供了科学依据。 | Yan-mei YANG Kai YAN Bei LIU Min CHEN Li-ya WANG Ying-zhi HUANG Ye-qing QIAN Yi-xi SUN Hong-ge LI Min-yue DONG | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，9： | 3 |
| 9 | Characterization and Expression Analysis of a Complement Component Gene in Sea Cucumber(Apostichopus japonicus)显示文摘The complement system plays a crucial role in the innate immune system of animals. It can be activated by distinct yet overlapping classical, alternative and lectin pathways. In the alternative pathway, complement factor B(Bf) serves as the catalytic subunit of complement component 3(C3) convertase, which plays the central role among three activation pathways. In this study, the Bf gene in sea cucumber(Apostichopus japonicus), termed Aj Bf, was obtained by rapid amplification of c DNA ends(RACE). The full-length c DNA of Aj Bf was 3231 bp in length barring the poly(A) tail. It contained an open reading frame(ORF) of 2742 bp encoding 913 amino acids, a 105 bp 5'-UTR(5'-terminal untranslated region) and a 384 bp 3'-UTR. Aj Bf was a mosaic protein with six CCP(complement control protein) domains, a VWA(von Willebrand factor A) domain, and a serine protease domain. The deduced molecular weight of Aj Bf protein was 101 k Da. Quantitative real time PCR(q RT-PCR) analysis indicated that the expression level of Aj Bf in A. japonicus was obviously higher at larval stage than that at embryonic stage. Expression detection in different tissues showed that Aj Bf expressed higher in coelomocytes than in other four tissues. In addation, Aj Bf expression in different tissues was induced significantly after LPS or Poly I:C challenge. These results indicated that Aj Bf plays an important role in immune responses to pathogen infection. | CHEN Zhong ZHOU Zunchun YANG Aifu DONG Ying GUAN Xiaoyan JIANG Bei WANG Bai | 2015 | Journal of Ocean University of China2015，14，6： | 3 |
| 10 | Impact of psychosocial stress on airway inflammation and its mechanism in a mUrine model of allergic asthma显示文摘 | LI Bei DUAN Xiao-hong WU Jin-feng LIU Bao-jun LUO Qing-li JIN Hua-liang DU Yi-jie ZHANG Hong-ying CAO Yu-xue DONG Jing-cheng | 2013 | Chinese Medical Journal2013，，2： | 3 |
| 11 | Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution显示文摘Inflammatory response plays a critical role in myocardial infarction(MI)repair.The neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been established.Here,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI repair.The eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation effects.In in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac function.This study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair. | Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin | 2022 | Bioactive Materials2022，7，3： | 3 |
| 12 | Identification of banana fusarium wilt using supervised classification algorithms with UAV-based multi-spectral imagery显示文摘The disease of banana Fusarium wilt currently threatens banana production areas all over the world.Rapid and large-area monitoring of Fusarium wilt disease is very important for the disease treatment and crop planting adjustments.The objective of this study was to evaluate the performance of supervised classification algorithms such as support vector machine(SVM),random forest(RF),and artificial neural network(ANN)algorithms to identify locations that were infested or not infested with Fusarium wilt.An unmanned aerial vehicle(UAV)equipped with a five-band multi-spectral sensor(blue,green,red,red-edge and near-infrared bands)was used to capture the multi-spectral imagery.A total of 139 ground sample-sites were surveyed to assess the occurrence of banana Fusarium wilt.The results showed that the SVM,RF,and ANN algorithms exhibited good performance for identifying and mapping banana Fusarium wilt disease in UAV-based multi-spectral imagery.The overall accuracies of the SVM,RF,and ANN were 91.4%,90.0%,and 91.1%,respectively for the pixel-based approach.The RF algorithm required significantly less training time than the SVM and ANN algorithms.The maps generated by the SVM,RF,and ANN algorithms showed the areas of occurrence of Fusarium wilt disease were in the range of 5.21-5.75 hm2,accounting for 36.3%-40.1%of the total planting area of bananas in the study area.The results also showed that the inclusion of the red-edge band resulted in an increase in the overall accuracy of 2.9%-3.0%.A simulation of the resolutions of satellite-based imagery(i.e.,0.5 m,1 m,2 m,and 5 m resolutions)showed that imagery with a spatial resolution higher than 2 m resulted in good identification accuracy of Fusarium wilt.The results of this study demonstrate that the RF classifier is well suited for the identification and mapping of banana Fusarium wilt disease from UAV-based remote sensing imagery.The results provide guidance for disease treatment and crop planting adjustments. | Huichun Ye Wenjiang Huang Shanyu Huang Bei Cui Yingying Dong Anting Guo Yu Ren Yu Jin | 2020 | International Journal of Agricultural and Biological Engineering2020，13，3： | 3 |
| 13 | Two New Iridoid Glucosides from Clerodendrum serratum显示文摘Two new iridoid glucosides, serratoside A and serratoside B, were isolated from the aerial parts of Clerodendrum serratum var. amplexifolium Moldenke. Their structures were elucidated by spectral and chemical methods. | Hui YANG Bei JIANG Zhi NA Yun Pin GUO Han Dong SUN | 2000 | Chinese Chemical Letters2000，11，3： | 2 |
| 14 | A New Phenolic Compound from Thamnolia vermicularis显示文摘A new phenolic compound, thamnolin (1), was isolated from the extract of Thamnolia vermicularis. Its structure was determined as 6-tricosyl-2,4-dimethoxy-phenol by spectral methods. | Bei JIANG, Shuang Xi MEI, Quan Bin HAN, Wei XIANG, Han Dong SUN* Laboratory of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204 | 2001 | Chinese Chemical Letters2001，12，1： | 2 |
| 15 | Quantification and prediction of enteric methane emissions from Chinese lactating Holstein dairy cows fed diets with different dietary neutral detergent fiber/non-fibrous carbohydrate(NDF/NFC)ratios显示文摘Methane(CH_(4))emissions from ruminant production are a significant source of anthropogenic greenhouse gas production,but few studies have examined the enteric CH_(4)emissions of lactating dairy cows under different feeding regimes in China.This study aimed to investigate the influence of different dietary neutral detergent fiber/non-fibrous carbohydrate(NDF/NFC)ratios on production performance,nutrient digestibility,and CH_(4)emissions for Holstein dairy cows at various stages of lactation.It evaluated the performance of CH_(4)prediction equations developed using local dietary and milk production variables compared to previously published prediction equations developed in other production regimes.For this purpose,36 lactating cows were assigned to one of three treatments with differing dietary NDF/NFC ratios:low(NDF/NFC=1.19),medium(NDF/NFC=1.54),and high(NDF/NFC=1.68).A modified acid-insoluble ash method was used to determine nutrient digestibility,while the sulfur hexafluoride technique was used to measure enteric CH4 emissions.The results showed that the dry matter(DM)intake of cows at the early,middle,and late stages of lactation decreased significantly(P<0.01)from 20.9 to 15.4 kg d^(–1),15.3 to 11.6 kg d^(–1),and 16.4 to 15.0 kg d^(–1),respectively,as dietary NDF/NFC ratios increased.Across all three treatments,DM and gross energy(GE)digestibility values were the highest(P<0.05)for cows at the middle and late lactation stages.Daily CH_(4)emissions increased linearly(P<0.05),from 325.2 to 391.9 kg d^(–1),261.0 to 399.8 kg d^(–1),and 241.8 to 390.6 kg d^(–1),respectively,as dietary NDF/NFC ratios increased during the early,middle,and late stages of lactation.CH_(4)emissions expressed per unit of metabolic body weight,DM intake,NDF intake,or fat-corrected milk yield increased with increasing dietary NDF/NFC ratios.In addition,CH_(4)emissions expressed per unit of GE intake increased significantly(P<0.05),from 4.87 to 8.12%,5.16 to 9.25%,and 5.06 to 8.17%respectively,as dietary NDF/NFC ratios increased during the early,middle,and late lactation stages.The modelling results showed that the equation using DM intake as the single variable yielded a greater R^(2)than equations using other dietary or milk production variables.When data obtained from each lactation stage were combined,DM intake remained a better predictor of CH_(4)emissions(R^(2)=0.786,P=0.026)than any other variables tested.Compared to the prediction equations developed herein,previously published equations had a greater root mean square prediction error,reflecting their inability to predict CH_(4)emissions for Chinese Holstein dairy cows accurately.The quantification of CH_(4)production by lactating dairy cows under Chinese production systems and the development of associated prediction equations will help establish regional or national CH_(4)inventories and improve mitigation approaches to dairy production. | DONG Li-feng JIA Peng LI Bin-chang WANG Bei YANG Chun-lei LIU Zhi-hao DIAO Qi-yu | 2022 | Journal of Integrative Agriculture2022，21，3： | 2 |
| 16 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 17 | Transcatheter coil embolization of multiple coronary artery-to-left ventricle fistulas: report of a rare case显示文摘 | LI Ruo-gu FANG Wei-yi SHI Hong-yu QU Xin-kai CHEN Hui QIU Xin-biao XU Ying-jia DONG Jia-lin GUAN Shao-feng JIANG Bei WU Wei-hua | 2008 | Chinese Medical Journal2008，，14： | 2 |
| 18 | Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration显示文摘Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Although microneedles are initially designed to penetrate stratum corneum of skin for transdermal drug delivery, they, recently, have been used to promote wound healing and regeneration of diverse tissues and organs and the results are promising. Despite there are reviews about microneedles, few of them focus on wound healing and tissue regeneration. Here, we review the recent advances of microneedles in this field. We first give an overview of microneedle system in terms of its potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs (e.g., multidrug structures, adhesive structures), material selection, and drug release mechanisms. Then we briefly summarize different microneedle fabrication methods, including their advantages and limitations. We finally summarize the recent progress of microneedle-assisted wound healing and tissue regeneration (e.g., skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, and uterine tissues). We expect that our article would serve as a guideline for readers to design their microneedle systems according to different applications, including material selection, drug selection, and structure design, for achieving better healing and regeneration efficacy. | Shang Lyu Zhifei Dong Xiaoxiao Xu Ho-Pan Bei Ho-Yin Yuen Chung-Wai James Cheung Man-Sang Wong Yong He Xin Zhao | 2023 | Bioactive Materials2023，，9： | 2 |
| 19 | Controllable biotinylated poly ( ethylene-co-glycidyl methacrylate ) ( PE-co-GMA ) nanofibers to bind streptavidin-horseradish peroxidase (HRP) for potential biosensor applications 显示文摘 | Wang Dong Sun Gang Xiang Bei | 2008 | Eur Polymer J2008，44，7： | 1 |
| 20 | Formation of the digestive system in zebrafish Ⅲ pancreas morphogenesis显示文摘 | Field HA Dong PD Beis D | 2003 | Dev Biol2003，253，2： | 1 |
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