|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gut hormones, and short bowel syndrome: The enigmatic role of glucagon-like peptide-2 in the regulation of intestinal adaptation显示文摘Short bowel syndrome (SBS) refers to the malabsorption of nutrients, water, and essential vitamins as a result of disease or surgical removal of parts of the small intestine. The most common reasons for removing part of the small intestine are due to surgical intervention for the treatment of either Crohn's disease or necrotizing enterocolitis. Intestinal adaptation following resection may take weeks to months to be achieved, thus nutritional support requires a variety of therapeutic measures, which include parenterai nutrition. Improper nutrition management can leave the SBS patient malnourished and/or dehydrated, which can be life threatening. The development of therapeutic strategies that reduce both the complications and medical costs associated with SBS/long-term parenterai nutrition while enhancing the intestinal adaptive response would be valuable. Currently, therapeutic options available for the treatment of SBS are limited. There are many potential stimulators of intestinal adaptation including peptide hormones, growth factors, and neuronally-derived components. Glucagon-like peptide-2 (GLP-2) is one potential treatment for gastrointestinal disorders associated with insufficient mucosal function. A significant body of evidence demonstrates that GLP-2 is a trophic hormone that plays an important role in controlling intestinal adaptation. Recent data from clinical trials demonstrate that GLP-2 is safe, well-tolerated, and promotes intestinal growth in SBS patients. However, the mechanism of action and the localization of the glucagon-like peptide-2 receptor (GLP-2R) remains an enigma. This review summarizes the role of a number of mucosal-derived factors that might be involved with intestinal adaptation processes; however, this discussion primarily examines the physiology, mechanism of action, and utility of GLP-2 in the regulation of intestinal mucosal growth. | GR Martin PL Beck DL Sigalet | 2006 | World Journal of Gastroenterology2006，12，26： | 3 |
| 2 | Roles for alpa 1 connexin in morphogenesis of chick embryos revealed using a novel antisense approach 显示文摘 | Beck DL McGonnell Ⅰ Makarenkova HP | 1999 | Dev Genet1999，24，12： | 1 |
| 3 | Perceived Level and Sources of Stress in Baccalaureate Nursing Students 显示文摘 | Beck DL Srivastava R | 1991 | Journal of Nursing Education1991，，3： | 1 |
| 4 | Perceived level and sources of stress in bac calaureate nursing students显示文摘 | Beck DL Srivastava R | 1991 | J Nurs Educ1991，30，3： | 1 |
| 5 | Interferon beta-1a for early multiple sclerosis: CHAMPS trial subgroup analyses显示文摘 | CHANDLER DL COLE SR | 2002 | Ann Neurol2002，51，4： | 1 |
| 6 | A randomized trial of patching regimens for treatment of moderate amblyopia in children显示文摘 | Repka MX Beck RW Holmes JM Birch EE Chandler DL Cotter SA | 2003 | Arch Ophthalmol2003，121，5： | 1 |
| 7 | Perceived level and source softness in baccal aureate nursing students显示文摘 | Beck DL Sriva stave R | 1991 | Journal of Nursing Education1991，30，3： | 1 |
| 8 | A randomized pilot study of near activities versus non-near activities during patching therapy for amblyopia显示文摘 | Holmes JM Edwards AR Beck RW Arnold RW Johnson DA Klimek DL | 2005 | J AAPOS2005，9，2： | 1 |
| 9 | Perceived level and sources of stress in university professional schools显示文摘 | BECK DL HACKETT M B SRIVASTAVA R | 1997 | J Nur Edu1997，36，4： | 1 |
| 10 | Perceived level and sources of stress in baccalaureate nursing students显示文摘 | Beck DL Srivastava R | 1991 | Journal of Narsing Education1991，30，3： | 1 |
| 11 | Perceived level and sources of stress in university professional schools显示文摘 | Beck DL Hackett MB Srivastava R | 1997 | Journal of Nursing Education1997，36，4： | 1 |
| 12 | Using patient focus groups for new patient services显示文摘 | Smith JA Scammon DL Beck SL | 1995 | Jt Comm J Quality Improvement1995，21，： | 1 |
| 13 | Disruption of virus movement confers broad-spectrum resistance against systemic infection by plant viruses with a triple gene block显示文摘 | Van Dolleweerd CJ Lough TJ Baimori E Voot DM Andersen MT O'Brien EW Forster LS | 1994 | Proc Nat/Acad Sci USA1994，91，10： | 1 |
| 14 | Perceived level and sources of stress in university professional schools显示文摘 | Beck DL Hackett MB Srivastava R | 1997 | Journal of Nursing Ed- ucation1997，36，4： | 1 |
| 15 | Perceived level and sources of stress in university professional school显示文摘 | Beck DL Hackett MB Srivastava R | | 0，，04： | 1 |
| 16 | Perceived level and sources of stress in university professional schools显示文摘 | Beck DL Hackett MB Srivastava R | 1997 | Journal of Nursing Education1997，36，4： | 1 |
| 17 | Perceived level and sources of stress in baccalaureate nursing students 显示文摘 | Beck DL Srivastava R | 1991 | Journal of Nuising Education1991，30，3： | 1 |
| 18 | Identification and gene expres sion analysis of a large family of transmembrane kinases related to the Ga1/Ga1NAc lectin in Entamoeba histolytica 显示文摘 | Beck DL Nozaki T Petri WA | 2005 | Eukaryotic Cell2005，4，： | 1 |
| 19 | Perceived level and sources of stress in baccalaureate nursing students 显示文摘 | BECK DL SRIVASTAVA R | 1991 | J Nurs Educ1991，30，3： | 1 |
| 20 | Primary treatment of nasolacrimal duct obstruction with probing in children younger than 4 years显示文摘 | Pediatric Eye Disease Investigator Group Repka MX Chandler DL Beck RW Crouch ER 3rd Donahue S Holmes JM Lee K Melia M Quinn GE Sala NA Schloff S Silbert DI Wallace DK | | 0，，03： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员