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| 1 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 2 | 婴儿配方奶中胰岛素样生长因子I水平显示文摘目的 肠道摄入的胰岛素样生长因子 I(IGF- I)能促进肠粘膜细胞的增殖和增加双糖酶的活性。本研究旨在确定和比较婴儿配方奶、鲜牛奶和人乳的 IGF- I含量。 方法 使用放射免疫分析法测定了 5种水解蛋白质配方奶、5种非水解蛋白质配方奶、2种鲜牛奶和 15份人乳中的 IGF- I水平。 结果 人乳的 IGF- I含量最高 ,为 (0 .6 1± 0 .2 8) nm ol/ L,其次是鲜牛奶为 (0 .2 3± 0 .0 9和 0 .2 7±0 .11) nmol/ L;非水解蛋白质配方奶的含量仅为 (0 .0 8± 0 .0 3)~ (0 .16± 0 .0 1) nmol/ L,而水解蛋白质配方奶的 IGF- I含量在可测范围之下 (<0 .0 2 nmol/ L)。 结论 母乳含丰富的 IGF- I,可能对新生儿和婴儿胃肠道的生长发育有利。婴儿配方奶中的 IGF- I含量明显低于鲜牛奶的 IGF- I含量 ,表明制造配方奶的加工程序 (尤其蛋白质的水解过程 )可破坏 IGF- I结构 ,使其活性和功能丧失。 | 肖昕 Kewitz G Bauer K Versmold H | 2001 | 中华围产医学杂志2001，4，2： | 2 |
| 3 | Glycyrrhizin, an active component of liquorice roots, and replication of SARSassociated coronavirus 显示文摘 | Cinatl J Morgenstern B Bauer G | 2003 | Lancet2003，361，9374： | 2 |
| 4 | Elevated Aortic Pulse Wave Velocity, a Marker of Arterial Stiffness, Predicts Cardiovascular Events in Well-Functioning Older Adults显示文摘 | Kim Sutton-Tyrrell Samer S. Najjar Robert M. Boudreau Lakshmi Venkitachalam Varant Kupelian Eleanor M. Simonsick Richard Havlik Edward G Lakatta Harold Spurgeon Stephen Kritchevsky Marco Pahor Douglas Bauer Anne Newman | 2005 | Circulation2005，，25： | 2 |
| 5 | Expression of small interfering RNAs targeted against HIV - 1 rev transcripts in human cells显示文摘 | Lee N S Dohjima T Bauer G | 2002 | Nat BiotechnoL2002，20，5： | 1 |
| 6 | Multimedia collaborative content creation ( mc3 ) - the MSU LectureOnline System 显示文摘 | Kortemeyer G Bauer W | 1999 | Journal of Engineering Education1999，88，4： | 1 |
| 7 | Bringing water markets down to earth:the political economy of water rights in chile,1976-95显示文摘 | BAUER G J | 1997 | World Development1997，25，5： | 1 |
| 8 | Selected fructooligosaccharide (l-kestose,nystose,and 1F-β-fructofuranosylnystose) composition of foods and feeds显示文摘 | CAMPBELL J M BAUER L L FAHEY G C | 1997 | Journal of Agricultural and Food Chemistry1997，45，8： | 1 |
| 9 | Signals from unconven- tional monetary policy显示文摘 | Bauer M Rudebusch G | 2011 | FRBSF Economic Let-ter2011，，36： | 1 |
| 10 | Pregnane X receptor (PXR) regulates P-glycoprotein at the blood-brain barrier:fimctional similarities between pig and human PXR显示文摘 | Oft M Fricker G Bauer B | 2009 | J Pharmacol Exp Ther2009，329，1： | 1 |
| 11 | Environmental regulation of xylem sap flow and total conductance of Larix grnelinii trees in eastern Siberia 显示文摘 | Ameth A Kelliher F M Bauer G | 1996 | Tree Physiology1996，16，： | 1 |
| 12 | Detection of Mycoplasma pneumoniae in serum specimens from patients with Myeoplasma pneumonia by PCR显示文摘 | Daxboeck F Khanakah G Bauer C | 2005 | Int J Med Microbiol2005，295，4： | 1 |
| 13 | Heart rate turbulence: standards of measurement, physiological interpretation, and clinical use: International Society for Holter and Noninvasive Eleetrophysiology Consensus显示文摘 | Bauer A Malik M Schmidt G | 2008 | J Am Coll Cardiol2008，52，17： | 1 |
| 14 | Operational tests on HVDC thyristor modules in a synthetic test circuit for the sylmar east restoration project显示文摘 | Bauer T Lips H P Thiele G | 1997 | IEEE Trans on Power Delivery1997，12，3： | 1 |
| 15 | 3 Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells显示文摘 | Lee NS Dohjima T Bauer G | 2002 | Nature Biotechnology2002，20，5： | 1 |
| 16 | Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus显示文摘 | Cinatl J Morgenstern B Bauer G | 2003 | Lacent2003，361，： | 1 |
| 17 | Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethysulphate and drug-directed Fe2, cleavage of 16S rRNA显示文摘 | Bauer G Berens C Projan S J | 2004 | JAntimicrob Chemother2004，53，4： | 1 |
| 18 | The Photo-fenton Reaction and the TiO2/UV Process for Waste Water Treatment novel Developments 显示文摘 | Bauer R Waldner G Fallmann H | 1999 | Catalysis Today1999，53，1： | 1 |
| 19 | Functional lower lip reconstruction with bilateral cheek advancement flaps: revisitation of Webster method with a minor modification in the technique显示文摘 | Wechselberger G Gurunluoglu R Bauer T | 2002 | Aesthetic Plast Surg2002，26，6： | 1 |
| 20 | A control strategy for parallel operation of single-phase voltage source inverters: analysis,design and experimental results显示文摘 | Lazzarin T B Bauer G A T Barbi I | 2013 | IEEE Transactions on Industrial Electronics2013，60，6： | 1 |
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