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| 1 | Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion disease显示文摘AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies (TSE). While PrPc enters the organism via the oral route, less data is available to know about its uptake and the role of gastrointestinal inflammation on the expression of prion precursor PrPc, which is constitutively expressed in the gastric mucosa.METHODS: We studied PrPc expression in the gastric mucosa of 10 Helicobacter pylori-positive patients before and after successful H pylori eradication compared to non-infected controls using RT-PCR and Western blotting.The effect of central mediators of gastric inflammation,i.e., gastrin, prostaglandin E2 (PGE2), tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) on PrPc expression was analyzed in gastric cell lines.RESULTS: PrPc expression was increased in H pyloriinfection compared with non-infected controls and decreased to normal after successful eradication. Gastrin,PGE2, and IL-1β dose-dependently upregulated PrPc in gastric cells, while TNF-α had no effect.CONCLUSION: H pylori infection leads to the upregulation of gastric PrPc expression. This can be linked to H pylori induced hypergastrinemia and increased mucosal PGE2 and IL-1β synthesis.H pylori creates a milieu for enhanced propagation of prions in the gastrointestinal tract. | Peter C Konturek Karolina Bazela Vitally Kukharskyy Michael Bauer Eckhart G Hahn Detlef Schuppan | 2005 | World Journal of Gastroenterology2005，11，48： | 9 |
| 2 | 口服碳酸氢钠对慢性肾脏病患者的影响显示文摘在慢性肾脏病(chronickidneydisease,CKD)患者,代谢性酸中毒促进肌肉分解,但碱治疗是否能改善CKD的功能性预后尚不清楚。而且在碱制剂的剂量选择和大剂量耐受性方面仍不明了。最近,美国学者在伴有轻度酸中毒的慢性肾脏病患者,评估了碱与血清碳酸氢盐的量一效关系、副反应、以及对肌肉力量的作用。 | Abramowitz MK Melamed ML Bauer C 王建中 | 2013 | 中华肾病研究电子杂志2013，2，5： | 3 |
| 3 | A role for c- myc in the regulation of thymocyte differentiation and possibly positive selection显示文摘 | Broussard- Diehl C Bauer SR Scheuermann RH | 1996 | J Immunol1996，156，9： | 2 |
| 4 | Bringing water markets down to earth: the political economy of water rights in Chile 1976-95 显示文摘 | Bauer C J | 1997 | World Development1997，25，5： | 1 |
| 5 | Improvement of continence with reoperation in selected patients after surgery for anorectal malformation 显示文摘 | Ardelean MA Bauer J Schimke C | 2009 | Dis Colon Rectum2009，52，1： | 1 |
| 6 | Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition显示文摘 | Bauer S Kirsching C J Hacker H | 2001 | Proc Natl Acad Sci USA2001，98，： | 1 |
| 7 | The Potential of Combining SSM/I and SSM/T2 Measurements to Improve the Identification of Snowcover and Precipitation显示文摘 | Bauer P Grody N C | 1995 | IEEE Transactions on Geoscience and Remote Sensing1995，33，2： | 1 |
| 8 | Klf4 is a transcription factor required for establishing the barrier function of the skin 显示文摘 | SEGRE J A BAUER C FUCHS E | 1999 | Nature Genetics1999，22，4： | 1 |
| 9 | Angiogenesis,vasculogenesis,and induction of healing in chronic wounds显示文摘 | Bauer S M Bauer R J Velazquez O C | 2005 | Vasc Endovascular Surg2005，39，4： | 1 |
| 10 | Breast cancer subtypes as defined by the estrogen receptor ( ER ), progesterone receptor ( PR ), and the human epidermal growth factor receptor 2 ( HER2 ) among women with invasive breast cancer in California, 1999-2004 显示文摘 | Parise C A Bauer K R Brown M M | 2009 | Breast J2009，15，6： | 1 |
| 11 | Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension显示文摘 | Jiang BH Semenza GL Bauer C | 1996 | Am J Physiol1996，271，： | 1 |
| 12 | Regulation of photosystem synthesis in Rhodobacter capsulatus显示文摘 | BAUER C | 2004 | Photosynthesis Research2004，80，： | 1 |
| 13 | Drought tolerance of selected Eragrostis species correlates with leaf tensile properties显示文摘 | Balsamo R A Willigen C V Bauer A M | 2006 | Annals of Botany2006，97，6： | 1 |
| 14 | Selected fructooligosaccharide (l-kestose,nystose,and 1F-β-fructofuranosylnystose) composition of foods and feeds显示文摘 | CAMPBELL J M BAUER L L FAHEY G C | 1997 | Journal of Agricultural and Food Chemistry1997，45，8： | 1 |
| 15 | A woman with red eye and hypokalemia:a case of acquired Gitelman' s syndrome显示文摘 | Schwarz C Barisani T Bauer E | | 0，，7： | 1 |
| 16 | Over-expression of the eukaryotic translation initiation factor 4G ( EIF4G1 ) in squamous cell lung carcinoma 显示文摘 | Bauer C Brass N Diesinger I | 2002 | Int J Cancer2002，98，2： | 1 |
| 17 | Parathy- roid hormone and teriparatide for the treatment of osteopo- rosis: A review of the evidence and suggested guidelines for its use显示文摘 | Hodsman A B Bauer D C Dempster D W | 2005 | Endocr Rev2005，26，5： | 1 |
| 18 | Detection of Mycoplasma pneumoniae in serum specimens from patients with Myeoplasma pneumonia by PCR显示文摘 | Daxboeck F Khanakah G Bauer C | 2005 | Int J Med Microbiol2005，295，4： | 1 |
| 19 | On the relationship between organizational complexity and organizational structuration显示文摘 | Moldoveanu M C Bauer R | 2004 | Organization Science2004，15，： | 1 |
| 20 | Lung function after lobectomy:a randomized,double-blinded trial comparing thoracic epidural ropivacaine/sufentann and intravenous morphine for patient-controlled analgesia显示文摘 | Bauer C Hentz JG Ducrocq X | 2007 | Anesth Analg2007，105，1： | 1 |
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