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| 1 | Ulcerative colitis in smokers,non-smokers and ex-smokers显示文摘Smoking is a major environmental factor that interferes in the establishment and clinical course of ulcerative colitis (UC). Firstly, the risk of smoking status impact in the development of UC is reviewed, showing that current smoking has a protective association with UC. Similarly, being a former smoker is associated with an increased risk of UC. The concept that smoking could have a role in determining the inflammatory bowel disease phenotype is also discussed. Gender may also be considered, as current smoking delays disease onset in men but not in women. No clear conclusions can be driven from the studies trying to clarify whether childhood passive smoking or prenatal smoke exposure have an influence on the development of UC, mainly due to methodology flaws. The influence of smoking on disease course is the second aspect analysed. Some studies show a disease course more benign in smokers that in non-smokers, with lower hospitalizations rates, less flare-ups, lower use of oral steroids and even less risk of proximal extension. This is not verified by some other studies. Similarly, the rate of colectomy does not seem to be determined by the smoking status of the patient. The third issue reviewed is the use of nicotine as a therapeutic agent. The place of nicotine in the treatment of UC is unclear, although it could be useful in selected cases, particularly in recent ex-smokers with moderate but refractory attacks of UC. Finally, the effect of smoking cessation in UC patients is summarised. Given that smoking represents a major worldwide cause of death, for inpatients with UC the risks of smoking far outweigh any possible benefit. Thus, physicians should advise, encourage and assist UC patients who smoke to quit. | Guillermo Bastida Belén Beltrán | 2011 | World Journal of Gastroenterology2011，17，22： | 13 |
| 2 | Anticorrosion behavior of conversion coatings obtained from unbuffered cerium salts solutions on AA6061-T6显示文摘The anticorrosive properties of cerium based conversion coatings deposited on AA6061-T6 alloy by immersion in unbuffered cerium chloride and cerium nitrate solutions in the presence of hydrogen peroxide were investigated and characterized by potentiodynamic polarization(PDP) and electrochemical impedance spectroscopy(EIS) in 0.5 mol/L NaCl aqueous solution.The microstructure and chemicalcomposition of the protective films were examined by scanning electron microscopy(SEM) and energy dispersive X-ray spectroscopy(EDS).It was found that the best corrosion protection was afforded by the samples treated during 600 s in cerium chloride solution at pH values~5.5-4,showing higher amounts of cerium and polarization resistance values greater than 10 Ω m2.Moreover,an ennoblement of the corrosion potential and decreasing of the cathodic and anodic currents were obtained compared with the cerium nitrate solutions application.Thisbehavior was attributed to the influence of the deposition parameters such as type of the salt anion,i.e.,chelating effect and chaotropic characteristics,pH fluctuations in the conversion solution and deposition time. | KIYOTA Sayuri VALDEZ Benjamin STOYTCHEVA Margarita ZLATEV Roumen BASTIDAS Jose Maria | 2011 | Journal of Rare Earths2011，29，10： | 11 |
| 3 | 淡水豚类mtDNA 16S rRNA基因的系统发生显示文摘mt DNA 16 S r RNA基因序列分析支持将现生淡水豚 4个属归入不同的科 ,即白暨豚科(L ipotiidae)、恒河豚科 (Platanistidae)、亚河豚科 (Iniidae)和弗西豚科 (Pontoporidae) .基于邻接法的系统发生分析显示淡水豚类由白暨豚 +恒河豚和弗西豚 +亚河豚两个单系组成 ,但两个单系之间并无姊妹关系 .淡水豚类是并系的 .16 S r RNA基因的系统发生树与 mt DNA细胞色素 b基因和12 S r RNA基因的系统发生树并不完全一致 .这种差异一方面可能反映了不同的基因树间的差异 ,但也可能与本文分析的 16 S r RNA基因片段中变异位点数和简约信息位点数较少有关 .因此 ,有必要增加序列长度来进一步验证 . | 刘珊 杨光 周开亚 Ricardo Bastida Laura Rivero | 2000 | 南京师大学报(自然科学版)2000，23，3： | 9 |
| 4 | 淡水豚类线粒体DNA12S rRNA基因的序列变异及其分子系统学研究显示文摘淡水豚类 4个代表属 [白暨豚 (Lipotes)、恒河豚 (Platanista)、弗西豚 (Pontoporia)和亚河豚(Inia) ]mtDNA 12SrRNA基因的序列差异水平 ,高于其他齿鲸类科间的差异 ,特别是远远高于海豚总科内的科间差异。研究结果支持它们应归属于不同的科 ,即白暨豚科 (Lipotiidae)、恒河豚科 (Platanistidae)、弗西豚科 (Pontoporidae)和亚河豚科 (Iniidae)。恒河豚科是鲸类中最早分化出来的独立支系 ,而其余 3个淡水豚科组成一个单系 ,作为海豚总科的姊妹群。淡水豚类的发生是多系的。白暨豚科、亚河豚科和弗西豚科是否隶属于同一个总科尚需进一步研究。 | 杨光 刘珊 季国庆 周开亚 Ricardo Bastida Laura Rivero | 2000 | Zoological Research2000，21，6： | 7 |
| 5 | Small intestinal bacterial overgrowth in inactive Crohn's disease:Influence of thiopurine and biological treatment显示文摘AIM:To investigate the influence of thiopurines and biological drugs on the presence of small intestinal bacterial overgrowth(SIBO) in patients with inactive Crohn's disease(CD).METHODS:This was a prospective study in patients with CD in remission and without corticosteroid treatment,included consecutively from 2004 to 2010.SIBO was investigated using the hydrogen glucose breath test.RESULTS:One hundred and seven patients with CD in remission were included.Almost 58%of patients used maintenance immunosuppressant therapy and 19.6%used biological therapy.The prevalence of SIBO was16.8%.No association was observed between SIBO and the use of thiopurine Immunosuppressant(12/62patients),administration of biological drugs(2/21 patients),or with double treatment with an anti-tumor necrosis factor drugs plus thiopurine(1/13 patients).Half of the patients had symptoms that were suggestive of SIBO,though meteorism was the only symptom that was significantly associated with the presence of SIBO on univariate analysis(P<0.05).Multivariate analysis revealed that the presence of meteorism and a fistulizing pattern were associated with the presence of SIBO(P<0.05).CONCLUSION:Immunosuppressants and/or biological drugs do not induce SIBO in inactive CD.Fistulizing disease pattern and meteorism are associated with SIBO. | Cristina Sánchez-Montes Vicente Ortiz Guillermo Bastida Ester Rodríguez María Yago Belén Beltrán Mariam Aguas Marisa Iborra Vicente Garrigues Julio Ponce Pilar Nos | 2014 | World Journal of Gastroenterology2014，20，38： | 4 |
| 6 | Adalimumab in prevention of postoperative recurrence of Crohn's disease in high-risk patients显示文摘AIM:To evaluate the effectiveness of adalimumab in preventing recurrence after intestinal resection for Crohn's disease in high-risk patients.METHODS:A multicenter,prospective,observational study was conducted from June 2009 until June 2010.We consecutively included high-risk Crohn's disease patients who had undergone an ileal/ileocolonic resection.High-risk patients were defined as two or more criteria:smokers,penetrating pattern,one or more previous surgical resections or prior extensive resection.Subcutaneous adalimumab was administered 2 wk(± 5 d) after surgery at a dose of 40 mg eow,with an initial induction dose of 160/80 mg at weeks 0 and 2.Demographic data,previous and concomitant treatments(antibiotics,5-aminosalicylates,corticosteroids,immunomodulators or biologic therapies),smoking status at the time of diagnosis and after the index operation and number of previous resections(type and reason for surgery) were all recorded.Biological status was assessed with C-reactive protein,erythrocyte sedimentation rate and fecal calprotectin.One year(± 3 mo) after surgery,an ileocolonoscopy and/or magnetic resonance enterography was performed.Endoscopic recurrence was defined as Rutgeerts score ≥ i2.Morphological recurrence was based on magnetic resonance(MR) score ≥ MR1.RESULTS:Twenty-nine patients(55.2% males,48.3% smokers at diagnosis and 13.8% after the index operation),mean age 42.3 years and mean duration of the disease 13.8 years were included in the study.A mean of 1.76(range:1-4) resections previous to adalimumab administration and in 37.9% was considered extensive resection.51.7% had previously received infliximab.Immunomodulators were given concomitantly to 17.2% of patients.Four of the 29(13.7%) developed clinical recurrence,6/29(20.7%) endoscopic recurrence and 7/19(36.8%) morphological recurrence after 1-year.All patients with clinical recurrence showed endoscopic and morphological recurrence.A high degree of concordance was found between clinical-endoscopic recurrence(k = 0.76,P < 0.001) and clinical-morphological recurrence(k = 0.63,P = 0.003).Correlation between endoscopic and radiological findings was good(comparing the 5-point Rutgeerts score with the 4-point MR score,a score of i4 was classified as MR3,i3 as MR2,and i2-i1 as MR1)(P < 0.001,r s = 0.825).During follow-up,five(17.2%) patients needed adalimumab dose intensification(40 mg/wk);Mean time to intensification after the introduction of adalimumab treatment was 8 mo(range:5 to 11 mo).In three cases(10.3%),a biological change was needed due to a worsening of the disease after the dose intensification to 40 mg/wk.One patient suffered an adverse event.CONCLUSION:Adalimumab seems to be effective and safe in preventing postoperative recurrence in a selected group of patients who had undergone an intestinal resection for their CD. | Mariam Aguas Guillermo Bastida Elena Cerrillo Belén Beltrán Marisa Iborra Cristina Sánchez-Montes Fernando Muoz Jesús Barrio Sabino Riestra Pilar Nos | 2012 | World Journal of Gastroenterology2012，18，32： | 3 |
| 7 | Microhabitat heterogeneity associated with Vanilla spp.and its influences on the microbial community of leaf litter and soil显示文摘The impact of forest microhabitats on physiochemical properties of the soil and that of microbial communities on tropical soils remain poorly understood.To elucidate the effect of tropical forest stand on leaf litter and soil microbial communities,we studied enzyme activities,microbial biomass,and diversity in three distinct microhabitats in terms of plant richness,diameter at breast height(DBH),and physiochemical properties of soil and litter,each associated with a different Vanilla sp.In the soil,positive correlations were found between electrical conductivity(EC)and total organic carbon(TOC)with phosphatase activity,and between nitrogen(N)and water-soluble carbon(WSC)content with urease activity(UA).In the litter,the water content was positively correlated with bacterial and fungal biomass,and N and WSC contents were positively correlated with fungal biomass.Positive correlations were found between plant richness and UA in the soil,plant richness and fungal biomass in the soil and litter,and DBH and fungal biomass in the litter.Amplicon sequencing revealed differences between microhabitats in the relative abundance of some fungal and bacterial taxa and in the bacterial community composition of both litter and soil.Bacterial richness and diversity were different between microhabitats,and,in litter samples,they were negatively correlated with DBH and plant richness,respectively.By contrast,none of the soil and litter physiochemical properties were significantly correlated with microbial diversity.Our results show that significant shifts in enzyme activity,microbial biomass,and diversity in the microhabitats were driven by key abiotic and biotic factors depending on the soil or litter sample type. | Gabriela Montes de Oca-Vasquez Frank Solano-Campos Bernal Azofeifa-Bolanos Amelia Paniagua-Vasquez Jose Vega-Baudrit Antonio Ruiz-Navarro Ruben Lopez-Mondejar Felipe Bastida | 2020 | Soil Ecology Letters2020，2，3： | 2 |
| 8 | Immunity:研究开发出最优的HIV疫苗递送模式显示文摘HIV已不再占据头条新闻。这主要是因为抗逆转录病毒药物的成功开发已将HIV病毒感染导致的艾滋病(AIDS)转化为一种慢性的可控制的疾病。然而。当前在全世界大约0.367亿名HIV感染者中,仅约一半的人能够获得控制这种病毒所需的药物。与此同时。新的HIV感染率持续保持在非常高的水平,这突出强调了需要开发一种预防性疫苗。然而,几十年来。 | Matthias Pauthner Colin Havenar-Daughton Devin Sok Joseph P. Nkolola Raiza Bastidas Archana V. Boopathy Diane G. Carnathan Abishek Chandrashekar Kimberly M. Cirelli Christopher A. Cottrell Alexey M. Eroshkin Javier Guenaga Kirti Kaushik Daniel W. Kulp Jinyan Liu Laura E. McCoy Aaron L. Oom Gabriel Ozorowski Kai W. Post Shailendra K. Sharma Jon M. Steichen Steven W. de Taeye Talar Tokatlian Alba Torrents de la Peña Salvatore T. Butera Celia C. LaBranche David C. Montefiori Guido Silvestri Ian A. Wilson Darrell J. Irvine Rogier W. Sanders William R. Schief Andrew B. Ward Richard T. Wyatt Dan H. Barouch Shane Crotty Dennis R. Burton | 2017 | 现代生物医学进展2017，17，27： | 2 |
| 9 | Chemical analysis of passive films on type 304 stainless steel using soft X-ray absorption spectroscopy显示文摘 | BASTIDAS J M LOPEZ M F GUTIERREZ A | 1998 | Corrosion Science1998，40，： | 1 |
| 10 | Adsorption of benzotriazole on copper electrode surfaces in citric acid media 显示文摘 | Bastidas J M Pinilla P Polo J L | 2002 | Corrosion2002，58，11： | 1 |
| 11 | Constipation during pregnancy: a longitudinal survey based on self-reported symptoms and the Rome II criteria显示文摘 | Julio Ponce Beatriz Martínez Alberto Fernández Marta Ponce Guillermo Bastida Encarna Plá Vicente Garrigues Vicente Ortiz | 2008 | European Journal of Gastroenterology & Hepatology2008，，1： | 1 |
| 12 | The Protective Action of Two Vapor-Phase Inhibitors on the Corrosion of Mild Steel显示文摘 | Bastidas J M Mora E M Feliu S | 1990 | Werkstoffe Korrosion1990，41，9： | 1 |
| 13 | Comparison between the radical scavenging activity and antioxidant activity of six distilled and nondistilled Mediterranean herbs and aromatic plants 显示文摘 | Parejo I Viladomat F Bastida J | 2002 | J Agric Food Chem2002，50，： | 1 |
| 14 | Study of the electrochemical noise generated by the mild steel/zinc - rich paint/NaCl solution system 显示文摘 | Bastidas J M Feliu S Jr Morcillo M | 1990 | Progress in Organic Coatings1990，18，3： | 1 |
| 15 | Reaction between sodium monofluorophosphate and portlandite and impact on steel reinforcement corrosion inhibition显示文摘 | A. La Iglesia V.M. La Iglesia S. Fajardo P.P. Gómez J.M. Bastidas | 2012 | Construction and Building Materials2012，，： | 1 |
| 16 | Microbiological degradation index of soils in a semiarid climate显示文摘 | Bastida F Moreno J L Hernández T García C | | 0，，： | 1 |
| 17 | Power-assisted suction lipectomy of fasciocutaneous flaps in the extremities显示文摘 | Reuben CM Bastidas N Sharma S | 2010 | Ann Plast Surg2010，65，1： | 1 |
| 18 | A method for assaying the rhamnosidase activity of naringinase显示文摘 | ROMERO C MANJON A BASTIDA J | 1985 | Anal Biochem1985，149，2： | 1 |
| 19 | Prevalence of irritable bowel syndrome (IBS)in first- degree relatives of patients with inflammatory bowel disease ( IBD ) 显示文摘 | Aguas M Garrigues V Bastida G | 2011 | J Crohns Colitis2011，5，3： | 1 |
| 20 | Complexes of Ti (Ⅳ) with Schiff Bases Containing Pyridine and N-methylpyrrole显示文摘 | Parrado C Bastida R Macias A | 1994 | Synth React Inorg Met Org Chem1994，24，9： | 1 |
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