|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Unexpected alliance between syndecan-1 and innatelike T cells to protect host from autoimmune effects of interleukin-17显示文摘Innate-like T cells, namely natural killer T(NKT) and γδ T cells, play critical roles in linking innate and adaptive immune responses through rapid production of cytokines. Prominent among these cytokines is interleukin-17(IL-17), which is a potent proinflammatory cytokine that plays a critical role in host defense against fungi and extracellular bacteria. However, excessive IL-17-production promotes autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus. IL-17 has also been implicated in regulating body fat, which is highly relevant given rises in obesity and type 2 diabetes. NKT cells, γδ T cells and mucosal-associated invariant T cells(MAIT) are the major sources of IL-17 involved in protection of mucosal surfaces from opportunistic infections and causing autoimmunity when become dysregulated. Given the pathogenic effects of IL-17, efforts have been directed towards understanding mechanisms that guard against IL-17 overproduction. One novel potent mechanism is mediated by the heparan sulfate proteoglycan, syndecan-1(sdc1), which is selectively expressed by IL-17-producing subsets of NKT and γδ T cells. This unexpected role for sdc1 is uncovered by analysis of NKT and γδ T cells in sdc1-deficient mice. In this mini-review, we discuss selective expression of sdc1 by these innate T cells and consequences of its absence on IL-17 homeostasis and pathological implications. | Anil Kumar Jaiswal Mohanraj Sadasivam Abdel Rahim A Hamad | 2018 | World Journal of Diabetes2018，9，12： | 5 |
| 2 | Rare earth(Gd,La) co-doped ZnO nanoflowers for direct sunlight driven photocatalytic activity显示文摘In this work Gd/La@ZnO nanoflower photocatalyst was successfully synthesized by a co-precipitation method and applied for rhodamine B(Rh B) and tetracycline(TCN) degradation under direct sunlight irradiation.The doping of rare earth elements extends the optical absorption wavelength of ZnO from UV region(390 nm) to visible-light region(401 nm).In addition,the co-doped ZnO nanoflower exhibits a lower charge recombination efficiency which was confirmed by photoluminescence emission analysis.Moreover,the co-doped ZnO nanoflower exhibits the maximum degradation efficiency of 91% for Rh B and 74% for TCN under sunlight irradiation.The calculated synergistic index of co-doped ZnO is higher than that of the pure ZnO.Reactive radicals’ production was confirmed by terephthalic acid(TA) and nitro-blue tetrazolium(NBT) tests.The holes and hydroxyl(·OH) radicals play the major role in degradation reaction and it was confirmed by scavenger’s test.Moreover,the recycling test confirms the stability of the photocatalyst. | Baskaran Palanivel Romulo R.Macadangdang Jr Md Shahadat Hossain Fahad A.Alharthi Mohanraj Kumar Jih-Hsing Chang Sreedevi Gedi | 2023 | Journal of Rare Earths2023，41，1： | 3 |
| 3 | Characterisation of titanium–titanium boride composites processed by powder metallurgy techniques显示文摘 | M. Selva Kumar P. Chandrasekar P. Chandramohan M. Mohanraj | 2012 | Materials Characterization2012，，： | 1 |
| 4 | Assessing HIV/AIDS stigma in south India: validation and abridgement of the Berger HIV stigma scale显示文摘 | Jeyaseelan L Kumar S Mohanraj R | 2013 | AIDS Behav2013，17，1： | 1 |
| 5 | Lack of Syndecan-1 produces significant alterations in whole-body composition, metabolism and glucose homeostasis in mice显示文摘BACKGROUND Obesity is a disease state with serious adverse metabolic complications,including glucose intolerance and type 2 diabetes that currently has no cure.Identifying and understanding roles of various modulators of body composition and glucose homeostasis is required for developing effective cures.Syndecan-1(Sdc1) is a member of the heparan sulfate proteoglycan family that has mainly been investigated for its role in regulating proliferation and survival of epithelia and tumor cells,but little is known about its roles in regulating obesity and glucose homeostasis.AIM To examine the role of Sdc1 in regulating body fat and glucose metabolism.METHODS We used female wild type and Sdc1 knockout(Sdc1 KO) mice on BALB/c background and multiple methods.Metabolic measurements(rates of oxygen consumption,carbon dioxide production,respiratory exchange ratio and energy expenditure) were performed using an open-flow indirect calorimeter with additional features to measure food intake and physical activity.Glucose intolerance and insulin resistance were measured by established tolerance test methods.RESULTS Although our primary goal was to investigate the effects of Sdc1 deficiency on body fat and glucose homeostasis,we uncovered that Sdc1 regulates multiple metabolic parameters.Sdc1 KO mice have reduced body weight due to significant decreases in fat and lean masses under both chow and high fat diet conditions.The reduced body weight was not due to changes in food intakes,but Sdc1 KO mice exhibited altered feeding behavior as they ate more during the dark phase and less during the light phase than wild type mice.In addition,Sdc1 KO mice suffered from high rate of energy expenditure,glucose intolerance and insulin resistance.CONCLUSION These results reveal critical multisystem and opposing roles for Sdc1 in regulating normal energy balance and glucose homeostasis.The results will have important implications for targeting Sdc1 to modulate metabolic parameters.Finally,we offer a novel hypothesis that could reconcile the opposing roles associated with Sdc1 deficiency. | Anil Kumar Jaiswal Mohanraj Sadasivam Susan Aja Abdel Rahim A Hamad | 2020 | World Journal of Diabetes2020，11，4： | 0 |
| 6 | Syndecan-1-coating of interleukin-17-producing natural killer T cells provides a specific method for their visualization and analysis显示文摘Natural killer T cells(NKT cells) are innate-like T cells that acquire effector functions while developing in the thymus, polarize into three distinct functional subsets viz. NKT1, NKT2 and NKT17 cells that produce interferon(IFN)-γ, interleukin(IL)-4 and IL-17, respectively. However, there has been no unique surface markers that define each subsets, forcing investigators to use intracellular staining of transcription factors and cytokines in combination of surface markers to distinguish among these subsets. Intracellular staining, however, causes apoptosis and prevents subsequent utilization of NKT cells in functional in vitro and in vivo assays that require viable cells. This limitation has significantly impeded understanding the specific properties of each subset and their interactions with each other. Therefore, there has been fervent efforts to find a specific markers for each NKT cell subset. We have recently identified that syndecan-1(SDC-1; CD138) as a specific surface marker of NKT17 cells. This discovery now allows visualization of NKT17 in situ and study of their peripheral tissue distribution, characteristics of their TCR and viable sorting for in vitro and in vivo analysis. In addition, it lays the ground working for investigating significance of SDC-1 expression on this particular subset in regulating their roles in host defense and glucose metabolism. | Anil Kumar Jaiswal Mohanraj Sadasivam Abdel Rahim A Hamad | 2017 | World Journal of Diabetes2017，8，4： | 0 |
| 7 | Numerical simulation of a hydrocarbon fuelled valveless pulsejet显示文摘Jet propulsion technology has been limited to being identified largely with turbojets and turbo-machinery driven jet engines.Of late there has been a renewed interest in pulsejet technology and it has once again caught the imagination of academia.The specific characteristics of the pulsejet,such as easy scalability,absence of moving parts,reduced combustion temperatures;lower NOX formation and the like make it possess varied capabilities for use in the field of jet propulsion and the most viable option for small-scale jet propulsion.In the current work,a numerical analysis encompassing feasibility and validation of a valveless pulsejet engine was attempted using CD-adapco's STAR-CCM+CFD package.Due to lack of comprehensive established mathematical laws to govern the working of a pulsejet,most experimental work being performed is done by trial and error.This necessitates in-depth computational studies in order to shed more light on the understanding of valveless pulsejets.The results have been encouraging and in agreement with observed experimental conclusions such as,i)changes in dimensions affect the working of a pulsejet,ii)presence of a flare enhances the working of a pulsejet,and the close agreement in the frequency of operation.Through continuous study,an optimum initial condition was achieved which enabled the pulsejet to begin operation even before 0.05 s,thereby greatly reducing computational costs if a higher time-scale were to be used. | Joseph Kalyan Raj Isac Logu Mohanraj Enumula Srikar Sai Vijay Kumar Kannan | 2014 | Propulsion and Power Research2014，3，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员