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您的检索式：作者名="Barbara Renga"
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| 1 | Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation显示文摘AIM: To investigate whether the farnesoid X receptor (FXR) regulates expression of liver cystathionase (CSE), a gene involved in hydrogen sulfi de (H2S) generation. METHODS: The regulation of CSE expression in response to FXR ligands was evaluated in HepG2 cells and in wild-type and FXR null mice treated with 6-ethyl chenodeoxycholic acid (6E-CDCA), a synthetic FXR ligand. The analysis demonstrated an FXR responsive element in the 5'-flanking region of the human CSE gene. The function of this site was investigated by luciferase reporter assays, chromatin immunoprecipitation and electrophoretic mobility shift assays. Livers obtained from rats treated with carbon tetrachloride alone, or in combination with 6-ethyl chenodeoxycholic acid, were studied for hydrogen sulphide generation and portal pressure measurement. RESULTS: Liver expression of CSE is regulated by bile acids by means of an FXR-mediated mechanism. Western blotting, qualitative and quantitative polymerase chain reaction, as well as immunohistochemical analysis, showed that expression of CSE in HepG2 cells and in mice is induced by treatment with an FXR ligand. Administration of 6E-CDCA to carbon tetrachloride treated rats protected against the down-regulation of CSE expression, increased H2S generation, reduced portal pressure and attenuated the endothelial dysfunction of isolated and perfused cirrhotic rat livers. CONCLUSION: These results demonstrate that CSE is an FXR-regulated gene and provide a new molecular explanation for the pathophysiology of portal hypertension. | Barbara Renga Andrea Mencarelli Marco Migliorati Eleonora Distrutti Stefano Fiorucci | 2009 | World Journal of Gastroenterology2009，15，17： | 7 |
| 2 | Nitric oxide modulates proapoptotic and antiapoptotic properties of chemotherapy a- gents: the case of NO-pegylated epirubicin 显示文摘 | Luca Santucci Andrea Mencarelli Barbara Renga | 2006 | FASEB J2006，20，6： | 1 |
| 3 | Pregnane-X-receptor mediates the anti-inflammatory activities of rifaximin on detoxification pathways in intestinal epithelial cells显示文摘 | Andrea Mencarelli Marco Migliorati Miriam Barbanti Sabrina Cipriani Giuseppe Palladino Eleonora Distrutti Barbara Renga Stefano Fiorucci | 2010 | Biochemical Pharmacology2010，，11： | 1 |
| 4 | Mechanistic role of p38 MAPK in gastric cancer dissemination in a rodent model peritoneal metastasis显示文摘 | Luigina Graziosi Andrea Mencarelli Chiara Santorelli Barbara Renga Sabrina Cipriani Emanuel Cavazzoni Giuseppe Palladino Stefan Laufer Michael Burnet Annibale Donini Stefano Fiorucci | 2011 | European Journal of Pharmacology2011，，2： | 1 |
| 5 | CCR5 Antagonism by Maraviroc Reduces the Potential for Gastric Cancer Cell Dissemination显示文摘 | Andrea Mencarelli Luigina Graziosi Barbara Renga Sabrina Cipriani Claudio D’Amore Daniela Francisci Angela Bruno Franco Baldelli Annibale Donini Stefano Fiorucci | 2013 | Translational Oncology2013，，6： | 1 |
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