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| 1 | Gut microbiota role in irritable bowel syndrome:Newtherapeutic strategies显示文摘In the last decade the impressive expansion of our knowledge of the vast microbial community that resides in the human intestine, the gut microbiota, has provided support to the concept that a disturbed intestinal ecology might promote development and maintenance of symptoms in irritable bowel syndrome(IBS). As a correlate, manipulation of gut microbiota represents a new strategy for the treatment of this multifactorial disease. A number of attempts have been made to modulate the gut bacterial composition, following the idea that expansion of bacterial species considered as beneficial(Lactobacilli and Bifidobacteria) associated with the reduction of those considered harmful(Clostridium, Escherichia coli, Salmonella, Shigella and Pseudomonas) should attenuate IBS symptoms. In this conceptual framework, probiotics appear an attractive option in terms of both efficacy and safety, while prebiotics, synbiotics and antibiotics still need confirmation. Fecal transplant is an old treatment translated from the cure of intestinal infective pathologies that has recently gained a new life as therapeutic option for those patients with a disturbed gut ecosystem, but data on IBS are scanty and randomized, placebo-controlled studies are required. | Eleonora Distrutti Lorenzo Monaldi Patrizia Ricci Stefano Fiorucci | 2016 | World Journal of Gastroenterology2016，22，7： | 60 |
| 2 | Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation显示文摘AIM: To investigate whether the farnesoid X receptor (FXR) regulates expression of liver cystathionase (CSE), a gene involved in hydrogen sulfi de (H2S) generation. METHODS: The regulation of CSE expression in response to FXR ligands was evaluated in HepG2 cells and in wild-type and FXR null mice treated with 6-ethyl chenodeoxycholic acid (6E-CDCA), a synthetic FXR ligand. The analysis demonstrated an FXR responsive element in the 5'-flanking region of the human CSE gene. The function of this site was investigated by luciferase reporter assays, chromatin immunoprecipitation and electrophoretic mobility shift assays. Livers obtained from rats treated with carbon tetrachloride alone, or in combination with 6-ethyl chenodeoxycholic acid, were studied for hydrogen sulphide generation and portal pressure measurement. RESULTS: Liver expression of CSE is regulated by bile acids by means of an FXR-mediated mechanism. Western blotting, qualitative and quantitative polymerase chain reaction, as well as immunohistochemical analysis, showed that expression of CSE in HepG2 cells and in mice is induced by treatment with an FXR ligand. Administration of 6E-CDCA to carbon tetrachloride treated rats protected against the down-regulation of CSE expression, increased H2S generation, reduced portal pressure and attenuated the endothelial dysfunction of isolated and perfused cirrhotic rat livers. CONCLUSION: These results demonstrate that CSE is an FXR-regulated gene and provide a new molecular explanation for the pathophysiology of portal hypertension. | Barbara Renga Andrea Mencarelli Marco Migliorati Eleonora Distrutti Stefano Fiorucci | 2009 | World Journal of Gastroenterology2009，15，17： | 7 |
| 3 | Relative contribution of acetylated cyclooxygenase (COX) -2 and 5- lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin显示文摘 | Fiorucci S Distrutti E Menezes de Lima O | 2003 | FASEB J2003，17，： | 2 |
| 4 | Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation显示文摘 | Zanardo RC Brancaleone V Distrutti E | 2006 | FASEB J2006，20，12： | 1 |
| 5 | The bile acid receptor FXR is a modulator of intestinal innate immunity 显示文摘 | Vavassori P Mencareni A Renga B Distrutti E Fiorucci S | 2009 | J Immuneol2009，183，10： | 1 |
| 6 | Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation显示文摘 | Zanardo RC Brancaleone V Distrutti E | | 0，，12： | 1 |
| 7 | Inhibition of hydmgen sulfide generation contributes to gastric injury caused by anti-inflammatory nonstemidal drags显示文摘 | Antonelli E Distrutti E | 2005 | Gastroenterology2005，129，： | 1 |
| 8 | The methionine connection:homocysteine and hydrogen sulfide exert opposite effects on hepatic microcirculation in rats显示文摘 | Distrutti E Mencarelli A Santucci L | 2008 | Hepatology2008，47，2： | 1 |
| 9 | Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammatio 显示文摘 | Distrutti E Fiorucci S Cirino G | 2006 | FASEB J2006，20，12： | 1 |
| 10 | Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation显示文摘 | Zanardo R C Brancaleone V Distrutti E | 2006 | FASEB J2006，20，12： | 1 |
| 11 | The farnesoid X-receptor is an essential regulator of cholesterol homeostasis显示文摘 | Fiorucci S Mencarelli A Distrutti E Zampella A | | 0，，： | 1 |
| 12 | Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation 显示文摘 | Zanardo RC Branealeone V Distrutti E | 2006 | FASEB J2006，20，12： | 1 |
| 13 | Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs显示文摘 | Fiorucci S Antonelli E Distrutti E | 2005 | Gastroenterology2005，129，4： | 1 |
| 14 | Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation显示文摘 | Zanardo RC Brancaleone V Distrutti E | 2006 | FASEB J2006，20，12： | 1 |
| 15 | Inhibition of hydrogen sulfide geeneration contributes to gastric injury caused by anti-in? ammatory nonsteroidal drugs显示文摘 | Fiorucci S Antonelli E Distrutti E | | 0，，： | 1 |
| 16 | Farnesoid X receptor:From medicinal chemistry to clinical applica- tions显示文摘 | Fiorucei S Mencarelli A Distrutti E | 2012 | Future Med Chem2012，4，7： | 1 |
| 17 | Role of PAR-2 in pain and inflammation显示文摘 | Fiorucci S Distrutti E | 2003 | Trends Pharmacol Sci2003，23，： | 1 |
| 18 | COXIBs,CINODs and H2S-releasing NSAIDs:current perspectives in the development of safer non steroidal anti-inflammatory drugs显示文摘 | Fiorucci S Distrutti E | 2011 | Curr Med Chem2011，18，23： | 1 |
| 19 | Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti-inflammatory nonsteroidal drugs 显示文摘 | Fiorucci S Antonelli E Distrutti E | 2005 | Gastroenterology2005，129，4： | 1 |
| 20 | Inhibition of hydrogen sulfide generation contributes to gastric injury caused by anti- inflammatory nonsteroidal drugs 显示文摘 | Fiorucci S Antonelli E Distrutti E | 2005 | Gastroenterology2005，129，4： | 1 |
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