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| 1 | Gut microbiota role in irritable bowel syndrome:Newtherapeutic strategies显示文摘In the last decade the impressive expansion of our knowledge of the vast microbial community that resides in the human intestine, the gut microbiota, has provided support to the concept that a disturbed intestinal ecology might promote development and maintenance of symptoms in irritable bowel syndrome(IBS). As a correlate, manipulation of gut microbiota represents a new strategy for the treatment of this multifactorial disease. A number of attempts have been made to modulate the gut bacterial composition, following the idea that expansion of bacterial species considered as beneficial(Lactobacilli and Bifidobacteria) associated with the reduction of those considered harmful(Clostridium, Escherichia coli, Salmonella, Shigella and Pseudomonas) should attenuate IBS symptoms. In this conceptual framework, probiotics appear an attractive option in terms of both efficacy and safety, while prebiotics, synbiotics and antibiotics still need confirmation. Fecal transplant is an old treatment translated from the cure of intestinal infective pathologies that has recently gained a new life as therapeutic option for those patients with a disturbed gut ecosystem, but data on IBS are scanty and randomized, placebo-controlled studies are required. | Eleonora Distrutti Lorenzo Monaldi Patrizia Ricci Stefano Fiorucci | 2016 | World Journal of Gastroenterology2016，22，7： | 60 |
| 2 | Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation显示文摘AIM: To investigate whether the farnesoid X receptor (FXR) regulates expression of liver cystathionase (CSE), a gene involved in hydrogen sulfi de (H2S) generation. METHODS: The regulation of CSE expression in response to FXR ligands was evaluated in HepG2 cells and in wild-type and FXR null mice treated with 6-ethyl chenodeoxycholic acid (6E-CDCA), a synthetic FXR ligand. The analysis demonstrated an FXR responsive element in the 5'-flanking region of the human CSE gene. The function of this site was investigated by luciferase reporter assays, chromatin immunoprecipitation and electrophoretic mobility shift assays. Livers obtained from rats treated with carbon tetrachloride alone, or in combination with 6-ethyl chenodeoxycholic acid, were studied for hydrogen sulphide generation and portal pressure measurement. RESULTS: Liver expression of CSE is regulated by bile acids by means of an FXR-mediated mechanism. Western blotting, qualitative and quantitative polymerase chain reaction, as well as immunohistochemical analysis, showed that expression of CSE in HepG2 cells and in mice is induced by treatment with an FXR ligand. Administration of 6E-CDCA to carbon tetrachloride treated rats protected against the down-regulation of CSE expression, increased H2S generation, reduced portal pressure and attenuated the endothelial dysfunction of isolated and perfused cirrhotic rat livers. CONCLUSION: These results demonstrate that CSE is an FXR-regulated gene and provide a new molecular explanation for the pathophysiology of portal hypertension. | Barbara Renga Andrea Mencarelli Marco Migliorati Eleonora Distrutti Stefano Fiorucci | 2009 | World Journal of Gastroenterology2009，15，17： | 7 |
| 3 | Relative contribution of acetylated cyclooxygenase (COX) -2 and 5- lipooxygenase (LOX) in regulating gastric mucosal integrity and adaptation to aspirin显示文摘 | Fiorucci S Distrutti E Menezes de Lima O | 2003 | FASEB J2003，17，： | 2 |
| 4 | Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa显示文摘 | Fiorucci S Santucci L Wallace JL | 2003 | PNAS2003，100，10： | 2 |
| 5 | Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers:A proof of concept endoscopic study显示文摘 | Fiorucci S Santucci L Gresele P | 2003 | Gastroenterology2003，124，： | 2 |
| 6 | Hazard and population vulnerability analysis: a step towards landslide risk assessment显示文摘In this paper, an attempt to analyse landslide hazard and vulnerability in the municipality of Pahuatlán, Puebla, Mexico, is presented. In order to estimate landslide hazard, the susceptibility,magnitude(area-velocity ratio) and landslide frequency of the area of interest were produced based on information derived from a geomorphological landslide inventory; the latter was generated by using very high resolution satellite stereo pairs along with information derived from other sources(Google Earth,aerial photographs and historical information).Estimations of landslide susceptibility were determined by combining four statistical techniques:(i) logistic regression,(ii) quadratic discriminant analysis,(iii) linear discriminant analysis, and(iv)neuronal networks. A Digital Elevation Model(DEM)of 10 m spatial resolution was used to extract the slope angle, aspect, curvature, elevation and relief.These factors, in addition to land cover, lithology anddistance to faults, were used as explanatory variables for the susceptibility models. Additionally, a Poisson model was used to estimate landslide temporal frequency, at the same time as landslide magnitude was obtained by using the relationship between landslide area and the velocity of movements. Then,due to the complexity of evaluating it, vulnerability of population was analysed by applying the Spatial Approach to Vulnerability Assessment(SAVE) model which considered levels of exposure, sensitivity and lack of resilience. Results were expressed on maps on which different spatial patterns of levels of landslide hazard and vulnerability were found for the inhabited areas. It is noteworthy that the lack of optimal methodologies to estimate and quantify vulnerability is more notorious than that of hazard assessments.Consequently, levels of uncertainty linked to landslide risk assessment remain a challenge to be addressed. | Franny G.MURILLO-GARCíA Mauro ROSSI Francesca ARDIZZONE Federica FIORUCCI Irasema ALCáNTARA-AYALA | 2017 | Journal of Mountain Science2017，14，7： | 2 |
| 7 | Effect of erythromycin on gallbladder emptying in diabetic patients with and without autonomic neuropathy and high levels of motilin显示文摘 | Stefano Fiorucci MD Luciano Scionti MD Rachele Bosso MD Antonio Desando MD Paolo Bottini MD Cecilia Marino MD Prof. Antonio Morelli MD | 1992 | Digestive Diseases and Sciences1992，，11： | 2 |
| 8 | Erythromycin stimulates gallbladder emptying and motilin release by atropine-sensitive pathways显示文摘 | Dr. Stefano Fiorucci MD Rachele Bosso MD Antonio Morelli MD | 1992 | Digestive Diseases and Sciences1992，，11： | 2 |
| 9 | Protective effects of 6-ethyl cheno-deoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis显示文摘 | Fiorucci S Clerici C Antonelli E | 2005 | J Pharmacol Exp Ther2005，313，2： | 1 |
| 10 | The third gas:H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis显示文摘 | Fiorucci S Antonelli E Mencarelli A | 2005 | Hepatology2005，42，3： | 1 |
| 11 | NO-aspirin protects from T cell mediated liver injury by inhibiting caspase-dependentprocessing ofThi-likecytokine显示文摘 | Fiorucci S Santucci L Antonelli E | 2000 | Gastroenterol2000，118，2： | 1 |
| 12 | The bile acid receptor FXR is a modulator of intestinal innate immunity 显示文摘 | Vavassori P Mencareni A Renga B Distrutti E Fiorucci S | 2009 | J Immuneol2009，183，10： | 1 |
| 13 | Role of tumor necrosis fac- tor alpha release and leukocyte margination in indomethacin-in-duced gastric injury in rats显示文摘 | Santucci L Fiorucci S Di M F M | 1995 | Gastroenterology1995，108，2： | 1 |
| 14 | 6alpha-ethylchenode- oxycholic acid (6-ECDCA), a potent and selective FXR agonist en- dowed with anticholestatic activity显示文摘 | Pellicciari R Fiorucci S Camaioni E | 2002 | J Med Chem2002，45，： | 1 |
| 15 | NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1like cytokine显示文摘 | Fiorucci S Santucci L Antonelli E | 2000 | Gastroenterology2000，118，： | 1 |
| 16 | An outbreak of febrile gastroenteritis associated with corn contaminated by Listeria monocytogenes显示文摘 | Aureli P Fiorucci GC Caroli D | 2000 | N Engl J Med2000，342，17： | 1 |
| 17 | Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammatio 显示文摘 | Distrutti E Fiorucci S Cirino G | 2006 | FASEB J2006，20，12： | 1 |
| 18 | Natural risk assessment and decision planning for disaster mitigation 显示文摘 | Fiorucci P Gaetani F Minciardi R | 2005 | Advances in Geo- sciences2005，，2： | 1 |
| 19 | Mast cell tryptase, a still enigmatic enzyme 显示文摘 | FIORUCCI L ASCOLI F | 2004 | Cell Mol Life Sci2004，61，11： | 1 |
| 20 | Colchicine, cyclophosphamide and prednisone in the treatment of mild-moderate idiopathic pul- monary fibrosis: comparison of three currently available therapeutic regimens显示文摘 | Fiorucci E Lucantoni G Paone G | 2008 | Eur Rev Med Pharmacol Sci2008，12，2： | 1 |
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