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| 1 | 1999-2005年我国婴幼儿人杯状病毒腹泻研究显示文摘人杯状病毒(HuCV)是世界范围内急性腹泻的重要病原。此文收集我国长春、北京、河北卢龙、兰州、昆明等13个地区1999-2005年5岁以下腹泻患儿检测轮状病毒为阴性的粪便标本4426份,用ELISA和RT-PCR方法检测HuCV,结果表明HuCV检测阳性率为19%(8.3%-38.6%)。对其中151株HuCV PCR产物测序进行核苷酸序列比对构建的系统发生树表明,我国流行的HuCV以诺如病毒(NV)为主(146/151,占96.7%),其中绝大多数为GGⅡ/4基因型(99/146),其它依次为GGⅡ/3(22/146)、GGⅡ/5(8/146)、GGⅡ/6(2/146)、GGⅡ/7(2/146)、GGⅡ/8(2/146)和GGⅠ/2(2/146),札如病毒(SV)共5株,均属SGⅡ。此外有9株NV GGⅡ遗传组毒株,尚不能归入现有基因型,可能为我国特有的新基因型,表明我国流行的HuCV毒株存在很高的遗传多样性。我国婴幼儿HuCV腹泻全年都有发生,但秋冬季(10月-次年1月)有一个发病高峰,病例以6-17月龄组最多,至3岁时超过96%的儿童都感染过HuCV。对我国流行的HuCV不同毒株的地区分布,不同年度HuCV检测阳性率的变化趋势进行了讨论。 | 方肇寅 谢华萍 吕红霞 刘娜 章青 段招军 Duncan Steele Baoming Jiang Xi Jiang | 2007 | 病毒学报2007，23，1： | 131 |
| 2 | 长春地区轮状病毒流行株VP7基因的遗传变异显示文摘A组轮状病毒是引起婴幼儿秋冬季病毒性腹泻的主要病原。目前没有有效的治疗药物,应用安全而有效的疫苗是控制重症腹泻的首要措施。对当地A组轮状病毒流行株的主要中和抗原VP7的编码基因进行遗传变异分析,可以为疫苗的应用和开发提供有益的指导。利用ELISA方法对长春地区1999~2005年的腹泻患儿标本检测A组轮状病毒,RT-PCR方法对阳性标本进行G血清分型,发现长春地区2001年以后流行的轮状病毒以G3型血清为主。选取1999~2005年的G3型轮状病毒标本31份,对其VP7基因进行扩增、克隆、测序,经过计算机分析比对,31株G3型轮状病毒VP7基因核苷酸序列没有显著差异。同一流行季节的毒株具有较相似的遗传变异特征。在2003年轮状病毒流行季节内,有6株G3型分离株的VP7基因在碱基1038位置上出现一个碱基缺失。毒株发生在A、B、C三个高变区的碱基突变,位点相同或者位置临近。2002年以后毒株的基因突变增加,非高变区的碱基变异增加,这可能有助于维持G3型轮状病毒成为流行株。有规律的变异多发生在高变区,但是非高变区的非连续性变异的增加值得引起注意。 | 王端可 章青 孙利炜 王承训 段招军 Xi Jiang Baoming Jiang 方肇寅 | 2008 | 病毒学报2008，24，1： | 10 |
| 3 | Unimodal productivity-biodiversity relationship along the gradient of multidimensional resources across Chinese grasslands显示文摘Resources can affect plant productivity and biodiversity simultaneously and thus are key drivers of their relationships in addition to plant-plant interactions.However,most previous studies only focused on a single resource while negle cting the nature of resource multidimensionality.Here we integrated four essential resources for plant growth into a single metric of resource diversity(RD)to investigate its effects on the productivity-biodiversity relationship(PBR)across Chinese grasslands.Results showed that habitats differing in RD have different PBRs—positive in low-resource habitats,but neutral in medium-and high-resource ones—while collectively,a weak positive PBR was observe d.However,when excluding direct effects of RD on productivity and biodiversity,the PBR in high-resource habitats became negative,which leads to a unimodal instead of a positive PBR along the RD gradient.By integrating resource effects and changing plant-plant interactions into a unified framework with the RD gradient,our work contributes to uncovering underlying me chanisms for inconsistent PBRs at large scales. | Yanfen Wang Jianqing Du Zhe Pang Yali Liu Kai Xue Yann Hautier Biao Zhang Li Tang Lili Jiang Baoming Ji Xingliang Xu Jing Zhang Ronghai Hu Shutong Zhou Fang Wang Rongxiao Che Di Wang Chaoting Zhou Xiaoyong Cui Nico Eisenhauer Yanbin Hao | 2022 | National Science Review2022，9，12： | 2 |
| 4 | Reducing feather pecking and cloacal cannibalism by providing layer breeders with nest boxes in colony cages for natural mating显示文摘Colony cages for natural mating have been applied on many layer breeder farms.However,feather pecking and cloacal cannibalism are considered as prominent problems for these systems.This study aimed to investigate the effects on feather pecking and vent pecking behaviors by providing layer breeders with nest boxes(0.90 m L×0.40 m W×0.60 m H)in colony cages for natural mating(4.80 m L×1.20 m W×0.71 m H).Video recording and artificial observation were adopted.The results showed that the usage of nest boxes gradually increased from the beginning of nest boxes providing at the age of 37 weeks to the end of the experiment at the age of 55 weeks.The utilization rates of nest boxes were 36.75%,44.75%and 50.38%at the ages of 41 weeks,47 weeks and 53 weeks,respectively.The hens in the cages without nest boxes showed significantly more frequent gentle feather pecks(both given and received)than hens in the cages with nest boxes at the ages of 41 weeks,47 weeks and 53 weeks.A decreasing trend of gentle feather pecking frequency(both given and received)was found with the increasing age for both the two groups.No significant difference was found in the number of given or received severe feather pecks at the age of 41 weeks.The hens in the cages without nest boxes showed a significantly higher frequency of given and received severe feather pecks than hens in the cages with nest boxes at the ages of 47 weeks and 53 weeks(p<0.05).Both cannibalistic injury occurrence and mortality rate in the cages with nest boxes were significantly lower than those in the cages without nest boxes.In conclusion,providing nest boxes in colony cages for natural mating could decrease abnormal pecking behaviors and improve animal welfare conditions of layer breeders. | Haipeng Shi Weichao Zheng Jiang Tu Baoming Li | 2018 | International Journal of Agricultural and Biological Engineering2018，11，6： | 1 |
| 5 | Rotavirus vaccines: current prospects and future challenges显示文摘 | Roger I Glass Umesh D Parashar Joseph S Bresee Reina Turcios Thea K Fischer Marc-Alain Widdowson Baoming Jiang Jon R Gentsch | 2006 | The Lancet . 2006 (9532)2006，，9532： | 1 |
| 6 | Enhancement of hydrolysis and acidification of solid organic waste by a rotational drum fermentation system with methanogenic leachate recirculation显示文摘 | Ling Chen Wei Zhong Jiang Yutaka Kitamura Baoming Li | 2006 | Bioresource Technology2006，，11： | 1 |
| 7 | Enhancement of hydrolysis and acidification of solid organic waste by a rotational drum fermentation system with methanogenic leachate recirculation显示文摘 | Chen Ling Jiang Weizhong Li Baoming | 2007 | Bioresource Technology2007，98，11： | 1 |
| 8 | Enhancement of hydrolysis and acidification of solid organic waste by a rotational drum fermentation system with methanogenic leachate recirculation显示文摘 | Ling Chen Wei Zhong Jiang Yutaka Kitamura Baoming Li | 2006 | Bioresource Technology2006，，11： | 1 |
| 9 | Differences in the changing trends of monophasic action potential duration and effective refractory period of the ventricular myocardium after myocardial infarction in viv 显示文摘 | Huang C BaoM Jiang H | 2004 | Cite J2004，68，： | 1 |
| 10 | Using porphyritic andesite as a new additive for improving hydrolysis and acidogenesis of solid organic wastes显示文摘 | Dawei Li Tao Zhou Ling Chen Weizhong Jiang Fan Cheng Baoming Li Yutaka Kitamura | 2009 | Bioresource Technology2009，，23： | 1 |
| 11 | Measurement of Pulse Wave Velocity Using Pulse Wave Doppler Ultrasound: Comparison with Arterial Tonometry显示文摘 | Benyu Jiang Baoming Liu Karen L. McNeill Philip J. Chowienczyk | 2008 | Ultrasound in Medicine & Biology2008，，3： | 1 |
| 12 | Application and Research Progress of PRB for Groundwater Pollution Remediation显示文摘Because of its long processing time,low operating cost,simultaneous processing of multiple pollutants,PRB( permeable reactive barrier) is a commonly used technique for groundwater pollution remediation in western countries. But relative research about the PRB technology in China is still in its infancy. We reviewed the PRB structure,PRB repair mechanism and application progress at home and abroad. Aiming at the problems of PRB technology at reaction material selection,pollutant repair mechanism,removal of various pollution components and site installation design,development direction of the PRB technology was prospected. | Li Haiting Chi Baoming He Cunzhe Gu Hongbiao Jiang Jiyi Kong Huimin Zhang Ying | 2015 | Meteorological and Environmental Research2015，6，5： | 0 |
| 13 | A subpopulation of CD146^(+) macrophages enhances antitumor immunity by activating the NLRP3 inflammasome显示文摘As one of the main tumor-infiltrating immune cell types, tumor-associated macrophages (TAMs) determine the efficacy of immunotherapy. However, limited knowledge about their phenotypically and functionally heterogeneous nature restricts their application in tumor immunotherapy. In this study, we identified a subpopulation of CD146+ TAMs that exerted antitumor activity in both human samples and animal models. CD146 expression in TAMs was negatively controlled by STAT3 signaling. Reducing this population of TAMs promoted tumor development by facilitating myeloid-derived suppressor cell recruitment via activation of JNK signaling. Interestingly, CD146 was involved in the NLRP3 inflammasome-mediated activation of macrophages in the tumor microenvironment, partially by inhibiting transmembrane protein 176B (TMEM176B), an immunoregulatory cation channel. Treatment with a TMEM176B inhibitor enhanced the antitumor activity of CD146+ TAMs. These data reveal a crucial antitumor role of CD146+ TAMs and highlight the promising immunotherapeutic approach of inhibiting CD146 and TMEM176B. | Lin Jing Yunhe An Tanxi Cai Jianquan Xiang Baoming Li Jiang Guo Xinran Ma Ling Wei Yanjie Tian Xiaoyan Cheng Xuehui Chen Zheng Liu Jing Feng Fuquan Yang Xiyun Yan Hongxia Duan | 2023 | Cellular & Molecular Immunology2023，20，8： | 0 |
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