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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | 人类世:人类将压倒大自然的威力吗?显示文摘我们探讨人类世的发展。人类世是当前世,在此期间人类及人类社会成为全球性的地球物理作用力。人类世开始于1800年左右,工业化开始之际,重要特征是矿物燃料极其广泛的使用。我们用大气CO_2浓度作为唯一的、简单的指标来追溯人类世的行进过程。前工业化时代的大气CO_2浓度为270~275 ppm,到1950年上升至大约310ppm。从此,人类事业经历了一个显著的爆发——大加速时期,对地球系统功能带来了明显的后果。自1950年以来,大气CO_2浓度从310ppm升至380ppm,自前工业化时代以来总上升值的大约一半发生在最后区区30年间。大加速即将达到临界状态。无论将来呈现的是何等景象,未来几十年肯定是人类世演进过程中的一个转折点。 | Will Steffen Paul J. Crutzen John R. McNeill 寒江(译) | 2007 | AMBIO-人类环境杂志2007，36，B12： | 8 |
| 3 | Parallel effects of β-adrenoceptor blockade on cardiac function and fatty acid oxidation in the diabetic heart: Confronting the maze显示文摘Diabetic cardiomyopathy is a disease process in which diabetes produces a direct and continuous myocardial insult even in the absence of ischemic, hypertensive or valvular disease. The β-blocking agents bisoprolol, carvedilol and metoprolol have been shown in large-scale randomized controlled trials to reduce heart failure mortality. In this review, we summarize the results of our studies investigating the effects of β-blocking agents on cardiac function and metabolism in diabetic heart failure, and the complex inter-related mechanisms involved. Metoprolol inhibits fatty acid oxidation at the mitochondrial level but does not prevent lipotoxicity; its benefi cial effects are more likely to be due to prosurvival effects of chronic treatment. These studies have expanded our understanding of the range of effects produced by β-adrenergic blockade and showhow interconnected the signaling pathways of function and metabolism are in the heart. Although our initial hypothesis that inhibition of fatty acid oxidation would be a key mechanism of action was disproved, unexpected results led us to some intriguing regulatory mechanisms of cardiac metabolism. The fi rst was upstream stimulatory factor-2-mediated repression of transcriptional master regulator PGC-1α, most likely occurring as a consequence of the improved function; it is unclear whether this effect is unique to β-blockers, although repression of carnitine palmitoyltransferase (CPT)-1 has not been reported with other drugs which improve function. The second was the identif ication of a range of covalent modifications which can regulate CPT-1 directly, mediated by a signalome at the level of the mitochondria. We also identif ied an important interaction between β-adrenergic signaling and caveolins, which may be a key mechanism of action of β-adrenergic blockade. Our experience with this labyrinthine signaling web illustrates that initial hypotheses and anticipat-ed directions do not have to be right in order to open up meaningful directions or reveal new information. | Vijay Sharma John H McNeill | 2011 | World Journal of Cardiology2011，3，9： | 8 |
| 4 | 新版国际植物命名法规(维也纳法规)中的主要变化显示文摘出版于2006年9月的最新版的《国际植物命名法规》,即维也纳法规(Vienna Code),取代了圣路易斯法规(Saint Louis Code)而成为管理植物学(包括藻类学和真菌学)科学命名的唯一有效法规。本文报道了维也纳法规和圣路易斯法规之间的主要区别。这些区别包括两版法规在起始日期、有效发表、合格发表、化石植物、多型真菌、拼写和附录诸方面的不同。 | 张丽兵 杨亲二 Nicholas J.TURLAND John MCNEILL | 2007 | 植物分类学报2007，45，2： | 6 |
| 5 | N-乙酰半胱氨酸对糖尿病大鼠肾脏NADPH氧化酶表达的影响显示文摘目的探讨N-乙酰半胱氨酸(NAC)对糖尿病大鼠肾脏尼克酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶表达的影响。方法大鼠随机分为正常对照(NC)组、正常对照NAC治疗组(CT组)、糖尿病组(DM组)和糖尿病NAC治疗组(DT组)。8周后测定血糖、胰岛素、肌酐、游离15-F2t-异前列烷和总抗氧化物水平、24小时尿蛋白排泄量(UPro/24h)、肾系膜基质增宽指数、肾皮质p22phox、p67phox、铜-锌-超氧化物歧化酶(Cu-Zn-SOD)和结缔组织生长因子(CTGF)蛋白表达。结果糖尿病大鼠UPro/24h、血浆游离15-F2t-异前列烷水平、系膜基质增宽指数、肾脏p22phox、p67phox和CTGF蛋白表达显著增高,血浆总抗氧化物浓度和肾脏Cu-Zn-SOD蛋白表达显著降低。NAC治疗能显著逆转糖尿病大鼠上述各项指标的变化。结论NAC显著降低糖尿病大鼠肾脏氧化应激水平,减轻氧化应激对肾组织的损伤,产生肾脏保护作用。 | 郭志新 John H McNeill | 2008 | 中国糖尿病杂志2008，16，9： | 5 |
| 6 | 国际植物命名法规中的术语介绍显示文摘现今,国际上已普遍接受国际植物命名法规(Internationalcodeofbotanicalnomenclature)作为管理植物学(包括藻类学和真菌学)科学命名的规则。该规则由历届国际植物学大会的命名法分会会议修订,因而每六年出版一次修订版。最新版的维也纳法规(ViennaCode;McNeilleta1.,2006;中文版:张丽兵译,2007)取代了前一版的圣路易斯法规(SaintLouisCode,Greutereta1.,2000;中文版:朱光华译,2001)。 | 张丽兵 Paul C.SILVA John MCNEILL Nicholas J.TURLAND | 2007 | 植物分类学报2007，45，4： | 4 |
| 7 | 小尺寸铕(Ⅲ)配合物荧光纳米颗粒的制备显示文摘利用再沉淀法分别制备出了小尺寸(~10nm)纯相和杂相的Eu3+配合物荧光纳米颗粒。所制备的纯相的荧光纳米颗粒在水溶液中容易聚集,并且荧光猝灭严重。相比较而言,掺有适量疏水性硅烷的杂相纳米颗粒则具有较强的荧光、均匀的尺寸和良好的分散性。硅烷在碱性环境下(pH=9)迅速地水解,而后在纳米微粒的表面形成二氧化硅薄层。亲水的二氧化硅薄层消除了Eu3+配合物纳米颗粒间的疏水相互作用,进而防止了纳米颗粒的聚集,从而导致了杂相荧光纳米颗粒发光性能的提高。 | 彭洪尚 吴长峰 黄世华 McNeill Jason | 2006 | 发光学报2006，27，5： | 4 |
| 8 | Identification of diapause-associated proteins in migratory locust, Locusta migratoria L.(Orthoptera: Acridoidea) by label-free quantification analysis显示文摘Maternal photoperiodic response is a key factor that affects offspring diapause in migratory locust,Locusta migratoria L.(Orthoptera:Acridoidea).Although many aspects of insect diapause have been studied,little is known about the molecular mechanisms of maternal photoperiodic response that influence diapause regulation.To gain insight into the possible mechanisms of maternal photoperiod influence on diapause regulation,proteomics data by label-free quantification analysis were generated from non-diapause and diapause eggs.A total of 175 proteins were differentially expressed between diapause and non-diapause eggs.Among them,24 proteins were upregulated,and 151 proteins were downregulated.Gene Ontology(GO)analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichments were performed on all differentially expressed proteins(DEPs)and showed that peroxisome,insect hormone biosynthesis,and longevity regulating pathway may be related to diapause of migratory locust.Furthermore,we used qRT-PCR to verify some results of the proteomic analysis.Proteins such as hexamerin-like protein 4,juvenile hormone epoxide hydrolase 1(JHEH1),cytochrome P450 and heat shock protein(HSP)20.7 were predicted to be involved in diapause.This study provides an important reference for future research that will explore the mechanisms of diapause induced by maternal effects in migratory locust. | CUI Dong-nan TU Xiong-bing HAO Kun Aftab Raza CHEN Jun Mark McNeill ZHANG Ze-hua | 2019 | Journal of Integrative Agriculture2019，18，11： | 3 |
| 9 | Including predator presence in a refined model for assessing resistance of alfalfa cultivar to aphids显示文摘The aphid quantity ratio(AQR) is defined as the number of aphids on each cultivar divided by the number of aphids on all cultivars. AQR is based on the correlation between aphid populations and their host plants and is an important tool that has been utilized in evaluating Medicago sativa(alfalfa) cultivar resistance to aphids. However, assessment of alfalfa resistance to aphids can be confused by the presence of aphid predators, causing the assessment of plant resistance to aphids to be based on incorrect aphid population data. To refine the AQR and account for the effect of predators on aphid population assessments, we introduced a parameter ‘α', corresponding to the predator quantity ratio, and used αAQR as the ratio to quantify aphid populations. Populations of both aphids(4 species) and their predators(12 species) occurring in 28 M. sativa cultivars were sampled over two years at a research station near Cangzhou, Hebei Province, China. Results showed that the most suitable evaluation period was from May to June, as the aphid population was stable during this period. Compared with the AQR method, the predator population numbers based on the αAQR had a significant inverse relationship with aphid population numbers and the 28 cultivars were clustered into three classes: the resistant class, tolerant class, and susceptible class. In addition, 17 cultivars were reassigned when evaluated using αAQR. All numerical values calculated by αAQR were displayed as a Gaussian distribution, which showed that the 28 cultivars could be clustered into nine groups using a median value(±SE) of 1±0.1. Hence, ongoing alfalfa breeding trials will be assessed using the αAQR to establish a robust system that includes agronomic performance parameters in order to generalize the new method for further studies. | TU Xiong-bing FAN Yao-li Mark McNeill ZHANG Ze-hua | 2018 | Journal of Integrative Agriculture2018，17，2： | 3 |
| 10 | Analysis of the pentafecta learning curve for laparoscopic radical prostatectomy显示文摘 | D. W. Good G. D. Stewart J. U. Stolzenburg S. A. McNeill | 2014 | World Journal of Urology2014，，： | 2 |
| 11 | Three-dimensional point cloud registration by matching surface features with relaxation labeling method显示文摘 | N. Li P. Cheng M. A. Sutton S. R. McNeill | 2005 | Experimental Mechanics2005，，1： | 2 |
| 12 | 在墨尔本召开的第18届国际植物学大会做出的有关名称发表要求的变化——电子出版物对你意味着什么?显示文摘《国际植物命名法规》的修订由每六年一次的国际植物学大会(IBC)命名分会来决定。第18届国际植物学大会在澳大利亚墨尔本举行;命名分会于2011年7月18日至22日召开,其决议获得7月30日的全体会议通过。'墨尔本法规'有几个重要的变化,将影响新名称的发表。这些变化中的两个将在'墨尔本法规'出版前的几个月,即于2012年1月1日起生效。通过以移动文档格式(Portable Document Format;pdf)在线发表的具有国际标准连续出版物号(ISSN)或国际标准图书编号(ISBN)的电子出版物,将构成有效发表。新分类群名称的合格发表所必须的拉丁文描述或特征集要将更改为拉丁文或英文描述或特征集要。此外,自2013年1月1日起,被处理为真菌的生物的新名称必须在原始资料(某一名称合格发表时与之有关的所有资料)中引证一个由一家公认的存储库(例如MycoBank)签发的标识码,才构成合格发表。本文提供了有关电子出版物的新规则的草案文本,并概述了相应的最佳做法。 | Sandra Knapp John McNeill Nicholas J.Turland 张丽兵 | 2011 | 植物分类与资源学报2011，33，5： | 2 |
| 13 | Metabolic disturbances in diabetic cardiomyopathy显示文摘 | Cam MC McNeill JH | 1998 | Mol Cell Biochem1998，180，： | 1 |
| 14 | Estrogen increases endothelial nitric oxide synthase via estrogen receptors in rat cerebral blood vessels: effect preserved after concurrent treatment with medroxyprogesterone acetate or progesterone显示文摘 | McNeill AM Zhang C Stanczyk FZ | 2002 | Stroke2002，33，： | 1 |
| 15 | I'm still waiting:Barriers to accessing cardiac rehabilitation services显示文摘 | Tod AM Lacey EA McNeill F | 2002 | J Adv Nurs2002，40，4： | 1 |
| 16 | Intracellular calcium levels are unchanged in the diabetic heart显示文摘 | Yu JZ Rodrigues B McNeill JH | 1997 | Cardiovas Res1997，34，： | 1 |
| 17 | Nitric oxide nerves in the uterus are parasympathetic, sensory, and con tainneuropeptides显示文摘 | Papka RE McNeill DL Thompson D | 1995 | Cell Tissue Res1995，279，2： | 1 |
| 18 | Selective inhibition of ~ctor inhibiting hypoxia-inducible factor 显示文摘 | McDonough M A McNeill L A Tilliet M | 2005 | JAm Chem Soc2005，127，21： | 1 |
| 19 | Childhood disorders of neurodegeneration with brain iron accumulation (NBIA) 显示文摘 | Kurian MA McNeill A Lin JP | 2011 | Dev Med Child Neurol2011，53，： | 1 |
| 20 | Altered inotropic responses in diabetic cardiomyopathy and hypertensive-diabetic cardiomyopathy 显示文摘 | Yu Z McNeill JH | 1991 | J Pharmacol Exp Ther1991，257，1： | 1 |
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