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| 1 | Diabetes and cardiac autonomic neuropathy: Clinical manifestations, cardiovascular consequences, diagnosis and treatment显示文摘Cardiac autonomic neuropathy(CAN) is a frequent chronic complication of diabetes mellitus with potentially life-threatening outcomes. CAN is caused by the impairment of the autonomic nerve fibers regulating heart rate, cardiac output, myocardial contractility, cardiac electrophysiology and blood vessel constriction anddilatation. It causes a wide range of cardiac disorders, including resting tachycardia, arrhythmias, intraoperative cardiovascular instability, asymptomatic myocardial ischemia and infarction and increased rate of mortality after myocardial infarction. Etiological factors associated with autonomic neuropathy include insufficient glycemic control, a longer period since the onset of diabetes, increased age, female sex and greater body mass index. The most commonly used methods for the diagnosis of CAN are based upon the assessment of heart rate variability(the physiological variation in the time interval between heartbeats), as it is one of the first findings in both clinically asymptomatic and symptomatic patients. Clinical symptoms associated with CAN generally occur late in the disease process and include early fatigue and exhaustion during exercise, orthostatic hypotension, dizziness, presyncope and syncope. Treatment is based on early diagnosis, life style changes, optimization of glycemic control and management of cardiovascular risk factors. Medical therapies, including aldose reductase inhibitors, angiotensin-converting enzyme inhibitors, prostoglandin analogs and alpha-lipoic acid, have been found to be effective in randomized controlled trials. The following article includes the epidemiology, clinical findings and cardiovascular consequences, diagnosis, and approaches to prevention and treatment of CAN. | Akif Serhat Balc?o?lu Haldun Müderriso?lu | 2015 | World Journal of Diabetes2015，6，1： | 22 |
| 2 | Probiotics as Control Agents in Aquaculture显示文摘Infectious diseases constitute a limiting factor in the development of the aquaculture production, and control has solely concentrated on the use of antibiotics. However, the massive use of antibiotics for the control of diseases has been questioned by acquisition of antibiotic resistance and the need of alternative is of prime importance. Probiotics, live microorganisms administered in adequate amounts that confer a healthy effect on the host, are emerging as significant microbial food supplements in the field of prophylaxis. | Gómez R. Geovanny D Balcázar José Luis | 2007 | Journal of Ocean University of China2007，6，1： | 10 |
| 3 | Effects of tyrosine kinase inhibitor E7080 and eNOS inhibitor L-NIO on colorectal cancer alone and in combination显示文摘Objective:To investigate the effects of E7080 and N5-(1-iminoethyl)-L-ornithine dihydrochloride(L-NIO)on colorectal cancer alone and in combination.Methods:HT29 colorectal cancer cell line from Sap Institute was used.Real-time cell analysis(xCELLigence system)was performed to determine the effects of E7080 and L-NIO on colorectal cell proliferation.While apoptosis was determined with Annexin V staining,and the effect of agents on angiogenesis was determined with chorioallantoic membrane(CAM)model.Results:We found that E7080 has a strong antiproliferative effect with an half maximum inhibition of concentration(IC50)value of 5.60×10–8mol/L.Also it has been observed that E7080 showed antiangiogenic and apoptotic effects on HT29 colorectal cancer cells.Antiangiogenic scores of E7080 were 1.2,1.0 and 0.6for 100,10 and 1 nmol/L E7080 concentrations,respectively.Furthermore,apoptosis has been detected in71%of HT29 colorectal cancer cells after administration of 100 nmol/L E7080 which may indicate strong apoptotic effect.Meanwhile administration of L-NIO alone did not show any effect,but the combination of E7080 with L-NIO increased the antiproliferative,antiangiogenic and apoptotic effects of E7080.Conclusions:Results of this study indicate that E7080 may be a good choice in treatment of colorectal tumors.Furthermore the increased effects of E7080 when combined with L-NIO raise the possibility to use a lower dose of E7080 and therefore avoid/minimize the side effects observed with E7080. | Ahmet Altun Tijen Kaya Temiz Ezgi Balc Zübeyde Ak n Polat Mustafa Turan | 2013 | Chinese Journal of Cancer Research2013，25，5： | 4 |
| 4 | The role of probiotics in aquaculture显示文摘 | José Luis Balcázar Ignacio de Blas Imanol Ruiz-Zarzuela David Cunningham Daniel Vendrell José Luis Múzquiz | 2006 | Veterinary Microbiology2006，，3： | 2 |
| 5 | Primary squamous cell carcinoma of the thyroid gland: New evidence in support of follicular epithelial cell orisin显示文摘 | Sahoo M Balcs Bhatnagar D | 2002 | Diagn Cytopathol2002，27，4： | 1 |
| 6 | Comparison of the ozonation and Fenton process performances for the treatment of antibiotic containing manure显示文摘 | Merih ?tker Uslu I??l Akmehmet Balc?o?lu | 2009 | Science of the Total Environment2009，，11： | 1 |
| 7 | Is bilateral lower limb lengthening appropriate for achondroplasia?: midterm analysis of the complications and quality of life 显示文摘 | Kim S J Balce G C Agashe M V | 2012 | Clin Orthop Relat Res2012，470，2： | 1 |
| 8 | Mining frequent closedrooted trees显示文摘 | JoséL Balcázar Albert Bifet Antoni Lozano | 2010 | Mach Learn2010，78，： | 1 |
| 9 | Immobilization of β-galactosidase from Kluyveromyces lactis onto a polysiloxane-polyvinyl alcohol magnetic(mPOS-PVA)composite for lactose hydrolysis显示文摘 | Neri D F M Balc?o V M Carneiro-da-Cunha M G | 2008 | Catal Commun2008，9，14： | 1 |
| 10 | Gradual detorsion of torsioned rat testis attenuates ischemia reperfusion injury显示文摘 | Bülent Ak?ora Muhammed E. Altu? Ali Balc? Sibel Hakverdi Zafer Y?nden Ali Akba? Atakan ?ztürk Sinem Karazincir Hüseyin ?zyurt | 2008 | Journal of Pediatric Surgery2008，，10： | 1 |
| 11 | Is chest x-ray-or high-resolution computed tomography scan of the chest sufficient investigation to detect pulmonary metastasis in pediatric differentia-ted thyroid cancer? 显示文摘 | BALC S KUMAR A CHANDRA P | 2004 | Thyroid2004，14，3： | 1 |
| 12 | Fludarabine, cytarabine, granulocyte, colony stimulating factor, and idarrbiein (FLAGIDA) for the treatment of children with poor-prognosis acute leulemia: the Hacettepe experience 显示文摘 | Tavil B Aytac S Balc YI | 2010 | Pediatr Hematol Oneol2010，27，7： | 1 |
| 13 | Gibberellic acid, a plant growth regulator, increases mast cell recruitment and alters Substance P levels显示文摘 | Nuray Erin Berna Afacan Yasemin Ersoy Feriha Ercan Mustafa Kemal Balc? | 2008 | Toxicology2008，，1： | 1 |
| 14 | The role of probiotics in aquaculture (Review)显示文摘 | Balcázar J L De Blas I Zarzuela-Ruiz I | | 0，，3： | 1 |
| 15 | Isolation ofVibrio alginolyticus and Vibrio splendidus fromcaptive-bred seahorses with disease symptoms 显示文摘 | Balcázar J L Gallo-Bueno A Planas M | 2010 | Antonie van Leeuwenhoek2010，97，2： | 1 |
| 16 | Evaluation of the turbinate hypertrophy by computed tomography in patients with deviated nasal septum显示文摘 | Ertap Akog lu Sinem Karazincir Ali Balc | 2007 | Otolaryngology-Head and Neck Surgery2007，136，3： | 1 |
| 17 | Host-microbiota interactions within the fish intestinal ecosystem显示文摘 | Pérez T Balcázar J L Ruiz-Zarzuela I | 2010 | Mucosal Immunol2010，3，4： | 1 |
| 18 | Correlation ofictal EEG and SPECT studies in patients of in tractable epilepsy with normal MRI显示文摘 | Bhatia M BalCS | 2002 | Neurol Lndia2002，50，3： | 1 |
| 19 | prevalenceofuri-narytractin fection and renalscarsinpatients with diabetsmellitus显示文摘 | Coswamir Balcs Tejaswis | 2001 | Diabete Res Clinpract2001，53，3： | 1 |
| 20 | Usefulness of procalcitonin for diagnosis of sepsis in the intensive care unit显示文摘 | Balc C Sungurtekin H Gurses E | 2003 | Crit Care2003，7，： | 1 |
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