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| 1 | 精索静脉曲张导致的睾丸功能障碍发病机理中TNF相关的调亡诱导配体的角色显示文摘不育男性中频发的精索静脉曲张备受关注,面向治疗的分子水平的研究也随之增加。本研究的目的是探讨大鼠模型中肿瘤坏死因子相关凋亡诱导配体(TRAIL)及其受体在精索静脉曲张起的睾丸功能障碍中的作用。大鼠被随机分为三组:对照组,假手术组和精索静脉曲张组。部分结扎左肾静脉与左睾丸构建大鼠精索静脉曲张模型。对手术13周后的大鼠进行分析。睾丸细胞内DNA片段程度用末端脱氧核苷酸转移酶的脱氧尿苷三磷酸缺口未端标记法(TUNEL)检测。用约翰逊得分评估肾小管退化情况。用免疫组化和Westernblot技术检测TRAIL及其受体的表达。检测了细胞凋亡指数,约翰逊得分,TRAIL和TRAIL受体的表达。数据以平均值±标准偏差(s.d.)表示,并用计算机软件进行了分析。用Kruskal—Wallis和Dunn’s多重比较试验进行数捌分析。与假手术组和对照组相比,精索静脉曲张的大鼠生殖细胞凋亡指数增加(P=0.0031),约翰逊得分显著下降(P〈0.0001)。免疫组化和Western blot分析表明,精索静脉曲张后,生殖细胞中的TRAIL-R1和TRAIL—R4的表达增加,TRAIL—R2的表达下降。在TRAIL和TRAIL—R3受体的表达上,各组间没有显著差异。这一研究结果表明,TRAIL及其受体可能神精索静脉曲张引起的罩丸功能障碍的发病机制中有潜在的作用。 | Orcun Celik Omer Kutlu Merih Tekcan CUer Celik-Ozenci Ismail T Koksal | 2013 | Asian Journal of Andrology2013，15，2： | 12 |
| 2 | Trabeculectomy with large area mitomycin-C application as a first-line treatment in advanced glaucoma: retrospective review显示文摘AIM: To evaluate the outcomes of trabeculectomy with large area mitomycin-C(MMC) application as a first line treatment in advanced glaucoma. ·METHODS: The records of 55 patients with severe visual field defects undergoing trabeculectomy were retrospectively reviewed. The patients were classified as first-line therapy to either early trabeculectomy(initial trabeculectomy-Group 1) or long term medical therapy followed by trabeculectomy(primary trabeculectomy-Group 2). Trabeculectomy was performed with large-area MMC application. Intraocular pressure(IOP) values,visual acuities,mean deviations,morphology and function of the blebs,necessity for anti-glaucomatous medications and surgical complications were reported. ·RESULTS: There were 20 eyes of 18 patients in Group 1 and 37 eyes of 37 patients in Group 2. The mean preoperative IOPs in Groups 1 and 2 were 40.2±10.0mmHg(27-68mmHg) and 29.0±4.4mmHg(21-41mmHg),respectively(P=0.001). Average preoperative mean deviations(MD) in Groups 1 and 2 were 17.4±2.8dB(13.3-23dB) and 17.9± 2.4dB(13.7-23.2dB),respectively(P=0.441). Postoperative IOPs significantly decreased and were comparable in both Groups. The mean number of medications was significantly higher in Group 2(P =0.005). No cystic bleb formation was observed in Group 1,whereas 4 patients from Group 2(10.8%) developed cystic bleb(P =0.040). No visually devastating complication has occurred in both Groups. ·CONCLUSION: Initial trabeculectomy with large areaMMC application might be applied in patients with advanced glaucoma with low complication rates. Long-term topically applied anti-glaucomatous medications seem to increase the risk of cystic bleb formation. | Zeynep Aktas Safak Korkmaz Murat Hasanreisoglu Merih Onol Berati Hasanreisoglu | 2014 | International Journal of Ophthalmology(English edition)2014，7，1： | 6 |
| 3 | Modeling surface fuels moisture content in Pinus brutia stands显示文摘Fuel moisture content is an important variable for forest fires because it affects fuel ignition and fire behavior. In order to accurately predict fuel ignition potential, fuel moisture content must be assessed by evaluating fire spread, fireline intensity and fuel consumption.Our objective here is to model moisture content of surface fuels in normally stocked Calabrian pine(Pinus brutia Ten.) stands in relation to weather conditions, namely temperature, relative humidity, and wind speed in the Mugla province of Turkey. All surface fuels were categorized according to diameter classes and fuel types. Six fuel categories were defined: these were 0–0.3, 0.3–0.6, and0.6–1 cm diameter classes, and cone, surface litter, and duff. Plastic containers 15 9 20 cm in size with 1 9 1 mm mesh size were used. Samples were taken from 09:00 to19:00 h and weighed every 2 h with 0.01 g precision for10 days in August. At the end of the study, samples were taken to the laboratory, oven-dried at 105 °C for 24 h and weighed to obtain fuel-moisture contents. Weather measurements were taken from a fully automated weather station set up at the study site prior to the study. Correlation and regression analyses were carried out and models were developed to predict fuel moisture contents for desorption and adsorption phase for each fuel type categories. Practical fuel moisture prediction models were developed for dry period. Models were developed that performed well with reasonable accuracy, explaining up to 92 and 95.6%of the variability in fuel-moisture contents for desorption and adsorption phases, respectively. Validation of the models were conducted using an independent data set and known fuel moisture prediction models. The predictive power of the models was satisfactory with mean absolute error values being 1.48 and 1.02 for desorption and adsorption as compared to the 2.05 and 1.60 values for the Van Wagner's hourly litter moisture content prediction model. Results obtained in this study will be invaluable for fire management planning and modeling. | Ertugrul Bilgili Kadir Alperen Coskuner Yetkin Usta Merih Goltas | 2019 | Journal of Forestry Research2019，30，2： | 6 |
| 4 | Effects of glutamine and curcumin on bacterial translocation in jaundiced rats显示文摘AIM: To investigate the effect of curcumin on bacterial translocation and oxidative damage in an obstructive jaundice model and compare the results to glutamine, an agent known to be effective and clinically used. METHODS: Twenty-four female Wistar-Albino rats, weighing 200-250 g, were randomly divided into three groups (8 in each group). After ligation of the common bile duct in all animals, GroupⅠ received oral normal saline, Group Ⅱ received oral glutamine and Group Ⅲ received oral curcumin for seven days. Blood samples via cardiac puncture, tissue samples (terminal ileum, liver and mesenteric lymph node) and peritoneal fluid were obtained from the animals at the time of death to investigate bacterial translocation and oxidative damage. RESULTS: We observed that both glutamine and curcumin reduced bacterial translocation in blood, hepatocellular damage, plasma cytokine levels, oxidative tissue damage and apoptosis significantly compared to the control group. Additionally, glutamine showed protective effects on ileal epithelium and reduced villus atrophy. CONCLUSION: On the basis of these findings, both curcumin and glutamine are thought to be effective in preventing or reducing bacterial translocation and oxidative damage in obstructive jaundice. | Oguzhan Karatepe Ersin Acet Muharrem Battal Gokhan Adas Ahu Kemik Merih Altiok Gulcin Kamali Safiye Koculu Atahan Catay Sedat Kamali Servet Karahan | 2010 | World Journal of Gastroenterology2010，16，34： | 5 |
| 5 | Cytomegalovirus colitis in a patient with Behcet’s disease receiving tumor necrosis factor alpha inhibitory treatment显示文摘Anti-tumor necrosis factor alpha (TNF-α) inhibitors are effective in the treatment of various inflammatory rheumatic conditions. Increased risks of serious infections are the major issues concerning the long-term safety of these agents. We present a case of a young male Behcet’s patient whose disease was complicated by cytomegalovirus (CMV) colitis. Colitis started 10 d after the third Infliximab dose and responded to the cessation of TNF blocking treatment and administration of ganciclovir. Tumor necrosis factor alpha and interferon gamma act at several levels in combating viral infections.CMV infections should be kept in mind and included in the differential diagnosis of severe gastrointestinal symptoms in patients receiving anti-TNF agents. | Ismail Sari Merih Birlik Can Gonen Servet Akar Duygu Gurel Fatos Onen Nurullah Akkoc | 2008 | World Journal of Gastroenterology2008，14，18： | 5 |
| 6 | Apoptosis in the iris and trabecular meshwork of medically treated and untreated primary open angle glaucoma patients显示文摘AIM:To compare the trabecular meshwork(TM)and iris apoptosis of treated and untreated primary open angle glaucoma(POAG)patients.METHODS:Eight treatment-naive,newly diagnosed(group 1)and 11 medlcaiy treated(group 2)patients with POAG were included in the study.Each patient underwent a limbus-based trabeculectomy.The TM and peripheral iris specimens were dissected out and were snap-frozen in liquid nitrogen and stored at-80t until they were assayed.Apoptosis in each group was assesed by TUNEL method.RESULTS:The mean patient age was 60.6±5.8 years(53-68 years)vs 58.9±8.9 years(47-70 years)in group 1and group 2(P=0.859).The mean treatment time in group 2 was 22.2±7.3 months(12-34 months).Apoptotic indexes in TM and iris were significantly higher in POAG patients using medication(group 2)compared to treatment-naive POAG patients(group 1)(P=0.004,0.015;respectively).CONCLUSION:Long term administration of topical antiglaucoma medications causes additional toxic effects on TM. | Zeynep Aktas Emine Esra Karaca Ipek Isik Gonul Murat Hasanreisoglu Merih Onol | 2013 | International Journal of Ophthalmology(English edition)2013，6，6： | 3 |
| 7 | Enhancement of the success rate in trabeculectomy: large‐area mitomycin‐C application显示文摘 | Merih?nol ZeynepAkta? BeratiHasanreiso?lu | 2008 | Clinical & Experimental Ophthalmology2008，，4： | 2 |
| 8 | Does the worldwide shift of FDI from manufacturing to services accelerate economic growth? A GMM estimation study显示文摘 | Nadia Doytch Merih Uctum | 2011 | Journal of International Money and Finance2011，，3： | 2 |
| 9 | Brucellar lumbar epidural abscess:case report and review显示文摘 | Merih Is Ferruh Gezen | 2006 | Neurosurg2006，16，2： | 1 |
| 10 | Modeling of the appliance, lighting, and space-cooling energy consumptions in the residential sector using neural networks显示文摘 | Merih Aydinalp V. Ismet Ugursal Alan S. Fung | 2002 | Applied Energy2002，，2： | 1 |
| 11 | Comparison of the ozonation and Fenton process performances for the treatment of antibiotic containing manure显示文摘 | Merih ?tker Uslu I??l Akmehmet Balc?o?lu | 2009 | Science of the Total Environment2009，，11： | 1 |
| 12 | Body composition,insulin,and leptin levels in patients with ankylosing spoodylitis显示文摘 | Ismail Sail Tevfik Demir Leyla Didem Kozaci Servet Akar Tulay Kayak Merih Birlik | 2007 | Clin Rheumatol2007，26，： | 1 |
| 13 | Treating denim fabrics with immobilized commercial cellulases显示文摘 | Nurdan K P Merih S A T | 2005 | Process Biochemistry2005，40，： | 1 |
| 14 | Treatment of pharmaceutical wastewater containing antibiotics by O3 and O3/H2O2 processes显示文摘 | Is(11) Akmehmet Balcloglu Merih Otker | | 0，，01： | 1 |
| 15 | Treatment of phar-maceutical wastewater containing antibiotics by O3 and O3/H2O2 proceses 显示文摘 | Isil Akmehment Balclog lu Merih Otker | 2003 | Chemophere2003，50，： | 1 |
| 16 | Treating denim fabrics with immo-bilized commercial cellulases显示文摘 | NURDAN K P MERIH S’AZMI T | 2005 | Process Biochemistry2005，40，2： | 1 |
| 17 | Does the worldwide shift of FDI from manufacturing to services accelerate economic growth? A GMMestimation study 显示文摘 | Nadia Doytch Merih Uctum | 2011 | Journal of International Money and Finance2011，，30： | 1 |
| 18 | Use of Cellulase and Their Effects on Denim Fabric Properties显示文摘 | Merih Sarisik | 2004 | AATCC REVIEW2004，，1： | 1 |
| 19 | Scouring of cotton with cellulases, pactinases and protease 显示文摘 | Emre Karapinar Merih Ones Sariisik | 2004 | FIBRES & TEXTILES in Eastern Europe2004，12，3： | 1 |
| 20 | Broadband Microstrip Antenna with Left-Handed Metarnaterials 显示文摘 | Merih Palandoken Andre Grede Heino Henke | 2009 | IEEE Transactions on Microwave Theory and Techniques2009，57，2： | 1 |
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