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| 1 | Epidermal stem cells and skin tissue engineering in hair follicle regeneration显示文摘The reconstitution of a fully organized and functional hair follicle from dissociated cells propagated under defined tissue culture conditions is a challenge stillpending in tissue engineering. The loss of hair follicles caused by injuries or pathologies such as alopecia not only affects the patients' psychological well-being, but also endangers certain inherent functions of the skin. It is then of great interest to find different strategies aiming to regenerate or neogenerate the hair follicle under conditions proper of an adult individual. Based upon current knowledge on the epithelial and dermal cells and their interactions during the embryonic hair generation and adult hair cycling, many researchers have tried to obtain mature hair follicles using different strategies and approaches depending on the causes of hair loss. This review summarizes current advances in the different experimental strategies to regenerate or neogenerate hair follicles, with emphasis on those involving neogenesis of hair follicles in adult individuals using isolated cells and tissue engineering. Most of these experiments were performed using rodent cells, particularly from embryonic or newborn origin. However, no successful strategy to generate human hair follicles from adult cells has yet been reported. This review identifies several issues that should be considered to achieve this objective. Perhaps the most important challenge is to provide threedimensional culture conditions mimicking the structure of living tissue. Improving culture conditions that allow the expansion of specific cells while protecting their inductive properties, as well as methods for selecting populations of epithelial stem cells, should give us the necessary tools to overcome the difficulties that constrain human hair follicle neogenesis. An analysis of patent trends shows that the number of patent applications aimed at hair follicle regeneration and neogenesis has been increasing during the last decade. This field is attractive not only to academic researchers but also to the companies that own almost half of the patents in this field. | María Eugenia Balaná Hernán Eduardo Charreau Gustavo Jose Leirós | 2015 | World Journal of Stem Cells2015，7，4： | 7 |
| 2 | An analysis of the in vitro and in vivo phenotypes of mutants of herpes simplex virus type 1 lacking glycoproteins gG, gE, gIor the putative gJ显示文摘 | Balan P Davis-Poynter N Bell S | 1994 | J Gen Virol1994，75，6： | 1 |
| 3 | Metamictization and chemical durability of detrital zircon显示文摘 | BALAN E DANIEL R N PATRICK T | 2001 | Am Mineral2001，86，： | 1 |
| 4 | 2013 Ambulatory Blood Pressure Monitoring Recommendations for the Diagnosis of Adult Hypertension, Assessment of Cardiovascular and other Hypertension-associated Risk, and Attainment of Therapeutic Goals显示文摘 | Ramón C. Hermida Michael H. Smolensky Diana E. Ayala Francesco Portaluppi Juan J. Crespo Fabio Fabbian Erhard Haus Roberto Manfredini Artemio Mojón Ana Moyá Luis Pi?eiro María T. Ríos Alfonso Otero Horia Balan José R. Fernández | 2013 | Chronobiology International2013，，3： | 1 |
| 5 | Symptomatic changes oforal mucosa during normal hormonal turnover in healthy youngmenstruating women 显示文摘 | Balan U Gonsalves N Jose M | 2012 | J Contemp Dent Pract2012，13，2： | 1 |
| 6 | Modeling studies of the longitudinal variation in TEC at equatorial-anomaly latitudes显示文摘 | Su Y Z Bailey G J Balan N | 1995 | J Atmos Terr Phys1995，57，8： | 1 |
| 7 | Immunohistochemical assessment of p16, COX-2 and EGFR in HPV-positive cervical squamous intraepithelial lesion s显示文摘 | Balan R Simion N Giusc a SE | 2011 | Rom J Morphol Embryol2011，2，4： | 1 |
| 8 | Equatorial plasma fountain and its effects:Possibility of an additional layer显示文摘 | Balan N Bailey G J | 1995 | J Geophys Res1995，100，21： | 1 |
| 9 | Patient compliance and supportive periodontal therapy:Study among young adults of Namakkal district显示文摘 | Gokulanathan S Balan N Aravind R J | 2014 | J Pharm Bioallied Sci2014，6，1： | 1 |
| 10 | An analysis of the in vitro and in vivo phenotypes of mutants of herpes simplex virus type 1 lacking glycoprotein gG,gE,gI or the putative gJ显示文摘 | BALAN P DAVIS-POYNTER N BELL S et at | 1994 | J Gen Virol1994，75，6： | 1 |
| 11 | An analysis of the in vitro and in vivo pheno- types of mutants of herpes simplex virus type 1 lacking glyco- proteins gG, gE, gl or the putative gJ 显示文摘 | Balan P N | 1994 | J Gen Virol1994，75，6： | 1 |
| 12 | Einstein equations for (h; v)-Berwald-Moor relativistic models显示文摘 | Balan V Brinzei N | 2006 | Balkan Jouirnal and Its Applications2006，11，1： | 1 |
| 13 | Differential susceptibility to 9-nitrocampptothecin (9-NC)-induced apoptosis in clones derived from a human ovarian cancer cell line: possible implications in the treatment of ovarian cancer patients with 9-NC显示文摘 | Hu XL Balan KV Ramos-DeSimone N | 2003 | Anticancer Drugs2003，14，： | 1 |
| 14 | 显示文摘 | ALEXANDRU N D BALAN A L | 2011 | Elec- tronics Letters2011，47，4： | 1 |
| 15 | Annual variations'of the ionosphere:A review based on MU radar observa- tions显示文摘 | Balan N Otsuka Y Fukao S | 2000 | Advances in Space Research2000，，： | 1 |
| 16 | Statistics of geomagnetic storms and ionospheric storms at low and mid latitudes in two solar cycles 显示文摘 | LEKSHMI D V BALAN N RAM S T L/U J Y | 2011 | J Geophys Res2011，，： | 1 |
| 17 | Attraction and killing of the nematode Panagrellus redivivus by the predacious fungus Arthrobotrys dactyloide显示文摘 | Balan J Gerber N N | 1972 | Nematologica1972，18，： | 1 |
| 18 | Annual variations of the ionosphere: A review based on the MU radar observations 显示文摘 | Balan N Otsuka Y Bailey | 2000 | Adv Space Res2000，25，： | 1 |
| 19 | A physical mechanism of positive ionospheric storms at low latitudes and midlatitudes 显示文摘 | BALAN N SHIOKAWA K OTSUKA Y KIKUCHI T VIJAYA D L KAWAMURA S YAMAMOTO M BAILEY G J | 2010 | J Geophys Res2010，115，02： | 1 |
| 20 | Physical mechanisms of the ionospheric storms at equatorial and higher latitudes during the recovery phase of geomagnetic storms 显示文摘 | BALAN N OTSUKA Y NISH1OKA M LIU J Y BAILEY G J | 2013 | J Geophys Res Space Physics2013，118，： | 1 |
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