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| 1 | Oral frailty and neurodegeneration in Alzheimer’s disease显示文摘Frailty is a critical intermediate status of the aging process with a multidimensional and multisystem nature and at higher risk for adverse health-related outcomes,including falls,disability,hospitalizations,institutionalization,mortality,dementia,and Alzheimer’s disease.Among different frailty phenotypes,oral frailty has been recently suggested as a novel construct defined as a decrease in oral function with a coexisting decline in cognitive and physical functions.We briefly reviewed existing evidence on operational definitions of oral frailty,assessment and screening tools,and possible relationships among oral frailty,oral microbiota,and Alzheimer’s disease neurodegeneration.Several underlying mechanism may explain the oral health-frailty links including undernutrition,sarcopenia linked to both poor nutrition and frailty,psychosocial factors,and the chronic inflammation typical of oral disease.Oral microbiota may influence Alzheimer’s disease risk through circulatory or neural access to the brain and the interplay with periodontal disease,often causing tooth loss also linked to an increased Alzheimer’s disease risk.On this bases,COR388,a bacterial protease inhibitor targeting Porphyromonas gingivalis implicated in periodontal disease,is now being tested in a double-blind,placebocontrolled Phase II/III study in mild-to-moderate Alzheimer’s disease.Therefore,oral status may be an important contributor to general health,including Alzheimer’s disease and latelife cognitive disorders,suggesting the central role of preventive strategies targeting the novel oral frailty phenotype and including maintenance and improvement of oral function and nutritional status to reduce the burden of both oral dysfunction and frailty. | Vittorio Dibello Madia Lozupone Daniele Manfredini Antonio Dibello Roberta Zupo Rodolfo Sardone Antonio Daniele Frank Lobbezoo Francesco Panza | 2021 | Neural Regeneration Research2021，16，11： | 10 |
| 2 | 磨牙症与咬合有因果关系么?显示文摘在牙医界,磨牙症与牙齿咬合(错)间存有因果关系的观点影响十分广泛,本综述就此问题对现有的相关文献做一严格评价。使用主题词'Bruxism[Majr]AND(Dental Occlusion[Majr]OR Malocclusion[Majr])'在PubMed数据库中检索英文文献,共检出93篇文章,最终本综述引用了其中的46篇。其中有部分论文是针对磨牙症和因素之间可能存在的相关关系而进行的研究,所得出的结论是:尚没有证据表明干扰或相关颌面骨骼解剖因素与磨牙症之间有病因联系,反而磨牙症其他的病因(即社会心理学因素和行为学因素)正越来越受到关注。另外一些论文评价了咬合在磨牙症和其所谓的后果(如牙齿磨耗、牙周组织的损失、颞下颌关节疼痛和功能紊乱)间可能存在的媒介作用。尽管大多数牙医同意磨牙症可能会对咀嚼系统产生一些不良影响,但是至今尚没有证据证明咬合及咬合接触在这些所谓的不良影响中发挥了什么作用。基于这些结果,本文结论是到目前为止尚没有任何证据能表明磨牙症和咬合有因果关系。 | F. LOBBEZOO J. AHLBERG D. MANFREDINI E. WINOCUR 周丽娟 | 2013 | 实用口腔医学杂志2013，29，4： | 6 |
| 3 | Liver hemangioma and vascular liver diseases in patients with systemic lupus erythematosus显示文摘AIM:To investigate whether systemic lupus erythematosus (SLE) is associated with benign focal liver lesions and vascular liver diseases, since these have been occasionally reported in SLE patients. METHODS:Thirty-five consecutive adult patients with SLE and 35 age-and sex-matched healthy controls were evaluated. Hepatic and portal vein patency and presence of focal liver lesions were studied by colour-Doppler ultrasound, computerized tomography and magnetic resonance were used to refine the diagnosis, clinical data of SLE patients were reviewed. RESULTS:Benign hepatic lesions were common in SLE patients (54% vs 14% controls, P < 0.0001), withhemangioma being the most commonly observed lesion in the two groups. SLE was associated with the presence of single hemangioma [odds ratios (OR) 5.05; 95% confidence interval (CI) 1.91-13.38] and multiple hemangiomas (OR 4.13; 95% CI 1.03-16.55). Multiple hemangiomas were associated with a longer duration of SLE (9.9 ± 6.5 vs 5.5 ± 6.4 years; P = 0.04). Imaging prior to SLE onset was available in 9 patients with SLE and hemangioma, showing absence of lesions in 7/9. The clinical data of our patients suggest that SLE pos- sibly plays a role in the development of hemangioma. In addition, a Budd-Chiari syndrome associated with nodular regenerative hyperplasia (NRH), and a NRH associated with hepatic hemangioma were observed, both in patients hospitalized for abdominal symptoms, suggesting that vascular liver diseases should be specifically investigated in this population. CONCLUSION:SLE is associated with 5-fold increased odds of liver hemangiomas, suggesting that these might be considered among the hepatic manifestations of SLE. | Annalisa Berzigotti Marilena Frigato Elena Manfredini Lucia Pierpaoli Rita Mulè Carolina Tiani Paola Zappoli Donatella Magalotti Nazzarena Malavolta Marco Zoli | 2011 | World Journal of Gastroenterology2011，17，40： | 5 |
| 4 | Heart and lung, a dangerous liaison-Tako-tsubo cardiomyopathy and respiratory diseases: A systematic review显示文摘AIM: To investigate the possible association between Tako-tsubo cardiomyopathy(TTC)-a reversible clini-cal condition mimicking an acute myocardial infarction characterized by multifactorial pathophysiologic mecha-nisms- and respiratory system diseases. METHODS: We systematically searched PubMed and EMBASE medical information sources, to identify the different triggering causes, limiting our search to ar-ticles in English. The search keywords were: 'tako-tsubo cardiomyopathy', 'takotsubo', 'takotsubo cardiomyopa-thy', 'broken heart syndrome', 'stress-induced cardio-myopathy', 'apical ballooning syndrome', and 'ampulla cardiomyopathy in combination with respiratory dis-eases, lung, pulmonary disease. For each kind of dis-ease, we registered: author, year and country of study, patient sex, age, concurring situation, and outcome. RESULTS: Out of a total of 1725 articles found, we se-lected 37 papers reporting a total of 38 patients. As ex-pected, most patients were women(81.6%), mean age was 65 ± 10 years. Outcome was favorable in 100% of cases, and all the patients have been discharged un-eventfully in a few days. CONCLUSION: An association between respiratory diseases and TTC is likely to exist. Patients with severe respiratory diseases, due to the high dosages of β2-agonists used or to the need of invasive procedures, are highly exposed to the risk of developing TTC. | Roberto Manfredini Fabio Fabbian Alfredo De Giorgi Marco Pala Alessandra Mallozzi Menegatti Claudia Parisi Elisa Misurati Ruana Tiseo Massimo Gallerani Raffaella Salmi Eduardo Bossone | 2014 | World Journal of Cardiology2014，6，5： | 3 |
| 5 | Pulmonary embolism and internal jugular vein thrombosis as evocative clues of Lemierre's syndrome:A case report and review of the literature显示文摘Lemierre’s syndrome(LS)is an uncommon condition with oropharyngeal infections,internal jugular vein thrombosis,and systemic metastatic septic embolization as the main features.Fusobacterium species,a group of strictly anaerobic Gram negative rod shaped bacteria,are advocated to be the main pathogen involved.We report a case of LS complicated by pulmonary embolism and pulmonary septic emboli that mimicked a neoplastic lung condition.A Medline search revealed 173 case reports of LS associated with internal jugular vein thrombosis that documented the type of microorganism.Data confirmed high prevalence in young males with Gram negative infections(83.2%).Pulmonary embolism was reported in 8.7% of cases mainly described in subjects with Gram positive infections(OR=9.786;95%CI:2.577-37.168,P=0.001),independently of age and gender.Only four fatal cases were reported.LS is an uncommon condition that could be complicated by pulmonary embolism,especially in subjects with Gram positive infections. | Alfredo De Giorgi Fabio Fabbian Christian Molino Elisa Misurati Ruana Tiseo Claudia Parisi Benedetta Boari Roberto Manfredini | 2017 | World Journal of Clinical Cases2017，5，3： | 2 |
| 6 | Sport ther- apy for hypertension: why, how, and how much显示文摘 | Manfredini F Malagoni AM Mandini S | 2009 | Angi- ology2009，60，2： | 1 |
| 7 | Temporomandibular joint total replacement prosthesis:current knowledge and considerations for the future显示文摘 | Guarda-Nardini L Manfredini D Ferronato G | | 0，，02： | 1 |
| 8 | Sudden death in diabetic Subjects:evidence for a peculiar circadian variation in occurance显示文摘 | Gallerani M Manfredini R Graziani R | 1994 | Panminerva Med1994，36，3： | 1 |
| 9 | Thermal spraying to coat traditional ceramic substrates: Case studies 显示文摘 | BARTULI C LUSVARGHI L MANFREDINI T | 2007 | Journal of the European Ceramic Society2007，27，： | 1 |
| 10 | Patella resurfacing in posterior stabilised total knee arthroplasty:A follow-up study in 56 patients显示文摘 | Gildone A Manfredini M Biscione R | 2005 | Acta Orthop Belg2005，71，4： | 1 |
| 11 | Chronic pain se-verity and depression/somatization levels in TMD patients显示文摘 | Manfredini D’Borella L Favero L | 2010 | Int J Prosthodont2010，23，6： | 1 |
| 12 | Research diagnostic criteria for temporomandibular disorders: a systematic review of axis Ⅰ epidemiologic findings 显示文摘 | Manfredini D Guarda-Nardini L Winocur E | 2011 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2011，112，4： | 1 |
| 13 | Premature o- varian failure显示文摘 | Vegetti W Marozzi A Manfredini E | 2000 | Molcell Endocrinol2000，161，1： | 1 |
| 14 | X-linked cataract显示文摘 | Fraccaro M Morone G Manfredini U | 1967 | Ann Hum Genet1967，31，： | 1 |
| 15 | The Brazilian Version of the Edmonton Symptom Assessment System(ESAS) is a feasible ,valid and reliable instrument for the measurement of symptoms in advanced cancer patients显示文摘 | Paiva CE Manfredini LL Paiva BS | 2015 | PLoS One2015，10，13： | 1 |
| 16 | Epi- demiology of bruxisnl in adults: a systenlatic review of the literature显示文摘 | Manfredini D Winocur E Guarda-Nardini L el al | 2013 | J Orofac Pain2013，27，2： | 1 |
| 17 | Premature ovarian failure显示文摘 | Marozzi A Manfredini E | 2000 | Mol Cell Endocrinol2000，161，： | 1 |
| 18 | Polygalaeturonase-inhihiting protein 2 of Phaseolus vulgaris inhibits BcPG1, a polygalacturonase of Botrytis cinerea important for pathogenicity, and protects transgenic plants from infection 显示文摘 | Manfredini C Sicilia F Ferrari S Pontiggia D Salvi G Caprai C Lorito M De Lorenzo G | 2006 | Physiol Mol Plant Pathol2006，67，： | 1 |
| 19 | sin- gle-needle technique for TMJ arthrocentesis plus hyaluronic acid injections: a comparativetrial over a six-month follow up显示文摘 | Guarda Nardini L Ferronato G Manfredini D | 2012 | Int J Oral Maxillofac Surg2012，41，4： | 1 |
| 20 | 2013 Ambulatory Blood Pressure Monitoring Recommendations for the Diagnosis of Adult Hypertension, Assessment of Cardiovascular and other Hypertension-associated Risk, and Attainment of Therapeutic Goals显示文摘 | Ramón C. Hermida Michael H. Smolensky Diana E. Ayala Francesco Portaluppi Juan J. Crespo Fabio Fabbian Erhard Haus Roberto Manfredini Artemio Mojón Ana Moyá Luis Pi?eiro María T. Ríos Alfonso Otero Horia Balan José R. Fernández | 2013 | Chronobiology International2013，，3： | 1 |
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