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| 1 | Is it possible to stop nucleos(t)ide analogue treatment in chronic hepatitis B patients?显示文摘Chronic hepatitis B(CHB) remains a challenging global health problem, with nearly one million related deaths per year. Nucleos(t)ide analogue(NA) treatment suppresses viral replication but does not provide complete cure of the hepatitis B virus(HBV) infection. The accepted endpoint for therapy is the loss of hepatitis B surface antigen(HBs Ag), but this is hardly ever achieved. Therefore, indefinite treatment is usually required. Many different studies have evaluated NA therapy discontinuation after several years of NA treatment and before HBs Ag loss. The results have indicated that the majority of patients can remain off therapy, with some even reaching HBs Ag seroconversion. Fortunately, this strategy has proved to be safe, but it is essential to consider the risk of liver damage and other comorbidities and to ensure aclose follow-up of the candidates before considering this strategy. Unanswered questions remain, namely in which patients could this strategy be effective and what is the optimal time point at which to perform it. To solve this enigma, we should keep in mind that the outcome will ultimately depend on the equilibrium between HBV and the host's immune system. Viral parameters that have been described as good predictors of response in HBe Ag(+) cases, have proven useless in HBe Ag(-) ones. Since antiviral immunity plays an essential role in the control of HBV infection, we sought to review and explain potential immunological biomarkers to predict safe NA discontinuation in both groups. | Elia Moreno-Cubero Robert T Sánchez del Arco Julia Pena-Asensio Eduardo Sanz de Villalobos Joaquín Míquel Juan Ramón Larrubia | 2018 | World Journal of Gastroenterology2018，24，17： | 5 |
| 2 | Genetic diversity among Jatropha species as revealed by RAPD markers显示文摘 | Ganesh Ram S Parthiban K T Senthil Kumar R | 2008 | Genet Resour Crop Evol2008，55，6： | 1 |
| 3 | Effects of mercury on the life table demography of the rotifer Brachionus calyciflorus Pallas (Rotifera)显示文摘 | Ramírez-Pérez T Sarma S S S Nandini S | 2004 | Ecotoxicology2004，13，6： | 1 |
| 4 | G protein pathways 显示文摘 | Neves S R Ram P T Iyengar R | 2002 | Sci- ence2002，296，： | 1 |
| 5 | Mossbauer spectroscopic studies on the transformations of iron-bearing minerals during combustion of coals: Correlation with fouling and slagging显示文摘 | Ram L C Tripa T Mishra S P | 1995 | Fuel Process Technol1995，42，1： | 1 |
| 6 | Effect of equatorial ionization anomaly on the occurrence of spread-F显示文摘 | JAYACHANDRAN P T RAM P S SOMAYAJUL V V | 1997 | Ann Geophys1997，15，2： | 1 |
| 7 | Institutions,Infrastructure and Economic Growth显示文摘 | Esfahani H S Ramírez M T | 2003 | Journal of Development Economics2003，，70： | 1 |
| 8 | Quorum-sensing cross talk: isolation and chemical characterization of cyclic dipeptides from Pseudomonas aeruginosa and other Gram-negative bacteria 显示文摘 | Holden M T Ram Chhabra S de Nys R | 1999 | Mol Microbiol1999，33，6： | 1 |
| 9 | Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels显示文摘 | María E Sáez María T Martínez-Larrad Reposo RamírezLorca1 | | 0，，： | 1 |
| 10 | Wear characterization of small PM rotors and oil pump bearings显示文摘 | RANGANATHAN G RAJ T H S RAM P V M | 2004 | Tribology2004，37，： | 1 |
| 11 | G protein pathways显示文摘 | Neves S R Ram P T Iyengar R | 2002 | Science2002，296，5573： | 1 |
| 12 | Thaumasite formation dur to atmospheric SO2-hydraulic mortar interaction显示文摘 | Blanco-Varela M T Aguilera J Mart i nez- Ram i rez S Puertas F | 2003 | Cement & Concrete Composites2003，25，： | 1 |
| 13 | Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia显示文摘 | Zaki A M van Boheemen S Bestebroer T M Osterhaus ADME Fouchier RAM | 2012 | N Engl J Med2012，367，19： | 1 |
| 14 | Valuation of permanent,transitory,and price-irrelevant components of reported earnings显示文摘 | Ramakrishnan Ram T S Thomas Jacob K | 1998 | Journal of Accounting Auditing & Finance1998，3，： | 1 |
| 15 | Statistics of geomagnetic storms and ionospheric storms at low and mid latitudes in two solar cycles 显示文摘 | LEKSHMI D V BALAN N RAM S T L/U J Y | 2011 | J Geophys Res2011，，： | 1 |
| 16 | The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats 显示文摘 | Ram Z Walbridge S Shawker T | 1994 | J Neurosurg1994，81，2： | 1 |
| 17 | A transient current based double line transmission system protection using fuzzywavelet approach in the presence of UPFC显示文摘 | GOLO R K SHAIK A G RAM S S T | 2015 | International Journal of Electrical Power&Energy Systems2015，70，： | 1 |
| 18 | The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats显示文摘 | Ram Z Walbridge S Shawker T | 1994 | J Neurosurg1994，81，： | 1 |
| 19 | On thermal and electrical properties of multiwalled carbon nanotubes/copper matrix nanocomposites 显示文摘 | KOPPAD P G RAM H R A RAMESH C S KASHYAP K T KOPPAD R G | 2013 | Journal of Alloys and Compounds2013，580，： | 1 |
| 20 | Herbal drug incorporated antibacterial nanofibrous mat fabricated byelectrospinning: an excellent matrix for wound dressings显示文摘 | Suganya S Senthil Ram T Lakshmi BS | 2011 | J Appl Polym Sci2011，121，5： | 1 |
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