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| 1 | Epidermal stem cells and skin tissue engineering in hair follicle regeneration显示文摘The reconstitution of a fully organized and functional hair follicle from dissociated cells propagated under defined tissue culture conditions is a challenge stillpending in tissue engineering. The loss of hair follicles caused by injuries or pathologies such as alopecia not only affects the patients' psychological well-being, but also endangers certain inherent functions of the skin. It is then of great interest to find different strategies aiming to regenerate or neogenerate the hair follicle under conditions proper of an adult individual. Based upon current knowledge on the epithelial and dermal cells and their interactions during the embryonic hair generation and adult hair cycling, many researchers have tried to obtain mature hair follicles using different strategies and approaches depending on the causes of hair loss. This review summarizes current advances in the different experimental strategies to regenerate or neogenerate hair follicles, with emphasis on those involving neogenesis of hair follicles in adult individuals using isolated cells and tissue engineering. Most of these experiments were performed using rodent cells, particularly from embryonic or newborn origin. However, no successful strategy to generate human hair follicles from adult cells has yet been reported. This review identifies several issues that should be considered to achieve this objective. Perhaps the most important challenge is to provide threedimensional culture conditions mimicking the structure of living tissue. Improving culture conditions that allow the expansion of specific cells while protecting their inductive properties, as well as methods for selecting populations of epithelial stem cells, should give us the necessary tools to overcome the difficulties that constrain human hair follicle neogenesis. An analysis of patent trends shows that the number of patent applications aimed at hair follicle regeneration and neogenesis has been increasing during the last decade. This field is attractive not only to academic researchers but also to the companies that own almost half of the patents in this field. | María Eugenia Balaná Hernán Eduardo Charreau Gustavo Jose Leirós | 2015 | World Journal of Stem Cells2015，7，4： | 7 |
| 2 | Chlamydia host cell interactions : recent advances on bacterial entry and intracellular development显示文摘 | Dautry-Varsat A Balan ME Wyplosz B | 2004 | Traffic2004，5，8： | 1 |
| 3 | Fast NMRjuice identification based on sugars and other plant metabolites fromfruits显示文摘 | BALAN M NIOCOLESCU A STAVARACHE C | 2013 | Revue Roumaine de Chimie2013，58，23： | 1 |
| 4 | Regulation of tumor progression by extracellular galectin-3显示文摘 | NANGIA MAKKER P BALAN V RAZ A | 2008 | Cancer Microenvironment2008，1，1： | 1 |
| 5 | Benzotriazole derivatives as long wavelength photosensitizers for diaryliodonium salt initiators显示文摘 | Bulut U Balan A Caliskan C | | 0，，： | 1 |
| 6 | AP-1-mediated multidrug resistance in Saccharomyces cerevisiae requires FLR1 encoding a transporter of the major facilitator superfamily显示文摘 | Alarco A M Balan I Talibi D | 1997 | J Biol Chem1997，272，19： | 1 |
| 7 | Group 15 elementgraphite composites synthesized by reduction of chlorides by KC8: Characterization and electrochemical lithiation 显示文摘 | DAILLY A BALAN L GHANBAJA J | 2005 | Carbon2005，43，： | 1 |
| 8 | Effi-cacy of protection by latex gloves during orthodontic therapy显示文摘 | Doll GM Zentner A Balan R | 2000 | J Orofac Orthop2000，61，2： | 1 |
| 9 | Regulation of tumor pro- gression by extracellular Galectin-3 显示文摘 | Nangia-Makker P Balan V Raz A | 2008 | Cancer Microenviron2008，1，1： | 1 |
| 10 | 2013 Ambulatory Blood Pressure Monitoring Recommendations for the Diagnosis of Adult Hypertension, Assessment of Cardiovascular and other Hypertension-associated Risk, and Attainment of Therapeutic Goals显示文摘 | Ramón C. Hermida Michael H. Smolensky Diana E. Ayala Francesco Portaluppi Juan J. Crespo Fabio Fabbian Erhard Haus Roberto Manfredini Artemio Mojón Ana Moyá Luis Pi?eiro María T. Ríos Alfonso Otero Horia Balan José R. Fernández | 2013 | Chronobiology International2013，，3： | 1 |
| 11 | Total Synthesis of (±)-Calanolide A,a Non-Nucleoside Inhibitor of HIV-1 Reverse Transcriptase显示文摘 | Balan Chenera Michael L West Joseph A Finkelstein Geoffrey B Dreyer | 1993 | J Org Chem1993，58，21： | 1 |
| 12 | Aqueous route to biocompatible ZnSe: Mn/ ZnO core/shell quantum dots using 1-thioglycerol as stabilizer显示文摘 | ABOULAICH A BALAN L GHANBAJA J | 2011 | ChemMater2011，23，16： | 1 |
| 13 | 显示文摘 | Akpmar H Balan A Baran D | 2010 | Polym2010，51，26： | 1 |
| 14 | Site-specific PEGylation of protein disulfide bonds using a three-carbon bridge 显示文摘 | Balan S Choi JW Godwin A | 2007 | Bioconjugate Chemistry2007，18，1： | 1 |
| 15 | Radiation induced oral mucositis 显示文摘 | Ps S K Balan A Sankar A | 2009 | Indian J Palliat Care2009，15，2： | 1 |
| 16 | Disulfide bridge based PEGylation of proteins 显示文摘 | Balan S Brocchini S Godwin A | 2008 | Advanced Drug Delivery Reviews2008，60，1： | 1 |
| 17 | The natural genomic variability of poliovirus analyzed by a restriction fragment length polymorphism assay显示文摘 | Balanant J Guillot S Candrea A | 1991 | Virology1991，184，： | 1 |
| 18 | Constitutive model for 3D cyclic analysis of concrete structures 显示文摘 | Balan T A Filippou F C Popov E P | 1997 | Journal of Engineering Mechanics ASCE1997，123，2： | 1 |
| 19 | Radiation induced oral mucositis显示文摘 | Ps SK Balan A Sankar A | 2009 | Indian J Palliat Care2009，15，2： | 1 |
| 20 | Mesenchymal stromal ceils in the antimicrobial host response of hematopoietic stem cell recipients with graft-versus-host disease-friends or foes&quest显示文摘 | Balan A Lucchini G Schmidt S | 2014 | Leukemia2014，28，10： | 1 |
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