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| 1 | 25-羟维生素D和甲状旁腺激素与高血压的相关性显示文摘有研究证实,维生素D缺乏和甲状旁腺激素(PTH)过高与高血压的发生密切相关。维生素D缺乏不仅可以影响肾素血管紧张素系统及PTH水平,而且可以直接参与血管炎性反应,影响高血压的发生发展。PTH可以通过促进血管炎性反应及血管钙化等参与高血压的进展。目前还没有前瞻性研究同时评估维生素D和PTH水平与高血压发病的关系。该研究分析多民族动脉粥样硬化研究的前瞻性数据,发现低水平25羟维生素D[25(OH)D]和高水平PTH与高血压发病相关,特别是在肥胖人群中。但在校正混杂因素后,25(OH)D水平与高血压发病的相关性无统计学意义,而PTH水平与高血压发病仍然相关。鉴于维生素D缺乏和PTH过量在人群中是普遍现象,该研究对于更好地了解高血压发病机制,在人群中开展高血压预防工作有重要意义。 | van Ballegooijen AJ Kestenbaum B Sachs MC de Boer IH Siscovick DS Hoofnagle AN Ix JH Visser M Brouwer IA 练桂丽 叶鹏 | 2014 | 中华高血压杂志2014，22，6： | 10 |
| 2 | 矿渣硅酸盐水泥水化反应的理论模型与应用显示文摘提出了一种矿渣硅酸盐水泥水化反应的理论模型,考虑了矿渣成分、熟料成分、矿渣掺量、矿渣水化程度对其水化产物成分和微观结构的影响,可以定量地预测C-S-H凝胶的成分和浆体不同组份的相对比例.与普通硅酸盐水泥浆体相比较,矿渣硅酸盐水泥浆体最主要的差别是Ca(OH)2含量显著降低、C-S-H的钙硅比明显降低,同时孔隙率也不断增加. | 陈伟 Brouwers H J H 水中和 | 2008 | 三峡大学学报(自然科学版)2008，30，2： | 9 |
| 3 | 柴北缘锡铁山榴辉岩退变质成因角闪石^40Ar/^39Ar年代学研究显示文摘采用激光阶段加热^40Ar/^39Ar技术,对柴达木盆地北缘锡铁山榴辉岩退变质作用形成的榴闪岩和斜长角闪岩之角闪石进行了定年分析。09NQ44Amp来自榴闪岩,各阶段表观年龄(以现代空气氩^40Ar/^36Ar比值295.5扣除非放射性成因^40Ar)构成了单调下降的阶梯状年龄谱。在反等时线图解上,2~4阶段数据点和5~18阶段数据点分别构成了两条等时线,等时年龄分别为427.6±10Ma和425.1±2.6Ma,对应的初始40Ar/36Ar比值则分别为435.2±6.1和705.3±13。角闪石09NQ43Amp来自榴辉岩强烈退变质作用形成的斜长角闪岩,40Ar/39Ar阶段加热分析也获得单调下降的年龄谱,在反等时线图解上其数据点3~6阶段和7~16阶段分别构成了两条等时线,等时年龄分别为418.9±2.9Ma和418.1±2.1Ma,对应的初始40Ar/36Ar比值则分别为493.7±2.8和685.8±34.3。等时线截距值高于现代大气40Ar/36Ar比值,表明角闪石中含过剩40Ar。同时,由低温和中-高温阶段加热数据点分别构成两条等时年龄基本一致,截距值却明显不同的等时线,表明在角闪石热力学性质不同的源区,存在两期明显不同且未混合的初始捕获Ar组分。等时年龄425~418Ma代表的是锡铁山榴辉岩角闪岩相退变质作用发生的时间。等时线图解法虽然有效的校正了角闪石中的过剩40Ar,但仅根据表观年龄图谱和等时线图谱还无法清晰判断过剩40Ar在角闪石中的赋存状态,有待进一步探讨。 | 胡荣国 王敏 Jan R WIJBRANS Fraukje M BROUWER 邱华宁 | 2013 | 岩石学报2013，29，9： | 5 |
| 4 | Retrograde metamorphism of the eclogite in North Qaidam,western China:Constraints by joint ^(40)Ar/^(39)Ar in vacuo crushing and stepped heating显示文摘Two amphiboles and a syn-metamorphic quartz vein from the Yuka terrane,North Qaidam,western China,have been analyzed by joint ^(40)Ar/^(39)Ar crushing in vacuo and stepwise heating techniques.The crushing in vacuo results provide information to directly constrain the timing of fluid activity and the age of amphibolite-facies retrogression.The stepwise heating results could further be used to decipher the thermal history of the UHP rocks.Amphiboles from amphibolites and quartz vein within garnetamphibolite lens analyzed by in vacuo crushing yield similarly shaped age spectra and exhibit relatively flat age plateaus for the last several steps.The characteristics of gas release patterns and geochronological data testify to the presence of significant excess ^(40)Ar within the fluid inclusions.The age plateaux with weighted mean ages(WMA) ranges from 488 to 476 Ma for amphiboles and 403 Ma for quartz(2σ).These data points constitute amphibole WMA yielding excellent isochrons with isochron ages of 469 and 463 Ma with initial ^(40)Ar/^(36)Ar ratios of 520 and 334,respectively.The isochron ages are interpreted to represent initial amphibolite-facies retrogression.The data points constituting the quartz age plateaux give an isochron age of 405 Ma with initial ^(40)Ar/^(36)Ar ratio of 295,recording a significant aqueous fluid flow episode during the early Devonian.Age spectra obtained by stepwise heating of amphibole residues remaining after crushing experiments are characterized by younger and relatively complex age spectra,which are probably influenced by the combined effects of resetting argon and/or mineral inclusions.Nevertheless,we note that the spectra shapes have features in common:excluding the last two steps,minimum apparent ages are found at temperatures of around 500 ℃,corresponding to319 and 249 Ma,perhaps representing the time of isotopic resetting or resulting from release gas from mineral inclusions of,e.g.,biotite or feldspar.Maximum apparent ages are obtained at temperatures of around 800℃,corresponding to 418 and 413 Ma,which probably reflect mixed ages of radiogenic resetting and original amphibole.These results indicate that the Yuka eclogites and their retrogressed equivalents were overprinted by multiple thermal events in the Silurian and possibly as young as the Triassic. | Rongguo Hu Jan Wijbrans Fraukje Brouwer Linghao Zhao Min Wang Huaning Qiu | 2015 | Geoscience Frontiers2015，6，5： | 4 |
| 5 | 水泥浆体液相离子浓度模拟显示文摘提出了一种基于三维水泥水化过程计算机模型的水泥基材料液相(孔溶液)离子浓度预测新方法。综合考虑了环境温度、湿度、材料配合比等因素,基于水泥化学和溶液化学理论,采用固-液相动态平衡分析方法,利用三维计算机模型CEMHYD3D来预测水泥浆体中孔溶液、水化产物的数量,通过溶液平衡方法模拟孔溶液中各主要离子浓度的变化规律。模型预测结果与实验结果对比分析表明,该方法可以成功地预测水泥基材料孔溶液组分的变化规律。 | 陈伟 Brouwers HJH 水中和 | 2010 | 武汉理工大学学报2010，32，11： | 4 |
| 6 | 一项关于恩替卡韦联合聚乙二醇干扰素治疗HBeAg阳性慢性乙型肝炎的多中心随机对照研究显示文摘恩替卡韦可以强有力地抑制HBV的复制,但是需要长期治疗。荷兰鹿特丹Erasmus MC大学医学中心的Brouwer WP等人通过一项全球、开放的多中心随机对照试验,研究恩替卡韦联合聚乙二醇干扰素是否可以提高病毒学应答效率。他们初始采用恩替卡韦(0.5 mg/d)单药治疗HBe Ag阳性慢性乙型肝炎(CHB)的代偿性肝病患者,在治疗24周后,将患者按1∶1随机分为2组,恩替卡韦联合聚乙二醇干扰素(180μg/周)治疗组和恩替卡韦单药治疗组,治疗至48周。 | Brouwer WP 王欢 赵旭 | 2015 | 临床肝胆病杂志2015，31，1： | 3 |
| 7 | 更新临床实践指南需要报告的条目:更新版指南的报告清单显示文摘目的临床指南需要根据相关研究结果定期审查以确保其可靠性,但在更新临床指南的过程中仍然缺乏对于更新过程表述的优先报告条目。本文旨在介绍更新版指南报告清单(Checklist for the Reporting of Updated Guidelines,Check Up)及其制定过程。方法基于临床指南更新的研究证据的概述,指南研究与评价工具(Appraisal of Guidelines for Research and EvaluationⅡ,AGREEⅡ)和报告清单专家组(33位)的建议开发了初始清单的各条目。然后,使用多个步骤对本清单进行了完善,包括评估10个现有的更新版临床指南,对关键信息提供者进行访谈[应答率为54.2%(13/24)],清单制定专家组内部进行的一个三轮的德尔菲(Delphi)共识调查,以及来自于临床指南方法学专家[应答率为90%(53/59)]和指南使用者[应答率为55.6%(10/18)]的外部评审意见。结果清单最终包括16个条目,主要涉及:(1)更新版指南的呈现;(2)编辑独立性;(3)更新过程采用的方法。结论更新版指南的报告清单作为一个工具可用于评估更新版指南报告的完整性,并为指南制定者提供撰写报告的要求。 | 王丽琼 严毓倩 梁宁 李迅 费宇彤 刘建平 Vernooij RW Alonso-Coello P Brouwers M Martínez García L | 2017 | 中国中西医结合杂志2017，37，5： | 3 |
| 8 | 水泥基材料孔溶液碱度计算机模拟技术显示文摘水泥基材料孔溶液的碱度对于材料的耐久性能和硬化过程十分重要。建立了一个水泥基材料孔溶液碱度的计算机模拟方法,它基于一个三维的水泥基材料水化过程和微观结构发展的计算机模型,结合C-S-H凝胶碱吸附理论,综合考虑环境温度、湿度、材料配合比等因素,模拟孔溶液中碱金属离子浓度变化的规律,并与实际试验结果进行了对比。模拟和对比结果表明:提出的模拟方法可以成功地预测水泥基材料孔溶液碱度的变化规律,为实际材料碱度控制提供可靠的理论支持和事前控制建议,并为材料长期耐久性能评价提供一定依据。 | 陈伟 BROUWERS H J H 王桂明 水中和 | 2008 | 混凝土2008，，6： | 3 |
| 9 | 强化降压治疗期间估算的肾小球滤过率初始降低与长期肾功能:收缩压干预试验与控制糖尿病患者心血管病风险行动研究-血压随机对照试验的事后分析显示文摘血压降低可导致估算的肾小球滤过率(estimated glomerular filtration rate,eGFR)的初始下降,但eGFR降低多少可以接受仍存在争议。研究人员对控制糖尿病心血管病风险行动(action to control cardiovascular risk in diabetes,ACCORD)-血压研究及收缩压干预试验(systolic blood pressure intervention trial,SPRINT)进行事后分析,两项研究均随机将患者分为强化或标准收缩压靶目标治疗。 | 赵狄(译) 刘莉(校) Collard D Brouwer TF Engberink RHGO Zwinderman AH Vogt L Born BJH | 2020 | 中华高血压杂志2020，28，5： | 3 |
| 10 | Occurrence of Excess ^40Ar in Amphibole: Implications of ^40Ar/^39Ar Dating by Laser Stepwise Heating and in vacuo Crushing显示文摘The joint methods of ^(40)/^(39)Ar laser stepwise heating and in vacuo crushing have been applied to date amphiboles from the North Qaidam ultra-high pressure metamorphic amphibolites. Two amphibole samples analyzed by laser heating yielded saddle-shaped age spectra with total gas ages of 574.5±2.5 and 562.5±2.5 Ma. These ages are much older than the reported zircon U-Pb ages(~495 Ma) from Yuka eclogite, indicating the presence of excess 40 Ar. In order to decipher the occurrence of excess ^(40) and constrain the age of amphibolite-facies retrogression, two duplicate amphibole samples were further employed for ^(40)Ar/^(39)Ar in vacuo crushing analyses. Both samples exhibit similar monotonically declining release spectra, which are characterized by rapid decline of anomalously old apparent ages in the early steps. The data of the late steps yielded concordant apparent ages with plateau ages of 460.9±1.2 and 459.6±1.8 Ma. We interpret that gases released in the early steps derive from the significant excess ^(40)Ar containing secondary fluid inclusions(SFIs) due to their distribution characteristics along cracks leading to be easily extracted, whereas those released in the later steps represent the contribution of the small primary fluid inclusions(PFIs). | Rong-Guo Hu Xiu-Juan Bai Jan Wijbrans Fraukje Brouwer Yi-Lai Zhao Hua-Ning Qiu | 2018 | Journal of Earth Science2018，29，2： | 3 |
| 11 | 鱼油对植入埋藏式心脏复律除颤器患者室性快速性心律失常及死亡的影响:ω-3脂肪酸与室性心律失常(SOFA)随机化研究 | Brouwer I.A. Zock P.L. Camm A.J. 任付先 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，0，11： | 2 |
| 12 | The firm relocation decision: An empirical investigation显示文摘 | Aleid E. Brouwer Ilaria Mariotti Jos N. van Ommeren | 2004 | The Annals of Regional Science2004，，2： | 2 |
| 13 | Clinical characteristics and outcome of brain abscess: Systematic review and meta-analysis显示文摘 | Matthijs C. Brouwer Jonathan M. Coutinho Diederik van de Beek | 2014 | Neurology2014，，9： | 2 |
| 14 | The use of 4D-CTA in the diagnostic work-up of brain arteriovenous malformations显示文摘 | Peter W. A. Willems Patamintita Taeshineetanakul Barry Schenk Patrick A. Brouwer Karel G. Terbrugge Timo Krings | 2012 | Neuroradiology2012，，2： | 2 |
| 15 | Comparison between three-dimensional speckle-tracking echocardiography and cardiac magnetic resonance imaging for quantification of left ventricular volumes and function显示文摘 | Sebastiaan A. Kleijn Wessel P. Brouwer Mohamed F.A. Aly Iris K. Rüssel Gerben J. de Roest Aernout M. Beek Albert C. van Rossum Otto Kamp | 2012 | European Heart Journal – Cardiovascular Imaging2012，，10： | 2 |
| 16 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 17 | Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients显示文摘 | G Fattovich G Giustina F Degos F Tremolada G Diodati P Almasio F Nevens A Solinas D Mura JT Brouwer H Thomas C Njapoum C Casarin P Bonetti P Fuschi J Basho A Tocco A Bhalla R Galassini F Noventa SW Schalm G Realdi | 1997 | Gastroenterology1997，，2： | 2 |
| 18 | Assessing the costs and benefits of improved land management practices in three watershed areas in Ethiopia显示文摘Unsustainable land use management and the resulting soil erosion are among the most pervasive problems in rural Ethiopia,where most of the country’s people live,jeopardizing food security.Despite various efforts to introduce soil conservation measures and assess their costs and benefits,it is unclear how efficient these measures are from an economic point of view in securing food production.This paper examines the costs and benefits of three soil conservation measures applied in the country in three different rural districts facing different degrees of soil erosion problems using survey data collected from 750 farm households.A production function is estimated to quantify the costs and benefits of more sustainable land use management practices.We show that the soil conservation measures significantly increase productivity and hence food security.Comparing the costs and benefits,the results indicate that implementing soil conservation measures would benefit farm communities in the case study areas through increased grain productivity and food security. | Abonesh Tesfaye Roy Brouwer Pieter van der Zaag Workneh Negatu | 2016 | International Soil and Water Conservation Research2016，4，1： | 2 |
| 19 | 柴北缘鱼卡多硅白云母40Ar/39Ar年代学研究及其外来40Ar来源探讨显示文摘采用激光阶段加热40Ar/39Ar定年技术,选取柴北缘超高压变质带鱼卡地体超高压变质岩及其围岩的6个多硅白云母进行了Ar同位素分析,获得丰富年代学数据。榴辉岩和云母斜长角闪岩多硅白云母具有高Si、高Mg含量的特征,阶段加热给出复杂的表观年龄图谱,总气体年龄(708~534 Ma)和等时年龄(681~513Ma)都明显老于区内榴辉岩锆石U-Pb年龄,暗示样品含大量外来40Ar。相比之下,围岩花岗质片麻岩和白云母石英片岩多硅白云母具有相对低Si高Fe的特征,阶段加热给出平坦的40Ar/39Ar年龄谱,对应坪年龄分别为454和418Ma。构成年龄坪的数据点形成了线性关系良好的反等时线,并获得同坪年龄一致的等时年龄,能与区域地质年龄很好地吻合。坪年龄454Ma解释为花岗质片麻岩冷却到约400℃时的时间,同时也代表了鱼卡变质岩在经历了深俯冲超高压变质作用后,从上地幔折返抬升至中-上地壳深度的时限;片岩多硅白云母坪年龄418Ma纪录的则是区内一次强韧性剪切事件发生的时代。考虑到榴辉岩和斜长角闪岩原岩为变基性玄武岩类,其主要含钾矿物角闪石的Ar封闭稳定性较高,同时在超高压变质过程中,它们处在一个相对封闭和缺乏流体活动的极端地质环境,所以认为鱼卡榴辉岩多硅白云母外来40Ar来自原岩而非后期渗入的流体,属于'继承'40Ar的范畴。 | 胡荣国 邱华宁 Jan WIJBRANS Fraukje BROUWER 王敏 | 2014 | 地学前缘2014，21，1： | 2 |
| 20 | A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice 显示文摘 | De Brouwer B Tetelin C Leroy T | 1997 | Br J Dermatol1997，137，5： | 2 |
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