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| 1 | Role of interleukin-6 in Barrett's esophagus pathogenesis显示文摘Barrett's esophagus (BE) is a metaplastic lesion of the distal esophagus arising as a consequence of chronic gastroesophageal reflux disease. Multiple studies show that BE is associated with increased risk of esophageal adenocarcinoma (EAC). Epidemiological studies and animal models demonstrate that chronic inflammation triggered by repeated exposure to refluxate predisposes to the development of BE and EAC. The chronic inflammation is associated with cytokine alterations. Interleukin 6 (IL-6) is a cytokine that stimulates cell proliferation and apoptosis resistance is frequently increased in different cancers. Importantly, IL-6 and transcriptional factor signal transducer and activator of transcription 3 (STAT3) that is activated by IL-6 are also increased in BE and EAC. This review critically appraises the role of IL-6/STAT3 pathway in progression of BE to EAC from the published evidence currently available. | Katerina Dvorak Bohuslav Dvorak | 2013 | World Journal of Gastroenterology2013，19，15： | 4 |
| 2 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet2014，，9911： | 3 |
| 3 | Single balloon enteroscopy for endoscopic retrograde cholangiography in patients with Roux-en-Y hepaticojejuno anastomosis显示文摘AIM:To evaluate single balloon enteroscopy in diagnostic and therapeutic endoscopic retrograde cholangiography(ERC)in patients with Roux-en-Y hepaticojejunoanastomosis(HJA).METHODS:The study took place from January 2009to December 2011 and we retrospectively assessed 15patients with Roux-en-Y HJA who had signs of biliary obstruction.In total,23 ERC procedures were performed in these patients and a single balloon videoen-teroscope(Olympus SIF Q 180)was used in all of the cases.A transparent overtube was drawn over the videoenteroscope and it freely moved on the working part of the enteroscope.Its distal end was equipped with a silicone balloon that was inflated by air from an external pump at a pressure of≤5.4 kPa.The technical limitations or rather the parameters of the single balloon enteroscope(working length-200 cm,diameter of the working channel-2.8 mm,absence of Albarran bridge)showed the need for special endoscopic instrumentation.RESULTS:Cannulation success was reached in diagnostic ERC in 12 of 15 patients.ERC findings were normal in 1 of 12 patients.ERC in the remaining 11 patients showed some pathological changes.One of these(cystic bile duct dilation)was subsequently resolved surgically.Endoscopic treatment was initialized in the remaining 10 patients(5 with HJA stenosis,2 with choledocholithiasis,and 3 with both).This treatment was successful in 9 of 10 patients.The endoscopic therapeutic procedures included:balloon dilatation of HJA stenosis-11 times(7 patients);choledocholitiasis extraction-five times(5 patients);biliary plastic stent placement-six times(4 patients);and removal of biliary stents placed by us-six times(4 patients).The mean time of performing a single ERC was 72 min.The longest procedure took 110 min and the shortest took34 min.This shows that it is necessary to allow for more time in individual procedures.Furthermore,these procedures require the presence of an anesthesiologist.We did not observe any complications in these 15 patients.CONCLUSION:This method is more demanding than standard endoscopic retrograde cholangiopancreatography due to altered postsurgical anatomy.However,it is effective,safe,and widens the possibilities of resolving biliary pathology. | Bohuslav Kianika Jan Lata Ivo Novotny Petr Dítě Jirí Vaníek | 2013 | World Journal of Gastroenterology2013，19，44： | 2 |
| 4 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | 2014 (9911)2014，，9911： | 2 |
| 5 | Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: a randomised, double-blind phase III trial显示文摘 | Bernard Escudier Anna Pluzanska Piotr Koralewski Alain Ravaud Sergio Bracarda Cezary Szczylik Christine Chevreau Marek Filipek Bohuslav Melichar Emilio Bajetta Vera Gorbunova Jacques-Olivier Bay Istvan Bodrogi Agnieszka Jagiello-Gruszfeld Nicola Moore | 2007 | The Lancet . 2007 (9605)2007，，： | 2 |
| 6 | FOLFOX/FOLFIRI pharmacogenetics:The call for a personalized approach in colorectal cancer therapy显示文摘While 5-fluorouracil used as single agent in patients with metastatic colorectal cancer has an objective response rate around 20%,the administration of combinations of irinotecan with 5-fluorouracil/folinic acid or oxaliplatin with 5-fluorouracil/folinic acid results in significantly increased response rates and improved survival.However,the side effects of systemic therapy such as myelotoxicity,neurotoxicity or gastrointestinal toxicity may lead to life-threatening complications and have a major impact on the quality of life of the patients.Therefore,biomarkers that would be instrumental in the choice of optimal type,combination and dose of drugs for an individual patient are urgently needed.The efficacy and toxicity of anticancer drugs in tumor cells is determined by the effective concentration in tumor cells,healthy tissues and by the presence and quantity of the drug targets.Enzymes active in drug metabolism and transport represent important determinants of the therapeutic outcome.The aim of this review was to summarize published data on associations of gene and protein expression,and genetic variability of putative biomarkers with response to therapy of colorectal cancer to 5-fluorouracil/leucovorin/oxaliplatin and 5-fluorouracil/leukovorin/irinotecan regimens.Gaps in the knowledge identified by this review may aid the design of future research and clinical trials. | Beatrice Mohelnikova-Duchonova Bohuslav Melichar Pavel Soucek | 2014 | World Journal of Gastroenterology2014，20，30： | 2 |
| 7 | Characterization of deoxyribonuclease I immobilized on magnetic hydrophilic polymer particles显示文摘 | Alena Spanova Yuriy Ohlashennyy | 2002 | Journal of Chromatography B2002，774，： | 1 |
| 8 | Magnetic hydrophilic methacrylate-based microspheres for genomic DNA isolation 显示文摘 | JANA Kiizova ALENA Spanova BOHUSLAV Rittich | 2005 | Chromatography A2005，1064，2： | 1 |
| 9 | The Effect of Mn and Si on the Properties of Advanced High Strength Steels Processed by Quenching and Partitioning 显示文摘 | Bohuslav M Hana J Daniela H | 2010 | Materials Science Forum2010，65，： | 1 |
| 10 | Immunomagnetic separation and detection of Salmonella cells using newly designed carriers显示文摘 | Alena ?panová Bohuslav Rittich Daniel Horák Ji??? Lenfeld Jana Prodělalová Jana Su?iková Soňa ?trumcová | 2003 | Journal of Chromatography A2003，，1： | 1 |
| 11 | Determination of neopterin, kynurenine, tryptophan and creatinine in human serum by high throuput HPLC显示文摘 | Krcmova L Dagmar S Bohuslav M | 2011 | Talanta2011，85，： | 1 |
| 12 | Compression and Packing Density of Fibrous Assemblies 显示文摘 | BOHUSLAV N | 1997 | Textile Research Jour- nal1997，67，2： | 1 |
| 13 | Comparison of Microstructures and Properties Obtained After Different Heat Treatment Strategies of High Strength Low Alloyed Steel显示文摘The influence of different heat treatment strategies on the microstructure and properties of 42SiCr steel was investigated.To compare the benefit of innovative treatment methods with more conventional ones,several strategies based on a new quenching and partitioning (Q-P) process were designed together with several strategies using more traditional quenching and tempering process.Different combinations of mechanical properties were obtained with ultimate strengths in the range of 1818-2120 MPa and ductility between 10% and 24%.Resulting microstructures were martensitic with 0-12% of retained austenite and they were analyzed by laser scanning confocal microscopy,transmission electron microscopy and X-ray diffraction phase analysis. | Kuerová Ludmila Jirková Hana Hauserová Daniela Masek Bohuslav | 2011 | Journal of Iron and Steel Research(International)2011，18，S1： | 1 |
| 14 | Complexing agents as modifiers in mineral flotation mechanism studies 显示文摘 | Orthgiess Erhard Dobias Bohuslav | 1994 | Colloids and Surfaces A: Physicochemical and Engineering Aspects1994，，2： | 1 |
| 15 | Multidimensional flow-cytometric analysis of dendritic cells in peripheral blood of normal donors and cancer patients显示文摘 | Cherylyn AS Monica LG Bohuslav M | 1998 | Cancer lmmunol lmmunother1998，45，： | 1 |
| 16 | p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1 显示文摘 | Bohuslav J Chen L F Kwon H | 2004 | J Biol Chem2004，279，26： | 1 |
| 17 | Case Studies In TRIZ: A Novel Heat Exchanger显示文摘 | Bohuslav Busov Darrell Mann Pavel Jirman | 1999 | TRIZ Journal1999，，12： | 1 |
| 18 | Case Studies In TRIZ:A Novel Heat Exchanger显示文摘 | Bohuslav Busov Darrer Mann Pavel Jirman | 1999 | TRIZ Journal1999，，12： | 1 |
| 19 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet . 2014 (9911)2014，，9911： | 1 |
| 20 | Immunomagnetie sepa- ration and detection of SalmoneUa ceils using newly de- signed carriers 显示文摘 | Alena Bohuslav R Daniel H et ai | 2003 | J Chromatogra A2003，，12： | 1 |
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