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| 1 | T2期胆囊癌肿瘤位置和手术范围对预后的影响:一项国际多中心研究显示文摘T2期胆囊癌根据肿瘤位置不同,进一步细分为T2a(腹膜侧)或T2b期(肝脏侧)。既往有研究认为对于腹膜侧(T2a)肿瘤,在不影响预后的情况下可避免肝脏切除,但是目前仍然缺乏可靠的证据。为了探讨肿瘤位置对T2期胆囊癌的预后价值并明确手术切除的适当范围,该研究分析了韩国、日本、智利和美国的14家医院中937例接受胆囊癌手术患者的临床及病理资料。 | Kwon W Kim H Han Y 杨发才(编译) | 2020 | 中华医学杂志2020，100，39： | 21 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 4 | 显示文摘 | Ju H Y Kwon C Li Q | 1995 | Appl Phys Rev Lett1995，75，： | 2 |
| 5 | Thermal and design sensitivity analyses for cooling system of injection mold, part 2: design sensitivity analysis显示文摘 | Park S J Kwon T H | 1998 | Journal of Manufacturing Science and Engineering1998，120，2： | 2 |
| 6 | Giant magnetoresistance in La1-xSrxMnOz films near room temperature显示文摘 | Ju H L Kwon C Qi Li | 1994 | Appl Phys Lett1994，65，： | 2 |
| 7 | White Matter Structure in Autism: Preliminary Evidence from Diffusion Tensor Imaging显示文摘 | Bamea-Goraly N Kwon H Menon V | 2004 | Society of Biological psychiatry2004，55，： | 1 |
| 8 | Effects of thermal and chemical surface-flame interaction on flame quenching显示文摘 | KIM K T LEE D H KWON S | 2006 | Combust and Flame2006，146，： | 1 |
| 9 | On New Stability Criterion for Delay - Differential Systems of Neutral Type 显示文摘 | JU H P KWON O | 2005 | Applied Mathematics and Computation2005，162，： | 1 |
| 10 | Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi:oxysterols block transport by binding to Insig显示文摘 | RADHAKRISHNAN A IKEDA Y KWON H J | 2007 | Proc Natl Acad Sci USA2007，104，： | 1 |
| 11 | Application of DEM model to breakage and liberation behavior of recycled aggregates from impact-breakage of concrete waste显示文摘 | Lee H Kwon J H Kim K H | 2008 | Minerals Engineering2008，，21： | 1 |
| 12 | Clinical characteristics and efficacy of bronchoscopic intervention for tracheobronchial leiomyoma显示文摘 | Kwon YS Kim H Koh WJ | 2008 | Respirology2008，13，6： | 1 |
| 13 | Over expression of CD24:association with invasiveness in urothelial carcinoma of bladder显示文摘 | Choi Y L Lee S H Kwon G Y | 2007 | Arch Pathol Lab Med2007，131，2： | 1 |
| 14 | Oil components modulate physical characteristics and functionof the natural oil emulsions as drug or gene delivery system 显示文摘 | Chung H Kim TW Kwon M | 2001 | J Control Release2001，71，3： | 1 |
| 15 | Bronchioloalveolar Carcinoma:Focal Area of Ground-Glass Attenuation at Thin-section CT as an Early Sign显示文摘 | Jang H J Lee KS Kwon OJ | 1996 | Radiology1996，199，2： | 1 |
| 16 | Forward-backward spatial smoothing techniques for the coherent signal identification显示文摘 | S U Pillai B H Kwon | 1989 | IEEE Trans on ASSP1989，37，1： | 1 |
| 17 | Laparoscopic management of bile duct and bowel injury during laparoscopic cholecystectomy显示文摘 | KWON AH INUI H KAMIYAMA Y | 2001 | World J Surg2001，25，： | 1 |
| 18 | Memoryless H∞ controllers of stste delayed systems显示文摘 | LEE J H KIM S W KWON W H | 1994 | IEEE Trans on Automat Contr1994，39，1： | 1 |
| 19 | Detection of single nucleonucleotide insertion of BCL/ABL region in imatinib-resistance human myelogenous leukemia SR-1 Cells显示文摘 | Park T H Kwon K E Kim H J | 2005 | Exp Mol Med2005，37，5： | 1 |
| 20 | The effect of hyperbaric oxygen on ischemia-reperfusion injury:an experimental study in a rat musculocutaneous flap显示文摘 | Hong JP Kwon H Chung YK | 2003 | Ann Plast Surg2003，51，5： | 1 |
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