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| 1 | Metastatic gastric cancer treatment: Second line and beyond显示文摘Advanced gastric cancer(a GC), not amenable to curative surgery, is still a burdensome illness tormenting afflicted patients and their healthcare providers. Whereas combination chemotherapy has been shown to improve survival and tumor related symptoms in the frontline setting, second-line therapy(SLT) is subject to much debate in the scientific community, mainly because of the debilitating effects of GC, which would impede the administration of cytotoxic therapy. Recent data has provided sufficient evidence for the safe use of SLT in patients with an adequate performance status. Taxanes, Irinotecan and even some Fluoropyrimidine analogs were found to provide a survival advantage in this subset of patients. Most importantly, quality of life measures were also improved through the use of adequate therapy. Even more pertinent were the findings involving antiangiogenic agents, which would add measurable improvements without significantly jeopardizing the patients' well-being. Further lines of therapy are cause for much more debate nowadays, but specific targeted agents have shown considerable promise in this context. We herein review noteworthy published data involving the use of additional lines of the therapy after failure of standard frontline therapies in patients with a GC. | Marwan Ghosn Samer Tabchi Hampig Raphael Kourie Mustapha Tehfe | 2016 | World Journal of Gastroenterology2016，22，11： | 10 |
| 2 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet2014，，9911： | 3 |
| 3 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | 2014 (9911)2014，，9911： | 2 |
| 4 | Green bulb light source induced epoxy cationic polymerization under air using tris (2,2' - bipyridine ) ruthenium ( II) and silyl radicals 显示文摘 | LALEVfiE J BLANCHARD N TEHFE M A | 2010 | Macromolecules2010，43，10： | 1 |
| 5 | Near UV-visible light induced cationic photopolymerization reactions:A three component photoinitiating system based on acridinedione/silane/iodonium salt显示文摘 | Tehfe M A Lalevée J Morlet-Savary F | 2010 | European Polymer Journal2010，46，11： | 1 |
| 6 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet . 2014 (9911)2014，，9911： | 1 |
| 7 | Near UV-visible light induced cationic photopolymerization reactions:a three component photoinitiating system based on acridinedione/silane/iodonium salt显示文摘 | Tehfe M A Lalevée J Morlet-Savary F | 2010 | European Polymer Journal2010，46，11： | 1 |
| 8 | Green chemistry: sunlight-induced cationic polymerization of re- newable epoxy monomers under air 显示文摘 | TEHFE M A LALEVEE J GIGMES D | 2010 | Macromolecules2010，43，3： | 1 |
| 9 | Phase 2, randomized, open-label study of ramucirumab in combination with first-line pemetrexed and platinum chemotherapy in patients with nonsqua- mous, advanced/metastatic non-small cell lung cancer显示文摘 | Doebele RC Splgel D Tehfe M | 2015 | Cancer2015，121，6： | 1 |
| 10 | Subtle Ligand ef{ects in oxidative photocatalysis with iridium complexes: application to photopolymerization 显示文摘 | Lalev6e J Peter M Dumur F Gigmes D Blanchard N Tehfe M A Morlet-Savary F Fouassier J P | 2011 | Chemistry A Euro- pean Journal2011，17，15： | 1 |
| 11 | Phase 2, randomized, open-label study of ramucirumab in combination with first-line pemetrexed and platinum chemotherapy in patients with nonsqua- non-small cell lung cancer显示文摘 | Doebele RC Spigel D Tehfe M | 2015 | Cancer2015，121，6： | 1 |
| 12 | Iridium photocatalysts in free radical photopolymerization under visible lights 显示文摘 | Laleve J Tehfe M A Dumur F Gigmes D Blarmhard N Morlet-Savary F Fouassier J P | 2012 | ACSMacro Letters2012，1，2： | 1 |
| 13 | Green Chemistry : Sunlight-lnduced Cationic Polymerization of Renewable Epoxy Monomers Under Air显示文摘 | MOHAMAD-ALI TEHFE JACQUES LALEVEE DIDIER GIGMES | 2010 | Macromolecules2010，43，： | 1 |
| 14 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet2014，，9911： | 1 |
| 15 | Phase 2, ran?domized, open -label study of ramucirumab in combination with first-line pemetrexed and platinum chemotherapy in patients with nonsquamous, advanced/metastatic non - small cell lung cancer显示文摘 | DOEBELE RC SPIGEL D TEHFE M et ol | 2015 | Cancer2015，121，6： | 1 |
| 16 | Design of new type I and type II photoinitiators possessing highly coupled pyrene-ketone moieties显示文摘 | Tehfe M Dumur F Graff B etal | 2013 | Polymer Chemistry2013，4，7： | 1 |
| 17 | Photoinitiators based on a phenazine scaffold:high performance systems upon near-UV or visible LED(385,395 and 405 nm) ir- radiations 显示文摘 | TEHFE M A DUMUR F XIAO P | 2014 | Polymer2014，55，： | 1 |
| 18 | On the use of bis ( cyclopentadienyl ) titanium ( IV ) dichloride in visible light-induced ring-opening photopoly- merization 显示文摘 | TEHFE M A LALEVfiE J MORLET-SAVARY F | 2012 | Macromolecules2012，45，： | 1 |
| 19 | Green chemistry:sunlight-induced cationic polymerization of renewableepoxy monomers under air显示文摘 | Mohamad-Ali Tehfe Jacques Lalevée Didier Gigmes | 2010 | Macromolecules2010，43，3： | 1 |
| 20 | New insights into radical and cationic polymerizations upon visible light exposure ; role of novel photoinitiator systems based on the pyrene chromophore 显示文摘 | TEHFE M A DUMUR F CONTAL E | 2013 | Polymer Chemistry2013，4，： | 1 |
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